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Richard Aplenc, MD, PhD, MSCE

Attending physician

Associate professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania


2004-2005, Faculty Teaching Honor Role, The Children's Hospital of Philadelphia
2003, Pfizer Scholar in Training Award, American Association for Cancer Research
2000-2005, Doris Duke Charitable Foundation Clinical Scientist Award
1999-2000, AACR-Bristol-Myers-Squibb Oncology Fellowship in Oncology Research
1998, Fellow Teaching Award, The Children's Hospital of Philadelphia
1997, Senior Resident Teaching Award, UCSD Department of Pediatrics
1993, Geographic Medicine Scholarship, University of Virginia School of Medicine 

Editorial and Academic Positions

Editorial positions

2009-present, Biology of Blood and Marrow Transplantation
2009-present, Journal of the American Medical Association
2009-present, Blood
2007-present, People Living With Cancer (, Editorial Board Member
2007-present, Cancer Research
2007-present, Pediatrics
2006-present, Leukemia
2005-present, Bone Marrow Transplant
2005-present, Annals of Hematology
2005-present, American Journal of Epidemiology
2005-present, Pharmacogenomics
2004-present, Journal of Clinical Oncology
2004-present, Journal of the National Cancer Institute
2003-present, Cancer Epidemiology, Biomarkers and Prevention
2003-present, International Journal of Cancer
2003-present, Pediatric Blood and Cancer
2003-present, Cancer
2002-present, Clinical Cancer Research
2001-present, Medical and Pediatric Oncology
2001-present, Journal of Pediatric Hematology-Oncology

Academic committees

2009-present, Clinical Research Quality Assurance Committee
2007-present, Hematopoietic Malignancies Clinical Steering Committee
2003-present, Certificate Program Working Group, Center for Clinical Epidemiology and Biostatistics
1999-present, Institutional Review Board, The Children's Hospital of Philadelphia


International societies

2004-2008, National Medical Research Council of Singapore, grant reviewer

National societies

American Association for Cancer Research
American Society of Clinical Oncology
American Society of Hematology
2009-present, COG ACCL0934 Study Committee, committee member
2008-present, COG ADVL0812 Study Committee, study chair
2007-present, COG AAML1031 Study Committee, study chair
2005-present, EPIC Study Section, NIH, ad hoc member
2005-present, COG ADVL0516 Study Committee, study chair
2004-2008, NIH Loan Repayment Program Review Committee, member
2004-present, COG AAML0531 Study Committee, study vice chair

Original Papers


Sutton RM, Niles D, Meaney PA, Aplenc R, French B, Abella BS, et al. Low-dose, high-frequency CPT training improves skill retention of in-hospital pediatric providers. Pediatrics. 2011 Jul;128(1):e145-51. Epub 2011 Jun 6. Cited in PubMed; PMID 21646262. Read the abstract

Rushefski M, Aplenc R, Meyer N, Li M, Feng R, Lanken PN, et al. Novel variants in the PRDX6 gene and the risk of acute lung injury following major trauma. BMC Med Genet. 2011 May 31;12:77. Cited in PubMed; PMID 2167785. Read the article

Sepe DM, McWilliams T, Chen J, Kershenbaum A, Zhao H, La M, et al. Germline genetic variation and treatment response on CCG-1891. Pediatr Blood Cancer. 2011 May 25. DOI: 10.1002/pbc.23192. Cited in PubMed; PMID 21618417. Read the abstract

Aplenc R, Blaney SM, Strauss LC, Balis FM, Shusterman S, Ingle AM, et al. Pediatric phase I trial and pharmacokinetic study of dasantinib: a report from the Children's Oncology Group phase I consortium. J Clin Oncol. 2011 mar 1; 29(7):839-44. Epub 2011 Jan 24. Cited in PubMed; PMID 21263099. Read the abstract 

Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, et al. ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med. 2011 May 15;183(10):1344-53. Epub 2011 Jan 21. Cited in PubMed; PMID 21257790. Read the abstract

Mao JJ, Su HI, Feng R, Donelson ML, Aplenc R, Rebbeck TR, et al. Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors. Breast Cancer Res. 2011 Jan 20;13(1):R8. Epub ahead of print. Cited in PubMed; PMID 21251330. Read the article

Johnson KA, Aplenc R, Bagatell R. Survival by race among children with extracranial solid tumors in the United States between 1985 and 2005. Pediatr Blood Cancer. 2011 mar;56(3):425-31. Cited in PubMed; PMID 21072824. Read the abstract 


Fox E, Aplenc R, Bagatell R, Chuk MK, Dombi E, Goodspeed W, et al.  A phase 1 trial and pharmacokinetic study of cediranib, an oral bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors. J Clin Oncol. 2010 Dec 10;28(35):5174-81. Epub 2010 Nov 8. Cited in PubMed; PMID 21060028. Read the abstract 

Fisher BT, Zaoutis TE, Leckerman KH, Localio R, Aplenc R. Risk factors for renal failure in pediatric patients with acute myeloid leukemia: a retrospective cohort study. Pediatr Blood Cancer. 2010 Oct;55(4):655-61. Cited in PubMed; PMID 20533519. Read the abstract

Aplenc R. Steps forward in neuroblastoma genetic epidemiology. Pediatr Blood Cancer. 2010 Aug;55(2):222-3. No abstract available.

