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Peter C. Adamson, MD

Chief, Division of Clinical Pharmacology and Therapeutics

Director, Experimental Therapeutics in Oncology

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2009

Widemann BC, Fox E, Adamson PC, Baruchel S, Kim A, Ingle AM, et al. Phase I study of sorafenib in children with refractory solid tumors: a Children's Oncology Group phase I consortium trial [abstract]. ASCO Meeting Abstracts; 2009 May 20, 2009;27(15S):10012-.

Wagner LM, Perentesis JP, Reid JM, Ames MM, Safgren SL, Nelson MD, et al. Phase I trial and pharmacokinetic study of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with refractory solid tumors: a Children's Oncology Group phase I consortium study [abstract]. ASCO Meeting Abstracts; 2009 May 20, 2009;27(15S):10017-.

Malempati S, Weigel B, Ingle AM, Ahern CH, Carroll JM, Roberts CT Jr, et al. A phase I trial and pharmacokinetic study of IMC-A12 in pediatric patients with relapsed/refractory solid tumors: a Children's Oncology Group phase I consortium study [abstract]. ASCO Meeting Abstracts; 2009 May 20, 2009;27(15S):10013-.

Awards

2005, National Cancer Institute Special Recognition Award for Exceptional Service to the Clinical Trials Working Group of the National Cancer Advisory Board.

2004, United States Army Medical Research and Material Command Certificate of Appreciation for Support of the Congressionally Directed Medical Research Programs' Neurofibromatosis Research Program 1999-2004.

2004, United States Army Medical Research and Material Command Certificate of Appreciation for Support of the Congressionally Directed Medical Research Programs' Tuberous Sclerosis Complex Research Program 2002-2004.

1992, Children's Cancer Foundation Research Scholar

1987, The Ritter Award: Overall Excellence in Clinical and Interpersonal Skills

1980, Phi Beta Kappa

1979, The Wesleyan Award: Overall Excellence in Leadership and Scholarship

Books

Chapters

2010

Widemann BC, Adamson PC. Fundamentals of Cancer Chemotherapy. In: Carroll WL, Finlay JL, editors. Cancer in Children and Adolescents. Boston: Jones and Bartlett; 2010. p. 95-112.

2008

Ratain MJ, Humphrey RW, Gordon GB, Fyfe G, Adamson PC, Fleming TR, Stadler WM, Berry DA, Peck CC. Recommended changes to oncology clinical trial design: Revolution or evolution? Eur J Cancer. 2008 Jan;44(1):8-11.

Editorial and Academic Positions

Editorial positions

Editorial board

Journal of Clinical Oncology
Pediatric Blood & Cancer
Pediatric Hematology and Oncology

Reviewer

Blood
Cancer
Cancer Chemotherapy and Pharmacology
Cancer Research
Clinical Cancer Research
Journal of Pediatric Hematology/Oncology
Journal of the National Cancer Institute
Leukemia
Leukemia Research 

Academic positions

2007-present, CHOP Task Force on Industrial Relations Policy
CHOP Research Subject Recruitment Committee
CHOP Grants & Contracts Compliance Sub-committee
CHOP Research Compliance Oversight Committee

Leadership

Memberships in professional organizations

American Society for Clinical Pharmacology and Therapeutics
American College of Clinical Pharmacology
American Association for Cancer Research
American Society of Clinical Oncology
American Society of Pediatric Hematology/Oncology, Board of Directors
Society for Pediatric Research

Participation in national scientific committees

2007-present, Office of the Director, National Cancer Institute, Clinical Trial Advisory Committee

2005-present, NCI Investigational Drug Steering Committee, National Cancer Institute

2001-present, Oncology Drug Advisory Committee (DAC) Pediatric Subcommittee, Food & Drug Administration

2000-present, Chair, Children's Oncology Group Development Therapeutics

Original Papers

2010

Su F, Nicolson SC, Gastonguay MR, Barrett JS, Adamson PC, Kang DS, et al. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesth Analg. 2010 May 1;110(5):1383-92. Cited in PubMed: PMID 20418300.  Read the article

Norris RE, Adamson PC. Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. Cancer Chemother Pharmacol. 2010 May;65(6):1125-30. Epub 2009 Sep 27. Cited in PubMed: PMID 19784838.  Read the abstract

Fouladi M, Park JR, Stewart CF, Gilbertson RJ, Schaiquevich P, Sun J, et al. Pediatric phase I trial and pharmacokinetic study of Vorinostat: A Children's Oncology Group phase I consortium report. J Clin Oncol. 2010 Jul 6. Cited in PubMed: PMID 20606092. Read the abstract

Lipsitz E, Moorthy G, Mosse Y, Fox E, Adamson PC. A sensitive and selective liquid chromatography/tandem mass spectrometry method for determination of MLN8237 in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2369-73. Epub 2010 Jul 3. Read the abstract.

Wagner LM, Perentesis JP, Reid JM, Ames MM, Safgren SL, Nelson MD Jr, et al. Phase I trial of two schedules of vincristine, oral irinotecan, and temozolomi VOIT) for children with relapsed or refractory solid tumors: A Children's Oncology Group phase I consortium study. Pediatr Blood Cancer. Pediatr Blood Cancer. 2010 Apr;54(4):538-45. Read the abstract

Jacobs S, Fox E, Krailo M, Hartley G, Navid F, Wexler L, et al. Days in children and young adults with refractory solid tumors: a report from the Children's Oncology Group. Clin Cancer Res. Epub 2010 Jan 12. Read the abstract

Fox E, Maris JM, Cohn SL, Goodspeed W, Goodwin A, Kromplewski M, et al. Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors. Cancer Chemother Pharmacol. 2010 Sep;66(4):737-43. Epub 2010 Jan 1. Read the abstract

Mondick J, Johnson B, Haberer L, Sale M, Adamson P, Coté C, et al. Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1−48 months. Eur J Clin Pharmacol. [10.1007/s00228-009-0730-8]. 2010;66(1):77-86. Read the abstract

Posters and Presentations

2009

Adamson P. Cancer drug development: 21st century science, 20th century clinical trials [grand rounds]. Texas Children's Cancer Center; 2009 Jan 22; Houston.

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