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Frank M. Balis, MD

Interim Chief, Division of Oncology

Director of Clinical Research, Center for Childhood Cancer Research

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Awards

2008, NIH Award of Merit for successful clinical development of glucarpidase

2008, NIH Award of Merit for successful implementation of a Clinical Trial Management System

2003, NIH Award of Merit for outstanding contributions as Clinical Director

2001, NCI Mentor of Merit Award

2000, Public Health Service Outstanding Service Medal

1998, Division of Clinical Sciences Director's Award

1990, Public Health Service Unit Commendation

1988, Society for Pediatric Research

1978, Amos Christie Award in Pediatrics

1974, Alpha Omega Alpha

1970, Phi Beta Kappa

Books

Chapters

2010

Adamson PC, Balis FM, Bagatell R, Blaney SM. General principles of chemotherapy. In Pizzo PA, Adamson PC, Poplack DG, editors. Principles and practice of pediatric oncology 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010.

2007

Fox E, Balis FM. Drug therapy in newborns and children. In Atkinson AJ, Daniels CE, Dedrick RL, Markey SP, editors. Principles of clinical pharmacology 2nd ed. San Diego: Academic Press; 2007. p. 359-73.

Lowe ES, Balis FM. Dose-effect and concentration-effect analysis. In Atkinson AJ, Daniels CE, Dedrick RL, Markey SP, editors. Principles of clinical pharmacology. 2nd ed. San Diego: Academic Pres; 2007. p. 289-300.

2006

Lowe ES, Balis FM. Dose-effect and concentration-effect analysis. In: Atkinson AJ, Daniels CE, Dedrick RL, Markey SP, editors. Principles of clinical pharmacology. 2nd ed. San Diego: Academic Press; 2006. p. 290-365.

2001

Balis FM, Holcenberg JS, Blaney SM. General principles of chemotherapy. In: Pizzo PA, Poplack DG, editors. Principle and practice of pediatric oncology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 237-308.

Fox E, Balis FM. Drug therapy in newborns and children. In: Atkinson AJ, Daniels CE, Dedrick RL, Grudzinskas CV, Markey SP, editors. Principles of clinical pharmacology. San Diego: Academic Press; 2001. p. 293-305.

Lowe ES, Balis FM. Dose-effect and concentrations-effect analysis. In: Atkinson AJ, Daniels CE, Dedrick RL, Grudzinskas CV, Market SP, editors. Principles of clinical pharmacology. San Diego: Academic Press; 2001. p. 235-44.

1998

Patel M, Blaney SM, Balis FM. Pharmacokinetics of drug delivery to the central nervous system. In: Growchow LB, Ames MM, editors. A clinician's guide to chemotherapy pharmacokinetics and pharmacodynamics. Philadelphia: Williams & Wilkins; 1998. p. 67-90.

Berg SL, Balis FM, Poplack DG. Cancer chemotherapy. In: Nathan DG, Orkin SH, editors. Hematology of infancy and childhood. 5th ed. Philadelphia: W.B. Saunders; 1998. p. 1201-32.

1997

Balis FM, Holcenberg JS, Poplack DG. General principles of chemotherapy. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 3rd ed. Philadelphia: Lippincott; 1997. p. 215-72.

1993

Balis FM, Poplack DG. Drug development and clinical pharmacology of antiretroviral agents. In: Pizzo PA, Wilfert CM, editors. Pediatric AIDS: the challenge of HIV infection in infants, children and adolescents. 2nd ed. Baltimore: Williams & Wilkins; 1993. p. 625-49.

Berg SL, Balis FM, McClure L, Poplack DG, Horowitz ME. The use of cardioprotectant agents in combination with anthracycline chemotherapy. In: Bricker JT, Green DM, D'Angio GJ, editors. Cardiac toxicity after treatment for childhood cancer. New York: Wiley-Liss; 1993. p. 115-20.

Balis FM, Holcenberg JS, Poplack DG. General principles of chemotherapy. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 2nd ed. Philadelphia: J.B. Lippincott; 1993. p. 197-245.

1992

Balis FM, Poplick DG. Cancer chemotherapy. In: Nathan DG, Oski FA, editors. Hematology of infancy and childhood. 4th ed. Philadelphia: W.B. Saunders; 1992. p. 1207-38.

1991

Bleyer WA, Poplack DG, Balis FM. Pharmacokinetics of commonly used anti-leukemic agents in children. In: Kobayashi N, Akera T, Mizutani S, editors. Childhood leukemia: present problems and future prospects. Boston: Kluwer Academic Publishers; 1991. p. 149-55.

