Brian Hanna, MDCM, PhD, FAAP, FACC

Brian Hanna, MDCM, PhD, FAAP, FACC, is a board-certified cardiologist and director of the Section of Pulmonary Hypertension at CHOP.

Areas of Expertise: Autonomic nervous system development and physiology, Interventional cardiac catheterization in children, Pulmonary hypertension, Thoracic organ transplantation
Locations: Main Campus
Phone: 215-590-4040

  • Education and Training

    Medical School

    MDCM - McGill University, Faculty of Medicine, Montreal, Canada


    Pediatrics - Montreal Children's Hospital, Montreal, Canada


    Pediatrics - Montreal Children's Hospital, Montreal, Canada


    Pediatric Cardiology - Montreal Children's Hospital, Montreal, Canada
    Pediatric Cardiology - Boston Children's Hospital, Boston, MA
    Pediatric Cardiology and Research - Boston Children's Hospital, Boston, MA

    Board Certification

    Pediatric Cardiology

    Graduate Degree

    PhD in Physiology - McGill University, Department of Physiology, Montreal, Canada

  • Titles and Academic Titles

    Director, Section of Pulmonary Hypertension

    Clinical Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Research Interests

    Natural history of pediatric pulmonary hypertension
    Treatment trials for pulmonary hypertension
    Role of pulmonary hypertension in congenital heart disease.

  • Publications




    Lin K, Bernadzikowski T, Walker S, Hanna BD, Kaufman B. Heart failure, cardiomyopathy and pulmonary hypertension. In: Gleason M, Rychick J, Shaddy RE, editors. Pediatric practice: cardiology. McGraw-Hill; 2011. p. 251-66.


    Ravishankar, C and BD Hanna. Pulmonary Hypertension, In The Requisites-Pediatric Critical Care. Ed: D. Davis and M. Helfaer, Elsevier Publishing Co, 2008.

    Tabbut, S, T Domiguez and BD Hanna. Myocarditis, In The Requisites-Pediatric Critical Care. Ed: D. Davis and M. Helfaer, Elsevier Publishing Co, 2008.

    Bergelson JM, Hanna BD. Myocarditis and pericarditis. In: Bergelson J, Zaoutis T, Shah SS, editors. Pediatric infectious diseases: the requisites in pediatrics. Philadelphia: Elsevier Publishing Co; 2008.


    Hanna BD. Blood flow in the normal and diseased pulmonary artery. In: Fogel M, editor. Ventricular function and blood flow in congenital heart disease. New York: Futura Publishing Co, Inc.; 2005.

    Hanna BD. Metabolic abnormalities. In: Shaddy RE, Wernovsky G, editors. Pediatric heart failure. New York: Marcel Decker, Inc.; 2005. 


    Paquet M, Hanna BD. Cardiomyopathy. In: Oski FA, Deangelis C, Feigin RD, editors. The principles and practice of pediatrics. 2nd ed. Philadelphia: J.B. Lippincott; 1990. p. 1606-14. 


    Paquet M, Hanna BD. Cardiomyopathy.  In: Garson A, Bricker JT, McNammara DG. The science and practice of pediatric cardiology. Philadelphia: Lea and Febiger; 1989.  p. 1617-46. 


    Polosa C, Lioy F, Hanna BD. The role of the ventral medulla in the control of sympathetic activity by systemic arterial CO2.  In: Schlaefke ME, Koepchen HP, See WR, editors. Central neurone environment. Berlin (Germany): Springer-Verlag; 1983. p. 214-20.



    Glatz AC, Geisser D, McCarthy AL, Daniels K, Gillespie M, Hanna B, et al. Prevalence and risk factors for acute occlusive arterial injury following pediatric cardiac catheterization in the modern era at a large volume center [abstract]. ACC.12; 2012 Mar 24-27; Chicago, IL.

    Koko E, Meluskey H, Hanna BD. Occurrence of pulmonary hypertension in pediatric heterotaxy syndromes [abstract]. Cardiology 2012 Feb 22-26; 2012; Orlando, FL.


    Frank DB, Bshouty Z, Meluskey H, Patterson K, Walker S, Hanna BD. Quantifying vascular loss predicts survival in pediatric pulmonary hypertension: validating a new computational model [abstract]. ATS 2011 International Conference; 2011 May 13-18; Denver, CO.

