Robert G. Kalb, MD

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Education and Training

    Medical School

    MD - Cornell University Medical College, New York, NY


    Medicine - Montefiore Hospital, Bronx, NY


    Medicine - Montefiore Hospital, Bronx, NY
    Neurology, Yale-New Haven Hospital, New Haven, CT


    Post-doctoral Fellow in Neurobiology - Yale University, New Haven, CT

    Board Certification


  • Titles and Academic Titles

    Neurology Researcher

    Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Publications



    Boccitto M, Lamitina T, Kalb RG. Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans. PLoS One. 2012;7(3):e33494. Epub 2012 Mar 20. Cited in PubMed; PMID 22457769. Read the article

    Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet. Epub 2012 Apr 6. Cited in PubMed; PMID 22454397. Read the abstract


    Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, et al. A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20881-90. Epub 2011 Nov 7. Cited in PubMed; PMID 2206782. Read the article

    Zhai J, Zhou W, Li J, Hayworth CR, Zhang L, Misawa H, et al. The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease. Hum Mol Genet. 2011 Nov 1;20(21):4116-31. Epub 2011 Aug 4. Cited in PubMed; PMID 21816949.Hum Mol Genet. 2011 Nov 1;20(21):4116-31. Epub 2011 Aug 4. Read the abstract

    Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, et al. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. PLoS One. 2011 Mar 29;6(3):e17951. Cited in PubMed; PMID 21479228. Read the article

    Jeong GB, Mojsilovic-Petrovic J, Boccitto M, Kalb R. Signaling events in axons and/or dendrites render motor neurons vulnerable to mutant superoxide dismutase toxicity. J Neurosci. 2011 Jan 5;31(1):295-9. Cited in PubMed; PMIC 21209215. Read the abstract

    Posters and Presentations


    Kalb RG. The role of growth factor signaling and aging pathways in neurodegenerative diseases [presentation]. Johns Hopkins University; 2011 Feb; Baltimore, MD.


    Kalb RG. From molecular machines to locomotor behavior [presentation]. Case Western Reserve University Department of Neurosciences; 2010 Oct; Cleveland, OH.

    Kalb RG. A few heresies along the road to effective therapy for motor neuron disease [presentation].  Neuroscience Center, Massachusetts General Hospital, Harvard Medical School; 2010 Jun; Boston, MA.

    Kalb RG. Aging pathways and neurodegenerative disease [presentation].  Department of Neurology Grand Rounds, University of Wisconsin; 2010 Jan;  Madison, WI.


  • Editorial and Academic Positions

    Editorial positions

    2009-present,  Associate Editor, Journal of Neuroscience
    2008-present,  Associate Editor, Frontiers in Molecular Neuroscience
    2004-present,  Associate Editor, Neuroscience Letters

    Ad hoc reviewer

    Journal of Neuroscience
    Journal of Physiology
    Proceedings of the National Academy of Science, USA
    European Journal of Neuroscience
    Journal of Neurophysiology
    Journal of Neurobiology
    Brain Research
    Journal of Neurocytology
    Neuroscience Letters
    Journal of Neurochemistry
    Experimental Brain Research
    Experimental Neurology

    Academic and institutional committees

    2010-present,  Evaluator, MD, PhD Admissions Committee
    2010-present,  Reviewer, Pediatric Cardiology Scholarship Oversight Committee
    2009-present, Chair, IACUC at CHOP
    2007-present,  Member, Institutional Intellectual Property Advisory Committee, CHOP