Randolph P. Matthews, MD, PhD

Randolph P. Matthews, MD, PhD, is a physician with the Division of Gastroenterology and Nutrition at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Education and Training

    Medical School

    MD - University of Washington, Seattle, WA

    Residency

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    Pediatric Gastroenterology and Nutrition - The Children's Hospital of Philadelphia, Philadelphia, PA
    Pediatric Gastroenterology, Hepatology and Nutrition - University of Pennsylvania School of Medicine/CHOP, Philadelphia, PA

    Board Certification

    Pediatric Gastroenterology
    Pediatrics

    Graduate Degree

    PhD in Pharmacology - University of Washington, Seattle, WA

  • Titles and Academic Titles

    Attending Physician

    Assistant Professor of Pediatrics, University of Pennsylvania School of Medicine

  • Centers and Programs
  • Publications

    Books

    Chapters

    2011

    Shuang Cui, Jessi Erlichman, Pierre Russo, Barbara A. Haber, and Randolph P. Matthews*: Intrahepatic biliary anomalies in a patient with Mowat-Wilson syndrome uncover a role for the zinc finger homeobox gene zfhx1b in vertebrate biliary development. J. Pediatr. Gastroenterol. Nutr. 52(3): 339-344, March 2011 Notes: *corresponding author.

    2009

    Randolph P. Matthews: Zebrafish as a model system for liver development and disease modeling. The Liver. I.R. Arias (eds.). 2009.

    2008

    Randolph P. Matthews: Metabolic Liver Disease: Tyrosinemia, Galactosemia, and Hereditary Fructose Intolerance. Pediatric Gastroenterology: The Requisites in Pediatrics. Chris A. Liacouras and David A. Piccoli (eds.). Mosby, Page: 267-275, 2008.

    Joel E. Friedlander and Randolph P. Matthews: Chronic Abdominal Pain. Pediatric Practice: Infectious Disease. Samir A. Shah (eds.). McGraw-Hill Medical, 2008.

    2004

    Matthews RP, Haber BA, Mamula P, Piccoli DA.: Cases in pediatric gastroenterology from The Children's Hospital of Philadelphia. A 5-year-old girl with massive hepatosplenomegaly, fever, and rash. MedGenMed 6: 14, 2004.

    2003

    Randolph P. Matthews: Chronic Abdominal Pain. Clinical Handbook of Pediatrics, 3rd ed. Schwartz W. (eds.). Lippincott, Williams, and Wilkins, 2003.

    2000

    Shah SS, Matthews RP, Cohen C.: Group C streptococcal meningitis: case report and review of the literature. Pediatr Infect Dis J 20: 445-448, 2000.

    Abstracts

    2013

    V. Tang and R.P. Matthews: Effects of histone deacetylation inhibitors on biliary formation in zebrafish  The Liver Meeting, annual meeting of the American Association for the Study of Liver Diseases November 2013.

    V. Sapp, L. Gaffney, S.F. EauClaire, R.P. Matthews: Characterizing Fructose-Induced Steatohepatitis in Zebrafish Larvae. The Liver Meeting, annual meeting of the American Association for the Study of Liver Diseases November 2013 Notes: Oral presentation.

    V. Tang, E.A. Tsai, N.B. Spinner, and R.P. Matthews: Evidence from human and zebrafish that ADD3 is a biliary atresia susceptibility gene. 26th annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition October 2013 Notes: Oral presentation.

    S.F. EauClaire, S. Cui, Z. Cofer, J. Tobias, C. Kim, H. Hakonarson, R.P. Matthews: Analysis of differential gene methylation in livers from biliary atresia patients uncovers a potential role platelet-derived growth factor (PDGF). 26th annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition October 2013.

    2012

    S.F. EauClaire, S. Cui, A. Alloy, J. Tobias, C. Kim, H. Hakonarson, R.P. Matthews: Methylation microarray studies of biliary atresia livers uncover potential role for PDGF. The Liver Meeting, annual meeting for the American Association for the Study of Liver Disease November 2012.

    R.P. Matthews, L. Gaffney, A.J. Edens, S.F. EauClaire: Multiple models of nonalcoholic steatohepatitis in zebrafish underscore the importance of metabolic and inflammatory pathways. 25th annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition October 2012.

