Ulf Beier, MD, FAAP

Areas of Expertise: Histone protein deacetylases, Molecular immunology, T-cell biology, Transplant tolerance
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Education and Training

    Medical School

    MD - Christian - Albrechts - University of Kiel, Kiel, Germany

    Internship

    Pediatrics - University of Illinois at Chicago, Chicago, IL

    Residency

    Pediatrics - University of Illinois at Chicago, Chicago, IL

    Fellowship

    Pediatric Nephrology - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Pediatrics

  • Titles and Academic Titles

    Attending Physician

    Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Targeting sirtuin-1 to enhance foxp3+ regulatory T-cell function
    HDAC9 and mitochondrial biology

  • Publications

    Books

    2011

    Beier UH, Copelovitch L. Disorders of the renal & urologic systems: congenital anomalies of the kidney & urologic system. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Amsterdam (The Netherlands): Elsevier; 2011. p. 408-13.

    2006

    Ruiz CE, Beier UH. Small intestinal submucosa: a new generation of valve replacement. In: Hijazi ZM, Ruiz CE, Bonhoeffer P, Feldmann L, editors. Transcatheter valve repair. London: Martin Dunitz & Parthenon Publishing, Taylor & Francis Medical Books; 2006. p. 75-7.

    Abstracts

    2011

    Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Hiebert SW, et al. Loss of HDAC3 in Foxp3+ Tregs causes sustained acetylation of lysine-310 of NFKB and uncontrolled expression of NFKB-dependent pro-inflammatory genes [abstract oral presentation]. American Transplant Congress; 2011 Apr 30-May 3; Philadelphia, PA.

    Beier UH, Wang L, Bhatti TR, Liu Y, Han R, Ge G, et al. Sirtuin-1 targeting enhances T regulatory (Treg) cell suppressive function by increasing Foxp3 and heat shock protein-70 expression and promotes Treg-dependent cardiac allograft survival [abstract oral presentation]. American Transplant Congress; 2011 Apr 30-May 3; Philadelphia, PA.

    2010

    Wang L, Liu Y, Ge G, Han R, Bhatti T, Larosa C, et al. DNA methyltransferase-1 (DNMT1) is indispensable for T regulatory (TREG) cell function [plenary presentation]. American Transplant Congress; 2010 May 1-5; San Diego, CA. Am J Transplant 2010,10(Suppl.4):39-40.

    Beier UH, Wang L, Bhatti, TR, Liu Y, Han R, Ge G, et al. Sirtuin 1 (Sirt1) inhibition promotes the development and suppressive function of Foxp3+ T regulatory (TREG) cells and induces long-term allograft survival [abstract oral presentation]. American Transplant Congress; 2010 May 1-5; San Diego, CA. Am J Transplant 2010, 10(Suppl.4):106.

    Papers

    2012

    Beier UH, Wang L, Hancock WW. Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle. Cell Cycle. 2012 Sep 15;11(18):3351-2. doi: 10.4161/cc.21876. Epub 2012 Aug 23. Cited in PubMed; PMID 22918251. Read the abstract

    Beier UH, Wang L, Han R, Akimova T, Liu Y, Hancock WW. Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal. 2012 Jun 19;5(229):ra45. Cited in PubMed; PMID 22715468. Read the abstract

    Liu Y, Wang L, Han R, Beier UH, Hancock WW. Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One. 2012;7(1):e29035. Epub 2012 Jan 11. Cited in PubMed; PMID 22247766. Read the article

    Akimova T, Beier UH, Liu Y, Wang L, Hancock WW. Histone/protein deacetylases and T cell immune responses. Blood. Epub 2012 Jan 12. Cited in PubMed; PMID 22246031. Read the abstract

    2011

    Beier UH, Wang L, Bhatti TR, Liu Y, Han R, Ge G, Hancock WW. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. Epub 2011 Jan 3. Cited in PubMed; PMID21444725. Read the article

    Akimova T, Beier UH, Wang L, Levine MH, Hancock WW. Helios Expression Is a Marker of T Cell Activation and Proliferation. PLoS ONE 2011 Aug 30; 6(8): e24226. Cited in PubMed; PMID 21918685. Read the article

    de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78. Epub 2011 Mar 28. Cited in PubMed; PMID 21444725. Read the article

    2010

    Beier UH, Schmidt ML, Hast H, Kecskes S, Valentino LA. Control of disseminated intravascular coagulation in Klippel-Trenaunay-Weber syndrome using enoxaparin and recombinant activated factor VIIa: a case report. J Med Case Reports. 2010 Mar 19;4:92. Cited in PubMed; PMID 20302608. Read the article

    Posters and Presentations

    2011

    Akimova T, Levine MH, Beier UH, Kamath B, Rand EB, Meyers KEC, et al. Contrasting effects of immunosuppression on FOXP3+ Treg biology in liver and kidney allograft recipients [poster]. Kidney Week 2011, American Society of Nephrology 44th Annual Meeting; 2011 Nov 8-13; Philadelphia, PA.

    Beier U. Differential effects on foxp3+ tregs of targeting histone/protein deacetylases 6, 9 and sirtuin-1 [poster presentation]. Kidney Week 2011, American Society of Nephrology 44th Annual Meeting; 2011 Nov 8-13; Philadelphia, PA.

    Akimova T, Beier UH, Hancock WW. Sexual dimorphism of Foxp3+ T-regulatory cell function is HDAC6-dependent [poster]. Kidney Week 2011, American Society of Nephrology 44th Annual Meeting; 2011 Nov 8-13; Philadelphia, PA.

    Beier U. Sirtuin-1 targeting enhances T regulatory (Treg) cell suppressive function by increasing foxp3 and heat shock protein-70 expression and promotes treg-dependent cardiac allograft survival [oral presentation]. American Transplant Congress; 2011 Apr 30-May 4; Philadelphia, PA.

    2010

    Beier U. Sirtuin 1 (Sirt1) inhibition promotes the development and suppressive function of foxp3+ T regulatory (TREG) cells and induces long-term allograft survival. American Transplant Congress; 2010 May 1-5; San Diego, CA.

  • Editorial and Academic Positions

    Editorial positions

    Reviewer, International Journal of Cancer