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Haralambos Ischiropoulos, PhD

Research Professor of Pediatrics and Pharmacology, Perelman School of Medicine at the University of Pennsylvania

Awards

2007, Gisela and Dennis Alter Chair in Pediatric Neonatology
1998, Bodossaki Foundation Academic Prize in Medicine
1997-present, Joseph Stokes Jr. Investigator, Children's Hospital of Philadelphia
1996-2001, Established Investigator, American Heart Association
1995, Young Investigator Award, Oxygen Society
1994, Young Investigator Award, International Society for Free Radical Research
1993-1996, Parker B. Francis Fellowship in Pulmonary Research
1988, Dr. Frederic Valergakis Graduate Grant
1984, Dreyfus Prize in Chemistry, American Institute of Chemists Student Award

Editorial and Academic Positions

Editorial positions

2009-2012, Editorial board, Journal of Biological Chemistry
2005-2009, Associate editor, Free Radical Biology and Medicine
2005-2009, Editorial Advisory Panel, Biochemical Journal
2005-2009, Current Respiratory Medicine Reviews
2003-present, Faculty Chemical Biology Section, Faculty 1000

Academic committees

2007-present, Research Institute Faculty Advisory Committee on Compliance, The Children's Hospital of Philadelphia
2007-present, Deputy Chair, Research Institute-Cores Committee, The Children's Hospital of Philadelphia
2006-present, Director of Neonatology Research, The Children's Hospital of Philadelphia Research Institute

Leadership

Memberships in professional organizations

American Association for the Advancement of Science
American Pediatric Society
American Physiological Society
American Society for Biochemistry and Molecular Biology
Society for Free Radical Biology and Medicine

  • President, 2010-2010
  • President-Elect, 2009-2010
  • Secretary General, 2005-2009

Nitric Oxide Society
Society for Neuroscience
Society for Pediatric Research

NIH review panels

2007-present, Special Emphasis Panel and ad hoc NOMD study section

Original Papers

2011

Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, et al. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. Epub 2011 Oct 2. Cited in PubMed; PMID 22017063. Read the abstract

Ziegler CG, Peng M, Falk MJ, Polyak E, Tsika E, Ischiropoulos H, et al. Parkinson's disease-like neuromuscular defects occur in prenyl diphosphate synthase subunit 2 (Pdss2) mutant mice. Cited in PubMed; PMID 21983691. Read the abstract

Raju K, Doulias PT, Tenopoulou M, Green JL, Ischiropoulos H. Strategies and tools to explore protein S-nitrosylation. Biochim Biophys Acta. Epub 2011 May 30. Cited in PubMed; PMID 21651963. Read the abstract

Bruno CJ, Greco TM, Ischiropoulos H. Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes. Free Rad Biol Med. 2011 Jul 15;51(2):474-9. Epub 2011 May 4. Cited in PubMed; PMID 21605665. Read the abstract

2010

Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, et al. Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol. 2010 Dec 1;185(11):6664-9. Epub 2010 Oct 27. Cited in PubMed; PMID 20980633. Read the abstract

Bangasser DA, Curtis A, Reyes BA, Bethea TT, Parastatidis I, Ischiropoulos H, et al. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology. mol Psychiatry. 2010 Sep;15(9):877-896-904. Epub 2010 Jun 15. Cited in PubMed; PMID 20548297. Read the article

Doulias PT, Greene JL, Greco TM, Tenopoulou M, Seeholzer SH, Dunbrack RL, et al. Structural profiling of endogenous S-nitrocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation. Proc Natl Acad Sci USA. 2010 Sep 28;107(39):16958-63. Cited in PubMed; PMID 20837516. Read the article

Greco TM, Seeholzer SH, Mak A, Spruce L, Ischiropoulos H. Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion. J Proteome Res. 2010 may 7;9(5):2764-74. Cited in PubMed; PMID 20329800. Read the article

Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, et al. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci. 2010 Mar 3;30(9):3409-18. Cited in PubMed; PMID 20203200. Read the article

Johnston LC, Gonzales LW, Lightfood RT, Guttentag SH, Ischiropoulos H. Opposing regulation of human alveolar type II cll differentiation by nitric oxide and hyperoxia. Pediatr Res. 2010 May;67(5):521-5. Cited in PubMed; PMID 20098340. Read the article 

Ramsey CP, Tsika E, Ischiropoulos H, Giasson BI. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity. Hum Mol Genet. 2010 Apr 15;19(8):1425-37. Epub 2010 Jan 20. Cited in PubMed; PMID 20089532. Read the article

Dingley S, Polyak E, Lightfoot R, Ostrovsky J, Rao M, Greco T, et al. Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans. Mitochondrion. 2010 Mar;10(20:125-36. Epub 2009 Nov 10. Cited in PubMed; PMID 19900588. Read the abstract

2009 

Heffron SP, Parastatidis I, Cuchel M, Wolfe ML, Tadesse MG, Mohler ER 3rd, et at. Inflammation induces fibrinogen nitration in experimental human endotoxemia. Free Radic Biol Med. 2009 Oct 15;47(8):1140-6. Epub 2009 Jul 22. Cited in PubMed; PMID 19631267. Read the abstract

Malkus KA, Tsika E, Ischiropoulos H. Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener. 2009 Jun 5;4:24. Cited in PubMed; PMID 19500376. Read the article

 Keene SD, Greco TM, Parastatidid I, Lee SH, Hughes EG, Balice-Gordon RJ, et al. Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics. 2009 Feb;9(3):768-82. Cited in PubMed; PMID 19132682. Read the article

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