Areas of Expertise:
Cell and molecular biology of asthma, Childhood respiratory diseases, Infant pulmonary function testing, Lung mechanics
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Dr. Grunstein is a pediatric pulmonologist with research interests in asthma and other chronic lung diseases that affect approximately 8 million children in the United States. His primary objective is to gain new insights into the causes and mechanisms of asthma and, thereby, develop new methods for treating asthma and other conditions associated with airway constriction, such as bronchiolitis and chronic bronchitis. A better understanding of the cellular and molecular mechanisms underlying asthma will lead to the development of new and more effective drugs and other therapeutic strategies.
The techniques used in Dr. Grunstein's laboratory are based on tissue and cellular experimental models of asthma which incorporate physiological, biochemical and molecular pharmacological approaches. His most active projects include an assessment of the roles of specific inherited genetic factors (atopy) and acquired factors (e.g. viral infections) in modifying the signal transduction mechanisms that regulate airway smooth muscle contractility and proliferation to produce the pro-asthmatic condition.
These studies examine pro-asthmatic modulation of gene expression of specific immunoglobulins, cytokines, their receptors, as well as the associated G proteins and second messenger systems which regulate airway smooth muscle growth and agonist responsiveness in the asthmatic state.
- Education and Training
McGill University, Faculty of Medicine, Montreal, Quebec, Canada
McGill University, Montreal, Quebec, Canada
University of Colorado School of Medicine, Denver, CO
University of California, San Francisco, CA
- Titles and Academic Titles
- Centers and Programs
- Research Interests
Immunobiology of airway smooth muscle
Nino G, Hu A, Grunstein JS, Grunstein MM. Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure. J Allergy Clin Immunol. 2010 May;125(5):1020-7. Epub 2010 Apr 14.
Campbell D, Destephan CM, Fatma S, Grunstein JS, Grunstein MM, Hu a, Orange JS, Veler H. Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal pro-asthmatic changes in airway function. J. Immunol. 178:3627-3636, 2007.
Chuang S, Fatma S, Grunstein JS, Grunstein MM, Shan X, Hu A, Veler H. Regulation of toll-like receptor 4-induced pro-asthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006; 291:L324-L333.
Chuang S, Grunstein J S, Grunstein MM, Larson J, Shan X, Veler H. Pro-Asthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle. J. Allergy Clin. Immunol. 2005;116:94-101.