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Jane E. Minturn, MD, PhD

Attending physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2010

Minturn JE, Evans AE, Villablanca JG, Yanik GA, Park JR, et al. Phase I trial of lestaurtinib for children with refractory neuroblastoma [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24; Stockholm, Sweden. 

Ho R, Minturn JE, Brown V, Iyer R, Sheen C, Hulitt J. Effect of phosphoinositide-3-kinase (PI3K) and mTOR dual inhibitors in human neuroblastomas [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24; Stockholm, Sweden.

Tetri LH, Ho R, Simpson AM, Iyer R, Minturn JE, Brodeur GM. Expression and function of RET in neuroblastoma cell lines [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24. Stockholm, Sweden.

Simpson AM, Light JE, Minturn JE, Ho R, Iyer R, Varela CR, et al. TrkAIII isoform expression is associated with aggressive behavior in human neuroblastomas [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24; Stockholm, Sweden.

Light JE, Koyama H, Gordin E, Minturn JE, Iyer R, Ho R, et al. Clinical significance of Trk family gene expression in neuroblastomas [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24; Stockholm, Sweden.

Mangino J, Iyer R, Chorny M, Alferiev I, Minturn JE, Ho R, et al. Nanoparticle delivery of the Trk inhibitor lestaurtinib in neuroblastomas [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24; Stockholm, Sweden.

Redden R, Iyer R, Urganski L, Minturn JE, Brodeur GM, Doolin E. Use of a microgravity culture system to assess biological behavior in neuroblastoma cell lines [abstract]. Advances in Neuroblastoma Research; 2010 Jun 21-24; Stockholm, Sweden.

Minturn JE, Villablanca J, Yanik GA, Park JR, Groshen SG, Hellriegel ET, et al. Phase I trial of lestaurtinib for children with refractory neuroblastoma: new approaches to neuroblastoma therapy (NANT) study [abstract]. American Society for Clinical Oncology Annual Meeting; 2010 Jun 4-8; Chicago, IL.

Doolin EJ, Redden R, Minturn JE, Brodeur GM. Microgravity culture provides a measurable clinical behavior of neuroblastoma [abstract]. American Pediatric Surgical Association Annual Meeting. 2010 May 16-19; Orlando, FL.

Norris R, Minturn JE, Brodeur GM, Maris JM, Adamson PC. Preclinical evaluation of lestaurtinib (CEP-701) with the retinoids for neuroblastoma [abstract]. American Association for Cancer Research; 2010 Apr 17-21; Washington, DC.

2009

Berry RM, Rosenblatt M, Brodeur GM, Minturn JE, Wolf B, Rogers J, et al. Analysis of Trk signaling pathways using rapid Western blot analysis in combination with kinase inhibitors and RNAi [abstract]. Society for Neuroscience; 2009 Oct 17-21; Chicago, IL.

Ho R, Minturn JE, Brown VI, Iyer R, Sheen C, Hulitt J, et al. Dual inhibition of phosphoinositide-3-kinase (PI3K) and mTOR show enhanced efficacy in human neuroblastomas [abstract]. American Association for Cancer Research; 2009 Apr 18-22; Denver, CO.

Light JE, Iyer R, Ho R, Varela CR, Killa V, Brodeur GM, et al. Inhibition of Trk-mediated signaling through PI3K but not MEK/ERK impairs cell survival in medulloblastoma [abstract]. American Association for Cancer Research; 2009 Apr 18-22; Denver, CO.

Iyer R, Minturn JE, Ho R, Varela C, Simpson AM, Light JE. Characterization of Trk inhibitor, AZ64, in pre-clinical models of neuroblastoma [abstract]. American Association for Cancer Research; 2009 Apr 18-22; Denver, CO.

Awards

2010, Advances in Neuroblastoma Research Annual Meeting Poster Award (best clinical poster)

2006-2009, American Cancer Society Mentored Research Scholar Grant

2004-2006, Wolfson Scholar in Neuroblastoma Research

2003-2006, American Society of Clinical Oncology Career Development Award

2003, Florence R.C. Murray Program Fund Award

2002-2003, American Society of Clinical Oncology Young Investigator Award

1989-96, Pre-doctoral Fellowship, Howard Hughes Medical Institute

1988, Medical Student Research Fellowship, American Heart Association

1986, Phi Kappa Phi, University of Southern California

1986, Phi Beta Kappa, University of Southern California

1986, Summa Cum Laude, University of Southern California

Books

Chapters
2011

Sievert AJ, Minturn JE. Brain tumors. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Philadelphia: Elsevier Publishing; 2011.

