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Michael D. Hogarty, MD

Attending Physician

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Awards

2009, St. Baldrick's Foundation Research Award
2009, Alex's Lemonade Stand Foundation Innovator Award
2005, Foerderer-Murray Award, The Children's  Hospital of Philadelphia
2005, University Research Foundation Award, University of Pennsylvania
2000, Burroughs Wellcome Fund Career Award in the Biomedical Sciences
1999, Career Development Award, American Society of Clinical Oncology

Books

Chapters

2011

Hogarty MD, Brodeur GM. Neuroblastoma. In: Arceci R, editor. Rudolph's pediatrics. 22nd ed. New York: McGraw-Hill Professional; 2011.

2010

Brodeur GM, Hogarty MD, Mosse YP, Maris JM. Neuroblastoma. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 6th ed. Philadelphia: Lippincott Williams & Wilkins, Inc.; 2010.

2009

Hogarty MD, Shusterman S, Evans A. Wilms tumor. In: Brodeur GM, Manno CS, editors. Pediatric hematology/oncology: requisites in pediatrics. Philadelphia: CV-Mosby; 2009.

Goldsmith KC, Hogarty MD, Nichols K. The childhood histiocytoses: Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis. In: Brodeur GM, Manno CS, editors. Pediatric hematology/oncology: requisites in pediatrics. Philadelphia: CV-Mosby; 2009.

2002

Hogarty MD, Brodeur GM. Gene amplification in human cancers: biological and clinical significance. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. 2nd ed. New York: McGraw-Hill; 2002. p. 115-58.

2000

Caron HN, Hogarty MD. Imprinting of 1p, MYCN, and other loci in neuroblastoma. In: Brodeur GM, Sawada T, Tsuchida Y, Voute PA, editors. Neuroblastoma. Philadelphia: Elsevier Science; 2000. p. 101-12.

Hogarty MD, Lange B. Oncologic emergencies. In: Fleisher GR, Ludwig S, editors. Textbook of pediatric emergency medicine. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 1157-90.

1998

Hogarty MD. Neuroblastoma. In: Altschuler SM, Ludwig S, editors. Pediatrics at a glance. Philadelphia: Current Medicine, Inc. and Appleton & Lange; 1998. p. 218-9.

Hogarty MD. Wilms tumor. In: Altschuler SM, Ludwig S, editors. Pediatrics at a glance. Philadelphia: Current Medicine, Inc. and Appleton & Lange; 1998. p. 320-1.

Hogarty MD. Hodgkins disease. In: Altschuler SM, Ludwig S, editors. Pediatrics at a glance. Philadelphia: Current Medicine, Inc. and Appleton & Lange; 1998. p. 154-5.

1996

Hogarty MD. Immune thrombocytopenic purpura. In: Schwartz MW, editor. The CHOP 5-minute pediatric consult. Baltimore: Williams & Wilkins; 1996.

Hogarty MD. Glucose-6-phosphate dehydrogenase deficiency. In: Schwartz MW, editor. The CHOP 5-minute pediatric consult. Baltimore: Williams & Wilkins; 1996.

Hogarty MD. Retinoblastoma. In: Schwartz MW, editor. The CHOP 5-minute pediatric consult. Baltimore: Williams & Wilkins; 1996.

Editorial and Academic Positions

Editorial positions

Ad hoc reviewer

Archives of Pediatric and Adolescent Medicine
Biochimica et Biophysica Acta -- Gene Structure and Function
BMC Cancer
Cancer Epidemiology, Biomarkers & Prevention
Cancer Cell
Clinical Cancer Research
Genes Chromosomes & Cancer
Human Genetics
Journal of Cellular Biochemistry
Journal of Clinical Investigation
Journal of Clinical Oncology
Laboratory Investigation
Medical and Pediatric Oncology
Oncogene
Pediatric Blood and Cancer
Pediatric and Developmental Pathology
Pediatric Emergency Medicine
The American Journal of Pathology
The FASEB Journal

Academic positions

2009, Member, Search Committee for Pediatric Oncology Survivorship Faculty Member

2008-present, Co-chair, Pediatric Protocol Review Committee, Division of Oncology and Abramson Family Cancer Center

2008-present, Resident Physician-Scientist Mentor Committee

Leadership

Memberships in professional organizations

2008-present, Advances in Neuroblastoma Research Association
2000-present, Children's Oncology Group
2000-present, International Histiocyte Society
1999-present, American Board of Pediatrics
1998-present, American Academy for the Advancement of Science
1998-present, American Society of Pediatric Hematology/Oncology
1996-present, American Association for Cancer Research
1995-present, American Society of Clinical Oncology

Participation in scientific committees

2009-present, US Member, International Neuroblastoma Tissue Banking Task Force

2008-present, Study Committee Member, Therapeutically Applicable Research to Generate Effective Treatments (TARGET) for Neuroblastoma (COG ANBL10B1)

2008-present, Advances in Neuroblastoma Research Association North American-South American Advisory Board

