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Francis X. McGowan, MD

Attending Anesthesiologist

Endowed Chair and Director of Pediatric Anesthesiology Research, The Children's Hospital of Philadelphia

Professor of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2012

Sun LS, Li G, Byrne M, Ing C, DiMaggio CJ, Miller T, Bellinger D, Han S, Roh A, McGowan FX: Pilot study of the pediatric anesthesia and neurodevelopment assessment (PANDA) project. Anesthesiology Page: A141, 2012.

He H, Poutias DN, Favre E, Balschi JA, McGowan FX: Upregulation of NOX4 triggers mitochondrial dysfunction during the progression of infant right ventricular hypertrophy. Circulation 126: A13534, 2012.

2011

 McGowan FX, Mukherjee R, Campbell P, Friehs I, Poutias DN, Baicu C, ZileMR, Spinale F, He H: Myocardial matrix dysregulation occurs in early in infant right ventricular pressure overload. Circulation 124: A15911, 2011.

Kussman B, Laussen P, Benni P, McElhinney D, McGowan F.: Validation of the FORE-SIGHT tissue oximeter for somatic oxygenation in children. Anesthesiology Page: LBC01, 2011.

Kheir JN, Black K, Reese J, McGowan FX: Lipid-based oxygen microparticles do not change in size following intravenous or intraosseous injection. Circulation Page: A259, 2011.

He H, Kawata M, Poutias DN, Campbell PH, Ablasser K, Friehs H, McGowan FX: AMP-activated protein kinase-dependent autophagy in the transition of right ventricular hypertrophy to failure. Circulation 124: A13638, 2011.

Awards

2013-present, Endowed Chair, Pediatric Anesthesiology Research, The Children's Hospital of Philadelphia

2011-Present J.G. Reves Professor, Medical University of South Carolina

2010, "Francis X. McGowan Endowed Chair in Pediatric Cardiac Anesthesia" established by Children's Hospital Boston and Children's Hospital Boston Department of Anesthesiology, Perioperative and Pain Medicine

2009-Present, "America's Top Pediatricians" (annually since 2009)

2008, President's Special Recognition Award, Society for Pediatric Anesthesia

2007, "Fellow Teacher of the Year Award", Department of Anesthesiology, Children's Hospital Boston

2006-2011, Children's Hospital Boston Endowed Chair in Pediatric Cardiac Anesthesia

2003, Master of Arts, Harvard University (Honorary)

1999, "Teacher of the Year Award", Department of Anesthesiology, Children's Hospital Boston

1998-Present, "Best Doctors in America" (annually since 1998)

1993-1995, Young Investigator Award, Foundation for Anesthesia Education and Research/Stuart Pharmaceuticals

1992, B.B. Sankey Anesthesia Advancement Award, International Anesthesia Research Society

1992, Children's Hospital of Pittsburgh Ambassador Award

1991, The University of Pittsburgh Department of Anesthesiology Teaching Award

1989, The R.D. Dripps Award, Department of Anesthesiology, Yale University School of Medicine

1986, Morris Y. Krosnick Award, Department of Pediatrics, Yale University

1981-1982, Pharmaceutical Manufacturer's Association Foundation Fellowship in Clinical Pharmacology

Books

Chapters

2011

Kussman BD, McGowan FX: Anesthesia for patients with congenital heart disease undergoing non-cardiac or non-cardiopulmonary bypass procedures.  Smith's Anesthesia for Infants and Children (8th Edition)  Davis PJ, Claddis FC, Motoyama EK Philadelphia: WB Saunders (8th Edition) 2011;pp674-712 (eds.). Philadelphia:  WB Saunders, Page: 674-712, 2011.

DiNardo JA, Shukla AC, McGowan FX: Anesthesia for pediatric heart, lung, and heart-lung transplantation. Smith's Anesthesia for Infants and Children (8th Edition). Davis PJ, Claddis FC (eds.), (eds.). Philadelphia: WB Saunders, Page: 605-673, 2011.

