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Randolph P. Matthews, MD, PhD

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2010

Cui S, Capecci L, Matthews R. Disruption of planar cell polarity leads to developmental biliary defects [poster presentation]. 9th International Conference on Zebrafish Development and Genetics; 2010 June; Madison, WI. 

Matthews RP, EauClaire SF, Mugnier M, Lorent K, Cui S, Ross M, et al. DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of biliary atresia [oral presentation]. 23rd annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; 2010 Oct; New Orleans, LA.

2009

Matthews RP, Ma L, EauClaire SA. Zebrafish pekin mutants demonstrate the importance of intracellular trafficking in hepatobiliary development [poster presentation]. Digestive Disease Week; 2009 May; Chicago, IL.

Matthews RP, Cui S, Capecci L. Defects in planar cell polarity pathway activity are associated with developmental biliary anomalies [oral presentation]. Digestive Disease Week; 2009 May; Chicago, IL.

EauClaire SA, Ma L, Matthews RP. Biliary and pigmentation defects in zebrafish pekin mutants [poster presentation]. Digestive Disease Week; 2009 May; Chicago, IL.

Matthews RP, Cui S, Capecci L. Defects in planar cell polarity pathway activity are associated with developmental biliary anomalies and are associated with specific infantile biliary disorders [oral presentation]. 22nd annual meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition; 2009 Nov; National Harbor, MD.

Matthews RP, EauClaire SF, Edens A. Zebrafish models of hepatic steatosis [poster presentation]. 22nd annual meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition; 2009 Nov; National Harbor, MD. 

Awards

2007-2008, Foerderer-Murray New Investigator Award, The Children's Hospital of Philadelphia

2005, Young Faculty Investigator Award, North American Society for Gastroenterology, Hepatology, and Nutrition

1996-1998, Achievement Reward for College Scientists (ARCS) Fellowship

1989, Phi Beta Kappa

1989, Sigma Xi

Books

Chapters

2009

Matthews RP. Zebrafish as a model system for liver development and disease. In: Arias IM, et al, editors. The Liver: Biology and Pathobiology. 5th edition; 2009.

2008

Matthews, RP: Metabolic liver disease: tyrosinemia, galactosemia, and hereditary fructose intolerance. In: Liacouras C and Piccoli D, editors. Pediatric Gastroenterology: The Requisites in Pediatrics. Mosby; 2008. Page: 267-275.

Friedlander JE, Matthews RP. Chronic abdominal pain. In: Shah S, editor. Pediatric Practices: Infectious Disease. McGraw-Hill; 2008.

2007

Matthews RP. Metabolic liver disease: glactosemia, tyrosinemia and hereditary fructose intolerance. In: Liacouras CA, Piccoli DA, editors. Essentials of Pediatric Gastroenterology. Mosby Elsevier; 2007.

2003

Matthews RP. Chronic abdominal pain. In: Schwartz W, editor. Clinical Handbook of Pediatrics 3rd edition. Philadelphia: Lippincott, Williams and Wilkins; 2003.

Editorial and Academic Positions

Editorial positions

2010-present, Hepatology (ad hoc reviewer)
2010-present, Disease Models and Mechanisms (ad hoc reviewer)
2009-present, Development (ad hoc reviewer)
2009-present, Developmental Biology (ad hoc reviewer)
2009-present, Genesis (ad hoc reviewer)
2008-present, Gastroenterology (ad hoc reviewer)
2008-present, Developmental Dynamics (ad hoc reviewer)
2007-present, Journal of Pediatric Gastroenterology and Nutrition (ad hoc reviewer)
2001-present, Pediatric Emergency Medicine (ad hoc reviewer)

Academic positions

2008-present, Fellowship selection committee, The Children's Hospital of Philadelphia Division of Gastroenterology, Hepatology, and Nutrition, ad hoc interviewer

2004-present, Residency Selection Committee, The Children's Hospital of Philadelphia, ad hoc interviewer

2010, Internal review committee for Pediatric Endocrinology Fellowship, The Children's Hospital of Philadelphia, member

Leadership

Memberships in professional organizations

2002-present, American Association for the Study of Liver Disease
2001-present, North American Society for Gastroenterology, Hepatology, and Nutrition

  • 2009-2011, member, Research Committee

Original Papers

2011

Leyva-Vega M, Weiss P, Ganesh J, Conlin L, Spinner N, Matthews R. Significant liver disease in a patient with Y116H mutation in the MVK gene. Am. J. Med. Genet. 2011 Jun;155A(6):1461-4. doi: 10.1002/ajmg.a.33915. Epub 2011 May 5. No abstract available.

Matthews R, EauClaire S, Mugnier M, Lorent K, Cui S, Ross M, et al. DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia. Hepatology. 2011 Mar;53(3):905-14. doi: 10.1002/hep.24106. Epub 2011 Feb 11. Read the abstract

Cui S, Erlichman J, Russo P, Haber B, Matthews R: Intrahepatic biliary anomalies in a patient with Mowat-Wilson syndrome uncover a role for the zinc finger homeobox gene zfhx1b in vertebrate biliary development. J. Pediatr. Gastroenterol. Nutr. 2011 Mar;52(3):339-44. Read the abstract

2010

Cullinane AR, Straatman-Iwanowska A, Zaucker A, Wakabayashi Y, Bruce CK, Luo G, Rahman F, et al. Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet. 2010 Apr;42(4):303-12. Epub 2010 Feb 28. Read the abstract

2009

Matthews RP, Lorent K, Mañoral-Mobias R, Huang Y, Gong W, Murray IV, et al. TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development. 2009 Mar;136(5):865-75. Read the abstract

Hand NJ, Master ZR, Eauclaire SF, Weinblatt DE, Matthews RP, Friedman JR. The microRNA-30 family is required for vertebrate hepatobiliary development. Gastroenterology. 2009 Mar;136(3):1081-90. Epub 2008 Dec 9. Read the abstract

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