Phyllis A. Dennery, MD, FAAP

Phyllis A. Dennery, MD, is chief of the Division of Neonatology at The Children’s Hospital of Philadelphia and a nationally recognized medical researcher.

Areas of Expertise: Bronchopulmonary dysplasia, Hyperoxic gene regulation, Neonatal jaundice, Neonatal lung injury
Locations: Main Campus
Phone: 215-590-1653

  • Background

    Phyllis Dennery, MD, FAAP, is chief of the Division of Neonatology and Newborn Service at The Children's Hospital of Philadelphia and the University of Pennsylvania Health System. She is also the director of the Neonatal-Perinatal Fellowship Training Program. In addition, Dr. Dennery is Professor of Pediatrics with tenure at the Perelman School of Medicine at the University of Pennsylvania and the Werner & Gertrude Henle Endowed Professor in Neonatology. She received an honorary Master in Arts from the University of Pennsylvania and an honorary Doctor of Science from Ursinus College.

    After receiving her medical degree from Howard University in Washington, DC, Dr. Dennery completed a residency in pediatrics at Children’s Hospital National Medical Center also in Washington, DC, and a fellowship in Neonatology at Case Western Reserve University (Rainbow Babies and Children’s Hospital) in Cleveland, Ohio.

    Dr. Dennery serves as an attending physician in the Newborn/Infant Intensive Care Unit at The Children's Hospital of Philadelphia as well as the Neonatal Intensive Care Unit at the Hospital of the University of Pennsylvania. She is also highly active in the training and supervision of medical students, house staff and neonatal post-doctoral fellows.

    Dr. Dennery is a nationally and internationally recognized speaker. Her area of basic science research is in the regulation of lung gene expression in oxidative stress, in particular the role of heme oxygenase, the rate-limiting enzyme in bilirubin production. Her clinical interest is in neonatal jaundice.

    She is the author of more than 100 publications including manuscripts, book chapters, editorials and abstracts and holds several grants from the National Institutes of Health.

    She is the recipient of many awards and honors including the first Mordechai Wyatt Johnson Scholarship, the Alma Wells Givens Award, the Grafton Rayner and Edna Spriggs Browne Award for highest cumulative average, The American Medical Women’s Association Award, the Andrew Mellon Fellowship, the Ross Young Investigator Award from the Western Society of Pediatrics, etc.

    Dr. Dennery was nominated and elected to Who’s Who Amongst Black Americans, Who’s Who in the World and to Leaders in Academic Achievements. She serves as an editor for Free Radicals in Biology and Medicine and she is a member of the Editorial Board for Pediatrics and Archives of Pediatric and Adolescent Medicine.

    In addition, she is a grant reviewer for the National Institutes of Health, the American Lung Association and the American Thoracic Society and serves on the Subboard of Neonatal-Perinatal medicine of the American Board of Pediatrics.

    Dr. Dennery is an active member of many professional and scientific societies including the American Thoracic Society, the Society for Pediatric Research and the American Pediatric Society.

  • Education and Training

    Medical School

    MD-Howard University, Washington, DC

    Internship

    Children's Hospital National Medical Center, Washington, DC

    Residency

    Pediatrics - Children's Hospital National Medical Center, Washington, DC

    Fellowship

    Neonatology - Case Western Reserve University, Cleveland, OH

    Board Certification

    Neonatal-Perinatal Medicine
    Pediatrics

  • Titles and Academic Titles

    Chief, Division of Neonatology

    Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests
  • Publications

    Books

    Chapters

    2013

    Series in Oxidative Stress, Studies on Perinatal and Prenatal Disorders. Springer Science, Dennery PA (ed.) Buonocore G, Saugstad O (co-eds), 2013 (In Press).

    2012

    Posencheg MA, Dennery PA. Hemolytic disease of the fetus and newborn. In: Bope E, Kellerman R, editors. Conn's current therapy. Philadelphia: Saunders Press, 2012.

    Dennery PA. Role and regulation of heme oxygenase in oxidant stress. In: Pantopoulos K, Schipper H, editors. Principles of free radical biomedicine Vol. II. Lady Davis Institute for Medical Research. Montreal: 2012, Chapter 23, pp 203-230.

