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Steven D. Douglas, MD

Medical Director, Immunogenetics Laboratory

Associate Chair, Academic Affairs, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Original Papers


 Vinet-Oliphant H, Alvarez X, Buza E, Borda JT, Mohan M, Aye PP, Tuluc F, Douglas SD, Lackner AA. Neurokinin-1 Receptor (NK1-R) Expression in the Brains of SIV-Infected Rhesus Macaques. Implications for Substance P in NK1-R Immune Cell Trafficking into the CNS. Am J Pathol. 2010 Jul 29. [Epub ahead of print]. Read abstract

Campbell DE, Lai JP, Tustin NB, Riedel E, Tustin R 3rd, Taylor J, Murray J, Douglas SD. Analytical and biological considerations in the measurement of cell-associated CCR5 and CXCR4 mRNA and protein. Clin Vaccine Immunol. 2010 Jul;17(7):1148-54. Epub 2010 May 12. Read abstract


Meshki J, Douglas SD, Lai JP, Schwartz L, Kilpatrick LE, Tuluc F. Neurokinin 1 receptor (NK1R) mediates membrane blebbing in HEK293 cells through a Rho/ROCK-dependent mechanism. J Biol Chem. 2009;Apr 3;284(14):9280-9

Douglas SD, Lai JP, Tuluc F, Kilpatrick LE. Neurokinin 1 receptor isoforms and the control of innate immunity. Trends Immunol. 2009 Jun;30(6):271-6. Epub 2009 May 7. 2009


Chernova I, Lai J-P, Li H, Tuluc F, Korchak HM, Douglas SD, Kilpatrick LE. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes which express the truncated neurokinin 1 receptor (NK1R). J Leukoc Biol. 2008;85 154-164

Douglas SD, Lai J-P, Tuluc F, Schwartz L, Kilpatrick LE. Neurokinin-1 Receptor Expression and Function in Human Macrophages and Brain - Role in HIV Neuropathogenesis - (Perspective. Ann N Y Acad Sci. 2008;1144:90-6

Lai JP, Lai S, Tuluc F, Tansky MF, Kilpatrick LE, Leeman SE, Douglas SD. Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2008 Aug 26;105(34):12605-12610.


Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD. Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2006 May 16;103(20):7771-7776.

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