Edward M. Behrens, MD

Edward M. Behrens, MD, is the chief of the Division of Rheumatology and the Joseph Lee Hollander Chair in Pediatric Rheumatology at The Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Medical School

    MD - University of Pennsylvania School of Medicine, Philadelphia, PA

    Internship

    Pediatrics -The Children's Hospital of Philadelphia, Philadelphia, PA

    Residency

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    Pediatric Rheumatology - The Children's Hospital of Philadelphia, Philadelphia, PA

    Additional Training

    Medical Student Research Training Fellowship - Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA

    Board Certification

    Pediatric Rheumatology
    Pediatrics

  • Titles and Academic Titles

    Chief, Division of Rheumatology

    Joseph Lee Hollander Chair in Pediatric Rheumatology

    Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Publications

    Abstracts

    2014

    Weaver LK, Behrens EM. Interleukin-10 Receptor Blockade During LCMV Infection Results in Macrophage Activation Syndrome-like Disease in Mice, American College of Rheumatology Scientific Meeting, Nov 2014.

    Weaver LK, Behrens EM. Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation, American College of Rheumatology Scientific Meeting, Nov 2014.

    2013

    Weaver LK, Behrens EM. Innate Immune Cell Production of Interleukin-12 Drives CpG-Induced Macrophage Activation Syndrome, American College of Rheumatology Scientific Meeting, Nov 2013.

    2012

    Canna SW, Costa Reiss AP, Bernal WE, Sullivan KE, Paessler ME and Behrens EM.  “Transcriptome and Surgace Phenotype Analyses Suggest an Alternatively Activated (M2) Function for Hemophagocytes”, American College of Rheumatology Scientific Meeting Nov. 2012. 

    Canna SW, Wrobel J, Kreiger PA, Paessler ME, Behrens EM. “Fulminant Toll-Like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis Occur  Independently of Interferon”, American College of Rheumatology Scientific Meeting, Nov 2012.

    Papers

    2014

    Weaver LK, Behrens EM. Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis. Curr Opin Rheumatol. 2014 Sep 26(5):562-9.

    Zhang M, Behrens EM, Atkinson TP, Shakoory B, Grom AA, Cron RQ. Genetic defects in cytolysis in macrophage activation syndrome. Curr Rheumatol Rep. 2014;16(9):439.

    Karimi MA, Lee E, Bachman MH, Salicioni AM, Behrens EM, Kambayashi T, Baldwin CL. Measuring cytotoxicity by bioluminescence imaging outperforms the standard chromium-51 release assay. PLOS One. 2014 Feb 19;9(2):e89357.

    Canna SW, Costa-Reis P, Bernal WE, Chu N, Sullivan KE, Paessler ME, Behrens EM. Alternative activation of laser-captured murine hemophagocytes. Arthritis Rheumatol. 2014 Jun;66(6):1666-71.

    2013

    Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA. The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal. 2013 Nov 26;6(303).

    Costa-Reis P, Weaver LK, Behrens EM, Sullivan KE. Chronic non-bacterial osteomyelitis in a patient with common variable immunodeficiency. Joint Bone Spine. 2014 Mar;81(2):193-4. Epub 2013 Sep 20.. 

    Canna SW, Wrobel J, Chu N, Kreiger P, Paessler M, Behrens EM. Interferon-γ mediates anemia but is dispensable for Fulminant Toll-Like Receptor 9-induced Macrophage Activation Syndrome and Hemophagocytosis. Arthritis & Rheumatism. 2013 Jul;65(7):1764-75.

    Rao S, Liu X, Freedman BD, Behrens EM. Spleen tyrosine kinase (Syk) dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor alpha (TNFα) in innate immune cells. J Biol Chem. 2013 May 3;288(18):12448-58,

    Weaver LK, Behrens EM. How to use... antinuclear antibodies in paediatric rheumatic diseases. Arch Dis Child Educ Pract Ed. 2013 Apr;98(2):64-70.

