Ann-Marie Leahey, MD

Ann-Marie Leahey, MD, is an attending physician at CHOP’s Cancer Center who specializes in treating children with malignant tumors of the eye.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Background

    I am responsible for caring for patients with retinoblastoma (a malignant tumor of the retina) and am in charge of The Children's Hospital of Philadelphia retinoblastoma clinical trials. I succeed the preeminent Dr. Anna Meadows in this position, having been fortunate to be trained by her for the last 20 years.

    Retinoblastoma was one of the last childhood cancer frontiers to be conquered. Previously, therapy involved radiation therapy and often surgical removal of the eye (enucleation). Children’s Hospital was among the first to pioneer systemic chemotherapy for these patients, and we partner with the renowned ophthalmologist Dr. Carol Shields at Wills Eye Institute.

    Now systemic chemotherapy, used with local ophthalmic therapy, can eliminate the need for radiation therapy and/or enucleation in many patients. Historically, approximately 10 percent of children with the genetic form of the disease developed a deadly tumor called pineoblastoma. With systemic chemotherapy, we are preventing the majority of these tumors from developing.

    Children's Hospital has the only certified laboratory in the U.S. to provide genetic testing for retinoblastoma. Our Genetic Predisposition to Cancer Clinic, run by my colleague Dr. Kim Nichols, provides detailed genetic counseling. We also work closely with scientists here at the University of Pennsylvania in conducting groundbreaking research into the possible causes of retinoblastoma.

    I believe in hands on, patient- and family-centered care. I am in constant contact with my patients’ local pediatricians and oncologists since our patients come from all over the U.S. Our goal is to increase the number of children with retinoblastoma who can be cured and who can retain vision. Our expert clinical team and research efforts are all focused on that goal.

     

  • Education and Training

    Medical School

    Dartmouth-Brown Program in Medicine (MD), Providence, RI

    Internship

    Pediatrics, The Mount Sinai Hospital, New York, NY

    Residency

    Pediatrics, The Mount Sinai Hospital, New York, NY

    Fellowship

    Hematology/Oncology, The Children's Hospital of Philadelphia, PA

    Bone Marrow Transplantation, Fred Hutchinson Cancer Center, Seattle, WA

    Board Certification

    American Board of Pediatrics
    American Board of Pediatrics/Pediatric Hematology/Oncology

    Undergraduate Degree

    Dartmouth College (BA, English), Providence, RI

  • Titles and Academic Titles

    Attending physician

    Clinical professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Publications

    Books

    Chapters

    2002

    Leahey A. Mediastinal mass. In: Schwartz MW, editor. Clinical handbook of pediatrics. Baltimore: Williams & Wilkins; 2002.

    1999

    Leahey A. Mediastinal mass. In: Schwartz MW, editor. Clinical handbook of pediatrics. Baltimore: Williams & Wilkins; 1999.

    1997

    Leahey A. Graft versus host disease. In: Schwartz MW, editor. The 5 minute pediatric consult. Baltimore: Williams & Wilkins; 1997. p. 3576-57.

    Leahey A. Bone marrow transplantation. In: Schwartz MW, editor. The 5 minute pediatric consult. Baltimore: Williams & Wilkins; 1997. p. 158-9.

    1995

    Leahey A. Acute lymphoblastic leukemia. In: Sinniah D, D'Angio G, editors. Atlas of Pediatric Oncology. London: Arnold; 1995. p. 10-18.

    Leahey A. Chronic myeloid leukemia and myelodysplasia. In: Sinniah D, D'Angio G, editors. Atlas of Pediatric Oncology. London: Arnold; 1995. p. 26-30.

    Leahey A. Acute myeloid leukemia. In: Sinniah D, D'Angio G, editors. Atlas of Pediatric Oncology. London: Arnold; 1995. p. 19-25.

    Leahey A. Mediastinal mass. In: Schwartz MW, editor. Clinical handbook of pediatrics. Baltimore: Williams & Wilkins; 1995.

    Papers

    2011

    Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, et al. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 2010 Dec 24;330(6012):1775-87. Epub 2010 Dec 22. Cited in PubMed: PMID 21177976. Read the article

    Bunin GR, Felice MA, Davidson W, Friedman DL, Shields CL, et al. Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation. Int J Cancer. 2011 May 15;128(10):2393-404. doi: 10.1002/iic.25565. Read the abstract

    2009

    Shields CL, Ramasubramanian A, Thangappan A, Hartzell K, Leahey A, Meadows AT, et al. Chemoreduction for group E retinoblastoma: comparison of chemoreduction alone versus chemoreduction plus low-dose external radiotherapy in 76 eyes. Ophthalmol. 2009 Mar; 116(3):544-51. Epub 2009 Jan 20. Cited in PubMed: PMID 19157557. Read the abstract

    Shields CL, Palamar M, Sharma P, Ramasubramanian A, Leahey A, Meadows AT, et al. Retinoblastoma regression patterns following chemoreduction and adjuvant therapy in 557 tumors. Arch Ophthalmol. 2009 Mar; 127(3):282-90. Cited in PubMed: PMID 19723791. Read the article
     

     

  • Editorial and Academic Positions

    Editorial positions

    2006-present, Reviewer, Pediatric Blood and Cancer
    1995-present, Associate Editor, Atlas of Pediatric Oncology

    Academic positions

    2000-present, Pediatric Oncology Protocol Review Committee