Daniel J. Licht, MD

Daniel J. Licht, MD, is a pediatric neurologist and director of the Neurovascular Imaging Lab at The Children's Hospital of Philadelphia.

Areas of Expertise: Coma and prognosis, Intensive care neurology, Neurologic complications of congenital heart disease, Pediatric stroke, Seizures
Locations: Main Campus; Specialty Care, Springfield
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Medical School

    MD - New Jersey Medical School - UMDNJ, Newark, NJ

    Internship

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Residency

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    Child Neurology - The Children's Hospital of Philadelphia, Philadelphia, PAEpilepsy - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Child Neurology
    Pediatrics

  • Titles and Academic Titles

    Director, Neurovascular Imaging Lab

    Neurologist, NeuroCardiac Care Program

    Associate Professor of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Functional Neuroimaging Hemodynamic Imaging Brain Injury in Newborns with CHD Diffuse Optical Imaging

  • Publications

    Books

    Chapters

    2014

    Licht DJ. What is a Migraine Variant? Are they treated differently? Chapter 21 In: Ryan NR and Licht DJ (eds) Curbside Consultation in Pediatric Neurology: 49 Clinical Questions.

    Lin, K., Beslow L.A., Licht D.J. Cardiac Neurocritical Care. Chapter 23 In: Abend N.S., Helfaer M. (eds.) Pediatric Neurocritical Care. New York, New York: Demos Medical Publishing (in press).

    Kessler SK, Licht DJ, Abend NS. Approach to Acute Encephalopathy and Coma: Chapter 1 In: Abend N.S., Helfaer M. (eds.) Pediatric Neurocritical Care. New York, New York: Demos Medical Publishing (in press).

    Naim MY, Licht DJ; Neurologic Complications: Stroke. Chapter 173, Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. da Cruz EM, Ivy DD, Hraska V, Jagger J Editors 2014. ISBN: 978-1-4471-4618-6

    2011

    Glanzman MM, Licht DJ, Wernovsky G; Neurodevelopment in Children with Complex Congenital Heart Disease. Chapter 11. Pediatric Practice: Cardiology Gleason MM, Rychik J and Shaddy RE Editors 2011.

    2009

    Harper MB, Campen CJ, Kranick SM, Licht DJ, Gorman M, Pomeroy SL. Chapter 16 Neuroinfectious Disease. Pediatric Practice: Neurology Carney P and Geyer J Editors, 2009

    Campen CJ, Kranick SM, Licht DJ Chapter 17 Viral Encephalitis Pediatric Practice: Infectious Disease Shah SS Editor, 2009

    Abend NS, Kilaru SV, Helfaer MA, Licht DJ. Evaluation of the Comatose Child. In: Rogers’ Textbook of Pediatric Intensive Care 4th Edition, 2009

    Abend NS, Kilaru SV, Helfaer MA, Licht DJ. Evaluation of the Comatose Child. In: Rogers’ Handbook of Pediatric Intensive Care 4th Edition, 2009

    2007

    Licht DJ. Concussion. In: Schwartz W, editor Pediatric 5-Minute Consult 4th Edition, Lippincott, Williams and Wilkins, Philadelphia 2007

    Papers

    2014

    Lynch Jennifer M, Buckley Erin M, Schwab Peter J, McCarthy Ann L, Winters Madeline E, Busch David R, Xiao Rui, Goff Donna A, Nicolson Susan C, Montenegro Lisa M, Fuller Stephanie, Gaynor J William, Spray Thomas L, Yodh Arjun G, Naim Maryam Y, Licht Daniel J: Time to surgery and preoperative cerebral hemodynamics predict postoperative white matter injury in neonates with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2014 Jun 27. pii: S0022-5223(14)00833-2. doi: 10.1016/j.jtcvs.2014.05.081. [Epub ahead of print]

    Beslow LA, Ichord RN, Gindville MC, Kleinman JT, Engelmann K, Bastian RA, Licht DJ, Smith SE, Hillis AE, Jordan LC. Pediatric Intracerebral Hemorrhage Score: A Simple Grading Scale for Intracerebral Hemorrhage in Children. Stroke. 2014 Jan;45(1):66-70. doi: 10.1161/STROKEAHA.113.003448. Epub 2013 Nov 26.

    Bruno CJ, Beslow LA, Witmer CM, Vossough A, Jordan LC, Zelonis S, Licht DJ, Ichord RN, Smith SE. Haemorrhagic stroke in term and late preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2014 Jan;99(1):F48-53

    Shaikh H, Pukenas BA, McIntosh A, Licht D, Hurst RW. Combined use of Solitaire FR and Penumbra devices for endovascular treatment of cerebral venous sinus thrombosis in a child. BMJ Case Rep. 2014 Feb 19;2014.

