Dr. Loomes’ primary research interest is in the genetics of liver and bile duct development. Following the identification of Jag1 as the disease gene for Alagille syndrome, a multisystem developmental disorder with bile duct paucity as a major feature, the Notch signaling pathway has been implicated in bile duct development.
In order to understand the roles of the members of this pathway in bile duct development, Dr. Loomes and her laboratory members have taken a dual approach. They utilize multiple mouse mutant models within the Notch signaling pathway to elucidate genetic interactions and to study bile duct development in detail.
In addition, they have generated a bipotential mouse hepatoblast cell line, capable of differentiation into hepatocytes or biliary epithelial cells. Through the manipulation of expression of regulatory genes in this in vitro system, they will be able to shed light on signaling mechanisms for bile duct differentiation.« Back to Previous Page