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James L. Kreindler, MD

Attending Pulmonologist

Assistant Professor, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2010

Savitski AN, Kreindler JL. Pharmacological evidence for a critical role of apical membrane two-pore potassium (K2P) channels in regulating sodium absorption and chloride secretion in normal human bronchial epithelial cells [abstract]. American Thoracic Society 2010 International Conference; 2010 May 14-19; New Orleans, LA.

Nguyen NL, Pilewski JM, Kreindler JL, Steele C, Ray A, Alcorn JF, et al. Immune tolerance to Aspergillus fumigatus versus allergic bronchopulmonary Aspergillosis: roles of TSLP, OX40L, and Vitamin D [abstract]. American Thoracic Society 2010 International Conference; 2010 May 14-19; New Orleans, LA.

2009

Kreindler JL, Savitski A, Cohen NA. Whole cigarette smoke inhibits chloride secretion in normal human bronchial epithelial cells [abstract]. American Thoracic Society 2009 International Conference. 2009 May 15-20; San Diego, CA.

Awards

2010, American Thoracic Society, Respiratory Cell and Molecular Biology Assembly Travel Award for meritorious abstract

2009, American College of Chest Physician's Leadership Development Program

2008, Best Doctors in America

2007, Five Star Service Award, Pediatric Research Consultants

2006, Outstanding Achievement in Patient Care, Children's Hospital of Pittsburgh

2006, Endowed Instructorship in Pediatric Research, Children's Hospital of Pittsburgh

2005, Praise from Patients Honoree, Children's Hospital of Pittsburgh

2003, Advanced Scientific Fellowship, Children's Hospital of Pittsburgh

2000, House Staff Clinical Research Award, Children's Hospital of New York

Books

2010

Kreindler JL, Foskett JK. Ion transport. In: Allen J, Panitch H, Rubenstein R, editors. Cystic fibrosis. Lung biology in health and disease series. New York: Informa Healthcare USA; 2010.

Editorial and Academic Positions

Editorial positions

Editor

2009-present, PLoS One

Reviewer

2007-present, American Journal of Physiology: Lung Cellular and Molecular Physiology

Academic positions

2010-present, Physician Leader, Solid Organ Transplant Center Committee for Quality
2009-present, Pediatric Solid Organ Transplant Outreach Committee
2008-2009, Intern Selection Committee, The Children's Hospital of Philadelphia 

Leadership

Memberships in professional organizations

2010-present, Society for Pediatric Research

2009-present, American College of Chest Physicians

2004-present, American Thoracic Society

  • RCMB Junior Professionals Working Group

Original Papers

2011

Zhao KQ, Goldstein N, Yang H, Cowan AT, Chen B, Zheng C, et al. Inherent differences in nasal and tracheal ciliary function in response to Pseudomonas aeruginosa challenge. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):209-13. Cited in PubMed: PMID 21819755. Read the abstract

Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JR. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011;6(5):e20333. Epub 2011 May 27. Cited in PubMed: PMID 21647421. Read the article

Suaud L, Miller K, Alvey L, Yan W, Robay A, Kebler C, et al. ERp29 regulates DeltaF508 and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) trafficking to the plasma membrane in cystic fibrosis (CF) and non-CF epithelial cells. J Biol Chem. 2011 Jun 17;286(24):21239-53. Epub 2011 Apr 21. Cited in PubMed: PMID 21525008. Read the abstract

Kong J, Crissey MA, Funakoshi S, Kreindler JL, Lynch JP. Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus. PLoS One.  2011 Apr 6;6(4):318280. Cited in PubMed: PMID 21494671. Read the article

Goldstein-Daruech N, Cope EK, Zhao KQ, Vukovic K, Kofonow JM, Doghramji L, et al. Tobacco smoke mediated induction of sinonasal microbial biofilms. PLoS One. 2011 Jan 6;6(1):315700. Cited in PubMed: PMID 21253587. Read the article

2010

Cheng G, Wang LC, Fridlender ZG, Cheng GS, Chen B, Mangalmurti NS, et al. Pharmacologic activation of the innate immune system to prevent respiratory viral infections. Am J Respir Cell Mol Biol. Epub 2010 Dec 10. Cited in PubMed: PMID 21148741. Read the abstract

Savitski AN, Mesaros C, Blair IA, Cohen NA, Kreindler JL. Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respir Res. 2009 Nov 27;10;120. Cited in PubMed: PMID 19943936. Read the article

Kreindler JL, Steele C, Nguyen N, Chan YR, Pilewski JM, Alcorn JF, et al. Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest. 2010 Sep 1;120(9):3242-54. doi: 10.1172/JCI42388. Epub 2010 Aug 16. Cited in PubMed: PMID 20714107. Read the article

Goldfarb SB, Gaynor JW, Fuller S, Kreindler J, Montenegro LM, Fynn-Thompson F, et al. Induction therapy with antithymocyte globulin before reperfusion. Ann Thorac Surg. 2010 Oct;90(4):1110-4; discussion 1114-5. Cited in PubMed: PMID 20868797. Read the abstract.

Kulkarni R, Rampersaud R, Aguilar JL, Randis TM, Kreindler JL, Ratner AJ. Cigarette smoke inhibits airway epithelial cell innate immune response to bacteria. Infect Immun. 2010 May;78(5):2146-52. Epub 2010 Mar 1. Cited in PubMed: PMID 20194598. Read the article

Kreindler JL. Cystic fibrosis: exploiting its genetic basis in the hunt for new therapies. Pharmacol Ther. 2010 Feb;125(2):219-29. Epub 2009 Nov 10. Review. Cited in PubMed: PMID 19903491. Read the article

2009

Tamashiro E, Xiong G, Anselmo-Lima WT, Kreindler JL, Palmer JN, Cohen NA. Cigarette smoke exposure impairs respiratory epithelial ciliogenesis. Am J Rhinol Allergy. 2009 mar-Apr;23(2):117-22. Cited in PubMed: PMID 19401033. Read the abstract

Posters and Presentations

2009

Kreindler JL. Inflammation and ion transport [invited lecture]. Pulmonary Grand Rounds, University of Miami School of Medicine; 2009 Jan; Miami, FL.

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