Find a Doctor

Alan W. Flake, MD, FACS, FAAP

Attending Surgeon

Director, General Surgery Fellowship Program

Director, Center for Fetal Research

Ruth M. and Tristram C. Colket Jr. Endowed Chair, Pediatric Surgery

Professor of Surgery, Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania

  • Phone 800-468-8376

Original Papers

2012

Danzer E, Zarnow D, Gerdes M, D'Agostino JA, Siegle J, Bebbington MW, et al. Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia. J Pediatr Surg. 2012 Mar;47(3):453-61. Cited in PubMed; PMID:22424337. Read the abstract

Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol. 2012;891:169-81. Cited in PubMed; PMID:22648772. Read the abstract 

Nijagal A, Flake AW, MacKenzie TC. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun;39(2):301-10. Epub 2012 May 8. Cited in PubMed; PMID:22682381. Read the abstract 

Abi-Nader KN, Boyd M, Flake AW, Mehta V, Peebles D, David AL. Animal models for prenatal gene therapy: the sheep model. Methods Mol Biol. 2012;891:219-48. Cited in PubMed; PMID:22648775. Read the abstract

Roybal JL, Endo M, Buckley SM, Herbert BR, Waddington SN, Flake AW. Animal models for prenatal gene therapy: rodent models for prenatal gene therapy. Methods Mol Biol. 2012;891:201-18. Cited in PubMed; PMID:22648774. Read the abstract 

Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, Adzick NS. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16. Cited in PubMed; PMID:22703795. Read the abstract 

2010

Laje P, Clark FH, Friedman JR, Flake AW. Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. J Pediatr Surg. 2010 Sep;45(9):1791-6. Read abstract.

Danzer E, Gerdes M, Bernbaum J, D'Agostino J, Bebbington MW, Siegle J, Hoffman C, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program. J Pediatr Surg. 2010 Sep;45(9):1759-66. Read abstract.

Roybal JL, Liechty KW, Hedrick HL, Bebbington MW, Johnson MP, Coleman BG, Adzick NS, Flake AW. Predicting the severity of congenital high airway obstruction syndrome. J Pediatr Surg. 2010 Aug;45(8):1633-9. Read abstract.

Danzer E, Layne MD, Auber F, Shegu S, Kreiger P, Radu A, Volpe M, Adzick NS, Flake AW.Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine.  Pediatr Res. 2010 Jul;68(1):23-8. Read abstract

 Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Siegle J, Hoffman C, Rintoul NE, Liechty KW, Flake AW, Adzick NS, Hedrick HL. Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. J Pediatr Surg. 2010 Apr;45(4):718-23. Read abstract

Watanabe M, Jo J, Radu A, Kaneko M, Tabata Y, Flake AW. A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor. Tissue Eng Part A. 2010 May;16(5):1645-55. Read abstract

Wilson RD, Lemerand K, Johnson MP, Flake AW, Bebbington M, Hedrick HL, Adzick NS. Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007). Am J Obstet Gynecol. 2010 May 27. Read abstract

Kaye AJ, Rand EB, Munoz PS, Spinner NB, Flake AW, Kamath BM. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol. J Pediatr Gastroenterol Nutr. 2010 Jun 30. Read abstract

Kaye AJ, Rand EB, Munoz PS, Spinner NB, Flake AW, Kamath BM. Effect of Kasai Procedure on Hepatic Outcome in Alagille Syndrome. J Pediatr Gastroenterol Nutr. 2010 Jun 30. Read abstract

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