Haresh Kirpalani, BM, MRCP, FRCP, MSc

Areas of Expertise: Bronchopulmonary dysplasia, Neonatal lung injury, Newborn medicine, Parent counseling, Randomized trials in neonatal medicine
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Background

    Haresh Kirpalani, BM, MRCP, FRCP, MSc, is an an attending neonatologist at The Children’s Hospital of Philadelphia, and a professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

    Dr. Kirpalani was born in India and educated in the United Kingdom. He trained as a pediatrician in the UK, and worked in Portsmouth, Southampton. After this, he completed his pediatric training in Newcastle-U-Tyne and was a senior fellow in neonatology at the Hospital for Sick Children in Toronto, Ontario. He also completed an MSc in clinical epidemiology and biostatistics at McMasterUniversity in Canada, defending the thesis: “Hope and Biology — Can Quality of Life Be Predicted in Spina Bifida?”        

  • Education and Training

    Medical School

    BM - South Hampton University, UK

    Internship

    Portsmouth and South Hampton, UK

    Residency

    Pediatrics - Newcastle-U-Tyne University Hospitals, UK

    Fellowship

    Neonatology - Hospital for Sick Children, Toronto, Canada

    Additional Training

    MSc in Clinical Epidemiology and Biostatistics - McMaster University, Hamilton, Ontario, Canada

    Undergraduate Degree

    Newcastle-U-Tyne University Hospital, UK

    Graduate Degree

    Portsmouth and South Hampton, UK

  • Titles and Academic Titles

    Attending Neonatologist

    Program Director, Newborn and Infant Chronic Lung Disease Program

    Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests
  • Publications

    Papers

    2014

    Posencheg M, Kirpalani H. Placental Transfusion at Birth: Do We Have All of the Answers?. JAMA Pediatr. 2014 Nov 3. doi: 10.1001/jamapediatrics.2014.2347. [Epub ahead of print]

    Lemyre B, Davis PG, De Paoli AG, Kirpalani H. Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation. Cochrane Database Syst Rev. 2014 Sep 4;9:CD003212. [Epub ahead of print] Read the abstract.

    DeMauro SB, Cairnie J, D’Ilario J, Kirpalani H, Schmidt B. Honesty, Trust, and Respect During Consent Discussions in Neonatal Clinical Trials. Pediatrics. 2014 Jul;134(1):e1-3. Epub 2014 Jun 9. Read the abstract.

    Jensen EA, Kirpalani H. Inhaled Nitric Oxide to Prevent Bronchopulmonary Dysplasia in Preterm Infants-Less than a Silver Bullet. J Pediatr. 2014 Sep 27. pii: S0022-3476(14)00787-2. doi: 10.1016/j.jpeds.2014.08.040. [Epub ahead of print] No abstract available.

    DeMauro S, D’Agostino J, Bann C, Bernbaum J, Gerdes M, Bell E, Carlo W, D’Angio C, Das A, Higgins R, Hintz S, Laptook A, Natarajan G, Nelin L, Poindexter B, Sanchez P, Shankaran S, Stoll B, Truog W, Van Meurs K, Vohr B, Walsh M, Kirpalani H. Developmental outcomes of very preterm infants with tracheostomies. J Pediatr. 2014. [Epub ahead of print] Read the abstract.

    Ghavam S, Batra D, Mercer J, Kugelman A, Hosono S, Oh W, Rabe H, Kirpalani H. Effects of placental transfusion in extremely low birthweight infants: meta-analysis of long- and short-term outcome. Transfusion. 2014 Apr;54(4):1192-8. Read the abstract.

    Jensen EA, Munson DA, Zhang H, Blinman TA, Kirpalani H. Anti-gastroesophageal reflux surgery in infants with severe bronchopulmonary dysplasia. Pediatr Pulmonol. 2014 Apr 21. [Epub ahead of print] Read the abstract.