2010

del Nido PJ, McGowan FX: Surgical approaches and cardiopulmonary bypass for congenital heart surgery. In Sabiston and Spencer Surgery of the Chest (8th Edition). Selke FW, del Nido PJ, Swanson SJ (eds.). Philadelphia: WB Saunders, Page: 1709-1733, 2010.

2009

Shukla AC, Steven JM, McGowan FX: Cardiovascular physiology and pharmacology in children. A Practice of Anesthesiology for Infants and Children (Fourth Edition) Cote CJ, Lerman JR, Todres ID (eds.). Philadelphia: Elsevier, Page: 361-397, 2009.

2005

McGowan FX, del Nido PJ: Surgical approaches and cardiopulmonary bypass for congenital heart surgery. Sabiston and Spencer Surgery of the Chest (7th Edition). Selke FW, del Nido PJ (eds.). Philadelphia: Elsevier, Page: 1825-1850, 2005.

Shukla AC, McGowan FX.: Anesthesia for pediatric heart, lung, and heart-lung transplantation. Smith's Anesthesia for Infants and Children (7th Edition). Davis PJ, Motoyama EK (eds.). Philadelphia: WB Saunders, 2005.

2001

McGowan FX, Steven JM.: Cardiovascular Physiology and Pharmacology in Children. In: A Practice of Anesthesiology for Infants and Children. Cote CJ, Todres ID, Ryan JF, Goudsouzian NG (eds.). Philadelphia: WB Saunders, Page: 353-389, 2001.

2000

Steven JM, McGowan FX: Neuraxial blockade for pediatric cardiac surgery: lessons yet to be learned. (Editorial). Anesth Analg 90: 1011-1013, 2000.

1996

Burrows FA, McGowan FX: Neurodevelopmental consequences of cardiac surgery for congenital heart disease. Pediatric Cardiac Anesthesia. Greeley WJ (eds.). Philadelphia: Lippincott, Page: 136-174, 1996.

1994

Chan KH, Riding KH, McGowan FX, Stool SE: Endoscopic Surgery of the Upper Aerodigestive Tract. Atlas of Pediatric Otolaryngology. Philadelphia: WB Saunders, Page: 419-445, 1994.

McGowan FX, Bailey P: Anesthesia for heart, heart-lung, and lung transplantation. Transplantation Anesthesiology. Cook DR, David PL (eds.). New York: Raven Press, Page: 85-157, 1994.

1993

McGowan FX, Snelling LK, Zucker HA: Case 40. Case Studies in Pediatric Intensive Care. Rogers MC, Helfaer MA (eds.). Baltimore: Williams and Wilkins, Page: 269-274, 1993.

1991

McGowan FX.: Anesthesia for Major Head and Neck Surgery. Anesthesia for Ophthalmic and Otolaryngologic Surgery. McGoldrick KE (eds.). Philadelphia: WB Saunders, Page: 64-89, 1991.

1990

McGowan FX, Chlebowski S: Renal and Endocrine Disorders The Pediatric Anesthesia Handbook. Bell C, Hughes C, Oh TH (eds.). St. Louis: Mosby Year Book, 1990.

1984

McGowan FX, Wagner GS. : The Electrocardiogram in Chronic Lung Disease. In: Pulmonary Heart Disease. Boston/The Hague. Rubin LJ (eds.). Martinus/Nijhoff, Page: 117-134, 1984.

