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Joshua R. Friedman, MD, PhD

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2010

Zahm AM, Thayu M, Hand NJ, Horner A, Leonard MB, Friedman JR. MicroRNA is a novel biomarker for pediatric Crohn disease [abstract]. NASPGHAN Annual Meeting; 2010 Nov 12-14; National Harbor, MD.

Awards

2008, Researcher of the Year, American Liver Foundation, Delaware Valley Chapter
2007, NASPGHAN Young Faculty Investigator Award
2006-2007, Foerderer-Murray Award, CHOP
2004-2006, Children's Digestive Health and Nutrition Foundation Young Investigator Development Award
2003, First Place in Science Research, Komarov Competition
1997, Rose Meadow Levinson Memorial Prize for research by a medical student
1995, Juan Grana Prize for research by a medical student
1994, Young Scientist Travel Grant, AACR
1987-1991, Harvard College Scholarship

Books

Chapters

Friedman JR, Liacouras CA. Pathophysiology of gastroesophageal reflux. In: Polin RA, Fox WA, Abman SH, editors. Fetal and neonatal physiology. 3rd ed. Philadelphia: Saunders; 2004. p. 1163-1168.

Friedman JR. Alpha-1 antitrypsin deficiency. In: Schwartz MW, editor. The five-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 30-31.

Le PP, Friedman JR. Alpha-1 antitrypsin deficiency. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites in pediatrics. Philadelphia: Mosby Elsevier; 2008. p. 233-236.

Editorial and Academic Positions

Editorial positions

Ad Hoc Reviewer

2011-present, BMC Systems Biology
2011-present, Journal of Pediatric Gastroenterology and Nutrition
2011-present, American Journal of Pathology
2010-present, Journal of Clinical Investigation
2010-present, Science Translational Medicine
2010-present, American Journal of Physiology
2007-present, Gastroenterology
2007-present, Hepatology 

Editor

2011-2013, Contributing Associate Editor-in-chief, World Journal of Gastroenterology
2009-2010, Consulting Editor, Journal of Clinical Investigation

Academic committees

2011-present, Chair, Research Steering Committee, Division of Gastroenterology, The Children's Hospital of Philadelphia

2011-present, Member, Research Mentoring Committee, The Children's Hospital of Philadelphia

2008-2009, Member, Pediatric Residency Program Director Search Committee, The Children's Hospital of Philadelphia

Leadership

Memberships in professional organizations

International organizations

2010-present, Childhood Liver Disease Research and Education Network

  • Member, Progressive Familial Intrahepatic Cholestasis Committee
National organizations

2005-present, American Association for the Study of Liver Disease

  • 2010-2013, Basic Science Research Committee
  • 2008-present, Pediatrics Special Interest Group (Chair, Membership Subcommittee)

2002-present, American Gastroenterological Association

  • 2011-2013, Member, Nominating Committee for Growth, Development, and Aging Section

2001-present, North American Society of Pediatric Gastroenterology, Hepatology and Nutrition

2009-2011, National Institutes of Health

  • 2011, Hepatobiliary Pathophysiology (HBPP) Study Section (Ad Hoc Member)
  • 2011, ZRG1-DKUS-D Special Emphasis Panel (Ad Hoc Member)
  • 2010, ZRG1-EMNR-C Special Emphasis Panel (Ad Hoc Member)
  • 2009, ZRG1-DKUS-B SBIR Special Emphasis Panel (Ad Hoc Member)

Original Papers

2011

Friedman JR, Kaestner KH. On the origin of the liver. J Clin Invest. Epub 2011 Nov 21:1-4. doi: 10.1172/JCI59652. Cited in PubMed; PMID 22105167. Read the abstract

Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, et al. MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathol. Epub 2011 Nov 15. doi: 10.1111/j.1750-3639.2011.00551.x. Cited in PubMed; PMID 22082152. Read the abstract