1990

Balis FM, Pizzo PA. Zidovudine (3'-azido-2',3'-deoxythymidine) for the treatment of human immunodeficiency virus infection in children. In: Kozlowski PB, Snider DA, Vietze PM, Wisniewski HM, editors. Brain in pediatric AIDS. Basel, Switzerland: Karger; 1990. p. 91-108.

Balis FM, Poplack DG. Drug development and clinical pharmacology. In: Pizzo PA, Wilfert CM, editors. Pediatric AIDS: the challenge of HIV infection in infants, children and adolescents. Baltimore: Williams & Wilkins; 1990. p. 457-77.

1988

Balis FM, Holcenberg JS, Poplack DG. General principles of chemotherapy. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. Philadelphia: J.B. Lippincott; 1988. p. 165-205.

Pizzo PA, Poplack DG, Magrath IT, Ungerleider RS, Cazenave L, Israel MA, et al. Cancers in children. In: Wittes R, editor. manual of oncologic therapeutics. Philadelphia: J.B. Lippincott; 1998. p. 394-416.

1987

Balis FM. The pharmacology of antineoplastic agents in children. In: Poplack DG, Massimo L, Cornaglia-Ferraris P, editors. The role of pharmacology in pediatric oncology. The Netherlands: Martinus Nijhoff Publishers; 1987. p. 15-27. 

Editorial and Academic Positions

Editorial positions

2002-present, Editorial Board, Clinical Cancer Research
2000-present, Editorial Board, Cancer Chemotherapy and Pharmacology
1995-present, Founding, Senior, and CME Editor, The Oncologist

Academic positions

2010-present, eIRB Smartform version 2 Advisory Committee
2009-present, CHOP IND Review Committee (Chair, 2010-present)
2009-present, CCCR Clinical Research Quality Assurance Committee
2009-present, CCCR Pediatric Protocol Review Committee
2009-present, Pediatric Subcommittee of the Oncological Drugs Advisory Committee, FDA
2009-present, CCCR Cancer Leadership Group
2009-present University of Pennsylvania Cancer Center Strategy Group

Leadership

Memberships in professional organizations

American Society of Clinical Oncology
American Association for Cancer Research
Society for Translational Oncology
Society for Pediatric Research
Children's Oncology Group

  • Member, Developmental Therapeutics Committee; Institutional PI, The Children's Hospital of Philadelphia
  • Member, Steering Committee, Pediatric Phase I/Pilot Consortium

Original Papers

2011

Marcus L, Murphy R, Fox E, McCully C, Cruz R, Warren KE, et al. The plasma and cerebrospinal fluid pharmacokinetics of the platinum analog satraplatin after intravenous administration in non-human primates. Cancer Chemother Pharmacol. E pub 2011 Jun 26. Cited in PubMed: PMID 21706317. Read the abstract

Aplenc R, Blaney SM, Strauss LC, Balis FM, Shusterman S, Ingle AM, et al. Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium. J Clin Oncol. 2011 Mar 1;29(7):839-44. Epub 2011 Jan 24. Cited in PubMed: PMID 21263099. Read the abstract

Bagatell R, Herzog CE, Trippett TM, Grippo JF, Cirrincione-Dall G, Fox E, et al. Pharmacokinetically guide phase I trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors. Clin Cancer Res. 2011 Reb 1;17(3):611-9. Epub 2010 Dec 2. Cited in PubMed: PMID 21127194. Read the abstract

Kelly RJ, Draper D, Chen CC, Robey RW, Figg WD, Piekarz RL, et al. A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer. Clin Cancer Res. 2011 Feb1;17(3):569-80. Epub 2010 Nov 16. Cited in PubMed: PMID 21081657. Read the abstract

Widemann BC, Arceci RJ, Jayaprakash N, Fox E, Zannikos P, Goodspeed W, et al. Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011 Feb;56(2):226-33. doi: 10.1002/pbc.22775. Epub 2010 Sep 21. Cited in PubMed: PMID 20860038. Read the abstract

Chuk MK, Cole DE, McCully C, Loktionova NA, Pegg AE, Parker RJ, et al. Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model. Cancer Chemother Pharmacol. 2011 Jun;67(6):1291-7. Epub 2010 Aug 20. Cited in PubMed: PMID 20725726. Read the abstract 