    Goff DA, Shera DM, Tang S, Lavin NA, Durning SM, Nicolson SC, Montenegro LM, Rome JJ, Gaynor JW, Spray TL, Vossough A, Licht DJ. Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. J Thorac Cardiovasc Surg. 2014 Apr;147(4):1312-8. Read the abstract.

    Jain V, Buckley EM, Licht DJ, Lynch JM, Schwab PJ, Naim MY, Lavin NA, Nicolson SC, Montenegro LM, Yodh AG, Wehrli FW. Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. J Cereb Blood Flow Metab. 2014 Mar;34(3):380-8. Read the abstract.

    Lynch JM, Buckley EM, Schwab PJ, Busch DR, Hanna BD, Putt ME, Licht DJ, Yodh AG. Noninvasive optical quantification of cerebral venous oxygen saturation in humans. Acad Radiol. 2014 Feb;21(2):162-7. Read the abstract.

    Wehrli FW, Rodgers ZB, Jain V, Langham MC, Li C, Licht DJ, Magland J. Time-Resolved MRI Oximetry for Quantifying CMRO2 and Vascular Reactivity. Acad Radiol. 2014 Feb;21(2):207-14. Read the abstract.

    2013

    Bruno Christie J, Beslow Lauren A, Witmer Char M, Vossough Arastoo, Jordan Lori C, Zelonis Sarah, Licht Daniel J, Ichord Rebecca N, Smith Sabrina E: Haemorrhagic stroke in term and late preterm neonates. Archives of disease in childhood. Fetal and neonatal edition 99(1): F48-53, 2013.  

    ain Varsha, Buckley Erin M, Licht Daniel J, Lynch Jennifer M, Schwab Peter J, Naim Maryam Y, Lavin Natasha A, Nicolson Susan C, Montenegro Lisa M, Yodh Arjun G, Wehrli Felix W: Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 34(3): 380-8, 2013.  

    Vossough A, Limperopoulos C, Putt ME, du Plessis AJ, Schwab PJ, Wu J, Gee JC, Licht DJ. Development and Validation of a Semiquantitative Brain Maturation Score on Fetal MR Images: Initial Results. Radiology. 2013 Jul;268(1):200-7. Read the abstract.

    Buckley EM, Naim MY, Lynch JM, Goff DA, Schwab PJ, Diaz LK, Nicolson SC, Montenegro LM, Lavin NA, Durduran T, Spray TL, Gaynor JW, Putt ME, Yodh AG, Fogel MA, Licht DJ. Sodium bicarbonate causes dose-dependent increases in cerebral blood flow in infants and children with single ventricle physiology. Pediatr Res. 2013 May;73(5):668-73. Read the abstract.

    Buckley EM, Lynch JM, Goff DA, Schwab PJ, Baker WB, Durduran T, Busch DR, Nicolson SC, Montenegro LM, Naim MY, Xiao R, Spray TL, Yodh AG, Gaynor JW, Licht DJ. Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: Effects of surgical duration. J Thorac Cardiovasc Surg. 2013 Jan;145(1):196-203, 205.e1; discussion 203-5. Read the abstract.

    Lin KY, Kerur B, Witmer CM, Beslow LA, Licht DJ, Ichord RN, Kaufman BD. Thrombotic events in critically ill children with myocarditis. Cardiol Young. 2013 Sep 9:1-8.

    Jalali A, Licht DJ, Nataraj C. Discovering hidden relationships in physiological signals for prediction of Periventricular Leukomalacia. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7080-7083.

    Jalali A, Buckley E, Lynch J, Schwab P, Licht DJ, Nataraj C. Prediction of Periventricular Leukomalacia Occurrence in Neonates After Heart Surgery. IEEE J Biomed Health Inform. 2013 Oct 9.

    Beslow LA, Ichord RN, Gindville MC, Kleinman JT, Bastian RA, Smith SE, Licht DJ, Hillis AE, Jordan LC. Frequency of Hematoma Expansion After Spontaneous Intracerebral Hemorrhage in Children. JAMA Neurol. 2013 [Epub ahead of print]

    2012

    Buckley EM, Hance D, Pawlowski T, Lynch J, Wilson FB, Mesquita RC, Durduran T, Diaz LK, Putt ME, Licht DJ, Fogel MA, Yodh AG. Validation of Diffuse Correlation Spectroscopic Measurement of Cerebral Blood Flow Using Phase-Encoded Velocity Mapping MRI J Biomed Optics 2012 Mar;17(3):037007

    Verbeek E, Meuwissen ME, Verheijen FW, Govaert PP, Licht DJ, Kuo DS, Poulton CJ, Schot R, Lequin MH, Dudink J, Halley DJ, de Coo RI, den Hollander JC, Oegema R, Gould DB, Mancini GM. COL4A2 mutation associated with familial porencephaly and small-vessel disease. Eur J Hum Genet. 2012 Aug;20(8):844-51.