    H. Lin, R. Rutstein, J. Cantor, S. Anupindi, R.P. Matthews: Cholangiocarcinoma in a Young Woman with Perinatally Acquired HIV. 25th annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition October 2012.

    Randolph P. Matthews, Shuang Cui, Melissa Leyva-Vega, Ellen A. Tsai, Steven F. EauClaire, Barbara A. Haber, Nancy B. Spinner: Human and zebrafish evidence for GPC1 as a biliary atresia risk gene. FASEB Liver Biology Conference July 2012.

    Papers

    2014

    Wilkins, B.J., Lorent, K., Matthews, R.P., and Pack, M: p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis. PLoS ONE in press.

    2013

    Shuang Cui, Melissa Leyva-Vega, Ellen A. Tsai, Steven F. EauClaire, Joseph T. Glessner, Hakon Hakonarson, Marcella Devoto, Barbara A. Haber, Nancy B. Spinner, and Randolph P. Matthews: Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene. Gastroenterology 144: 1107-1115, May 2013.

    Shuang Cui, Steven F. EauClaire, Randolph P. Matthews: Interferon-gamma directly mediates developmental biliary defects. Zebrafish 10: 177-183, May 2013.

    Henry Lin, Richard Rutstein, Joshua Cantor, Sudha Anupindi, and Randolph P. Matthews: Cholangiocarcinoma in a Young Woman with Perinatally Acquired HIV. J. Pediatr. Gastroenterol. Nutr. Page: e43-46, June 2013.

    Shah, S., Conlin, L.K., Gomez, L., Aagenaes, Ø., Eiklid, K., Knisely, A.S., Mennuti, M., Matthews, R.P., Spinner, N.B., and Bull, L.N.: CCBE1 mutation identified in two siblings, one of whom manifested Lymphedema-Cholestasis syndrome, and the other, Fetal Hydrops. PLoS ONE 8: e75770, September 2013.

    2012

    Steven F. Eauclaire, Shuang Cui, Liyuan Ma, James Matous, Florence L. Marlow, Tripti Gupta, Harold A. Burgess, Eliott W. Abrams, Lee D. Kapp, Michael Granato, Mary C. Mullins, and Randolph P. Matthews.: Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish. Dev Biol 365(2): 434-444, May 2012.

  • Awards and Honors

    2013, CHOP Resident Faculty Honor Roll
    2012, Society for Pediatric Research
    2007-2008, Foerderer-Murray New Investigator Award, CHOP
    2005, Young Faculty Investigator Award, North American Society for Gastroenterology, Hepatology, and Nutrition
    1996-1998, Achievement Reward for College Scientists (ARCS) Fellowship
    1989, Sigma Xi
    1989, Phi Beta Kappa

  • Editorial and Academic Positions

    Editorial positions

    2012-present, Frontiers in Pediatric Gastroenterology, Hepatology and Nutrition, Review Editor

    Ad hoc reviewer

    2013-present, Epigenetics
    2013-present, BMC Systems Biology
    2012-present, Zebrafish
    2012-present, BBA - Molecular Basis of Disease
    2010-present, Hepatology
    2010-present, Disease Models and Mechanisms
    2009-present, Development
    2009-present, Genesis
    2009-present, Developmental Biology
    2008-present, Gastroenterology
    2008-present, Developmental Dynamics
    2007-present, Journal of Pediatric Gastroenterology and Nutrition

    Academic and institutional committees

    2012-present, Therapeutic Standards Committee
    2011-present, Disciplinary Hearing Panel for the University of Pennsylvania
    2009-2013, Undergraduate Student Scholars Program, Selection Committee member
    2008-present, Fellowship selection committee, CHOP Division of Gastroenterology, Hepatology, and Nutrition
    2004-present, Residency Selection Committee

  • Leaderships

    Memberships in professional organization

    American Association for the Study of Liver Disease

    • 2011-present, Member, Pediatric Special Interest Group
    • 2013-present, Member, Pediatric Special Interest Group Single Topic Conference subcommittee

    North American Society for Gastroenterology, Hepatology, and Nutrition

    • 2009-present, Member, Research Committee
    • 2011-present, Chair, Study Section Grant Review

    Society for Pediatric Research