Robert N. Baldassano, MD

Robert N. Baldassano, MD, is a board certified pediatric gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition, and is director of the Center for Pediatric Inflammatory Bowel Disease at The Children's Hospital of Philadelphia. He holds the Colman Chair and Professorship in Inflammatory Bowel Diseases at CHOP.

Locations: Main Campus; CHOP Pediatric Care at Abington Memorial Hospital; Specialty Care, Abington
Phone: 215-590-3630

  • Education and Training

    Medical School

    MD - SUNY Health Science Center at Brooklyn, College of Medicine, Brooklyn, NY

    Residency

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    Pediatric Gastroenterology and Nutrition (clinical and research fellowships) - The Children's Hospital of Philadelphia

    Board Certification

    Diplomate, National Board of Medical Examiners
    Pediatric Gastroenterology and Nutrition
    Pediatrics

    Undergraduate Degree

    BS - State University at Albany, Albany, NY

  • Titles and Academic Titles

    Co-Director, Center for Pediatric Inflammatory Bowel Disease

    Colman Family Chair in Pediatric Inflammatory Bowel Disease, CHOP

    Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Research Interests

    Pediatric inflammatory bowel disease

  • Publications

    Books

    Mamula P, Markowitz J, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease 2nd Edition. Mamula P, Markowitz J, Baldassano RN (eds.). Springer Science+Business Media, New York, NY, 2012.

    Mamula P, Markowitz J, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease. Mamula P, Markowitz J, Baldassano RN (eds.). Springer Science+Business Media, New York, NY, 2008.

    Chapters

    2013

    Albenberg L, Baldassano RN: What is the Current Understanding of the Etiology of Inflammatory Bowel Disease? Curbside Consultation in Pediatric GI: 49 Clinical Questions. Rosh J, Bousvaros A (eds.). Slack, Inc., Thorofare, NJ, 2013 Notes: in press.

    Albenberg L, Kelsen J, Baldassano RN: Pediatric Issues in Treating Ulcerative Colitis. Medical Therapy of Ulcerative Colitis. Lichtenstein GR (eds.). Springer, NY, 2013 Notes: In press.

    Grossman AB, Baldassano RN: Inflammatory Bowel Disease. Nelson Textbook of Pediatrics, 20th Edition. Kliegman R, Stanton B, St. Geme J, Schor N. (eds.). Elsevier, Inc., Philadelphia, PA, Chapter 328, 2013 Notes: submitted.

    Grossman AB, Baldassano RN.: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 20th Edition. Kliegman R, Stanton B, St. Geme J, Schor N. (eds.). 2013 Notes: submitted.

    Kelsen J, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Crohn's Disease. The Complete Guide to Medical Management, 2nd Edition. Lichtenstein GR (eds.). 2013 Notes: in press.

    2011

    Ghanem LR, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Inflammatory Bowel Disease. Crohn's Disease: The Complete Guide to Medical Management. Lichtenstein GR (eds.). Slack, Inc., Thorofare, NJ, Apr 2011 Notes: Chapter 5.

    Ghanem LR, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Inflammatory Bowel Disease. Ulcerative Colitis: The Complete Guide to Medical Management. Lichtenstein GR (eds.). Slack, Inc., Thorofare, NJ, Apr 2011 Notes: Chapter 5.

    Kelsen J, Hunter A, Baldassano RN: Pediatric Therapies in Inflammatory Bowel Disease. Advanced Therapy in Inflammatory Bowel Disease, 3rd Edition Vol 2: IBD and Crohn's Disease, Crohn's Disease Therapy. Bayless TM, Hanauer SB (eds.). People's Medical Publishing House-USA August 2011.

    Grossman AB and Baldassano RN: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 329), 1304, 2011.

    Grossman AB and Baldassano RN: Inflammatory Bowel Disease. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328), 1294-1295, 2011.

    Grossman AB and Baldassano RN: Chronic Ulcerative Colitis. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328.1), 1295-1300, 2011.

    Grossman AB and Baldassano RN: Crohn Disease (Regional Enteritis, Regional Ileitis, Granulomatous Colitis). Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328.2), 1300-1304, 2011.

    2008

    Grant SF, Baldassano RN, Hakonarson H: Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene. Expert Rev Mol Diagn 8(2): 199-207, Mar 2008.

    Jacobstein D, Baldassano RN: Crohn Disease. The 5-Minute Pediatric Consult, 5th Edition. Schwartz MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 228-229, 2008.

    Jacobstein D, Baldassano RN: Inflammatory Bowel Disease. Pediatric Gastroenterology: The Requisites in Pediatrics. Liacouras CA, Piccoli DA (eds.). Mosby Elsevier, Philadelphia, PA, Page: 131-136, 2008.

    2007

    Kelsen J, Baldassano RN: Inflammatory Bowel Disease: The Difference between Children and Adults, Inflammatory Bowel Disease: Epidemiology, Pathogenesis, Diagnosis and Management 2007 Notes: Fiorcchi C, Katz J, Prantera C, Thomson A

    2006 

    Jacobstein D, Baldassano RN. Pediatric considerations in medical therapy in patients with ulcerative colitis and Crohn’s disease. In: Lichtenstein GR, editor. Inflammatory bowel disease: The complete guide to medical management. Philadelphia: Slack Inc.; 2006.

    2004

    Mamula P, Markowitz J, Baldassano RN. Clinical features and natural history of pediatric inflammatory bowel disease (Chapter 21). In: Sartor RB, Sandborn WJ, editors. Kirsner’s inflammatory bowel diseases. 6th ed. Philadelphia: Saunders Company; 2004. p. 301-315.

    Russo P, Brown K, Baldassano RN. Colitis in childhood (Chapter 5). In: Russo P, Rucchelli ED, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag Inc.; 2004. p. 100-127.

    2003

    Batres AL, Baldassano RN. Evaluation of the patient suspected of having inflammatory bowel disease (Chapter 16). In: Lichtenstein GR, editor. The clinical guide to inflammatory bowel disease. Thorofare: Slack Inc.; 2003. p. 315-324.

    Batres AL, Baldassano RN. Special considerations for the pediatric and adolescent patients with inflammatory bowel disease (Chapter 17). In: Lichtenstein GR, editor. The clinical guide to inflammatory bowel disease. Thorofare: Slack Inc.; 2003. p. 325-342.

    Mamula P, Markowitz J, Baldassano RN. Clinical features and natural history of pediatric inflammatory bowel disease In: Sandborn WJ, Sartor RB, editors. Kirsner’s inflammatory bowel disease. 6th ed. Philadelphia: Saunders Company; 2003.

    1999

    Baldassano RN. Crohn’s disease. In: Schwartz MW, editor. The 5-minute pediatric consult. 2nd ed. Baltimore: Williams & Wilkins; 1999. p. 290-291.