2010

Fox E, Aplenc R, Bagatell R, Chuk MK, Dombi E, Goodspeed W, et al. A phase I trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors. J Clin Oncol. 2010 Dec 10;28(35):5174-81. E pub 2010 Nov 8. Cited in PubMed: PMID 21060028. Read the abstract

Sepe DM, Ginsberg JP, Balis FM. Dexrazoxane as a cardioprotectant in children receiving anthracyclines. Oncologist. 2010;15(11):1220-6. Epub 2010 Nov 4. Cited in PubMed: PMID 21051660. Read the abstract

Kim A, McCully C, Cruz R, Cole DE, Fox E, Balis FM, et al. The plasma and cerebrospinal fluid pharmacokinetics of sorafenib after intravenous administration in non-human primates. Invest New Drugs. E pub 2010 Nov 12. Cited in PubMed: PMID 21072558. Read the abstract

Widemann BC, Balis FM, Kim A, Boron M, Jayaprakash N, Shalabi A, et al. Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome. J Clin Oncol. 2010 Sep 1;28(25):3979-86. Epub 2010 Aug 2. Cited in PubMed: PMID 20679598. Read the abstract.

Fox E, Maris JM, Cohn SL, Goodspeed W, Goodwin A, Kromplewski M, et al. Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors. Cancer Chemother Pharmacol. 2010 Sep;66(4):737-43. Epub 2010 Jan 1. Cited in PubMed: PMID 20044751. Read the abstract

Meany H, Balis FM, Aikin A, Whitcomb P, Murphy RF, Steinberg SM, et al. Pediatric phase I trial design using maximum target inhibition as the primary endpoint. J Natl Cancer Inst. 2010 Jun 16;102(12):909-12. Epub 2010 May 11. Cited in PubMed: PMID 20460632.  Read the article

Jacobs S, Fox E, Krailo M, Hartley G, Navid F, Wexler L, et al. Phase 2 trial of ixabepilone administered daily for five days in children and young adults with refractory solid tumors: a report from the Children’s Oncology Group. Clin Cancer Res 16:750-4, 2010. Cited in PubMed: PMID 20068084.  Read the article

Jacobs S, McCully CL, Bacher J, Balis FM, Fox E. Extracellular fluid concentrations of cisplatin, carboplatin and oxaliplatin in brain, muscle and blood measured using microdialysis in non-human primates. Cancer Chemother Pharmacol 65:817-24, 2010. Cited in PubMed: PMID 19662415. Read the abstract

2009

Fox E, Widemann BC, Hawkins D, Jayaprakash N, Dagher R, Aikin AA, et al. Randomized trial of pegfilgrastim vs. filgrastim after chemotherapy in children and young adults with newly diagnosed sarcoma. Clin Cancer Res 15:7361-7, 2009. Epub 2009 Nov 17. Cited in PubMed: PMID 19920107. Read the article

Meany HJ, Sackett DL, Maris JM, Ward Y, Krivoshik A, Cohn SL, et al. Clinical outcome in children with recurrent neuroblastoma treated with ABT 751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in. Pediatr Blood Cancer 54:47-54, 2009. Cited in PubMed: PMID 19731320. Read the article

Wojtuszewski Poulin K , Smirnov AV, Hawkins ME, Balis FM, Knutson JR. Conformational heterogeneity and quasi-static self quenching in DNA containing fluorescent guanine analogs 3MI or 6MI. Biochemistry 48:8861-8, 2009. Cited in PubMed: PMID 19610668. Read the abstract

Meany HJ, Warren KE, Fox E, Cole DE, Aikin AA, Balis FM. Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors. Cancer Chemother Pharmacol 65:137-42, 2009. Cited in PubMed: PMID 19430790. Read the abstract

Abraham J, Edgerly M, Wilson R, Chen C, Rutt A, Bakke S, et al.  A Phase I study of the P-glycoprotein (Pgp) antagonist tariquidar (XR9576) in combination with vinorelbine. Clin Cancer Res 15:3574-82, 2009. Epub 2009 May 5. Cited in PubMed: PMID 19417029.  Read the article

Widemann BC, Goodspeed W, Goodwin A, Fojo T, Balis FM, Fox E. Phase I trial and pharmacokinetic study of ixabepilone administered daily for five days in children and adolescents with refractory solid tumors. J Clin Oncol 27:550-6, 2009. Epub 2008 Dec 15. Cited in PubMed: PMID 19075272.  Read the article

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