Editorial and Academic Positions

Editorial positions

1994-Present, Reviewer, Anesthesia and Analgesia
1996-Present, Reviewer, Circulation Research
1996-Present, Reviewer, Anesthesiology
1998-Present, Reviewer, Journal of Thoracic and Cardiovascular Surgery
1998-Present, Reviewer, Annals of Thoracic Surgery
2001-Present, Reviewer, Circulation
2002-Present, Reviewer, American Journal of Physiology
2008-2012, Editorial Board, Anesthesiology Research and Practice

Academic and institutional committees

2002-2011 Member, Faculty Research Council, Children's Hospital Boston

2002-2011 Member, Cardiovascular Program Governance Committee, Children's Hospital Boston

2005-2011 Member, Committee on Professors, Harvard Medical School

2011 Member, Cardiovascular Sciences Strategy and Development Group, College of Medicine, Medical University of South Carolina

2011-2013 Member, Strategic Planning Committee, Children's and Perinatal Service Lines, Medical University of South Carolina

2011-Present Chair, Pediatric Operating Room Executive Committee, Medical University of South Carolina

2011-Present Chair, Pediatric Sedation Committee, Medical University of South Carolina

2011-Present Chair, Research Committee, Pediatric Cardiovascular Program, Medical University of South Carolina

2011-Present Chair, Research Committee, Pediatric Cardiovascular Program, Medical University of South Carolina

Leadership

Memberships in professional organizations

International organizations

2013-present, Netherlands Organization for Scientific Research (Grant Reviewer 2012)

2012 Society for Pediatric Anesthesia Australia and New Zealand (SPANZA) (Grant and Awards Review Panel 2012)

1992-Present International Society for Heart Research

1987-Present International Anesthesia Research Society

National organizations

2007-Present Foundation for Anesthesia Education and Research (Board of Directors 2007-Present)

2013-Present National Institutes of Health (Special Emphasis Panel, Surgery and Bioengineering Study Section 2013-Present)

2011-2013 American Board of Anesthesiology (Examination Development Committee for Subspecialty Certification in Pediatric Anesthesia 2011-2013)

2006-Present American Academy of Pediatrics (Fellow 2006-Present)

2006-Present Congenital Cardiac Anesthesia Society (Founding member; Database Design and Implementation Committee, 2007-present)

2006-Present Society for Pediatric Anesthesia National Quality Improvement Organization ("Wake Up Safe"; co-founded project while President of the Society; Board of Directors 2008-2012; Chair, Research Committee, 2011-present)

2001-Present American Physiological Society

2001-Present National Institutes of Health (Program Review Panel, Pediatric Cardiovascular Diseases Research Network)

1989-Present Society for Pediatric Anesthesia

1988-Present American Academy of Pediatrics

1988-Present American Association for the Advancement of Science

1987-Present American Society of Anesthesiologists

Original Papers

2013

Graham EM, Taylor SN, Zyblewski SC, Wolf B, Bradley SM, Hollis BW, McGowan FX, Atz AM: Vitamin D status in neonates undergoing cardiac operations: relationship to cardiopulmonary bypass and association with outcomes. J Pediatr 162(4): 823-826, 2013.

2012

Sun LS, Li G, DiMaggio CJ, Byrne MW, Ing C, Miller TL, Bellinger DC, Han S, McGowan FX: Feasibility and pilot study of the Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Project. J Neurosurg Anesth 24: 382-388, 2012.

Niklova A, Ablasser K, Wyler von Ballmoos MC, Poutias D, Kaza E, McGowan FX, Moses MA, del Nido PJ, Friehs I: Endogenous angiogenesis inhibitors prevent adaptive capillary growth in left ventricular pressure overload hypertrophy. Ann Thorac Surg 94: 1509-1517, 2012.

Mehta NM, Costello JM, Bechard LJ, Johnson VM, Zurakowski D, McGowan FX, Laussen PC, Duggan CP: Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects. J Parenter Enteral Nutr 36: 685.692, 2012.

Kheir JH, Scharp LA,, Borden MA, Swanson EJ, Loxley A, Reese JH, Black K, Velazquez LA, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX: Oxygen gas-filled microparticles provide intravenous oxygen delivery. Science Transl Med 4 (140): 140ra88, 2012.

