Clinical Research Study Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!

Find a Clinical Research Study

1 - 10 of 200

CureGN Study

Cure Glomerulonephropathy Network (CureGN) is a multi-year study of 2,400 children and adults with four rare glomerular (kidney) diseases at over 50 centers in the US, Canada, and Italy. The purpose of CureGN is to create a patient research network to learn about four major causes of glomerular disease : 1. Minimal Change Disease (MCD) 2. Focal Segmental Glomerulosclerosis (FSGS) 3. Membranous Nephropathy (MN) 4. IgA Nephropathy (IgAN)

Mitochondrial Myopathy Rating Scale

The purpose of this research study is to 1) validate the use of surveys such as fatigue scales, Mitochondrial Disease scales, and quality of life scales, 2) validate clinical exams, such as muscle strength tests, and the 6 minute walk test, and 3) to define the natural history of the disease in the Mitochondrial Disease patient population.

Research Study for Individuals with Hyperinsulinism, Type 1 Diabetes Mellitus, and Healthy Children

Our team is working on a study to better understand neurological problems, including seizures and developmental delays, that occur in children with hyperinsulinism, including HI/HA syndrome, and type 1 diabetes mellitus. The study involves a one day visit to The Children’s Hospital of Philadelphia and The University of Pennsylvania for a specialized magnetic resonance imaging scan (MRI) of the brain, an electroencephalogram (EEG), blood draw, and completion of questionnaires to evaluate development and behavior. The entire study visit is expected to take about five hours. If you are interested in learning more, please contact us at HIResearch@email.chop.edu.

Allo CD7 CAR WU-CART-007

The purpose of this study is to determine the safety and tolerability of an experimental form of therapy, known as WU-CART-007 (“study drug”).  WU-CART-007 uses immune cells, called T cells, that are genetically changed to identify cancer cells. In this study, T cells are collected from a healthy human donor and have been modified in a laboratory. If the genetically changed T cells recognize and attach to cancer cells, they may have the ability to kill those cancer cells.

Patients with T-cell Acute Lymphoblatic Leukemia (T-ALL) or Lymphoblastic Lymphoma (LBL), where the disease has come back (relapsed) or has not responded to treatment (refractory) may be eligible for the study.

Elamipretide for Adult Patients with Primary Mitochondrial Disease

The goal of this study is to evaluate the safety and efficacy of an investigational drug called "Elamipretide" in adult patients with mitochondrial disease. "Investigational" means the study drug has not been approved by the U.S. Food and Drug Administration (FDA) and its use in this study is experimental.

The study will last for approximately 13 months and will include at least 7 outpatient visits at CHOP, where participants will be provided the study drug (randomized to active drug or placebo) and monitored for safety.  The clinical trial also involves blood and urine tests, cardiac tests, physical exercise tests, and other study procedures.  For more information: https://clinicaltrials.gov/ct2/show/NCT05162768

You will also receive travel support and reimbursement for related expenses.

17-SIBS study

The purpose of this research study is to understand the impact of transplant on the quality of life of the entire family including sibling donors, other siblings and parents.

MICRO study

The purpose of this study is to collect and store data samples, such as stool samples, mouth swabs and saliva specimens for research about the microbiome. The microbiome is a collection of the microbes, or very small forms of life, that live on and inside the human body.

Telemedicine in Early Childhood Constraint Therapy in Cerebral Palsy

Children at a higher risk for Cerebral Palsy or children diagnosed with Cerebral Palsy within the age range of 4-13 months (corrected age) are being recruited for an Early Detection study.

For 3-months, two programs will be offered that may help babies with cerebral palsy move and use their arms more like other children at an early age. If you decide to participate, your participation may mean:

  • 6-week telehealth therapy program (with one in-person visit) with our occupational/physical therapist to learn simple exercises to help your baby use their weaker arm. Your baby would also wear a soft mitt on their stronger arm to help them use their weaker arm.
  • 6-week telehealth parent support program, (with one in-person visit) with our counselor to learn more about movement, how babies learn, and parenting tips specifically designed for your family.

  • Two to three total in-person visits to our lab space to complete assessments and answer questions about how your baby is growing




Polyethylene Glycol Safety in Children

This study will measure components or metabolites of PEG 3350 in blood and urine from children who are already taking PEG 3350 and compare these levels to measurements of the same molecules from a group of children who are not taking PEG 3350. PEG 3350 will not be prescribed as part of this study. Participants will complete questionnaires and provide access to their medical records. The study is being conducted in collaboration with Ohio State University and the US Food and Drug Administration.

TACL-2020-003; IDEAL2 study

The purposes of this study is to examine efficacy of the IDEAL2 (Improving Diet and Exercise in ALL) caloric restriction and activity intervention integrated into HR B-ALL induction to reduce incidence of end of induction (EOI) MRD ≥0.01%.


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