Carolyn A. Felix, MD

Carolyn A. Felix, MD, is an attending physician at CHOP’s Cancer Center with an expertise in treating leukemia in children.

Areas of Expertise: Leukemia as a complication of anticancer treatment, Leukemia in infants, Molecular pathogenesis of childhood leukemia
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Medical School

    MD - Boston University School of Medicine, Boston, MA


    Pediatrics - Children's Hospital of Pittsburgh, PA


    Pediatrics - Children's Hospital of Pittsburgh, PA


    Medical Staff Fellow - National Cancer Institute, Pediatric Branch, NIH, Bethesda, MD
    Biotechnology Fellow - Pediatric Branch, National Cancer Institute, Bethesda, MD

    Board Certification


  • Titles and Academic Titles

    Attending Physician

    Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Publications


    Barker, D.E., Dragnani, T.A., Dunnick, J.K., Felix, C.A., Ferguson, L.R., Joel, S.P., von Kries, R., van Leeuwen, F.E., Little, J., Olin, S., Olsen, J.H., Poirier, M.C., Shearer, M.J., Slikker Jr., W., Sullivan, F.M., Tursov, V., Walker, V.E.: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 76. Lyon: IARC Press, 2000.



    O'Sullivan, M.J, Felix, C.A., Fletcher, J.A.: Chapter 45. Cytogenetic and Molecular Pathology of Pediatric Cancer, in ‘Oncology of Infancy and Childhood’, 8th Edition, Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., Nathan, D.G., Editors. Saunders Elsevier, Philadelphia (In Press).


    Felix, C.A.: Therapy-Related Leukemias, in ‘Childhood Leukemias’ 3rd Edition, Pui, C.-H., Editor, Cambridge University Press, Cambridge, UK. pp 723-771, 2012.


    Felix, C.A.: Infant leukemia 2010: A call to action for the West and the “Four Asian Tigers”. Pediatr Blood Cancer. 55(7):1247-9, 2010. Epub 2010/10/29

    Brown, P.A., Felix, C.A.: Molecularly Targeted Therapy for Infant ALL, in ‘Molecularly Targeted Therapy for Childhood Cancer’, Arceci, R.J. & Houghton, P.J., Editors. pp. 31-58. Springer Science, New York, 2010.


    O'Sullivan, M.J, Fletcher, J.A., Felix, C.A.: Chapter 5. Cytogenetic and Molecular Pathology of Pediatric Cancer, in ‘Oncology of Infancy and Childhood’, 7th Edition, Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., Nathan, D.G., Editors. Saunders Elsevier, Philadelphia. pp. 99-174, 2009.


    Felix, C.A.: Chapter 29. Secondary Myelodysplasia/Acute Myeloid Leukemia, in 'Clinical Hematology' 1st Edition, Young, N.S., Gerson, S.L., High, K.A. Editors, Elsevier, Philadelphia.  p. 374-389, 2006.

    Felix, C.A.: Chapter 31. Therapy-Related Leukemias, in ‘Childhood Leukemias’ 2nd Edition, Pui, C.-H., Editor, Cambridge University Press, Cambridge, UK. p. 774-804, 2006.


    Iannone, R., Pulsipher, M., Slayton, W., Felix, C.A.: A review of hematopoietic stem cell transplantation for infant acute lymphoblastic leukemia with MLL gene rearrangement. (Minireview) In: BloodMed, Cotter, FE (Ed), BloodMed, Blackwell Publishing, Oxford, 2004.


    Felix, C.A.: Chemotherapy-related second cancers. In: Multiple Primary Cancers: Incidence, Etiology, Diagnosis and Prevention, A.I. Neugut, A.T. Meadows & E. Robinson (Eds), Williams & Wilkins, Baltimore, MD, pp. 137-164, 1999.