    Baldassano RN. Ulcerative colitis. In: Schwartz MW, editor. The 5-minute pediatric consult. 2nd ed. Baltimore: Williams & Wilkins; 1999. p. 846-847

    1997

    Baldassano RN. Inflammatory bowel disease. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed.  Philadelphia: Mosby-Year Book, Inc.; 1997. p. 543-547. 

    Kelsen J, Baldassano RN: Pediatric Considerations In Medical Therapy in Patients with Ulcerative Colitis. The Complete Guide to Medical Management, 2nd Edition. Lichtenstein GR (eds.). 2013 Notes: in press.

    Abstracts

    2013

    Baldassano RN, Colletti R, Cucchiara S, Dubinsky M, Escher J, Faubion W, Fell J, Gold B, Griffiths A, Hyams J, Koletzko S, Kugathasan S, Markowitz J, Ruemmele F, Veereman G, Callegari P, Molenda M, Tang KL, Wright R, Geldhof A, Winter H.: Serious infections and associated risk factors in patients receiving infliximab and immunotherapies for children with inflammatory bowel disease: DEVELOP Registry Data.   8th Congress of the European Crohn's and Colitis Organisation (ECCO), Vienna, Austria.  Feb 14-16 2013.

    Colletti R, Cucchiara S, Dubinsky M, Escher J, Faubion W, Fell J, Gold B, Griffiths A, Hyams J, Koletzko S, Kugathasan S, Winter H, Baldassano RN, Markowitz J, Ruemmele F, Callegari P, Goldhof A, Molenda M, Tang KL, Wright R, Veereman G. : Malignancies in children receiving infliximab and other inflammatory bowel disease therapies: An inflammatory bowel disease multicenter, prospective, long-term registry of pediatric patients (DEVELOP) registry data. Poster Presentation. 8th Congress of the European Crohn's and Colitis Organisation (ECCO), Vienna, Austria. Feb 14-16 2013.

    Albenberg L, Judge CP, Esipova TV, Sinha R, Bailey AG, Bittinger K, Grunberg S, Chen J, Bhopale VM, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov S, Wu GD.  : Biological oximetry using phosphorescence quenching reveals a dynamic oxygen equilibrium maintained between the gut microbiota and the host.  American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology 144(5; S1): S-156-157, May 2013.

    Baldassano RN, Colletti RB, Cucchiara S, Dubinsky M, Escher JC, Faubion WA, Fell J, Gold BD, Griffiths AM, Hyams JS, Koletzko S, Kugathasan S, Markowitz J, Ruemmele F, Veereman G, Callegari P, Geldhof A, Molenda MR, Wright R, Tang KL, Winter HS.: Serious infections and associated risk factors in patients receiving infliximab and immunotherapies for children with inflammatory bowel disease: DEVELOP Registry Data. American Gastroenterological Association:  American Gastroenterological Association; Digestive Disease Week 2013, Orlando, FL, May 19-21; Gastroenterology 144(5; S1): S-11, May 19-21 2013.

    Colletti RB, Cucchiara S, Dubinsky M, Escher JC, Faubion WA, Fell J, Gold BD, Griffths AM, Hyams JS, Koletzko S, Kugathasan S, Winter HS, Baldassano RN, Markowitz J, Ruemmele F, Callegari P, Geldhof A, Molenda MR, Tang KL, Wright R, Veereman G. : Malignancies in children receiving infliximab and other inflammatory bowel disease therapies: An inflammatory bowel disease multicenter, prospective, long-term registry of pediatric patients (DEVELOP) registry data.  American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology 144(5; S1): S-147, May  2013.

    Haberman Y, Jurickova I, Dexheimer PJ, Karns R, Tang D, Bonkowski EL, Fey B, Noe JD, Markowitz J, Heyman MB, Crandall W, Snapper SB, Kellermayer R, Kappelman M, Rosh JR, Otley AR, Pfefferkorn MD, Cohen SA, Patel AS, Kirschner BS, Baldassano RN, Dubinsky M, Walters TD, Aronow BJ, Denson L.  : Ileal RNA-Seq analyses reveal decreased mucosal myeloid cell immune responses in pediatric Crohn disease patients with phagocyte dysfunction due to neutralizing granulocyte macrophage colony stimulating factor (GM-CSF) auto-antibodies. Poster Presentation. American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013.  Gastroenterology 144(5; S1): S-708-709, May 2013.

    Hyams JS, Kim M, Denson L, Griffiths AM, Dubinsky M, Markowitz J, Baldassano RN, Crandall W, Rosh JR, Pfefferkorn MD, Otley AR, Heyman MB, Leleiko NS, Baker SS, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens MC, Mack DR, Oliva-Hemker M, Essers JB, Patel AS, Kirschner BS, Moulton E, Cohen SA, Liu C, Kugathasan S, Walters TD.: Early anti-TNFa therapy is superior to early immunomodulator therapy in newly diagnosed children with Crohn's disease. American Gastroenterological Association; Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology  144(5; S1): S-146, May 2013.

    Kelsen JR, Posivak L, Pauly-Hubbard H, Baily AG, Bittinger K, Grunberg S, Baldassano RN, Lewis JD, Bushman FD, Wu GD. : Longitudinal characterization of the subgingival microbiota in pediatric Crohn's disease. Poster Presentation. American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology  144(5; S1): S-309-310, May 2013.

    Kugathasan S, Dubinsky M, Guthery SL, Okou DT, Bose P, Zwick ME, Cutler DJ, Waters JP, Hymans JS, Baldassano RN, Stephens MC, Heyman MB, Griffths AM, Crandall W, Markowitz J, Essers JB, Snapper SC, Walters TD, Aronow BJ, Denson L.: Early onset Crohn's disease exhibit distinct allele architecture differences and reveal new IBD loci.   American Gastroenterological Association; Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013. Gastroenterology  144(5; S1): S-178, May 2013.

    Baldassano RN, Ruemmele F, Rosh J. Faubion WA, Kierkus J, Hyams JS, Lazar A, Wang Y, Eichner S, Thakkar RB. : Long-term safety of adalimumab in paediatric patients with Crohn's disease.  United European Gastroenterology (UEG) Week Berlin 2013, Berlin, Germany Oct 12-16 2013.Griffiths A, Baldassano RN, Walters T, Bronksy J, Hyams JS, Lazar A, Wang Y, Eichner S. Thakkar RB. : Improvement in markers of bone metabolism with adalimumab in children with moderately to severely active Crohn's disease: Results from Imagine 1.   United European Gastroenterology (UEG) Week Berlin 2013, Berlin, Germany Oct 12-16 2013.