    2012

    Sriram U, Varghese L, Bennett HL, Jog NR, Shivers DK, Ning Y, Behrens EM, Caricchio R, Gallucci S. Myeloid Dendritic Cells from B6.NZM Sle1/Sle2/Sle3 Lupus-prone Mice express an Interferon Signature that Precedes Disease Onset. J Immunol. 2012 Jul 1;189(1):80-91. Epub 2012 Jun 1.

    Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA. Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol. 2012 Jun;42(6):1429-35.

    Canna SW, Behrens EM. Making sense of the cytokine storm: a conceptual framework for understanding, diagnosing and treating hemophagocytic syndromes. Pediatr Clin North Am. 2012 Apr;59(2):329-44.

    Ravelli A, Grom AA, Behrens EM, Cron RQ. Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment. Genes Immun. 2012 Jun;13(4):289-98. Epub 2012 Mar 15.

    Canna SW, Behrens EM. Not all hemophagocytes are created equally: appreciating the heterogeneity of the hemophagocytic syndromes. Curr Opin Rheumatol. 2012 Jan;24(1):113-8.

    Posters and Presentations

    2012

    Canna SW, Wrobel J, Kreiger PA, Paessler ME, Behrens EM. "Interferon-gamma independent hemophagocytosis in a Murine model of MAS," Histiocyte Society Meeting, Oct. 2012.

    Invited Lectures

    2015

    Behrens EM. “New Thoughts on the Pathogenesis and Treatment of Cytokine Storm Syndromes: Moving Beyond the T-cell”, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, IL; May 2015.

    Behrens EM. “Rheumatology in Primary Care: Decision Making in Your Practice,” 16th Annual APN Conference, Philadelphia, PA; April 2015.

    2014

    Behrens EM. “You’ve Just Been Diagnosed with Juvenile Arthritis, Now What?” Keynote Speaker, JA Family Day, Arthritis Foundation, Philadelphia, PA; November 2014.

    Behrens EM. “Macrophage Activation Syndrome: Insights into Pathogensis,” Pennsylvania Rheumatology Society Scientific Meeting, Hershey, PA; September 2014.

    Behrens EM. “The Antigen Presenting Cell – Link Between Innate and Adaptive Immunity,” American Association of Immunology Course in Immunology, Long Beach, CA; July 2014.

    Behrens EM. “Pathogenesis of Macrophage Activation Syndrome: Lesson from Murine Models,” Pediatric Rheumatology Symposium (PRSYM), Orlando, FL; April 2014.

    Behrens EM. “Meet the Professor: Macrophage Activation Syndrome,” Pediatric Rheumatology Symposium (PRSYM), Orlando, FL; April 2014.

    Behrens EM. “Lymphopoiesis in Systemic Inflammation: To B or not to B”, University of Pittsburgh, Pittsburgh, PA; February 2014.

    2013

    Behrens EM. “Early Career Funding Opportunities for Physician Scientists,” American College of Rheumatology Annual Scientific Meeting, San Diego, CA; October 2013.

    Behrens EM. “Macrophage Activation Syndrome: A State of the Art Review,” American College of Rheumatology Annual Scientific Meeting, San Diego, CA; October 2013

    Behrens EM. “The Antigen Presenting Cell – Link Between Innate and Adaptive Immunity”, American Association of Immunology Course in Immunology, Philadelphia, PA; July, 2013.

    Behrens EM. “Another Piece of the pY:  Novel Tyrosine Phosphorylation Events in Toll-like Receptor Signaling”, Temple University, Philadelphia, PA; March, 2013.

    2012

    Behrens EM. “The Role of IL-10 in Macrophage Activation Syndrome,” American College of Rheumatology Macrophage Activation Syndrome Study Group, Washington DC; November, 2012.

    Behrens EM. “Macrophage Activation Syndrome Update,” Central Pennsylvania Rheumatology Meeting, Harrisburg, PA; September, 2012.

    Behrens EM. “The Antigen Presenting Cell – Link Between Innate and Adaptive Immunity”, American Association of Immunology Course in Immunology, Philadelphia, PA; July, 2012.

