Michele Lambert, MD, is the medical director of the Clinical Coagulation Laboratory with a special interest in inherited and acquired platelet disorders and the interplay between genetic disorders and hematologic disease. Her clinical and research focus has been on the diagnosis and management of platelet related bleeding disorders.
- Education and Training
MD - University of Medicine and Dentistry of New Jersey, Newark, NJ
Pediatrics - St. Christopher's Hospital for Children, Philadelphia, PA
Pediatrics (Chief Resident) - St. Christopher's Hospital for Children, Philadelphia, PA
Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA
American Board of PediatricsAmerican Board of Pediatrics/Hematology-Oncology
BS in Biology - Rensselaer Polytechnic Institute, Troy, NY
MTR - University of Pennsylvania, Philadelphia, PA
- Titles and Academic Titles
Medical Director, Clinical Coagulation Laboratory
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Departments and Services
Lambert, MP, Poncz, M: Inherited Thrombocytopenias. Platelets. Michelson, AD (eds.). Elsevier Science, 2nd edition; 3rd edition: 985-998, 2007, 2013.
Lambert, M: Autoimmune Hemolytic Anemia. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Lambert, M: Glucose-6 Phosphate Dehydrogenase Deficiency. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Lambert, MP: Anemia of Chronic Disease. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Lambert, MP: Hereditary Spherocytosis. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.
Ben J. Samelson-Jones, Michele P. Lambert: Use of Recombinant Factor VIIa (rVIIa) in Glanzmann's Thrombasthenia: A Systematic Review of the Literature. American Society of Hematology/Oncology Annual Meeting, Chicago, IL April 2014.
Ingmar Bruns, MD, Daniel Lucas, PhD, Sandra Pinho, PhD, Jalal Ahmed, Michele P Lambert, MD, Christoph Scheiermann, PhD, Yuya Kunisaki, MD, PhD, Mortimer Poncz, MD and Paul S. Frenette, MD: Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence Via PF4 Secretion. American Society of Hematology Plenary Session December 2013.
David T. Teachey, MD, TIffaney Vincent, Kim Smith-Whitley, MD, Michele P Lambert, MD, Alix E. Seif, MD, MPH, James T. Casper, MD and Stephan A Grupp, MD, PhD: Targeting mTOR Signaling Leads To Complete and Durable Responses In Children With Multi-Lineage Autoimmune Cytopenias, Including ALPS, SLE, Evans and CVID. American Society of Hematology, Oral Presentation December 2013.
Corinna L. Schultz, MD and Michele P Lambert, MD: Influence Of Updated ASH Guidelines On Practice Patterns In Management Of Newly Diagnosed Childhood ITP, 2007-2012. American Society of Hematology, Oral Presentation December 2013.
Cassie N. Kline, MD; Richard Hodinka, MD; Michele P. Lambert, MD: Investigating correlation between common upper respiratory and gastrointestinal viral infections and Idiopathic Thrombocytopenic Purpura. American Society of Pediatric Hematology/Oncology annual meeting; Poster presentation Apr 2013.
Michele P. Lambert, Donna McDonald-McGinn, Elaine Zakai: Hematologic Manifestations of 22qDS. 22qDeletion Syndrome meeting, Lake Buena Vista, FL July 2012.
Xiao L, Poncz M, Lambert MP: Platelet Factor 4 (PF4) causes cell cycle arrest in megakaryocytes by inactivating CDC2 (CDK1) and CDK2 Gordon Research Conference on Hemostasis March 2012.
Lambert MP, Xiao L, Meng R, Marks M, Poncz M: Alpha-granule protein recycling during megakaryopoiesis: Platelet factor 4 (PF4) is taken up by megakaryocytes (Megs) through a lipoprotein receptor related protein-1 (LRP1) dependent process and is available for release by stimulated Megs Platelets 2012; 7th International Platelet Symposium March 2012.
Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P.: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123(5): 753-7, Jan 2014. PMCID: PMC3907760
Lambert Michele P, Sullivan Spencer K, Fuentes Rudy, French Deborah L, Poncz Mortimer: Challenges and promises for the development of donor-independent platelet transfusions. Blood 121(17): 3319-24, Jan 2013. PMCID: PMC3976218
Teachey DT, Lambert MP.: Diagnosis and management of autoimmune cytopenias in childhood. Pediatr Clin North Am. 60(6): 1489-511, December 2013.
Lambert Michele P, Jiang Jing, Batra Vandana, Wu Chao, Tong Wei: A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia. American journal of hematology 87(5): 532-4, May 2012. PMCID: PMC3388505
Lambert Michele P, Reznikov Alisa, Grubbs Allison, Nguyen Yvonne, Xiao Liqing, Aplenc Richard, Raouva Lubica, Poncz Mortimer: Platelet Factor 4 Platelet Levels Are Inversely Correlated with Steady-State Platelet Counts and with Platelet Transfusion Needs in Pediatric Leukemia Patients. Journal of thrombosis and haemostasis : JTH 10(7): 1442-6, May 2012. PMCID: PMC3389572
- Awards and Honors
2011, International Society on Thrombosis and Haemostasis New Investigator Travel Award
2009, International Society of Thrombosis and Haemostasis Young Investigator Travel Award
2006, American Society of Pediatric Hematology/Oncology Young Investigator Travel Award
2005, American Society of Hematology Young Investigator Travel Award
1998, UMDNJ-NJMS Alumni Association Award in honor of Dr. Franklin Behrle
1997, UMDNJ-NJMS Alumni Association Scholarship
1985-1998, UMDNJ-NJMS Joseph Muscarelli Memorial Scholarship
1995, Alpha Epsilon Delta - Premedical honor society
- Editorial and Academic Positions
2009-present, Pediatric Blood and Cancer, Ad Hoc Reviewer
2009-preswent, Blood, Ad Hoc Reviewer
Academic and institutional committees
2008-2012, Member IRB-C, The Children's Hospital of Philadelphia
Memberships in professional organizations
2007-present, International Society of Thrombosis and Haemostasis
2014, NIH/NHLBI (Grant Reviewer; Microfluidic Assays SBIR/STTR)
2011-present, Society for Pediatric Research/Pediatric Academic Society
2008-present, Platelet Disorder Support Association
2008-present, Cornelia De Lange Foundation, Member Medical Advisory Board
2007-present, American Society of Pediatric Hematology/Oncology
2007-present, American Society of Hematology
1999-present, American Medical Association
- Awards and Honors