PhD, Biochemistry/Immunology, Georgetown University, Washington, DC
BS, Biology, University of Patras, Greece
Functional-structural aspects of histocompatibility molecules
Dr. Monos’s research interests cover a wide spectrum of HLA-related topics. His lab, in conjunction with other laboratories, has pioneered the DNA-based methodologies for HLA typing. He has worked on a number of structure/function relationships of HLAs, which are very important for the immune response and he has identified associations of HLAs with several diseases, including Type 1 Diabetes, Pemphigus Vulgaris, Tuberculoid Leprosy, Berylliosis, Sarcoidosis, Guillain Barre Syndrome, Ovarian Carcinoma and Crohn’s Disease.
His work has also contributed on the development of the very key concept that the strong linkage disequilibrium observed within the MHC does not simply reflect the significance of several genes within this genomic region for the physiological functioning of the immune system but also for the observed disease associations with the HLAs. Genes within the MHC in coordination or independently of particular HLA alleles generate the disease phenotype. The realization that there are additional genes, besides HLAs within the MHC for predisposing to disease susceptibility has been the guiding principle for the recent intense efforts to fully characterize this genomic region and investigate disease associations with a dense set of SNPs.
He also collaborates with the Stem Cell Transplant team, the Nephrology, Cardiology and Gastroenterology Divisions at CHOP and perform research on a number of clinically related projects, where support from the Immunogenetics lab is necessary. His work has been funded by NIH, ADA, JDRF, NMDP and other external sources.
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