Fisher BT, Zaoutis TE, Leckerman KH, Localio R, Aplenc R. Risk factors for renal failure in pediatric patients with acute myeloid leukemia: a retrospective cohort study. Pediatr Blood Cancer. 2010 Jun 8. Read abstract 

Sutton RM, Niles D, Meaney PA, Aplenc R, French B, Abella BS, et al. Booster training: evaluation of instructor-led bedside cardiopulmonary resuscitation skill training and automated corrective feedback to improve cardiopulmonary resuscitation compliance of pediatric basic life support providers during simulated cardiac arrest. Pediatr Crit Care Med. 2011 May;12(3):e116-21. Read abstract

Gor PP, Su HI, Gray RJ, Gimotty PA, Horn M, Aplenc R, et al. Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study. Breast Cancer Res. 2010;12(3):R26. Epub 2010 May 10. Read abstract.

Ginsberg JP, Aplenc R, McDonough J, Bethel J, Doyle J, Weiner DJ. Pre-transplant lung function is predictive of survival following pediatric bone marrow transplantation. Pediatr Blood Cancer. 2010 Mar;54(3):454-60. Read abstract. 


Guerrouahen BS, Wieder E, Blanchard EG, Lee FY, Aplenc R, Corey SJ. Flow cytometric determination of Src phosphorylation in pediatric patients treated with dasantinib. Pediatr Blood Cancer. 2009 Dec;53(6):1132-5. Cited in PubMed; PMID 19484755. Read the article

Fisher BT, Aplenc R, Localio R, Leckerman KH, Zaoutis TE. Cefepime and mortality in pediatric acute myelogenous leukemia: a retrospective cohort study. Pediatr Infect Dis J. 2009 Nov;28(11):971-5. Cited in PubMed; PMID 19859014. Read the abstract

Rajić V, Aplenc R, Debeljak M, Prestor VV, Karas-Kuzelicki N, Mlinaric-Rascan I, et al. Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood. Leuk Lymphoma. 2009 Oct;50(10):1693-8. Read abstract.

Lehrnbecher T, Ethier MC, Zaoutis T, Creutzig U, Gamis A, Reinhardt D, et al. International variations in infection supportive care practices for paediatric patients with acute myeloid leukemia. Br J Haematol. 2009 Oct;147(1):125-8. Epub 2009 Aug. Cited in PubMed; PMID 19663826. Read the abstract

 Reddy AJ, Christie JD, Aplenc R, Fuchs B, Lanken PN, Kleeberger SR. Association of human NAD(P)H: quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury. J Cell Mol Med. 2009 Aug;13(8B):1784-91. Cited in PubMed; PMID 19017358. Read the article

DeMichele A, Gray R, Horn M, Chen J, Aplenc R, Vaughan WP, Tallman MS. Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer. Cancer Res. 2009 May 15;69(10):4184-91. Epub 2009 May 12. Cited in PubMed; PMID 1943522. Read the article

Sung L, Alibhai SM, Beyene J, Gamis A, Almeida R, Smith S, et al. Hematopoietic colony-stimulating factor priming does not influence survival in acute myeloid leukemia: a meta-analysis of randomized trials. Leukemia. 2009 Apr;23(4):811-3. Epub 2008 Nov 6. Cited in PubMed; PMID 18987652. No abstract available.

Posters and Presentations

Aplenc R. Stem cell transplantation in pediatric AML: the American perspective [presentation]. 2009 Mar.

Aplenc R. Acute lymphoblastic leukemia [presentation]. American Austrian Foundation; 2009 Mar; Salzburg, Austria.

Aplenc R. Acute myeloid leukemia [presentation]. American Austrian Foundation; 2008 Oct; Salzburg, Austria.

Aplenc R. Clinical trials [presentation]. American Austrian Foundation; 2008 Oct; Salzburg, Austria.

Aplenc R. Pediatric lymphoma [presentation]. American Austrian Foundation; 2008 Oct; Salzburg, Austria.

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