2008-present, Co-chair, Biological Predictors of High-risk Neuroblastoma Outcomes Task Force, COG Neuroblastoma Disease Committee

2007-present, Neuroblastoma Executive Committee, Children's Oncology Group

2006-present, High-risk Neuroblastoma Task Force, Children's Oncology Group

2006-present, Study Committee Member, Phase III Randomized Trial of Single vs. Tandem Transplant as Consolidation Therapy for High-risk Neuroblastoma (COG-ANBL0532)

2006-present, Study Chair, Neuroblastoma Biology Studies (COG-ANBL00B1)

2006-present, Biopathology and Translational Research Committee, Children's Oncology Group

2006-present, Chair, Neuroblastoma Biology Committee, Children's Oncology Group

2005-present, Neuroblastoma Steering Committee, Children's Oncology Group

2001-present, Neuroblastoma Biology Committee, Children's Oncology Group

2000-present, Neuroblastoma Strategy Group, Children's Oncology Group

2000-present, US Advisory Committee, HLH Study Group, International Histiocyte Society

2000-present, US Advisory Committee, LCH Study Group, International Histiocyte Society

1999-present, American Board of Pediatrics PRCP Test Committee

Original Papers

2011

Hogarty, MD. IL-17A in LCH: systemic biomarker, local factor, or none of the above? Mol Ther. 2011 Aug; 19(8):1405-6. doi: 10.1038/mt.2011.150. Cited in PubMed: PMID 21804617. Read the abstract 

2010

Shields CL, Hogarty MD, Kligman BE, Christian C, Ehya H, Shields JA. Langerhans cell histiocytosis of the uvea with neovascular glaucoma: diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy. J AAPOS. 2010 Dec;14(6):534-7. Cited in PubMed: PMID 21168078. Read the abstract

Hogarty MD. Mcl1 becomes ubiquitin-ous: new opportunities to antagonize a pro-survival protein. Cell Res. 2010 Apr;20(4):391-3. Cited in PubMed: PMID 20357805. No abstract available.

Goldsmith KC, Lestini BJ, Gross M, Ip L, Bhumbla A, Zhang X, et al. BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists. Cell Death Differ. 2010; 17:872-882. Cited in PubMed; PMID: 19893570. Read the abstract

2009

Vermeulen J, De Preter K, Naranjo A, Vercruysse L, Van Roy N, Hellemans J, et al. Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study. Lancet Oncol. 2009;10:663-670. Cited in PubMed; PMID: 19515614. Read the article

Goldsmith KC, Hogarty MD. Small molecule BH3 mimetics to antagonize Bcl2-homologue survival functions in cancer. Curr Opin Investig Drugs. 2009; 10 (6): 559-571. Cited in PubMed;PMID: 19513945. Read the abstract

Evageliou NF, Hogarty MD. Molecular pathways: disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma. Clin Cancer Res. 2009;15 (19): 5956-61. Cited in PubMed; PMID: 19789308. Read the article

Lestini BJ, Goldsmith KC, Fluchel MN, Liu X, Chen NL, Goyal B, et al. Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. Cancer Biol Ther. 2009; 8(16): 1587-95. Cited in PubMed; PMID: 19556859. Read the abstract

Chayka O, Corvetta D, Dews M, Caccamo AE, Piotrowska I, Santilli G, et al. Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst. 2009;101:663-77. Cited in PubMed; PMID: 19401549. Read the article

Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, et al. Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer. 2009; 53: 563-69. Cited in PubMed; PMID: 19301388. Read the article

Combaret V, Hogarty MD, London W, McGrady P, Iacono I, Brejon S, et al. Influence of neuroblastoma stage on serum-based detection of MYCN amplification. Pediatr Blood Cancer. 2009;53(3):329-31.Cited in PubMed; PMID: 19301388. Read the article

Posters and Presentations

2010

Hogarty MD. Polyamine inhibition blocks initiation and progression of neuroblastoma [presentation]. Advances in Neuroblastoma Research; 2010 Jun 22; Stockholm, Sweden.

Hogarty MD. Bc12 family proteins, chemoresistance, and apoptosis-directed therapies for neuroblastoma [invited lecture]. Program in Cell Biology Seminar, The Hospital for Sick Children, University of Toronto; 2010 Mar 19; Toronto, CA.

2009

 Hogarty MD. Genetic alterations in neuroblastoma and their clinical utility [invited lecture]. Medical Genetics I (GC550), Arcadia University; 2009 Dec 10; Philadelphia, PA.

Hogarty MD. Polyamine depletion as a therapeutic strategy for MYC-driven embryonal tumors [invited lecture]. Aflac Cancer Center Visiting Professor Seminar, Children's Healthcare of Atlanta; 2009 Jun 4; Atlanta, GA.

Hogarty MD. Polyamine dependence in neuroblastoma: a novel therapeutic opportunity [invited lecture]. Visiting Professor Research Seminar, Vanderbilt-Ingram Cancer Center, Vanderbilt University; 2009 Apr 6; Nashville, TN.

 

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