Claudio G. Giraudo, PhD

Claudio G. Giraudo, PhD, is a senior scientist at The Children's Hospital of Philadelphia Research Institute. His lab's focus is intracellular membrane trafficking events during the cytotoxic immune response.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Additional Training

    Postdoctoral Fellow - CIQUIBIC-CONICET, Centro de Investigaciones en QuímicaBiologica, Department of Biological Chemistry, National University of Córdoba, Córdoba, Argentina

    Postdoctoral Fellow - Department of Cellular Biophysics and Biochemistry, Memor

    Graduate Degree

    PhD in Chemical Sciences - National University of Córdoba, Córdoba, Argentina

  • Titles and Academic Titles

    Senior Scientist

    Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Intracellular membrane trafficking events during the cytotoxic immune response

  • Publications

    Papers

    2011

    Shi L, Daniel K, Melia T, Coleman J, Giraudo C. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Syntaxin 1 H3 domain and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60. Read the abstract

    Li F, Pincet F, Perez E, Giraudo C, Tareste D, Rothman J. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol. 2011 Jul; 24;18(8):941-6. Read the abstract

    Shyam K, Daniel R, Daniel K, Giraudo C, Li F, Khandan L, et al. A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol. 2011 Jul 24;18(8):934-40. Read the abstract

    Daniel K, Shyam K, Daniel R, Feng L, Giraudo C, Frederic P, et al. Complexin cross-link pre-fusion SNAREs into a zigzag array: a structure-based model for complexin clamping. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. Read the abstract 

    2010

    Quinteros CA, Giraudo CG, Villareal M, Montich G, Maccioni HJ. Identificatification of a site in Sar1 involved in the interaction with the Cts of Glycolipid Glycosyltransferases. J Biol Chem. 2010 Sept 24; 285(39): 30340–30346. Read the article

    2009

    Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an On-Off switch of SNARE-mediated membrane fusion. Science. 2009 Jan 23;323(5913):512-6. Read the abstract

    Posters and Presentations

    2010

    Giraudo C, Khandam L, Coleman J, Rothman J. Novel fluorescent probes to study sphingomyelin dynamics in living cells [poster]. American Society of Biochemistry and Molecular Biology (ASMBM): Symposia Biochemistry of Membrane Traffic: secretory and endocytic pathways; 2010 Oct; Tahoe, NV.

    2009

    Giraudo C. A clamping mechanism for calcium regulated exocytosis [presentation]. SAIB XLV Argentinean Society for Research in Biochemistry and Molecular Biology; 2009 Nov 10-13; Tucuman, Argentina.

    Giraudo C, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an on-off switch for snare-mediated membrane fusion [poster]. Molecular Membrane Biology Gordon Research Conference; 2009 Jul; Proctor Academy, NH.