John Flibotte, MD

Areas of Expertise: Infant brain injury, Neonatal neurocritical care, Neuroimaging
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Background

    I am a neonatologist with longstanding interest in the neurosciences. I am continuing my research development under the mentorship of Robert G. Kalb, MD, using C. elegans (a worm) to model hypoxic injury in developing animals.

    The relationship between evolving oxygen-sensing ability and hypoxic injury is not well studied. Currently, we are using the worm to begin to address this question and investigate whether intercellular signaling events influence whole animal survival and neural injury.

    My ultimate goal is to leverage this information towards the development of neuroprotective therapies for brain-injured infants.

  • Education and Training

    Medical School

    MD - Harvard Medical School, Boston, MA

    Internship

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Residency

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    Neonatology - The Children's Hospital of Philadelphia, Philadelphia, PA

    Additional Training

    Neonatology Research Fellow - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Neonatal-Perinatal Medicine
    Pediatrics

  • Titles and Academic Titles

    Attending Neonatologist

    Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Oxygen sensing and molecular response to hypoxia
    Mechanisms of neuronal injury after hypoxia
    Neural development after hypoxic injury
    Model organisms

     

  • Publications

    Books

    Flibotte J (2011). Gastrointestinal disorders. In T Florin and S Ludwig (Eds.), Netter’s Pediatrics (pp. 652-657). Oxford: Elsevier.

    Abstracts

    2014

    Flibotte J, Kalb RG: Neural oxygen sensing and neuropeptide signaling influence survival after anoxia in C. elegans. Vancouver, Canada, 5/6/2014. [poster presentation] Pediatric Academic Societies/Asian Society for Pediatric Research Annual Meeting 2014.

    2012

    Flibotte J & Kalb RG (2012) “Oxygen Sensing Neurons and Selective Neuronal Vulnerability in C. elegans.” Perinatal and Developmental Symposium, Aspen, CO, 6/8/2012. [platform presentation]

    Flibotte J, Lee GE, Buser G, Sen S, Chandra S, Baorto EP, Feja KN, Tolan RW, McSherry GD, Nolan SM, Zhang H (2012) “Congenital Tuberculosis in Five Neonates Conceived by In Vitro Fertilization.” Pediatric Academic Societies Annual Meeting, Boston, MA, 4/28-5/1/2012. [poster presentation]

    Flibotte J, Lee GE, Buser G, Sen S, Chandra S, Baorto EP, Feja KN, Tolan RW, McSherry GD, Nolan SM, Zhang H (2012) “Congenital Tuberculosis in Five Neonates Conceived by In Vitro Fertilization.” Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA, 3/30-4/1/2012. [poster presentation]

    2011

    Lee GE, Flibotte J, Buser G, Nolan S, Zhang H, Baorto EP, McSherry GD, Feja KN, Tolan RW (2011) “Congenital Tuberculosis Following In Vitro Fertilization: Case Series of Five Indian Infants from New Jersey.” Infectious Diseases Society of America Annual Meeting, Boston, MA, 10/20-10/23/2011.

    Papers

    2013

    Flibotte JJ, Lee GE, Buser GL, et al. (2013) “Infertility, In Vitro Fertilizaiton, and Emerging Congenital Tuberculosis.” J. Perinatology, 33: 565-568.

  • Editorial and Academic Positions

    Academic and institutional committees

    2012-present, Fellow representative. Trainees and Early Career Neonatologists, American Academy of Pediatrics
    2011-present, Resident Lecture Committee
    2011-2013, Neonatology-Perinatology Fellowship Improvement Committee