    Dubey S, Meluskey H, Ramsey EZ, Patterson K, Walker S, Hanna. Sildenafil use in pediatric pulmonary hypertension (PH): minimal risk [abstract]. ATS 2011 International Conference; 2011 May 13-18; Denver, CO.

    Meluskey HL, Hanna BD, Munson D, Kirpalani H. Mortality estimates for severe BPD complicated by pulmonary hypertension [abstract]. SPR International Meeting, 2011.

    Hanna BD, Frank DB, Bshouty Z, Meluskey H. In pre-transplant pulmonary hypertension, does PVR tell the story? [abstract] ISHLT 2011; 2011 Apr 13-16; San Diego, CA.

    Hanna, BD, Frank, DB, HL Meluskey, KL Patterson, S Walker, Z. Bshouty. Paradigm shift: quantifying vascular growth in bronchopulmonary dysplasia and pulmonary hypertension [abstract]. SPR 2011.

    Rossano J, Hanna BD, et al. Increasing prevalence and decreasing mortality in pulmonary hypertension related hospitalizations in the United States: an analysis of over 20,000 hospital admissions [abstract]. AHA, Fall meeting, 2011.


    Mirarchi N, Goldberg DJ, Glatz AC, Marino B, Paisley AM, Paridon S, et al. Sildenafil is well tolerated in children and young adults late after the Fontan operation [abstract]. AHA Fall Meeting, 2010

    Healy F, Hanna BD, Hedrick H, Panitch HB. An association between pulmonary hypertension and impaired lung function in infants with congenital diaphragmatic hernia. American Thoracic Society (ATS) International Conference; 2010 May 14-19; New Orleans, LA.

    Glatz AC, Akash P, Xiaowei Z, Yoav D, Hanna BD, Gillespie MJ, et al. Radiation exposure from diagnostic and interventional cases in a modern, large-volume pediatric cardiac catheterization laboratory [abstract]. AHA, 11/17/2010.

    Lin KY, Sullivan P, Salam A, Kaufman B, Paridon S, Hanna BD, et al. Donor troponin I levels and graft survival in pediatric heart transplantation [abstract]. SPR, 2010.

    Niles DE, Hanna BD, Joar E, Diaz LK, Gillespie MJ, Rome JJ, et al. Sternal wall pressure comparable to leaning during CPR impacts intrathoracic pressure and hemodynamics in anesthetized children during cardiac catheterization [abstract]. Journal of Critical Care Medicine, Supplement Dec 2010. 



    Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6. Read the abstract.


    Goldberg DJ, French B, Szwast AL, McBride MG, Marino BS, Mirarchi N, et al. Impact of sildenafil on echocardiographic indices of myocardial performance after the Fontan operation. Pediatr Cardiol. 2012 Jun;33(5):689-96. Epub 2012 Feb 14. Cited in Pubmed; PMID 22331056. Read the abstract


    Mallory GB Jr, Hanna BD, Ivy DD, Shardonofsky F, Farber HJ. Management and controversies in pediatric pulmonary hypertension. Pediatr Allergy Immunol Pulmonol. 2011 Mar 4;22(4):139-150. Cited in PubMed; PMCID: PMC3136886. Read the article

    Goldberg DJ, Quartermain MD, Glatz AC, Hall EK, Davis E, Kren SA, et al. Doppler tissue imaging in children following cardiac transplantation: a comparison to catheter derived hemodynamics. Pediatr Transplant. 2011 Aug;15(5):488-94. doi: 10.1111/j.1399-3046.2011.01503.x. Epub 2011 Apr 25. Cited in PubMed; PMCID: PMC3140578. Read the article

    Lin KY, Sullivan P, Salam A, Kaufman B, Paridon S, Hanna BD, et al. Troponin I levels from donors accepted for pediatric heart transplantation do not predict recipient graft survival. J Heart Lung Transplant. 2011 Aug;30(8):920-7. Epub 2011 Apr 13. Cited in PUbMed; PMCID: PMC3129377.  Read the article 

    Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD, et al. Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation: a randomized, double-blind, placebo-controlled, crossover trial. Cited in PubMed; PMID 21382896. Read the article


    Glatz AC, Zhu X, Gillespie MJ, Hanna BD, Rome JJ. Use of angiographic CT imaging in the cardiac catheterization laboratory for congenital heart disease. JACC Cardiovasc Imaging. 2010 Nov;3(11):1149-57. Cited in PubMed; PMID 21071003. Read the abstract