    Kirsch, I.R., Aplan, P.D., Begley, C.G., Bertness, V., Felix, C.A., Lipkowitz, S., Nakahara, K., Nussmeier, M., Reynolds, L., Seibel, N., Stern, M.H., Tchorz, K.:  Abnormal antigen receptor formation in normal, ataxia-telangiectasia, and malignant lymphocytes.  In:  The Molecular Basis of Immune Diseases, Miami Biotechnology Winter Symposia, IRL Press/Oxford University Press, pp 22-24, 1990.


    Felix, C.A., Korsmeyer, S.J.:  Immunology and molecular biology of lymphomas. In:  Thoracic Oncology, J. Roth, J. Ruckerderschel & T. Weisenburger (Eds), Orlando, W.B. Saunders, pp. 403-447, 1988.


    Graninger, W., Wright, J.J., Felix, C.A., Korsmeyer, S.J.:  Characterization of acute leukemia using lineage associated molecular probes.  In:  The Acute Leukemias: Biologic, Diagnostic, and Therapeutic Determinants, S.A. Stass (Ed), New York, Marcel Decker, Inc., pp. 299-325, 1987.

    Kirsch, I.R., Bertness, V., Denny, C., Felix, C.A., Seibel, N., Hollis, G.F.: Gene rearrangements in B and T-cells.  In:  Chronic Lymphocytic Leukemia:  Recent Progress, Future Directions, R.P. Gale & K. Rai (Eds), New York, Alan R. Liss, Inc., pp. 1-10, 1987.


    Korsmeyer, S.J., Bakhshi, A., Wright, J.J., Graninger, W.C., Felix, C.A., Seto, M.: Molecular markers of clonality, lineage, differentiation, and translocation in B-cell neoplasms.  In:  The Molecular Basis of B-Lymphocyte Differentiation and Function, M. Ferrarini (Ed), New York, Plenum Press, pp 131-139, 1986.



    Peng, M., Ostrovsky, J., Kwon, Y., Polvak, E., Licata, J., Tsukikawa, M., Marty, E, Thomas, J., Felix, C.A., Xiao, R., Zhang, Z., Gasser, D., Argon, Y., Falk, M. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Hum Mol Genet [Epub 2015 Jun 3. doi: 10.1093/hmg/ddv207] Accession number 26041819


    Dreyer, Z.E., Hilden, J.M., Jones, T., Devidas, M., Winick, N.J., Willman, C.L., Harvey, R.C., Chen, I.-M., Behm, F.G., Pullen J., Wood, B.L., Carroll A.J., Heerema, N.A., Felix, C.A., Robinson, B., Reaman G.H., Salzer,W.L., Hunger, S.P., Carroll, W.L., Camitta, B.M. Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3). Pediatr Blood Cancer. 62(3) 419-426,2015 [Epub Nov 2014. doi: 10.1002/pbc.25322]


    Urtishak, K.A., Edwards, A.Y.Z., Wang, L.-S., Hudome, A., Robinson, B.W., Barrett, J.S., Cao, K., Cory, L., Moore, J.S., Bantly, A.D., Yu, Q.-C., Chen, I.-M. L., Atlas,S.R., Willman, C.L., Kundu, M., Carroll, A.J., Heerema, N.A., Devidas, M. Hilden, J.M., Dreyer, Z.E., Hunger, S.P. Reaman, G.H., Felix, C.A. : Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia (ALL). Blood. 2013 (121) 2689-2703, 2013 Apr 4.  [Epub date 2013/02/07] PMID 23393050

    Posters and Presentations


    Urtishak, K.A., Wang, L.-S., Teachey, D.T., Tasian, S.K., Barrett, J.S., Chen, I-M.L., Atlas, S.R., Harvey, R.C., Heerema, N.A., Carroll, A.J., Hunger, S.P., Willman, C.L., Felix, C.A. PI3K/AKT/mTOR Signaling is a Significant Druggable Pathway in Infant Acute Lymphoblastic Leukemia (ALL). Proc 55th Annual Meeting American Society of Hematology, 2013. (Presented by K. Urtishak)

    Invited Lectures


    “Dysregulated Gene Expression and Molecular Targeting of Infant ALL”, ACC Hematologic Malignancies Program / Normal & Malignant Hematopoiesis RAG Joint Retreat, Philadelphia, PA, September 2014.


