Garrett M. Brodeur, MD, is associate chair for Research in Pediatrics, as well as professor of Pediatrics at the University of Pennsylvania and adjunct professor at The Wistar Institute in Philadelphia.
Dr. Brodeur is a graduate of the Washington University School of Medicine in St. Louis, Missouri, where he completed his pediatric residency. He continued his specialty training with a fellowship in pediatric hematology-oncology at St. Jude’s Children’s Research Hospital in Memphis. He returned to Washington University for a post-doctoral fellowship in molecular genetics in 1981, and he joined the faculty at CHOP in 1993.
Dr. Brodeur maintains a special interest in the biology, genetics and treatment of neuroblastoma, the most common solid tumor in childhood, and is internationally recognized for his work in this area. He is currently studying certain genes, proteins and pathways that play important roles in the development and progression of neuroblastomas. For example, he is looking for a tumor suppressor gene on the short arm of chromosome 1 that is frequently deleted or inactivated in aggressive neuroblastomas. He is also examining the role that TRK (pronounced “track”) receptors play in these tumors. TRK-A is expressed on the surface of favorable neuroblastomas that are prone to regress, differentiate or respond well to modest treatment. TRK-B is expressed on the more aggressive neuroblastomas, particularly those that also amplify the MYCN proto-oncogene (a very high risk feature). Finally, he is evaluating a novel drug that can block the function of either TRK-A or TRK-B, and this causes cells expressing these receptors to die by a cellular “suicide”.
Recently, he has been invited to give lectures on his work at the National Institutes of Health/National Cancer Institute in Bethesda, Maryland; at Kyushu University in Japan, at Washington University in St. Louis, Missouri, and at Memorial Sloan-Kettering Cancer Center in New York City.
He is the author of more than 160 papers and has contributed numerous textbook chapters on topics related to the biological and clinical significance of genetic changes in neuroblastomas. Dr. Brodeur is also the principal investigator or co- investigator of six NIH/NCI grants studying the genetic basis of neuroblastomas.« Back to Previous Page