    Foglia EE, Kirpalani H, DeMauro SB. Long-Term Respiratory Morbidity in Preterm Infants: Is Noninvasive Support in the Delivery Room the Solution? J Pediatr. 2014 May 16. pii: S0022-3476(14)00347-3. doi: 10.1016/j.jpeds.2014.04.018. [Epub ahead of print] Read the abstract.

    2013

    H. Kirpalani, D. Millar. B. Lemyre, BA. Yoder, A. Chiu. RS. Roberts. A trial to compare non-invasive ventilation strategies in preterm infants. N Eng J Med 2013 Aug 15;369(7):611-20

    B. Lemyre, PG Davis, H. Kirpalani, AG DePaoli. NIPPV vs NCPAP for apnea of prematurity. In Press: Updated Cochrane review, Cochrane Library 2013

    Sarvin Ghavam; Dushyant Batra; Judith Mercer; Amir Kugelman; Shigeharu Hosono; William Oh, Heike Rabe, Haresh Kirpalani Effects of Placental Transfusion in Extremely Low Birth Weight Infants: Meta-analysis of Long and Short term outcomes. In Press Transfusion 2013.

    2012

    Economic evaluation alongside the premature infants in need of transfusion (PINT) randomized controlled trial. Karen I. Kamholz, Dmitry Dukhovny, Haresh Kirpalani, Robin K. Whyte, Robin S. Roberts, Na Wang, WenYang Mao, John AF Zupancic and the Premature Infants in Need of Transfusion Study Group.
    Archives Disease Childhood 2012;97(2):F93-8

    Ursula Guillen, Sara DeMauro, Li Ma, John Zupancic, Robin Roberts, Barbara Schmidt, Haresh Kirpalani Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18-24 months: A systematic review; Arch Pediatr Adolesc Med. 2012 Feb;166(2):178-84

    Guillen U, Suh S, Munson D, Posencheg M, Truitt E, Zupancic J, Gafni A, Kirpalani H. The development and pre-testing of a decision-aid to use when counseling parents facing imminent extreme premature delivery. J Pediatr. 2012; 160(3):382-7

    Nicolas Bamat, David Millar, Sanghee Suh, Haresh Kirpalani: Positive End-Expiratory Pressure for Preterm Infants Requiring CMV for RDS or BPD: A Systematic Review. In Press: The Cochrane Neonatal Data Base of Systematic Reviews. 2012 18;1:CD004500

    Haresh Kirpalani and John A. F. Zupancic. Do transfusions cause Necrotizing Enterocolitis The complementary role of randomized trials and observational studies. Semin Perinatol. 2012 Aug;36(4):269-76.

    Ursula Guillen, James J. Cummings, Edward F. Bell, Shigerharu Hosono, Axel R. Frantz, Rolf F. Maier, Robin K Whyte, Elaine Boyle, Max Vento, John A. Widness, Haresh Kirpalani; International Survey of Transfusion Practices for Extremely Premature Infants; Semin Perinatol. 2012 Aug;36(4):244-7. PMID: 22818544

    2011

    Jacobs SE, Morley CJ, Inder TE, Stewart MJ, Smith KR, McNamara PJ, Wright 1M, Kirpalani HM, Darlow BA, Doyle LW; for the Infant Cooling Evaluation Collaboration. Whole-Body Hypothermia for Term and Near-Term Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Controlled Trial. Arch Pediatr Adolesc Med. 2011 ;165(8):692-700.