2008

Fisher MJ, Minturn J, Phillips PC. Brain tumors. In: Brodeur GM, Manno CS, editors. Pediatric hematology/oncology: the requisites in pediatrics. Philadelphia: C.V. Mosby Publishing; 2008.

Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 840-41.

2005

Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 834-35.

2002

Minturn JE, Friedman DL. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 812-13.

Minturn JE. Idiopathic thrombocytopenic purpura. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 464-65.

Minturn JE, Kelly KM. Hemophilia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 420-21.

Minturn JE, Kelly KM. Aplastic anemia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 130-31.

Editorial and Academic Positions

Editorial positions

Reviewer

Clinical Cancer Research
Journal of Neuro-Oncology
Neuropediatrics
Pediatric Blood & Cancer

Academic positions

2010, Proton Therapy Triage Committee
2008-present, Pediatric Protocol Review Committee, Oncology
2006-present, Pediatric Residency Program Faculty Interviewer

Leadership

Memberships in professional organizations

American Association for Cancer Research
American Society of Clinical Oncology
American Society of Pediatric Hematology/Oncology
Children's Oncology Group
Pediatric Brain Tumor Consortium (Institutional Co-principal Investigator)
Society for Neuro-Oncology

Participation in scientific committees

2009-present, Pediatric Brain Tumor Consortium

  • 2008-present, Co-principal Investigator
  • 2008-present, Quality Assurance Committee

2008-present, Children's Oncology Group Study Committee, Study ANBL0823 

Original Papers

2011

Long PM, Stradecki HM, Minturn JE. Wesley UV, Jaworski DM. Differential aminoacylase expression in neuroblastoma. Int J Cancer. 2011 Sep 15;129(6):1322-30. doi: 10.1002/ijc.25798. Epub 2011 Apr 1. Cited in PubMed: PMID 21128244. Read the abstract

deBlank PM, Minturn JE. A rare case of ectopic recurrence of a craniopharyngioma diagnosed 17 years after initial presentation. J Pediatr Oncol. 2011 Jul;33(5):392-7. Cited in PubMed: PMID 21602726. Read the abstract

Ho R, Minturn JE, Simpson AM, Iyer R, Light JE, Evans AE, et al. The effect of P75 on Trk receptors in neuroblastomas. Cancer Lett. 2011 Jun 1;305(1):76-85. Epub 2011 Mar 17. Cited in PubMed: PMID 21419569. Read the abstract

Norris RE, Minturn JE, Brodeur GM, Maris JM, Adamson PC. Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma. Cancer Chemother Pharmacol. Epub 2011 Apr 12. Cited in PubMed: PMID 21484309. Read the abstract

Haas-Kogan DA, Banerjee A, Poussaint TY, Kocak M, Prados MD, Geyer JR, et al. Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas. Neuro Oncol. 2011 Mar;13(3):298-306. Cited in PubMed: PMID 21339191. Read the abstract.

Minturn JE, Evans AE, Villablanca JG, Yanik GA, Park JR, Shusterman S, et al. Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study. Cancer Chemother Pharmacol. Epub 2011 Feb 22. Cited in PubMed: PMID 21340605. Read the abstract

Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, et al. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28;331(6016):435-9. Epub 2010 Dec 16. Cited in PubMed: PMID 21163964. Read the article
 

Minturn JE, Janss AJ, Fisher PG, Allen JC, Patti R, Phillips PC, et al. A phase II study of metronomic oral topotecan for recurrent childhood brain tumors. Pediatr Blood Caner. 2011 Jan;56(1):39-44. Cited in PubMed: PMID 21108437. Read the abstract

2010

Long PM, Stradecki HM, Minturn JE, Wesley UV, Jaworski DM. Differential aminoacylase expression in neuroblastoma. Int J Cancer. 2010 Dec 2. Read the abstract

Minturn JE, Janss AJ, Fisher PG, Allen JC, Patti R, Phillips PC, Belasco JB. A phase II study of metronomic oral topotecan for recurrent childhood brain tumors. Pediatr Blood Cancer. 2011 Jan;56(1):39-44. Read the abstract

Posters and Presentations

2009

Minturn JE. Preclinical and early phase clinical experience with lestaurtinib in refractory neuroblastoma [invited lecture]. Cephalon, Inc.; 2009 Jun 29; West Chester, Pa.

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