Graham EM. Atz AT, Gillis G, DeSantis S, Haney AL, Deardorff RL; Uber WE, Reeves RT, McGowan FX; Bradley SM, Spinale FG : Differential effects of aprotonin and tranexamic acid on outcomes and cytokine profiles in pediatric cardiac surgery. J Thorac Cardiovasc Surg 143: 1069-1076, 2012.

2011

Salvin JW, Scheurer MA, Laussen PC, Wypij D, Polito A, Bacha A, Pigula F, McGowan FX, Costello JM, Thiagarajan RR. : Transfusion following pediatric cardiac surgery is associated with prolonged hospital stay. Ann Thorac Surg 91: 204-210, 2011.

Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF : Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 114: 862-871, 2011.

Chow M-J, He H, Zurakowski D, McGowan FX, Zhang KY: Obstruction-induced pulmonary vascular remodeling. J Biomechan Engin 133: 1110-1-1110-9, 2011.

Posters and Presentations

2012

Dec, 2012,"Ways to Use and Abuse Blood Products During Congenital Cardiac Surgery" Invited Speaker, Pediatric Cardiac Intensive Care Society, Miami, FL

Nov, 2012,"Coagulation Issues in Pediatric Cardiac Surgery: The Good, the Bad, and the Sticky"; "SNPs, ChiPs, and Biomarkers"; and "Accreditation of Pediatric Anesthesiology; The US Experience". Invited Distinguished Lecturer, Australian-New Zealand Society for Pediatric Anesthesia (SPANZA), New Zealand, Australia

Oct, 2012,"What to Do When You Can't Find a Pediatric Cardiac Anesthesiologist" Clinical Forum Organizer and Participant, American Society of Anesthesiologists Annual Meeting, Washington, DC

Oct, 2012,"Surgery in the Adult with Congenital Heart Disease" Refresher Course Lecturer, American Society of Anesthesiologists Annual Meeting, Washington, DC

Sep, 2012,"The Systemic Inflammatory Response to Pediatric Cardiac Surgery" and "Injury and Repair of the Infant Right Ventricle" Visiting Professor, National Children's Hospital, Tokyo, Japan

Feb, 2012,"Oxygen and Oxygen Toxicity in Congenital Cardiac Surgery" Invited Speaker, Congenital Cardiac Anesthesia Society, Tampa, FL

2011

Nov, 2011,"Advances in Physiology and Pharmacology in Anesthesia and Critical Care"; "The Adult with Congenital Heart Disease"& "Current Status of Anesthetic-Induced Neurotoxicity", Invited Speaker Wake Forest University School of Medicine, Isle of Palms, SC

Oct, 2011, Invited Speaker and Visiting Professor, Fudan University, Shanghai, China

Oct, 2011,"Cerebral Monitoring in Single Ventricle Surgery" Invited Participant, Pediatric Cardiac Anesthesia Problem-Based Learning, Society for Pediatric Anesthesia Annual Meeting, Chicago, IL

Apr, 2011,"Implications of Board Certification in Pediatric Anesthesiology", Invited Speaker, Fundamentals of Pediatric Anesthesia/Society for Pediatric Anesthesia San Diego, CA

Apr, 2011,"Con: Early Extubation-What the Fast-trackers Don't Want You to Know", Congenital Cardiac Anesthesia Society, San Diego, CA

Apr, 2011,"Con: Early Extubation-What the Fast-trackers Don't Want You to Know", Congenital Cardiac Anesthesia Society, San Diego, CA

Feb, 2011,"Fourth Annual John J. Downes Lecture in Pediatric Anesthesiology and "Fourth Annual John J. Downes Lecture in Pediatric Anesthesiology and Critical Care Medicine: How Come We Don't Know What We Still Don't Know"; "The Inflammatory Response to Pediatric Cardiopulmonary Bypass"; "Role of Reactive Oxygen Species in Infant RV Dysfunction"; "Anesthetic Issues for Infant Cardiac Catheterization" Cardiology 2011, Phoenix, AZ

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