    Kierkus J, Crandall W, Hyams JS, Rosh J, Markowitz J, Baldassano RN, Lazar A, Wang Y, Eichner S, Thakkar RB.: Early response to treatment with adalimumab in children with moderately to severely active Crohn's disease: Results from Imagine 1.   United European Gastroenterology (UEG) Week Berlin 2013, Berlin, Germany Oct 12-16 2013.

    2012

    Hyams J, Griffiths A, Markowitz J, Baldassano RN, Lazar A.: Induction and maintenance adalimumab therapy for the treatment of moderate to severe Crohn's disease in children. 2012 Canadian Digestive Diseases Week (CDDW), Montreal, Quebec, Canada. Feb 24-27 2012.

    Flint RA, Jarvis HW, Overton MH, Baldassano RN, Kim SC.: Characterization of mucosally-adherent Escherichia coli in pediatric inflammatory bowel disease patients. Poster Presentation. American Gastroenterological Assocation; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S-373, May 2012.

    Hyams JS, Kim M, Denson L, Stephens MC, Markowitz J, Griffiths AM, Crandall W, Essers JB, Baldassano RN, Dubinsky M, Rosh JR, Pfefferson MD, Kim SC, Otley AR, Kellermayer R, Heyman MB, Leleiko NS, Baker SS, Guthery SL, Evans J, Ziring D, Kugathasan S, Walters TD.: Effect of deep ulceration at diagnostic colonoscopy on initial therapy and one year outcome in children with Crohn's disease. American Gastroenterological Assocation; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S-36, May 2012.

    Overton M, Jarvis W, Flint R, Baldassano RN, Kim SC.: Quantification and characterization of Klebsiella pneumoniae in pediatric patients with inflammatory bowel disease. Poster Presentation. American Gastroenterological Association; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S373-374, May 2012.

    Walters TD, Dubinsky M, Griffiths AM, Baldassano RN, Hyams JS, Stephens MC, Markowitz J, Crandall W, Heyman MB, Kellermayer R, Mack DR, Oliva-Hemker M, Patel AS, Kirschner BS, Moulton DE, Cohen SA, Aronow B, Denson L, Kugathasan S. : Anti-microbial serology patterns in 824 children with newly diagnosed Crohn's disease: Association with GM-CSF auto-antibodies and specific clinical phenotypes. American Gastroenterological Association; Digestive Disease Week 2012. Gastroenterology 142(5; S1): S36-37, May 2012.

    Albenberg L, Spengler C, Klink A, Mattei P, Baldassano RN, Mamula P, Kelsen JR.: Diverting ileostomy for the treatment of severe refractory indeterminate colitis. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 203, Oct 2012.

    Gold BD, Kirschner BS, Cohen SA, O'Conner S, Heyman MH, Ferry GD, Baldassano RN, Garnett EA, Thompson AD, Tierney M, Yakrus MA, Winter HS. : Molecular analysis of Mycobacterium Avium Subspecies Paratuberculosis(MAP) in mucosal biopsies from treatment naïve children with IBD and controls Poster presentation. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 205, Oct 2012.

    Judge CP, Albenberg LG, Esipova T, Grunberg S, Chen J, Li H, Baldassano RN, Lewis JD, Bushman FD, Vinogradov SA, Wu GD.: An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 237, Oct 2012.

    Judge CP, Lee DY, Long J, Zemel BS, Baldassano RN, Leonard MB.: Children with Crohn disease continue to exhibit inflammatory cachexia despite advances in therapies. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55 (S1): 197, Oct 2012.

    Kaplan J, Bhasin M, Gold BD, Kirschner BS, Ward NL, Cohen SA, Heyman MB, Ferry GD, Baldassano RN, Moran CJ, Steven B, Garnett EA, Tierney MP, Drake L, Dowd SE, Cox SB, Mir SA, Kellermayer R, Libermann TA, Winter HS. : Ileal mucosa-associated microbiota changes in children with newly diagnosed, treatment-naïve Crohn's Disease. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 205, Oct 2012.

    Kelsen JR, Posivak L, Grunberg S, Bailey A, Baldassano RN, Lewis J, Bushman F, Wu G.: The oral microbiome in pediatric Crohn Disease. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 235, Oct 2012.

    Lee D, Kachelries KE, Gupta K, Lorusso M, Whitehead KM, Herskovitz RM, Leonard MB, Baldassano RN.: The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn's Disease. Poster of Distinction Award. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 295, Oct 2012.

    Lee D, Kachelries KE, Gupta K, Lorusso M, Whithead KM, Herskovitz RM, Leonard MB, Baldassano RN. : The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn's disease. Poster Presentation. Food and Nutrition Conference and Expo (FNCE), Academy of Nutrition and Dietetics Annual Conference, Philadelphia, PA Oct 6-9 2012.

    Lee D, Lorusso M, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Baldassano RN, Lewis J.: Response to enteral nutritional therapy versus anti-TNFS in pediatric Crohn's Disease. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 202, Oct 2012.

    Lorusso M, Lee D, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Lewis J, Baldassano RN. : Children with Crohn's Disease on 100% vs. 80% enteral nutritional therapy: Interim analysis of a prospective cohort study. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 234, Oct 2012.

    Procopi T, Zimmerman A, Grossman A, Baldassano RN.: Infusion and post-infusion reactions to infliximab in pediatric inflammatory bowel disease patients. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 227, Oct 2012.

    Zahm AM, Baldassano RN, Friedman J. : Rectal micro RNA levels are altered in pediatric ulcerative colitis. Poster Presentation. NASPGHAN Annual Meeting, Salt Lake City, UT. JPGN 55(S1): 217, Oct 2012.

    Cardinale CJ, Panossian S, Wang F, Frackelton EC, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H.: Targeted resequencing identifies secretion-defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease. 62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA. Poster Presentation. Nov 6-10 2012.

    Kao C, Wei Z, Li J, Wang W, Glessner J, Cardinale C, Bradfield J, Frackelton E, Kim C, Mentch F, Qui H, Grant S, Baldassano RN, Hakonarson H and The International IBD Genetics Consortium: Pathway-based meta analysis of ulcerative colitis genome-wide association studies. 62nd Annual Meeting of the American Society of Human Genetics, San Francisco CA. Poster Presentation. Nov 6-10 2012.

    Pandey R, Cardinale CJ, Panossian S, Wang F, Frackelton E, Kim C, Mentch F, Chiavacci R, Kachelries K, Grant S, Baldassano RN, Hakonarson H.: Functional characterization of DcR3 and NF-kB in EBV transformed cell lines from IBD patients of different allelic background and role in disease pathogenesis 62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA. Poster Presentation. Nov 6-10 2012.