    2010

    Dennery PA, Kirpalani, H: Neonatal Respiratory Distress Syndrome in First Consult (MD Consult e-journal). Elsevier Publishing Lazoff M ed.), 2010.

    2009

    Stevenson DK, Wong RJ, Dennery PA. Specific conditions associated with fetal and neonatal brain injury: hyberbilirubinemia and kernicterus. In: Benitz W, Sunshine P, Hintz SR, Druzin ML, Stevenson DK, editors. Fetal and neonatal brain injury: fourth edition. Cambridge: Cambridge University Press; 2009: 3(27): 311-317.

    2006

    Dennery PA. Novel functions of heme oxygenase protein. In: Otterbein LE, Zuckerbraun BS, editors. Heme oxygenase: the elegant orchestra of its products in medicine. Hauppauge, New York: Nova Science Publishers; 2006.

    2001

    Dennery PA. Developmental biology of heme oxygenase and carbon monoxide in the cardiopulmonary system. In: Wang R, editor. Carbon monoxide and cardiovascular functions. CRC Press; 2001.

    1996

    Dennery PA, Stevenson DK. Specific abnormalities associated with fetal and neonatal brain injury: hyperbilirubinemia. In: Sunshine P, Stevenson DK, editors.  Fetal and neonatal brain injury: mechanisms, management, and the risks of practice. 2nd Edition. Oxford University Press;1996.

    1995

    Dennery PA, Stevenson DK. Delivery room care. In: Reed GTB, Claireaux AE, Cockbury F, editors. Diseases of the fetus and newborn: pathology, imaging, genetics, and management. Chapman and Hall Ltd.; 1995.

    Dennery PA, Stevenson DK. Neonatal management of hemolytic hyperbilirubinemia. In: Reed GTB, Claireaux AE, Cockbury F, editors. Diseases of the fetus and newborn: pathology, imaging, genetics, and management. Chapman and Hall Ltd.; 1995, 2008.

    1993

    Dennery PA, Stevenson DK. Neonatal hyperbilirubinemia. In: Polin RA, editor. Workbook of practical neonatology. Philadelphia: W.B. Saunders Company; 1993.

    1992

    Dennery PA, Baxter LM, Stevenson DK. Respiratory distress in the newborn. In: Prober CG, Behrman RE, editors. Nelson self-assessment program, neonatology. Philadelphia: W.B. Saunders Company; 1992.

    Dennery PA, Stevenson DK. Neonatal jaundice. In: Prober CG, Behrman RE, editors. Nelson self-assessment program, neonatology. Philadelphia: W.B. Saunders Company; 1992.

    Papers

    2014

    Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G, Dennery PA. Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2 Impacting Metabolic and Anti-oxidant Defenses. J Biol Chem. 2014 Aug 8. pii: jbc.M114.567685. [Epub ahead of print]. Read the abstract.

    McKenna S, Michaelis KA, Agboke F, Liu GT, Han K, Yang G, Dennery PA, Wright CJ. Sustained hyperoxia-induced NFkB activation improves survival and preserves lung development in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 18. [Epub ahead of print] Read the abstract.

    2013

    La P, Dennery PA. Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism. J Bioi Chem 3:288(18):12901-9,2013. 

    Yang G, Biswas C, Lin QS, La P, Namba F, Zhuang T, Muthu M, Dennery PA. Heme oxygenase-1 regulates gene expression and protein translation in the postnatal lung after hyperoxia via hnRNPK/B-catenin signaling. Redox Biology 1:234-243,2013.

    Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ. IkBB-mediated NF-kB activation confers protection against hyperoxic lung injury. Am J Resp Cell Mol Bioi [Epub ahead of print] PMID: 24066808 2013.

    Yang G, Wright CJ, Hinson M, Fernando PA Dennery PA. Oxidative stress and inflammation alter circadian rhythmicity via conserved NFkB and NrF2 sites on the Rev-ERBa promoter. Antiox Redox Signaling (In review), 2013. 

    Namba F, Go H, Murphy JA, La P, Yang G, Sengupta S, Fernando PA, Yohannes M, Dennery PA. Expression Ievel and subcellular localization of heme oxygenase-1 modulates its cytoprotective properties in response to lung injury. Am J Resp Cell Mol BioI (In review), 2013. 

