Karl Degenhardt, MD, PhD

Karl Degenhardt, MD, PhD, is an attending cardiologist with CHOP’s Cardiac Center and Fetal Heart Program.

Locations: Main Campus
Phone: 215-590-4040

  • Education and Training

    Medical School

    MD - Mount Sinai School of Medicine, New York, NY


    Pediatrics - Schneider Children’s Hospital, New Hyde Park, NY


    Pediatric Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Pediatric Cardiology

    Graduate Degree

    PhD - Mount Sinai School of Medicine, New York, NY

  • Titles and Academic Titles

    Attending Cardiologist

  • Departments and Services
  • Publications


    Degenhardt K.  Embryology of the cardiovascular system. In: Rychik J, Tian Z, editors. Fetal cardiovascular imaging: a disease based approach. Philadelphia: Elsevier; 2011. p. 10-16.


    Degenhardt K, Singh MK, Massera D, Wang Q, Li J, Lu M, et al. Anomalous pulmonary venous connections result from disruption of sema3D [abstract]. Weinstein Cardiovascular Development Conference; 2011 May 5-7; Cincinnati, OH.



    Patel MR, Pandya KG, Lau-Cam CA, Singh S, Pino MA, Billack B, et al. Design and synthesis of N-substituted indazole-3-carboxamides as poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors(†). Chem Biol Drug Des. 2012 Apr;79(4):488-96. doi: 10.1111/j.1747-0285.2011.01302.x. Epub 2012 Jan 30. Cited in PubMed; PMID 22177599. Read the abstract  

    Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, et al. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell. 2012 Mar 13;22(3):639-50. Cited in PubMed; PMID 22421048. Read the abstract


    Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging. 2010 May;3(3):314-22. Epub 2010 Feb 27. Cited in PubMed; PMID 20190279. Read the article

    Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, et al. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15;339(2):519-27. Epub 2010 Jan 4. Cited in PubMed; PMCID: PMC2830354. Read the article