    “Pharmacologic Targeting of Cell Death and Signaling Alterations in Infant ALL,” CHOP Research Institute 2013 Scientific Symposium: Collaboration Fueling Discovery; in Plenary Session II: Mito Cell, the Search for a Signal Answer, Philadelphia, PA, May 2013.

    “Flow Cytometric Assays in Therapeutic Targeting of Infant ALL,” PennFlow 2013: Measuring the Life and Death of a Cell, Philadelphia, PA, April 2013.

  • Awards and Honors

    2012, Joshua Kahan Endowed Chair in Pediatric Leukemia
    2007, America's Top Doctors For Cancer
    2006, Eagles Fly for Leukemia Award for Excellence in Treatment of Pediatric Cancer Patients
    2006, Association of American Physicians (Elected Member)
    2005-2006, 2009-2012, Philadelphia Magazine Top Doctors
    2003, Society for Pediatric Research (Elected Member)
    2001, Stohlman Scholar Award, Leukemia & Lymphoma Society
    2000, Honorary Master of Arts Degree, University of Pennsylvania
    2000, Eastern Pennsylvania Chapter Leukemia & Lymphoma Society Distinguished Leadership Award
    1999, Klaus and Mary Hummeler Endowed Research Prize, The Children's Hospital of Philadelphia
    1999, Eastern Pennsylvania Chapter Leukemia Society of America Distinguished Leadership Award
    1992, American Society of Clinical Oncology Young Investigator Award
    1991, American Association for Cancer Research Travel Award
    1990, American Society of Pediatric Hematology-Oncology Young Investigator Award
    1988, American Society of Hematology Travel Award
    1987, American Society of Clinical Oncology Young Investigator in Training Travel Award
    1977, Alpha Sigma Nu
    1977, Alpha Epsilon Delta
    1976, Phi Beta Kappa-junior year induction
    1977, Graduated summa cum laude - Boston College, Chestnut Hill, MA
    1973-1977, Boston College Honors Program

  • Editorial and Academic Positions

    Editorial Positions

    2013-present, Blood, editorial board
    2004-2014, Pediatric Blood & Cancer, editorial board

    Ad Hoc Reviewer

    American Journal of Hematology
    American Journal of Human Genetics
    British Journal of Cancer
    British Journal of Haematology
    Cancer Genetics and Cytogenetics
    Cancer Letters
    Cancer Research
    Clinical Cancer Research
    Clinical and Diagnostic Laboratory Immunology
    Genes, Chromosomes and Cancer
    International Journal of Pediatric Hematology/Oncology
    Journal of Clinical Investigation
    Journal of Clinical Oncology
    Journal of the National Cancer Institute
    Journal of Pediatrics
    Molecular Diagnosis
    New England Journal of  Medicine
    Pediatric Blood & Cancer
    Proceedings of the National Academy of Sciences
    The American Journal of Human Genetics
    The Journal of Pediatric Hematology-Oncology
    European Journal of Hematology 

    Academic and Institutional Committees

    2011-2014, Hearings List for the Faculty Grievance Commission
    2004-present, Research Affinity Group (RAG) Council, Joseph Stokes, Jr. Research Institute
    2003-present, Normal and Malignant Hematopoiesis Research Affinity Group Leader
    1999-present, University of Pennsylvania School of Medicine Combined Degree Admissions/Advisory Committee
    1998, Founding Member, Center for Cancer Pharmacology, University of Pennsylvania Cancer Center

  • Leaderships

    Memberships in Professional Organizations

    2006-present, Association of American Physicians
    2003-present, Society for Pediatric Research
    2000-present, Children’s Oncology Group
    1999-present, American Association for the Advancement of Science
    1994-present, American Society of Hematology
    1992-present, American Society of Clinical Oncology
    1991-present, American Association for Cancer Research
    1988-present, American Society of Pediatric Hematology-Oncology