Katherine A. High, MD

Areas of Expertise: Hemophilia, Thrombosis, Molecular basis of blood coagulation, Gene therapy for hemophilia
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Education and Training

    Medical School

    University of North Carolina School of Medicine, Chapel Hill, NC

    Residency

    North Carolina Memorial Hospital, Chapel Hill, NC

    Fellowship

    Yale University School of Medicine, New Haven, Conn.

    Board Certification

    American Board of Internal Medicine
    American Board of Internal Medicine, Hematology

  • Titles and Academic Titles

    Investigator, Howard Hughes Medical Institute

    Attending physician

  • Centers and Programs
  • Publications

    Papers

     Mingozzi F, Meulenberg JJ, Hui DJ, Basner-Tschakarjan E, Hasbrouck NC, Edmonson SA, Hutnick NA, Betts MR, Kastelein JJ, Stroes ES, High KA. AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells. Blood. 2009 Sep 3;114(10):2077-86. Epub 2009 Jun 8. Read abstract.

    Couto LB, High KA. Viral vector-mediated RNA interference. Curr Opin Pharmacol. 2010 Jul 8. [Epub ahead of print]. Read abstract

    Haurigot V, Mingozzi F, Buchlis G, Hui DJ, Chen Y, Basner-Tschakarjan E, Arruda VR, Radu A, Franck HG, Wright JF, Zhou S, Stedman HH, Bellinger DA, Nichols TC, High KA. Safety of AAV factor IX peripheral transvenular gene delivery to muscle in hemophilia B dogs. Mol Ther. 2010 Jul;18(7):1318-29. Epub 2010 Apr 27. Read abstract

    Margaritis P, High KA. Gene therapy in haemophilia--going for cure?. Haemophilia. 2010 May;16 Suppl 3:24-8. Read abstract

     

    Pien GC, Basner-Tschakarjan E, Hui DJ, Mentlik AN, Finn JD, Hasbrouck NC, Zhou S, Murphy SL, Maus MV, Mingozzi F, Orange JS, High KA. Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest. 2009 Jun;119(6):1688-95. doi: 10.1172/JCI36891. Epub 2009 May 11. Read abstract.

     Finn JD, Hui D, Downey HD, Dunn D, Pien GC, Mingozzi F, Zhou S, High KA. Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction. Mol Ther. 2010 Jan;18(1):135-42. Epub 2009 Nov 10. Read abstract