Ian Krantz, MD

Ian Krantz, MD is an attending physician in the Division of Genetics at The Children's Hospital of Philadelphia and co-director of the Individualized Medical Genetics Center.

Areas of Expertise: Alagille syndrome, Clinical Genetics and Dysmorphology, Cornelia de Lange syndrome, The Genetics of Hearing Loss
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Medical School

    University of Tel Aviv, Sackler School of Medicine, Tel Aviv, Israel

    Residency

    New York University, New York, NY

    Fellowship

    The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    American Board of Pediatrics
    Clinical Cytogenetics
    Clinical Genetics

  • Titles and Academic Titles

    Attending Physician

    Director, Individualized Medical Genetics Center

    Associate Professor, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    The molecular etiology of structural birth defects
    The molecular etiology of hearing loss
    Cornelia de Lange Syndrome
    Alagille Syndrome

  • Publications

    Papers

    Descipio C, Morrissette JD, Conlin LK, Clark D, Kaur M, Coplan J, Riethman H, Spinner NB, Krantz ID. Two siblings with alternate unbalanced recombinants derived from a large cryptic maternal pericentric inversion of chromosome 20. Am J Med Genet A. 2010 Feb;152A(2):373-82. Read abstract.

    Leyva-Vega M, Gerfen J, Thiel BD, Jurkiewicz D, Rand EB, Pawlowska J, Kaminska D, Russo P, Gai X, Krantz ID, Kamath BM, Hakonarson H, Haber BA, Spinner NB. Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3. Am J Med Genet A. 2010 Apr;152A(4):886-95. Read abstract.

    Coughlin CR 2nd, Krantz ID, Schmitt ES, Zhang S, Wong LJ, Kerr DS, Ganesh J. Somatic mosaicism for PDHA1 mutation in a male with pyruvate dehydrogenase complex deficiency. Mol Genet Metab. 2010 Jul;100(3):296-9. Epub 2010 Apr 14. Read abstract.

    Wang K, Dickson SP, Stolle CA, Krantz ID, Goldstein DB, Hakonarson H. Interpretation of association signals and identification of causal variants from genome-wide association studies. Am J Hum Genet. 2010 May 14;86(5):730-42. Epub 2010 Apr 29. Read abstract.

    Bauer RC, Laney AO, Smith R, Gerfen J, Morrissette JJ, Woyciechowski S, Garbarini J, Loomes KM, Krantz ID, Urban Z, Gelb BD, Goldmuntz E, Spinner NB. Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis. Hum Mutat. 2010 May;31(5):594-601. Read abstract.

    Liu J, Zhang Z, Bando M, Itoh T, Deardorff MA, Li JR, Clark D, Kaur M, Tatsuro K, Kline AD, Chang C, Vega H, Jackson LG, Spinner NB, Shirahige K, Krantz ID. Genome-wide DNA methylation analysis in cohesin mutant human cell lines. Nucleic Acids Res. 2010 May 30. [Epub ahead of print].  Read abstract.

    Leyva-Vega M, Gerfen J, Thiel BD, Jurkiewicz D, Rand EB, Pawlowska J, Kaminska D, Russo P, Gai X, Krantz ID, Kamath BM, Hakonarson H, Haber BA, Spinner NB. Genomic alterations in biliary atresia suggest region of potential disease susceptibility in 2q37.3. Am J Med Genet A. 2010 Apr;152A(4):886-95. Read abstract.