    Hinson M, Yang G, Dennery PA. Role of Rev-Erb in oxidative injury. Cell Signaling (Submitted). 2013. 

    Szczepanski KA, Yang G, Lin Q, Foster CD Dennery PA. Maturational differences in hypoxic induction of lung heme oxygenase-1 (HO-1) in mice and possible physiologic implications. (Submitted), 2013.

    La P, Fernando PA, Yang G, Hinson M, Dennery PA. Nuclear HO-1 modulates oxidative DNA repair after hyperoxic injury. J BioI Chern (SubmiLIed), 2013.

    Yang G, Hinson M, Dennery PA. Developmental regulation of the nuclear receptor Rev-ERBa in the lung. Am J Resp Cell Mol BioI (In preparation), 2013.

    2012

    Dennery PA. Evaluating the beneficial and detrimental effects of bile pigments in early and later life. Front Pharmacol. 2012;3:115. Epub 2012 Jun 22. Cited in PubMed; PMID 22737125. Read the article

    Wright CJ, Agboke F, Muthu M, Mundy M, La P, Yang G, et al. Oxidative stress signaling through the NF-kB inhibitory protein I-kBß prevents apoptotic cell death. J Biol Chem. 2012 Feb 24;287(9):6230-9. Epub 2012 Jan 5. Cited in PubMed; PMID 22223647. Read the abstract

    Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, et al. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012 Jan 1;52(1):1-6. Epub 2011 Oct 2. Cited in PubMed; PMID 22027063. Read the abstract

    2011

    Dennery PA. Introduction to the special issue on translational research involving oxidative stress. Free Radic Biol Med. 2011 Sep 1;51(5):923-4. Epub 2011 Jun 6. Cited in PubMed; PMID 21679766. No abstract available.

    Yang G, Hinson MD, Bordner JE, Lin QZ, Fernando AP, La P, et al. Silencing hyperoxia-induced C/EBPα in neonatal mice improves lung architecture via enhanced proliferation of alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L187-96. Epub 2011 May 13. Cited in PubMed; PMID 21571903. Read the abstract

    2010

    Wright CJ, Agboke F, Chen F, La P, Yang G, Dennery PA. Nitric oxide inhibits hyperoxia-induced NF-kappaB activation in neonatal pulmonary microvascular endothelial cells. Pediatr Res. 2010 Dec;68(6):484-9. Epub 2010 Aug 27. Cited in PubMed; PMID 20805787. Read the article.

    Zhuang T, Zhang M, Zhang H, Dennery PA, Lin QS. Disrupted postnatal lung development in heme oxygenase-1 deficient mice. Respir Res. 2010 Oct 10;11:142. Cited in PubMed; PMID 20932343. Read the article.

    Dennery PA. Oxidative stress in development: nature or nurture? Free Radic Biol Med. 2010 Oct 15;49(7):1147-51. Epub 2010 Jul 23. Cited in PubMed; PMID 20656021. Read the abstract

    Dennery, PA. Oxygen administration in the care of neonates: a double-edged sword. Chin Med J (Engl). 2010 Oct;123(20):2938-42. Cited in PubMed; PMID 21034610. Read the abstract

  • Editorial and Academic Positions

    Editorial positions

    2013-present, National Journal Club, American Thoracic Society

    2012-present, SPR Strategic Planning Committee

    2010-present, Editorial Board, Journal of Neonatal Perinatal Medicine

    2007-present, Associate Editor, Pediatrics

    2003-present, Editorial Board, Pediatrics

    2002-present, Associate Editor, Free Radicals in Biology and Medicine

    Academic and institutional positions

    2012- present, Chair, N/IICU 50th Anniversary Committee, The Children’s Hospital of Philadelphia

    2008-present, Member, Special Delivery Unit, Executive Committee, The Children’s Hospital Of Philadelphia

    2007-present, Executive Committee of the Medical Staff, The Children’s Hospital of Philadelphia

    2006-present, Neonatology-Perinatology Workgroup, The Children's Hospital of Philadelphia

    2006-present, Committee for Appointments and Promotions (COAP), The Children's Hospital of Philadelphia