    Behrens EM. “The Expanding Spectrum of Macrophage Activation Syndrome,” CIS Annual Primary Immunodeficiency Meeting, Chicago, IL; May, 2012.

    Behrens EM. “Lyme Disease” Separating Fact from Myth.” Advanced Pediatric Nursing National Conference, Philadelphia, PA; May, 2012.

    Behrens EM. “Dissecting the Cytokine Network of the Macrophage Activation Syndrome,” Distinguished Speaker Series – Humigen, Hamilton, NJ; January, 2012.

  • Awards and Honors

    2014, Joseph L. Hollander Endowed Chair in Pediatric Rheumatology, University of Pennsylvania
    2013, American Society for Clinical Investigators – Young Physician-Scientist Award
    2012, Nezelof Award in Basic Science – Histiocyte Society
    2012, Stuart McKracken Award for Research – Arthritis Foundation
    2011, Nezelof Award in Basic Science – Histiocyte Society
    2011, Arthritis Foundation Profession Education Award
    2010, University of Pennsylvania Department of Medicine Austrian Award
    2009, Howard Hughes Medical Institute Physician Scientist Early Career Award
    2007, American College of Rheumatology Distinguished Fellow Award
    2007, Clinical Immunology Society School of Autoimmune Diseases Travel Grant
    2006, MedImmune Inflammation and Autoimmunity Abstract Competition Finalist
    2006, Earl J. Brewer Research Travel Grant Award in Pediatric Rheumatology
    2006, American College of Rheumatology REF Pediatric Rheumatology Research Award
    2005-2008, National Institutes of Health Loan Repayment Program Recipient
    2005, Philadelphia Rheumatism Society Fellows Research Forum Award
    2005, Clinical Immunology Society Travel Grant Award – FOCIS meeting
    2004, AMGEN Rheumatology Fellowship Award
    2003, Seymour Warshaw Distinguished First Year Resident Award – The Children’s Hospital of Philadelphia
    2002, Judy S. Finkelstein Memorial Symposium Award
    2001, Howard Hughes Medical Institute Medical Student Continued Support Award
    2000, Howard Hughes Medical Institute Medical Student Research Training Fellowship
    2000, Four Schools Physician Scientist Fellowship
    1998, National Institutes of Health Short Term Research Grant

  • Editorial and Academic Positions

    Editorial Positions

    Review Editor

    Frontiers in Primary Immunodeficiencies

    Peer Reviewer

    Up To Date – Allergy and Immunology Section

    Book Reviewer

    Neonatology Secrets: 1st Edition

    Ad-Hoc Reviewer
    Arthritis & Rheumatism 
    Clinical and Vaccine Immunology
    Clinical Immunology
    European Journal of Pediatrics
    Immunology
    International Archives of Allergy and Immunology
    Journal of Clinical Immunology
    Journal of Clinical Investigation
    Journal of Clinical Rheumatology
    Journal of Rheumatology
    Nature Clinical Practice Rheumatology
    Pediatric Rheumatology Online Journal
    Pediatrics
    Rheumatology

    Institutional Committees

    2013-present, University of Pennsylvania Institute for Immunology – Autoimmunity Program, Director
    2011-present, Clinical Data Reporting and Quality Subcommittee, Member
    2011-present, Center for Protective Immunity and Immunopathology Affinity Group, Co-Director
    2011-2012, 2013-present, Rheumatology T32 Executive Committee
    2009-present, School of Medicine MD/PhD Admission Committee

  • Leaderships

    Memberships in Professional Organizations

    International

    International Macrophage Activation Syndrome Study Group, Founding Member

    National 

    American Association of Immunologists
    American Board of Pediatrics
    - Rheumatology Sub-board Member
    American College of Rheumatology
    - 2011 & 2013, Abstract Reviewer for Scientific Meeting
    American Society of Hematologists
    - 2012, Abstract Reviewer for Scientific Meeting
    Clinical Immunology Society
    Histiocyte Society
    National Arthritis Foundation
    - Grant Review Study Section
    Rheumatology Research Foundation
    - Grant Review Study Section