Shana E. McCormack, MD

Shana E. McCormack, MD, is an attending physician in the Diabetes Center for Children and the Congenital Hyperinsulinism Center at CHOP.

Locations: Main Campus; Specialty Care, Market Street
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Background

    Shana McCormack, MD, is an attending physician in the Division of Endocrinology and Diabetes and in the Healthy Weight Program and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. McCormack cares for children with pediatric endocrine disease, including obesity and its complications, such as type 2 diabetes mellitus and pseudotumor cerebri syndrome, and with inherited and acquired forms of hypopituitarism, in particular those associated with abnormal energy balance. She also cares for patients with endocrine dysfunction related to primary forms of mitochondrial disease.

    Dr. McCormack is a physician-scientist investigating the role of mitochondrial metabolism in disorders of energy balance in humans. To understand the primary effects of abnormal mitochondrial metabolism on endocrine function, she studies individuals with genetic forms of mitochondrial disease. In addition, she applies these insights to children with obesity and its complications, including type 2 diabetes and pseudotumor cerebri syndrome.
     

  • Education and Training

    Medical School

    MD - Harvard Medical School and Massachusetts Institute of Technology, Boston, MA

    Internship

    Pediatrics - Massachusetts General Hospital, Boston, MA

    Residency

    Pediatrics - Massachusetts General Hospital, Boston, MA

    Fellowship

    Pediatric Endocrinology - Children's Hospital Boston, Boston, MA

    Board Certification

    Pediatrics

  • Titles and Academic Titles

    Attending Physician

    Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Research Interests

    Dr. McCormack is a physician-scientist investigating the role of mitochondrial metabolism in disorders of energy balance in humans. To understand the primary effects of abnormal mitochondrial metabolism on endocrine function, she studies individuals with genetic forms of mitochondrial disease. In addition, she applies these insights to children with obesity and its complications, including type 2 diabetes and pseudotumor cerebri syndrome.

  • Publications

    Books

    Chapters

    McCormack SE and Grant SFA: Genetic variation and obesity prior to the era of genome-wide association studies. In: Grant SFA, editor. The Genetics of Obesity. New York: Springer; 2014.

    Papers

    2015

    Chesi A, Mitchell JA, Kalkwarf HJ, Bradfield JP, Lappe JM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA, Kelly A, Zemel BS, Grant SFA.: A Trans-ethnic Genome-wide Association Study Identifies Gender Specific Loci Influencing Pediatric aBMD and BMC at the Distal Radius. Human Molecular Genetics June 2015.

    Roy SM, Chesi A, Mentch F, Xiao R, Chiavacci R, Mitchell JA, Kelly A, Hakonarson H, Grant SF, Zemel BS, McCormack SE.: Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity. The Journal of Clinical Endocrinology and Metabolism April 2015.

    Mitchell JA, Chesi A, Elci O, McCormack SE, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF: Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions. Journal of Bone and Mineral Research March 2015.

    McCormack S, Polyak E, Ostrovsky J, Dingley SD, Rao M, Kwon YJ, Xiao R, Zhang Z, Nakamaru-Ogiso E, Falk MJ.: Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegant. Mitochondrion March 2015.

    Paley GL, Sheldon CA, Burrows EK, Chilutti MR, Liu GT, McCormack SE: Overweight and obesity in pediatric secondary pseudotumor cerebri syndrome. American Journal of Ophthalmology 159(2), February 2015.

    2014

    Schrier Vergano Samantha, Rao Meera, McCormack Shana, Ostrovsky Julian, Clarke Colleen, Preston Judith, Bennett Michael J, Yudkoff Marc, Xiao Rui, Falk Marni J: In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans. Molecular genetics and metabolism 111(3): 331-41, March 2014.

    2013

    Zhang Zhe, Tsukikawa Mai, Peng Min, Polyak Erzsebet, Nakamaru-Ogiso Eiko, Ostrovsky Julian, McCormack Shana, Place Emily, Clarke Colleen, Reiner Gail, McCormick Elizabeth, Rappaport Eric, Haas Richard, Baur Joseph A, Falk Marni J: Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PloS one 8(7): e69282, July 2013.

    McCormack S, McCarthy M, Harrington S, Farilla L, Hrovat M, Systrom D, Thomas B, Torriani M, McInnis K, Grinspoon S, Fleischman A.: Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation, and intramyocellular lipid content in obese children and adolescents. Pediatric Obesity June 2013.

    McCormack S, Shaham O, McCarthy M, Deik A, Wang TJ, Gerszten R, Clish C, Mootha V, Grinspoon S, Fleischman A.: Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatric Obesity 8(1): 52-61, February 2013.

  • Awards and Honors

    2013, University of Pennsylvania School of Medicine Institute for Translational Medicine and Therapeutics (ITMAT) Fellowship
    2012, Travel Award for Young Investigators Pediatric Academic Society, Boston MA
    2011, Outstanding Abstract and Travel Award Endocrine Society, Boston MA
    2010, Fellow Travel Award, Lawson Wilkins Pediatric Endocrine Society
    2008, Resident Teaching Award, Harvard Medical School
    2006, Family-Centered Care Award, Massachusetts General Hospital for Children
    2002, Howard Hughes Medical Institute Medical Student Research Fellowship
    1999, Phi Beta Kappa Society, Harvard College
    1996, Howard Hughes Medical Institute Undergraduate Research Fellowship

  • Editorial and Academic Positions
    Ad hoc reviewer

    2015-present, Metabolism
    2015-present, PLOS ONE
    2014-present, American Journal of Human Genetics
    2014-present, Annals of Clinical Biochemistry
    2014-present, Pediatric Obesity
    2013-present, Journal of Clinical Endocrinology and Metabolism
    2013-present, Circulation: Cardiovascular Genetics

  • Leaderships

    Endocrine Society
    Pediatric Endocrine Society
    Obesity Society
    American Society for Bone and Mineral Research
    Mitochondrial Medicine Society
    United Mitochondrial Disease Foundation
    National Institutes of Health, National Institute of Neurological Disorders and Stroke
    - Chair, Mitochondrial Disease Common Data Element Working Group on Endocrinology, Diabetes, GI, Nutrition