    Goff DA, Luan X, Gerdes M, Bernbaum J, D’Agostino J, Rychik J, Wernovsky G, Licht DJ, Nicolson SC, Clancy RR, Spray TL, Gaynor WJ. Younger gestational age is associated with worse neurodevelopmental outcomes after cardiac surgery in infancy. J Thorac Cardiovasc Surg 2012;143:535-42

    Lo WD, Ichord RN, Dowling MM, Rafay M, Templeton J, Halperin A, Smith SA, Licht DJ, Moharir M, Askalan R, deVeber G. The Pediatric Stroke Recurrence and Recovery Questionnaire: Validation in a Prospective Cohort Neurology 2012 Aug 28;79(9):864-870

    Hirsch JC, Jacobs M, Andropoulos D, Austin E, Jacobs JP, Licht DJ, Pigula F, Tweddell J, Gaynor JW. Protecting the Infant Brain During Cardiac Surgery: A Systematic Review. Ann Thorac Surg 2012;94:1365–73

    Ravishankar C, Zak V, Williams IA, Bellinger DC, Gaynor JW, Ghanayem NS, Krawczeski CD, Licht DJ, Mahony L, Newburger JW, Pemberton VL, Williams RV, Sananes R, Cook AL, Atz T, Khaikin S, Hsu DT; Association of Impaired Linear Growth and Worse Neurodevelopmental Outcome in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial J Peds August 2012 (epub)

    Beslow LA, Vossough A, Dahmoush HM, Kessler SK, Stainman R, Favilla CG, Wusthoff CJ, Zelonis S, Licht DJ, Ichord RN, Smith SE. Modified Pediatric ASPECTS Correlates with Infarct Volume in Childhood Arterial Ischemic Stroke. Front Neurol. 2012;3:122. Epub 2012 Jul 31.

    McGuire JL, Zorc J, Licht D, Hodinka RL, Shah SS. Herpes simplex testing in neonates in the emergency department. Pediatr Emerg Care. 2012 Oct;28(10):949-55.

    Buckley EM, Lynch JM, Goff DA, Schwab PJ, Baker WB, Durduran T, Busch DR, Nicolson SC, Montenegro LM, Naim MY, Xiao R, Spray TL, Yodh AG, Gaynor JW, Licht DJ. Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: Effects of surgical duration. J Thorac Cardiovasc Surg. 2013 Jan;145(1):196-203, 205.e1; discussion 203-5.

    Dowling MM, Hynan LS, Lo W, Licht DJ, McClure C, Yager JY, Dlamini N, Kirkham FJ, Deveber G, Pavlakis S; for the International Paediatric Stroke Study Group. International Paediatric Stroke Study: stroke associated with cardiac disorders. Int J Stroke. 2013 Oct;8 Suppl 100:39-44.

    Jalali A, Licht DJ, Nataraj C. Application of decision tree in the prediction of periventricular leukomalacia (PVL) occurrence in neonates after heart surgery. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:5931-4.

    Posters and Presentations

    2013

    Nov. 18th, 2013 “Time to Surgery and Pre-Operative Cerebral Oxygenation Predict Post-Operative Ischemic Injury in HLHS” AHA Scientific Sessions 2013, Dallas TX

    “Cerebral CO2 Reactivity is Decreased in Children with Bidirectional Glenn Physiology” AHA Scientific Sessions 2013, Dallas TX

    2012

    April 30th, 2012 “Cerebral Oxygen Metabolism Following Neonatal Cardiac Surgery: The Effect of Surgical Support Time” American Academy for Thoracic Surgery 93rd annual meeting, San Francisco

    2010

    October 15th, 2010 “Development of a Semiquantitative Fetal Brain Maturation Score on MRI”, 39th Annual Child Neurology Society, Providence RI

  • Editorial and Academic Positions

    Editorial positions

    Editorial Board Member

    • Frontiers Obstetric and Pediatric Pharmacology
    • Recent Patents on Medical Imaging, Bentham Science Publishers

    Ad Hoc Reviewer of Manuscripts

    • Pediatric Research
    • Circulation
    • Pediatrics
    • Stroke
    • Neuroimage
    • Neuropediatrics
    • Pediatric Emergency Care
    • Pediatric Neurology
    • Pediatrics International

    Academic and institutional committees

    2008-present, Faculty member of Center for Pediatric Clinical Effectiveness (CPCE)
    2008-present, Therapeutic Standards Committee, Children’s Hospital Philadelphia
    2007-present, Cardiovascular Institute (CVI), University of Pennsylvania
    2007-present, Institute of Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
    2005-present, Admission Committee for Child Neurology, Children’s Hospital Philadelphia
    2004-present, Joseph Stokes Jr. Research Institute, Children’s Hospital Philadelphia
    2002-present,  NeuroCardiac Research Program (NCRP), Children’s Hospital Philadelphia