    Wei Z, Wang W, Bradfield J, Frackelton E, Kim C, Mentch F, Baldassano RN, Hakonarson H and The International IBD Genetics Consortium : Large-sample size, comprehensive catalog of variants and advanced machine learning technique boost risk prediction for inflammatory bowel disease. 62nd Annual Meeting of the American Society of Human Genetics, San Franciso, CA Nov 6-10 2012.

    Albenberg L, Judge C, Esipova T, Grunberg S, Chen J, Baldassano RN, Lewis J, Bushman F, Vinogradov S, Wu G. : An oxygen equilibrium at the host-microbial interface determined by phosporescent nanoprobe technology. Poster Presentation. 2012 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012. Inflamm Bowel Dis. 18(S)(12): S112,P-257, Dec 2012.

    Kelsen J, Posivak L, Bailey A, Grunberg S, Baldassano RN, Lewis J, Bushman F, Wu G.: The subgingival oral microbiome in pediatric patients with Crohn's Disease. 2012 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's National Clinical & Research Conference, Hollywood, FL, Dec 13-15,2012. Poster presentation. Inflamm Bowel Dis. 18(S)(12): S61,P-117, Dec 2012.

    Zahm A, Tsoucas D, Baldassano RN, Friedman J.: MicroRNA-regulated pathways in pediatric IBD. 2012 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation's National and Clinical Research Conference, Hollywood, FL, Dec 13-15, 2012. Oral and Poster presentations. Inflamm Bowel Dis. 18(S)(12): S7,O-15 and S103,P-226, Dec 2012 Notes: Crohn's & Colitis Foundation's National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.

    Papers

    2015

    Griffin LM, Thayu M, Baldassano RN, DeBoer MD, Zemel BS, Denburg MR, Denson LA, Shults J, Herskovitz R, Long J, Leonard MB. Improvements in bone density and structure during anti-TNF-α therapy in pediatric Crohn’s disease. J Clin Endocrinol Metab, April 28, 2015.  jc20144152 [Epub ahead of print].  PMID: 25919459.

    Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonenberg GF.  Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ Tcells. Science, April 23, 2015.  pii:aaa4812. [Epub head of print].  PMID: 25908663.

    Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest, 125(3):1363, March 2 2015. doi: 10.1172/JC179657. Epub March 2 2015.  PMID: 25729854.

    Lee D, Albenberg L, Compher C, Baldassano RN, Piccoli D, Lewis JD, Wu GD.  Diet in the pathogenesis and treatment of inflammatory bowel diseases.  Gastroenterology, 15 Jan 2015.  Pii: S0016-5085(15)00069-4. Doi: 10.1053/j.gastro.2015.01.007. [Epub ahead of print]. PMID: 25597840.

    Gray WN, Boyle SL, Graef DM, Janicke DM, Jolley CD, Denson LA, Baldassano RN, Hommel KA. Health-related quality of life in youth with Crohn’s disease.  J Pediatr Gastroenterol Nutr, 5 Jan 2015. [Epub  ahead of print]. PMID: 25564807.

    Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium; Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD, [Collaborators 168: Baldassano RN].  High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.  Nat Genet, 47(2):172-9, Feb 2015.  doi: 10.1038/ng.3176.  Epub Jan 5 2015.  PMID: 25559196.

    2014

    Kelsen JR, Grossman AB, Pauly-Hubbard H, Gupta K, Baldassano RN, Mamula P. Infliximab therapy in pediatric patients 7 years of age and younger.  J Pediatr Gastroenterol Nutr, 59(6):758-62,Dec 2014.  doi: 10.1097/MPG.  PMID: 25419596.

    Turner D, Doveh E, Cohen A, Wilson ML, Grossman AB, Rosh JR, Lu Y, Bousvaros A, Deslandres C, Noble A, Baldassano RN, Levine A, Lerner A, Wilson DC, Griffths AM. Efficacy of oral methotrexate in paediatric Crohn’s disease: a multicenter propensity score study. Gut, Nov 21, 2014, pii:gutjnl-2014-307964. doi: 10.1136/gutjnl-2014-307964. [Epub ahead of print].  PMID: 25416066.

    Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA.  Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest, 124(8):3617-33, Aug 2014, doi: 10.1172/JC175436. Epub Jul 8 2014. Erratum in: J Clin Invest,125(3):1363, March 2, 2015.  PMID: 25003194.

    Boyle BM, Kappelman MD, Colletti RB, Baldassano RN, Milov DE, Crandall WV. Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease.  World J Gastroenterol, 20(27):9185-90, July 21, 2014, doi. 10.3748/wjg.v20.i27.9185. PMID 25083093.

    Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD.  Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota in humans and mice.  Gastroenterology, Jul 18 2014, pii: S0016-5085(14)00916-0, doi: 10.1053/j.gastro.2014.07.020. [Epub ahead of print]. PMID: 25046162.

    Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of neutrophil Fcy receptor l (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn’s disease. Inflamm Bowel Dis, 20(6):1037-48, June 2014.  PMID: 24788216.

    Cardinale CJ, Wei Z, Li J, Zhu J, Gu M, Baldassano RN, Grant SF, Hakonarson H: Transcriptome profiling of human ulcerative colitis mucosa reveals altered expression of pathways enriched in genetic susceptibility loci. PLoS One, 9(5): May 1, 2014, e96153.doi:10.1371/journal.pone.0096153. eCollection 2014. PMID 24788701; PMCID: PMC4006814.

    Tsampalieros A, Berkenstock MK, Zemel BS, Griffin L, Shults J, Burnham JM, Baldassano RN, Leonard MB.  Changes in trabecular bone density in incident pediatric Crohn disease: A comparison of imaging methods.  Osteoporosis Int., 25(7):1875-83, Jul 2014, doi: 10.1007/s00198-014-2701-x. Epub 2014 April 24. PMID: 24760243.

    Gevers D, Kugathasan S, Denson LA, Vazquez-Baeza Y, Van Treuren W…Baldassano RN, et al. The treatment-naïve microbiome in new-onset Crohn’s disease.  Cell Host Microbe, 15(3):382-392, March 12, 2014.  doi:10.1016/j.chom.2014.02.005. PMID: 24629344.

    Augustine MV, Leonard MB, Thayu M, Baldassano RN, et al.  Changes in Vitamin-D-related mineral metabolism after induction with anti-tumor necrosis factor-α therapy in Crohn’s disease.  J Clin Endocrinol Metab, 99(6):E991-8, Jun 2014, doi: 10.1210/jc.2013-3846. Epub March 11 2014. PMID: 24617709.      

    Zahm AM, Hand NJ, Tsoucas DM, Le Guen Cl,  Baldassano RN, Friedman JR.  Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon.  J Crohns Colitis, March 6, 2014, pii: S1873-9946(14)00061-0, doi: 10.1016/j.crohns.2014.02.012. [Epub adhead of print].  PMID: 24613022.