    Whyte R, Kirpalani H. Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev. 2011; 11 :CD000512

    Ursula Guillen, Sara DeMauro, Li Ma, John Zupancic, Eileen Wang, Amiram Gafni, Haresh Kirpalani. Survival rates in extremely low birth weight infants depend upon the denominator used: Avoiding potential for bias by specifying denominators. Am J Obstet Gynecol. 2011; 205(4):329.e1-7
    This article was selected as the Editor's Choice

    Wright C and Kirpalani H; "Targeting Inflammation to Prevent BPD: Can New Insights Be Translated into Better Therapies?" Pediatrics 2011; 128(1):111-26

    DeMauro, Sara; Giaccone, Annie; Kirpalani, Haresh; Schmidt, Barbara K. The Quality of Reporting of Neonatal and Infant Trials in High Impact Journals Pediatrics. 2011 Sep; 128(3):e639-44

    Kirpalani H, Whyte R. Truths, associations, and hypotheses. J Pediatr. 2011 Sep;159(3):359-61. Epub 2011 Jun 16. Cited in PubMed; PMID 21679967. No abstract available.

    Demauro SB, Giaccone A, Kirpalani H, Schmidt B. Quality of reporting of neonatal and infant trials in high-impact journals. Pediatrics. Epub 2011 Aug 22. Cited in PubMed; PMID 21859916. Read the abstract

    Wright CJ, Kirpalani H. Targeting inflammation to prevent bronchopulmonary dysplasia: Can new insights be translated into therapies? Pediatrics. 2011 Jul;128(1):111-26. Epub 2011 Jun 6. Cited in PubMed; PMID 21646264. Read the abstract

    Economic evaluation alongside the premature infants in need of transfusion randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. Epub 2011 Jul 6. Cited in PubMed; PMID 21733926. Read the abstract

    Guillen U, Demauro S, Ma L, Zupancic J, Wang E, Gafni A, et al. Survival rates in extremely low birthweight infants depend on the denominator: Avoiding potential for bias by specifying denominators. Am J Obstet Gynecol. Epub 2011 May 20. Cited in PubMed; PMID 2174613. Read the abstract

    Jacobs SE, Morley CJ, Inder TE, Steward MJ, Smith KR, McNamara PJ, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: A randomized controlled trial. Arch Pediatr Adolesc Med. 2011 Aug;165(8):692-700. Epub 2011 Apr 4. Cited in PubMed; PMID 21464374. Read the abstract

    Binenbaum G, Ying GS, Quinn GE, Dreiseitl S, Karp K, Roberts RS, et al. A clinical prediction model to stratify retinopathy of prematurity risk using postnatal weight gain. Pediatrics. 2011 Mar;27(3):e607-14. Epub 2011 Feb 14. Cited in PubMed; PMID 21321036. Read the abstract

    Ma L, Liu C, Wang Y, Li S, Zhai S, Gu X, et al. Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China. Neonatology. 2011; 100(1):14-22. Epub 2010 Dec 10. Cited in PubMed; PMID 21150226. Read the abstract

    2010

    Bassler 0, Kreutzer K, McNamara P, Kirpalani H. Milrinone for persistent pulmonary hypertension of the newborn. Cochrane Database Syst Rev. 2010 Nov 10;(11):CD007802.

    Sun B, Kirpalani H. Development of neonatal respiratory support and intensive care in emerging regions of China. Chin Med J (Engl). 2010 Oct;123(20):2757-8. Cited in PubMed; PMID 21034577. 

    2009

    Williams C, Cairnie J, Fines V, Patey C, Schwarzer K, Aylward J, et al. Construction of a parent-derived questionnaire to measure end-of-life care in the neonatal intensive care unit. Pediatrics. 2009;123(1):e87-95. Cited in PubMed; PMID 19117852. Read the article

    Whyte RK, Kirpalani H, Asztalos EV, Andersen C, Blajchman M , Heddle N, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics. 2009;123(1):207-13. Cited in PubMed; PMID 19117884. Read the article

    Vanderveen JA, Bassler D, Robertson CM, Kirpalani H. Early interventions involving parents to improve neurodevelopmental outcomes of premature infants: a meta-analysis. J Perinatol. 2009 May;29(5):343-51. Epub 2009 Jan 15. Cited in PubMed; PMID 19148113. Read the abstract