Areas of Expertise:
Enterovirus entry into cells, Management and treatment of common pediatric infectious diseases, Viral pathogenesis, Virus receptors, Cell biology of virus entry
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
- Education and Training
University of Pennsylvania School of Medicine, Philadelphia, Pa.
University of California, San Francisco, Cal.
Children's Hospital, Boston, Mass.
American Board of Pediatrics
- Titles and Academic Titles
Attending Physician, Division of Infectious Diseases
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Departments and Services
- Research Interests
How viruses enter cells to begin infection
Harris KG, Morosky SA, Drummond CG, Patel M, Kim C, Stolz DB, Bergelson JM, Cherry S, Coyne CB. RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. Cell host & microbe. 2015; 18(2):221-32. NIHMSID: NIHMS715934
Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JM. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. Journal of virology. 2015; 89(8):4311-8.
Pan J, Zhang L, Organtini LJ, Hafenstein S, Bergelson JM. Specificity of coxsackievirus B3 interaction with human, but not murine, decay-accelerating factor: replacement of a single residue within short consensus repeat 2 prevents virus attachment. Journal of virology. 2015; 89(2):1324-8.
Kim C, Bergelson JM. Echovirus 7 entry into polarized caco-2 intestinal epithelial cells involves core components of the autophagy machinery. Journal of virology. 2014; 88(1):434-43.
Krieger SE, Kim C, Zhang L, Marjomaki V, Bergelson JM. Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis. Journal of virology. 2013; 87(16):8884-95.
Nishimura Y, Lee H, Hafenstein S, Kataoka C, Wakita T, et al. Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction. PLoS pathogens. 2013; 9(7):e1003511.
Bergelson JM, Coyne CB. Picornavirus entry. Advances in experimental medicine and biology. 2013; 790:24-41.