    Fish S, Baldassano RN.  Can we change the natural history of Crohn’s disease? “Are we under- or mistreating patients at the time of presentation?” Dig Dis, 32(4):364-9, 2014, doi 10.1159/000358139. Epub Jun 23 2014.  PMID: 24969281.

    Walters TD, Kim MO, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano RN…Hyams JS; PRO-KIIDS Research Group.  Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn’s disease.  Gastroenterology, 146(2):383-91, Feb 2014.  doi: 10.1053/J.gastro.2013.10.027. Epub 2013 Oct 23. PMID: 24162032.

    Crandall WV, Baldassano RN, Bousvaros A, Denson LA, Gupta N, Mackner LM.  NASPGHAN single-topic symposium: Discovering the future of pediatric IBD care.  J Pediatric Gastroenterol Nutr, 58(1):130-8, Jan 2014.  PMID: 24378522.

    2013

    Prosnitz Aaron R, Leonard Mary B, Shults Justine, Zemel Babette S, Hollis Bruce W, Denson Lee A, Baldassano Robert N, Cohen Aaron B, Thayu Meena: Changes in vitamin D and parathyroid hormone metabolism in incident pediatric Crohn's disease. Inflamm Bowel Dis Jan 2013.

    Tsampalieros Anne, Lam Carol K L, Spencer Jenna C, Thayu Meena, Shults Justine, Zemel Babette S, Herskovitz Rita M, Baldassano Robert N, Leonard Mary B: Long Term Inflammation and Glucocorticoid Therapy Impair Skeletal Modeling during Growth in Childhood Crohn Disease. The Journal of Clinical Endocrinology and Metabolism May 2013 Notes: Epub ahead of print.

    Wei Zhi, Wang Wei, Bradfield Jonathan, Li Jin, Cardinale Christopher, Frackelton Edward, Kim Cecilia, Mentch Frank, Van Steen Kristel, Visscher Peter M, Baldassano Robert N, Hakonarson Hakon: Large Sample Size, Wide Variant Spectrum, and Advanced Machine-Learning Technique Boost Risk Prediction for Inflammatory Bowel Disease. American Journal of Human Genetics May 2013 Notes: Epub ahead of print.

    Gupta Kernika, Noble Angela, Kachelries Kelly E, Albenberg Lindsey, Kelsen Judith R, Grossman Andrew B, Baldassano Robert N: A novel enteral nutrition protocol for the treatment of pediatric Crohn's disease. Inflammatory Bowel Dis 19(7): 1374-8, Jun 2013.

    Cardinale CJ, Kelsen J, Baldassano RN, Hakonarson H.  Impact of exome sequencing in inflammatory bowel disease.  World J Gastroenterol, 19(40):6721-9, Oct 28, 2013. doi:10.3748/wjg.v19.i40.6721. PMID: 24187447; PMCID: PMC3812471.

    Cardinale CJ, Wei Z, Panossian S, Wang F, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H.  Targeted resequencing identifies defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease.  Genes Immun, 14(7):447-52, Oct 2013. doi:10.1038/gene.2013.43. Epub 2013 Aug 22.  PMID: 23965943.

    Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A…International IBD Genetics Consortium [Baldassano RN]. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet, 9(9):e1003723, Sept 12, 2013. doi: 10.1371/journal.pgen.1003723. Epub2013 Sept 12. PMID: 24068945.

    Tsampalieros A, Lam CK, Spencer JC, Thayu M, Shults J, Zemel BS, Herskovitz RM, Baldassano RN, Leonard MB.  Long-term inflammation and glucocorticoid therapy impair skeletal modeling during growth in childhood Crohn disease.  J Clin Endocrinol Metab, 98(8):3438-45, Aug 2013. doi: 10.1210/jc.2013-1631. Epub 2013 May 20.  PMID: 23690309.

    Wei Z, Wang W, Bradfield J, Li J, Cardinale C, Frackelton E, Kim C, Mentch F, Van Steen K, Visscher PM, Baldassano RN, Hakonarson H; The International IBD Genetics Consortium,  Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease.  Am J Hum Genet, 92(6):1008-12, Jun 6, 2013. doi: 10.1016/j.ajhg.2013.05.002 Epub 2013 May 23.  PMID: 23731541.  PMCID: 

    2012

    Crandall Wallace V, Margolis Peter A, Kappelman Michael D, King Eileen C, Pratt Jesse M, Boyle Brendan M, Duffy Lynn F, Grunow John E, Kim Sandra C, Leibowitz Ian, Schoen Bess T, Colletti Richard B: Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics 129(4): e1030-41, Apr 2012.

    Gray Wendy N, Denson Lee A, Baldassano Robert N, Hommel Kevin A: Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology 37(3): 282-91, Apr 2012.

    Hyams Jeffrey, Damaraju Lakshmi, Blank Marion, Johanns Jewel, Guzzo Cynthia, Winter Harland S, Kugathasan Subra, Cohen Stanley, Markowitz James, Escher Johanna C, Veereman-Wauters Gigi, Crandall Wallace, Baldassano Robert, Griffiths Anne: Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis. Clinical Gastroenterology and Hepatology: The official clinical practice journal of the American Gastroenterological Association 10(4): 391-9.e1, Apr 2012.

    Yatsunenko Tanya, Rey Federico E, Manary Mark J, Trehan Indi, Dominguez-Bello Maria Gloria, Contreras Monica, Magris Magda, Hidalgo Glida, Baldassano Robert N, Anokhin Andrey P, Heath Andrew C, Warner Barbara, Reeder Jens, Kuczynski Justin, Caporaso J Gregory, Lozupone Catherine A, Lauber Christian, Clemente Jose Carlos, Knights Dan, Knight Rob, Gordon Jeffrey I: Human gut microbiome viewed across age and geography. Nature 486(7402): 222-7, Jun 2012.

    Hyams Jeffrey S, Griffiths Anne, Markowitz James, Baldassano Robert N, Faubion William A, Colletti Richard B, Dubinsky Marla, Kierkus Jaroslaw, Rosh Joel, Wang Yaqin, Huang Bidan, Bittle Barry, Marshall Michael, Lazar Andreas: Safety and Efficacy of Adalimumab for Moderate to Severe Crohn's Disease in Children. Gastroenterology Aug 2012.

    Horton DB, Sherry DD, Baldassano RN, Weiss PF. : Enthesitis is an extraintestinal manifestation of inflammatory bowel disease. Ann Paediatr Rheum 1(4): 214-221, 2012.

    Posters and Presentations

    2014

    Cardinale C, Li J, Wei Z, Chang X, Baldassano RN, Hakonarson H.  Pathway-based genome-wide association study reveals an association between ErbB signaling and inflammatory bowel disease.  2014 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando FL, Dec 4-6, 2014; Inflamm Bowel Dis 29():S103-S104, Dec 2014.  Poster presentation.