Friedman JR, Voeltz, GK. The ER in 3D: a multifunctional dynamic membrane network. Trends Cell Biol. 2011 Dec;21(12):709-17. Epub 2011 Sep 6. Cited in PubMed; PMID 21900009. Read the abstract

Friedman JR, Lackner LL, West M, DiBenedetto JR, Nunari J, Voeltz GK. ER tubules mark sites of mitochondrial division. Science 2011 Oct 21; 334(6054):358-62. Epub 2011 Sep 1. Cited in PubMed; PMID 21885730. Read the abstract

Zahm AM, Thayu M, Hand NJ, Horner A, Leonard MB, Friedman JR. Circulating microRNA is a biomarker of pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2011 Jul;53(1):26-33. Cited in PubMed; PMID 21546856. Read the abstract

2010

Laje P, Clark FH, Friedman JR, Flake AW. Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. J Pediatr Surg. 2010 Sep;45(9):1791-6. Cited in PubMed; PMID 20850622. Read the abstract.

McKenna LB, Schug J, Vourekas A, McKenna JB, Bramswig N, Friedman JR, et al. MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology. Epub 2010 Jul 23. Cited in PubMed; PMCID: PMD3156097. Read the article

2009

Hand NJ, Master ZR, Eauclaire SF, Weinblatt DE, Matthews RP, Friedman JR. The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology. 2009 Mar;136(3):1081-90. Epub 2008 Dec 9. Cited in PubMed; PMCID: PMC2672911. Read the article

Hand NJ, Master ZR, Le Lay J, Friedman JR. Hepatic function is preserved in the absence of mature microRNAs. Hepatology. 2009 Feb;49(2):618-26. Cited in PubMed; PMCID: PMC2635423. Read the article  

Posters and Presentations

2011

Friedman JR. MicroRNA in gastrointestinal development and disease [presentation]. Baylor College of Medicine; 2011 Sep; Houston, TX.

Friedman JR. MicroRNAs as biomarkers in biliary atresia [presentation]. Children Annual Meeting; 2011 Sep; Baltimore, MD.

Friedman JR. MicroRNA in gastrointestinal development and disease [presentation]. University of Nebraska Medical Center Pathology Grand Rounds; 2011 Mar;

Friedman JR. Designing a research project [presentation]. Children Annual Meeting; 2011 Sep; Baltimore, MD.; Fort Lauderdale, FL.

2010

Friedman JR. MicroRNA in liver development and disease [presentation]. Mount Sinai School of Medicine; 2010 Nov; New York, NY.

Friedman JR. MicroRNA in liver development and disease [presentation]. Digestive Health Center, University of Cincinnati School of Medicine; 2010 Oct; Cincinnati, OH.

Friedman JR. MicroRNA in liver development and cholestatic liver disease [presentation]. FASEB Summer Research Conference; 2010 Aug 15-20; Snowmass Village, CO.

Friedman JR. MicroRNA in liver development and biliary atresia [presentation]. University of Pittsburgh Department of Pathology; 2010 Mar; Pittsburgh, PA.

Friedman JR. MicroRNA: from a roundworm to a clinic near you [presentation]. Penn State College of Medicine, Department of Pediatrics Grand Rounds; 2010 Mar; Hershey, PA.

Friedman JR. MicroRNA in liver development and disease [presentation]. American Society for Investigative Pathology Annual Meeting; 2010 Apr; New Orleans, LA.

2009

Hand NH, Master Z, Horner A, Clark HF, Friedman JR. MicroRNA in clinical and experimental biliary atresia [oral abstract presentation]. American Association for the Study of Liver Disease 60th Annual Meeting; 2009 Oct 30-Nov 3; Boston, MA .

Zahm A, Hand NH, Master Z, Clark HF, Friedman JR. Serum microRNA is a novel biomarker for experimental biliary atresia [oral abstract presentation]. American Association for the Study of Liver Disease 60th Annual Meeting; 2009 Oct 30-Nov 3; Boston, MA .

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