    O'Connor MJ, Rider NL, Thomas Collins R, Hanna BD, Holmes Morton D, Strauss KA. Contemporary management of congenital malformations of the heart in infants with Ellis - van Creveld syndrome: a report of nine cases. Cardiol Young. 2011 Apr;21(2):145-52. Epub 2010 Nov 12. Cited in PubMed; PMID 21070693. Read the abstract

     O'Connor MJ, Menteer J, Chrisant MR, Monos D, Lind C, Levine S, et al. Ventricular assist device-associated anti-human leukocyte antigen antibody sensitization in pediatric patients bridged to heart transplantation. J Heart Lung Transplant. 2010 Jan;29(1):109-16. Cited in PubMed; PMID 20123248. Read the abstract

    Posters and Presentations


    Hanna BD. Use of PAH directed therapies in patients with single ventricles [presentation]. ISHLT 2012: 32nd Annual Meeting and Scientific Sessions of International Society for Heart & Lung Transplantation; 2012 Apr 18; Prague, Czech Republic.


    Hanna BD. Bronchopulmonary Dysplasia and CDH [presentation]. 60th Annual ACC Scientific Sessions; 2011 Apr 5; New Orleans, LA.

    Hanna BD. The who, what, why and when of PH in Pediatric CLD [presentation]. Pittsburgh Children’s Hospital, PICU and NICU Rounds; 2011 Apr 28; Pittsburgh, PA.

    Hanna BD. PH in pediatric CLD [presentation]. Pittsburgh Children’s Hospital, Pulmonary Rounds; 2011 Apr 29; Pittsburgh, PA.

    Hanna BD. The fun of cathing pediatric PH [presentation]. Pittsburgh Children’s Hospital, Cardiology Rounds; 2011 Apr 29; Pittsburgh, PA.

    Hanna BD. Pulmonary hypertension in sickle cell disease [presentation]. ATS 2011; 2011 May 15; Denver, CO.

    Hanna BD. Plenary session: Pulmonary hypertension in sickle cell disease [presentation]. Sickle Cell Disease Association of America: Philadelphia/Delaware Valley Chapter; 2011 Sep 17; Philadelphia, PA.

    Hanna BD. Off-label use of medications in PH [panel presentation]. 2011 PH Resource Network Symposium; 2011 Sep 24; Arlington, VA.

    Hanna BD. The crossroads of congenital heart defects and PH [presentation]. 2011 Sep 24; Arlington, VA.

    Hanna BD. Moving toward improved prognosis for pediatric PH [presentation]. The 9th Annual Macdonald Dick Lecture, Pediatric Grand Rounds, University of Michigan; 2011 Oct 11; Ann Arbor, MI.


    Hanna BD. Pediatric pulmonary hypertension: the angst and the hope [presentation]. Divisional Conference, John Hopkins Division of Pulmonary Medicine; 2010 Jan 26; Baltimore, MD.

    Hanna BD. The changing face of pediatric pulmonary hypertension [presentation]. St Joseph’s Hospital: Eller Congenital Heart Center Grand Rounds; 2010 Feb 5; Phoenix, AZ.

    Hanna BD. Pulmonary vascular capacity, a unifying concept for pediatric pulmonary hypertension [presentation]. Hackensack Medical Center Neonatal Rounds; 2010 Feb 10; Hackensack, NJ>

    Hanna BD. Neonatal and childhood lung transplantation, where are we? [presentation]. 3rd International Neonatal and childhood pulmonary vascular disease conference; 2010 Mar 11; Banff, Canada.

    Hanna BD. Neonatal and childhood pulmonary hypertension [presentation]. I.W.K. Women’s and Children’s Hospital; 2010 Oct 29; Halifax, Nova Scotia, Canada.

  • Editorial and Academic Positions

    Editorial positions


    2008-present, Pediatric Critical Care Medicine
    2008-present, Pediatrics
    2008-Present, Journal of Pediatrics
    2007-present, Congenital Heart Disease
    2006-present, Pediatric Transplantation
    2006-present, Cardiology
    2001-present, Pediatric Emergency Care
    2001-present, The Annals of Thoracic Surgery
    1996-present, Journal of Critical Care Medicine
    1995-present, Journal of Heart and Lung Transplantation

    Academic and institutional committees

    Department committees

    The Children’s Hospital of Philadelphia, Cardiac Center

    • 2003-present Director, Section of Pulmonary Hypertension
    Hospital committees

    The Children's Hospital of Philadelphia

    • 2001-present, Central Line Committee