    Kelsen J, Moran C, Noor D, Pauly-Hubbard H, Rapprt E, Mamula P, Piccoli DA, Winter H, Daly M, Sonnenberg G, Artis D, Baldassano RN, Marcella D.  Digenic inheritance of primary immunodeficiency gene variants identified by whole exome sequence in very early onset IBD patients.  2014 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando FL, Dec 4-6, 2014; Inflamm Bowel Dis 20():S9-S10, Dec 2014. Oral presentation.

    Stein RE, Lee DY, Leonard MB, Thayu M, Herskovitz RM, Kerbowski T, Chuang E, Baldassano RN. The association between drug levels, anti-drug antibodies, and therapeutic response during infliximab therapy in pediatric Crohn disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting and Postgraduate Course, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S165. Poster presentation.

    Kelsen J, Moran C, Sasson A, Pauly-Hubbard H, Rappaport E, Mamula P, Piccoli D, Artis D, Sonnenberg G, Winter H, Baldassano RN, Devoto M.  Analysis of candidate genes by whole exome sequencing in very early-onset IBD. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S147. Poster presentation.  NASPGHAN Young Investigator Award.

    Lee D, Baldassano RN, Compher C, Albenberg L, Otley A, Griffiths A, Bushman F, Wu GD, Lewis JD.  Effectiveness of nutritional and anti-TNF therapy in North American children with active Crohn’s disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S37. Poster presentation.

    Sahn B, De Matos, V, Ruchelli E, Masur S, Klink A, Baldassano RN, Piccoli, DA, Russo P, Mamula P.  A histological scoring system for ileitis in children with inflammatory bowel disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S34. Poster presentation.

    Walters T, Faubion W, Griffiths A, Baldassano RN, Escher J, Ruemmele F, Hyams J, Lazar A, Eichner S, Li Y, Papparlardo B, Thakkar R.  Growth improvement in adalimumab-treated pediatric patients with Crohn’s disease: Data from Imagine I.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2014 Annual Meeting, Atlanta GA, Oct 23-26, 2014; JPGN:59(S2),S22. Poster presentation.

    Lee DY, Baldassano RN, Compher CW, Albenberg LG, Otley AR, Griffths AM, Bushman FD, Wu GD, Lewis JD.  Effectiveness of nutritional and anti-TNF therapy in North American children with active Crohn’s disease.  3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Oral presentation – accepted for Best Abstract.

    Otley R, Lee DY, Baldassano RN, Griffths AM, Compher CW, Albenberg LG, Bushman FD, Wu GD, Lewis JD. Comparison of quality of life among children treated with nutritional and anti-TNF therapies for active Crohn’s disease in North America. 3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Poster presentation.

    Stein RE, Lee DY, Leonard MB, Thayu M, Herskovitz RM, Kerbowski T, Baldassano RN. The association between drug levels, anti-drug antibodies, and therapeutic response during infliximab therapy in pediatric Crohn disease. 3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Poster presentation.

    Walters T, Faubion WA, Griffths A, Baldassano RN, Escher J, Ruemmele F, Hyams JS, Lazar A, Eichner S, Li Y, Pappalardo B, Thakkar RB.  Growth improvement in adalimumab-treated paediatric patients with Crohn’s disease: Data from Imagine 1.  3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands, Sept 10-13, 2014. Poster presentation.

    2013

    Cardinale CJ, Wei Z, Li J, Zhu J, Baldassano RN, Hakonarson H.  Transcriptome profiling of human ulcerative colitis mucosa shows altered expression of pathways overlapping genome-wide association susceptibility loci.  American Society of Human Genetics 63rd Annual Meeting, Boston, Oct 22-26, 2013.  Poster presentation. 

    Baldassano RN, Ruemmele F, Rosh J. Faubion WA, Kierkus J, Hyams JS, Lazar A, Wang Y, Eichner S, Thakkar RB.  Long-term safety of adalimumab in paediatric patients with Crohn’s disease. United European Gastroenterology (UEG) Week 2013, Berlin, Germany, Oct 12-16, 2013.  Poster presentation.

    Griffiths A, Baldassano RN, Walters T, Bronksy J, Hyams JS, Lazar A, Wang Y, Eichner S. Thakkar RB.  Improvement in markers of bone metabolism with adalimumab in children with moderately to severely active Crohn’s disease: Results from Imagine 1.  United European Gastroenterology (UEG) Week 2013, Berlin, Germany, Oct 12-16, 2013.  Poster presentation.

    Kierkus J, Crandall W, Hyams JS, Rosh J, Markowitz J, Baldassano RN, Lazar A, Wang Y, Eichner S, Thakkar RB.  Early response to treatment with adalimumab in children with moderately to severely active Crohn’s disease: Results from Imagine 1.  United European Gastroenterology (UEG) Week 2013, Berlin, Germany, Oct 12-16, 2013.  Poster presentation.

    Rosh J, Kierkus J, Crandall W, Hyams J, Markowitz J, Baldassano RN, Lazar A, Wang Y, Eichner S, Thakkar RB.  Early response to treatment with adalimumab in children with moderately to severely active Crohn’s disease: Results from IMAGINE 1.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E148, Oct 2013.  Oral and Poster presentation.

    Rosh J, Baldassano RN, Ruemmele F, Faubion WA, Kierkus J, Hyams J, Lazar A, Wang Y, Eichner S, Thakkar RB.  Long-term safety of adalimumab in pediatric patients with Crohn’s disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E110, Oct 2013. Poster presentation.

    Fish S, Wei Z, Bradfield J, Gupta K, Spengler C, Martin A, Judge C, Ghanem L, Hakonarson H, Baldassano RN, Kelsen J.  SLC11A1 polymorphism increases the risk of early surgery in pediatric patients with inflammatory bowel disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E97, Oct 2013.  Oral and Poster presentation.

    Moran CJ, Kelsen J, Kaplan JL, Baril-Dore M, Schindelar L, Vais B, Kirschner B, Baldassano RN, Xavier R, Winter H, Daly MJ.  Whole exome sequencing in very early onset inflammatory bowel disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013;JPGN:57(S1),E69, Oct 2013. Poster presentation.

    Lee D, Lewis JD, Baldassano RN, Leonard M.  Decomposing PCDAI into constituent components in the analysis of body composition in pediatric Crohn’s disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013; JPGN:57(S1),E67, Oct 2013. Poster presentation.

    Augustine M, Leonard M, Thayu M, Baldassano RN, Shults J, Denburg M.  Changes in Vitamin D-related mineral metabolism following infliximab induction in Crohn’s disease.  North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Annual Meeting, Chicago, IL, Oct 10-12, 2013; JPGN:57(S1),E13, Oct 2013.  Poster presentation.

    Haberman Y, Jurickova I, Dexheimer PJ, Karns R…Baldassano RN…Denson L.  Ileal RNA-Seq analyses reveal decreased mucosal myeloid cell immune responses in pediatric Crohn disease patients with phagocyte dysfunction due to neutralizing granulocyte macrophage colony stimulating factor (GM-CSF) auto-antibodies. American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013.  Poster presentation. Gastroenterology 144(5);S1, pS-708-709, May 2013.

    Kelsen JR, Posivak L, Pauly-Hubbard H, Baily AG…Baldassano RN…Wu GD.  Longitudinal characterization of the subgingival microbiota in pediatric Crohn’s disease.  American Gastroenterological Association: Digestive Disease Week 2013, Orlando, FL, May 19-21, 2013.  Poster presentation. Gastroenterology 144(5);S1, pS-309-310, May 2013.

    Colletti R, Cucchiara S, Dubinsky M, Escher J…Baldassano RN, et al.  Malignancies in children receiving infliximab and other inflammatory bowel disease therapies: an inflammatory bowel disease multicenter, prospective, long-term registry of pediatric patients (DEVELOP) registry data.  8th Congress of the European Crohn’s and Colitis Organisation (ECCO), Vienna, Austria, Feb 14-16, 2013; Poster presentation.

    2012

    Albenberg L, Judge C, Esipova T, Grunberg S, Chen J, Baldassano RN, Lewis J, Bushman F, Vinogradov S, Wu G.  An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. 2012 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.  Inflamm Bowel Dis 18(S);12: S112,P-257, Dec 2012.  Poster presentation.

    Kelsen J, Posivak L, Bailey A, Grunberg S, Baldassano RN, Lewis J, Bushman F, Wu G.  The subgingival oral microbiome in pediatric patients with Crohn’s Disease.  2012 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.  Inflamm Bowel Dis 18(S);12: S61,P-117, Dec 2012.  Poster presentation.

    Zahm A, Tsoucas D, Baldassano RN, Friedman J.  MicroRNA-regulated  pathways in pediatric IBD.  2012 Advances in Inflammatory Bowel Diseases: Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, FL, Dec 13-15, 2012.  Inflamm Bowel Dis 18(S);12: S7,O-15 and S103,P-226, Dec 2012. Oral and Poster presentations.

    Lee D, Kachelries KE, Gupta K, Lorusso M, Whitehead KM, Herskovitz RM, Leonard MB, Baldassano RN.  The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn’s Disease. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster of Distinction Award; JPGN  55(S1):295, Oct 2012.

    Lee D, Kachelries KE, Gupta K, Lorusso M, Whitehead KM, Herskovitz RM, Leonard MB, Baldassano RN.  The impact of supplemental nasogastric tube nutrition on height and weight in pediatric Crohn’s Disease. Food and Nutrition Conference and Expo (FNCE), Academy of Nutrition and Dietetics Annual Conference, Philadelphia, PA, Oct 6-9, 2012, Poster Presentation. 

    Kelsen JR, Posivak L, Grunberg S, Bailey A, Baldassano RN, Lewis J, Bushman F, Wu G.  The oral microbiome in pediatric Crohn Disease. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012,  Poster presentation; JPGN 55(S1):235, Oct 2012. 

    Lorusso M, Lee D, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Lewis J, Baldassano RN.  Children with Crohn’s disease on 100% vs. 80% enteral nutritional therapy: Interim analysis of a prospective cohort study. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):234, Oct 2012.

    Procopi T, Zimmerman A, Grossman A, Baldassano RN.  Infusion and post-infusion reactions to infliximab in pediatric inflammatory bowel disease patients.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):227, Oct 2012. 

    Zahm AM, Baldassano RN, Friedman J.  Rectal micro RNA levels are altered in pediatric ulcerative colitis.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):217, Oct 2012.

    Albenberg L, Spengler C, Klink A, Mattei P, Baldassano RN, Mamula P, Kelsen JR.  Diverting ileostomy for the treatment of severe refractory indeterminate colitis.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):203, Oct 2012.

    Lee D, Lorusso M, Klink A, Gupta K, Martin A, Gilroy E, Nessel L, Otley A, Griffiths A, Lionetti P, Bushman F, Wu G, Baldassano RN, Lewis J. Response to enteral nutritional therapy versus anti-TNFS in pediatric Crohn’s Disease.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):202, Oct 2012. 

    Judge CP, Albenberg LG, Esipova T, Grunberg S, Chen J, Li H, Baldassano RN, Lewis JD, Bushman FD, Vinogradov SA, Wu GD.   An oxygen equilibrium at the host-microbial interface determined by phosphorescent nanoprobe technology. NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):237, Oct 2012.

    Kaplan J, Bhasin M, Gold BD, Kirschner BS, Ward NL, Cohen SA, Heyman MB, Ferry GD, Baldassano RN, Moran CJ, Steven B, Garnett EA, Tierney MP, Drake L, Dowd SE, Cox SB, Mir SA, Kellermayer R, Libermann TA, Winter HS.  Ileal mucosa-associated microbiota changes in children with newly diagnosed, treatment-naïve Crohn’s Disease.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55(S1):220, Oct 2012.

    Gold BD, Kirschner BS, Cohen SA, O’Conner S, Heyman MH, Ferry GD, Baldassano RN, Garnett EA, Thompson AD, Tierney M, Yakrus MA, Winter HS.  Molecular analysis of Mycobacterium Avium Subspecies Paratuberculosis (MAP) in mucosal biopsies from treatment naïve children with IBD and controls.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012,  Poster presentation; JPGN 55(S1):205, Oct 2012.

    Judge CP, Lee DY, Long J, Zemel BS, Baldassano RN, Leonard MB.  Children with Crohn disease continue to exhibit inflammatory cachexia despite advances in therapies.  NASPGHAN Annual Meeting, Salt Lake City, UT, Oct 18-20, 2012, Poster presentation; JPGN 55 (S1):197, Oct 2012.

    Kao C, Wei Z, Li J, Wang W, Glessner J, Cardinale C, Bradfield J, Frackelton E, Kim C, Mentch F, Qui H, Grant S, Baldassano RN, Hakonarson H and The International IBD Genetics Consortium.  Pathway-based meta analysis of ulcerative colitis genome-wide association studies.  62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Nov 6-10, 2012.  Poster presentation. 

    Pandey R, Cardinale CJ, Panossian S, Wang F, Frackelton E, Kim C, Mentch F, Chiavacci R, Kachelries K, Grant S, Baldassano RN, Hakonarson H.  Functional characterization of DcR3 and NF-қB in EBV transformed cell lines from IBD patients of different allelic background and role in disease pathogenesis.  62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Nov 6-10, 2012.  Poster presentation. 

    Cardinale CJ, Panossian S, Wang F, Frackelton EC, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H.  Targeted resequencing identifies secretion-defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease.  62nd Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Nov 6-10, 2012.  Poster presentation. 

    Overton M, Jarvis W, Flint R, Baldassano RN, Kim SC.  Quantification and characterization of Klebsiella pneumoniae in pediatric patients with inflammatory bowel disease. American Gastroenterological Association; Digestive Disease Week, May 20-22, 2012. Poster Presentation. Gastroenterology 142(5):S1, p S-373-374, May 2012.

    Flint RA, Jarvis HW, Overton MH, Baldassano RN, Kim SC.  Characterization of mucosally-adherent Escherichia coli  in pediatric inflammatory bowel disease patients. American Gastroenterological Association; Digestive Disease Week, May 20-22, 2012. Poster Presentation. Gastroenterology 142(5):S1,p S-373, May 2012.

    Invited Lectures

    2014

    December 6, 2014:  “Stump the Panel: Challenging Inpatient IBD Cases”, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

    December 6, 2014: Meet the Experts, “What  Approaches will Help Us Treat Refractory Pediatric Ulcerative Colitis?, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

    December 5, 2014: “Stump the Panel: Challenging Outpatient IBD Cases”, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

    December 5, 2014: Debate: Thiopurines in Pediatric IBD: Love Them or Leave Them, “Con: Thiopurines Have No Role in the Management of Pediatric IBD”, 2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

    December 5, 2014: “Can Nutritional Therapy Be Used on a Practical Basis for Maintenance?”,  2014 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Orlando, FL.

    October 23, 2014: “Diet and the Microbiome”, NASPGHAN 2014 Postgraduate Course, Atlanta, GA.

    October 23, 2014: “Fad or Fiction: Case-Based Discussion of Alternative Diets”, NASPGHAN 2014 Postgraduate Course, Atlanta, GA.

    September 12, 2014: “Enteral Nutrition for IBD – Is It In The Nutrition Or In The Environment”, 3rd International Symposium on Pediatric Inflammatory Bowel Disease (PIBD 2014), Rotterdam, The Netherlands.

    2013

    December 14, 2013:  “Stump the Panel: Challenging Inpatient IBD Cases”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood, FL.

    December 13, 2013:  “Stump the Panel: Challenging Outpatient IBD Cases”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood, FL.

    December 13, 2013: Debate: What Should Be Our End-Points of Therapy?, “Con: The Only End-Points of Therapy That Matter Are Mucosal Healing, Normal Blood Work, and Negative Radiologic Studies”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood, FL.

    December 13, 2013: “What Do We Do When the Patient Loses Their Response to an Anti-TNF: Minor Tweaks or Major Treatment Changes?”, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation’s Clinical & Research Conference, Hollywood , FL.

    October 12, 2013:  “Nutrition in Inflammatory Bowel Disease”, NASPGHAN Nutrition Symposium for Dieticians, 2013 Annual Meeting and Postgraduate Course, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL.

    October 10, 2013: “Enteral Nutrition in Crohn Disease: Where Should This Be in Our Treatment Algorithm?” 2013 Annual Meeting and Postgraduate Course, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL.

    October 10, 2013: “Crohn Disease: Challenging Cases”, 2013 Annual Meeting and Postgraduate Course, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL.

    October 2, 2013: “Are We Under-Treating or Mistreating Patients at the Time of Presentation?”, Challenges in the Care of IBD in Patients of All Ages, Falk Symposium 190, London, Great Britain.

    March 8, 2013: “Nutritional Therapy for Children and Adults”, Therapeutic Options – What’s New; The 8th Penn Inflammatory Bowel Disease Symposium, Philadelphia, PA.

  • Awards and Honors

    2014, America’s Top Doctors, 14th Edition
    2013 & 2014, Top Doctors for Kids, Philadelphia Magazine
    2013, Fellows Faculty Honor Roll
    2012, Blockley-Osler Award
    2003, Pediatric Resident Teaching Honor Roll
    2003-2008, Best Doctors in America
    2003-2012, America's Top Doctors
    2002, Best Pediatricians in America, Best Doctors List
    2002, Physician of the Year Award
    2001, Doctors Who Make a Difference, Child Magazine
    2001, David Cornfeld Bedside Teaching Award
    2001-2013, Top Doctors for Kids, Philadelphia Magazine,
    1993, Education Award for Excellence in Inflammatory Bowel Disease Teaching, Research and Clinical Care
    1992, Golden Apple Award for Excellence in Pediatric Resident Teaching
    1990-1993, Crohn's and Colitis Foundation of American Research Fellowship Award
    1988, Pediatric Housestaff Humanitarian Award
    1988, NIH Research Fellowship Award
    1984-1985, Honor Scholarship, SUNY Health Science Center
    1983-1987, Alpha Omega Alpha-SUNY Health Science Center
    1975-1977, Mathematical Association of American, Mathematics Honor Society
    1975-1977, Summa Cum Laude-State University of New York
    1975-1977, Phi Beta Kappa-State University of New York
    1975-1977, Sigma Phi Sigma, Physics Honor Society-State University of New York

  • Editorial and Academic Positions

    Editorial positions

    2006-present, Editorial Advisory Board, Gastroenterology and Hepatology
    2003-present, Reviewer, Clinical Gastroenterology and Hepatology
    2002-present, Section Editor, Inflammatory Bowel Disease
    2001-present, Medical Editor, emedicine: PEDIATRICS, Medical Textbook for Health Professionals and Consumers
    1997-present, Reviewer, Journal of Parenteral and Enteral Nutrition
    1996-present, Reviewer, Journal of Pediatric Gastroenterology and Nutrition

    Academic committees

    2012-present, Resident Search Committee, The Children's Hospital of Philadelphia
    2001-present, Target TNF, Evolving the Course of Inflammatory Bowel Disease Therapy, International Round Table, Barcelona, Spain
    1998-present, General Pediatrics Search Committee, The Children's Hospital of Philadelphia
    1997-present, Physician Compensation Committee, The Children's Hospital of Philadelphia

  • Leaderships

    Memberships in professional organizations

    American Academy of Pediatrics
    American Gastroenterological Association
    Crohn's and Colitis Foundation of America
    International Consortium of Pediatric IBD Centers
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

    • 2013, Publications Committee, Committee Member
    • 2013, Clinical Trials Committee, Committee Member
    • 2013, Quality Measures for Pediatric IBD, C0mmittee Member
    • 2013, Scientific Advisory Board, Clinician Research Registry (CRR), Committee Member

    World Congress of Pediatric Gastroenterology, Hepatology and Nutrition