Goli Mostoufi-Moab, MD, MSCE

Dr. Mostoufi-Moab is a dual-certified pediatric oncologist and endocrinologist with clinical expertise in endocrine late effects after childhood cancer therapy.

Areas of Expertise: Endocrine late effects in survivors of childhood cancer, Thyroid cancer
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Background

    I am a dual-certified pediatric oncologist and endocrinologist with clinical expertise in endocrine late effects after childhood cancer therapy.

    The development of intensified oncology treatment regimens has greatly improved the survival of children with cancer. Currently, more than 80 percent of children with acute lymphoblastic leukemia (ALL) and upwards of 50 percent of pediatric patients treated for solid tumors will survive into adulthood. Similarly, five year cure rates for childhood Bone Marrow Transplantation (BMT) exceed 60 percent. It is estimated that by 2010, one in every 250 adults will be a survivor of childhood cancer.

    However, treatment-related disorders of endocrine systems are common in this growing population of cancer survivors. As the endocrinologist for the Cancer Survivorship Program, I treat childhood cancer survivors with endocrine abnormalities such as abnormal growth, thyroid disorders, pubertal disorders, and thyroid malignancy.

    Over the course of my unique dual training, I developed an interest in understanding childhood bone health and cancer treatment-related threats to childhood skeletal development. Cancer survivors are at risk for poor bone health, given their numerous endocrine morbidities. Skeletal development during childhood is characterized by specific changes in bone dimensions with coordinated actions of growth hormone and sex steroids in the setting of adequate biomechanical loading and nutrition.

    Chemotherapy, irradiation, steroid exposure, poor muscle strength, vitamin D deficiency and poor nutrition all negatively impact the growing, vulnerable skeleton in this at-risk patient population. Understandably, a multidisciplinary team care approach is necessary to provide comprehensive care for this growing patient population with various treatment-related morbidities. I have been lucky to be part of the wonderful Cancer Survivorship team at Children's Hospital, providing necessary care to these patients.

    Children's Hospital houses one of the premier childhood cancer programs for research, training and comprehensive care in the world. The division of oncology treats many newly diagnosed patients from different regions each year, and also has a national referral base for complex cases. We have successfully integrated a state-of-the-art basic, translational and clinical research environment dedicated to eradicating the pain and suffering caused by cancer in children.

    My research program focuses on bone health and body composition abnormalities in childhood cancer survivors. My dual training experience provides me with unique expertise for treatment of multiple, complex endocrine abnormalities after various childhood cancer regimens such as high risk neuroblastoma treatment.

    As a pediatric oncologist and endocrinologist at Children's Hospital, I have been blessed with outstanding individualized mentorship and role models in providing the best care for children with cancer. Treating children with cancer is my passion and addressing life-long treatment-related challenges in survivors of childhood cancer my ultimate goal. I am proud to be at Children's Hospital and part of the team.

  • Education and Training

    Medical School

    MD - The Pennsylvania State University-Hershey Medical Center, Hershey, PA

    Internship

    The Children's Hospital of Philadelphia, Philadelphia, PA

    Residency

    The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Pediatrics

  • Titles and Academic Titles

    Attending Physician

    Assistant Professor, Perelman School of Medicine at the University of Pennsylvania

  • Conditions Treated
  • Centers and Programs
  • Research Interests

    Bone health in survivors of bone marrow transplantation

  • Publications

    Papers

    2011

    Hobbie WL, Moab SM, Carlson CA, Gruccio D, Ginsberg JP. Prevalence of advanced bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma. Pediatr Blood Cancer. 2011 Mar;56(3):474-6. Cited in PubMed: PMID 21072832. Read the abstract

    2010

    Mostoufi-Moab S, Grimbery A. Pediatric brain tumor treatment: growth consequences and their management. Pediatr Endocrinol Rev. 2010 Sep;8(1):6-17. Cited in PubMed: PMID 21037539. Read the abstract

    Werner AH, Scarfone R, Mostoufi-Moab S. A febrile young infant with splenomegaly and ecchymoses. Pediatr Emerg Care. 2010 Jun;26(6):442-4. Cited in PubMed: PMID 20531132. Read the abstract

    Leonard MB, Elmi A, Mostoufi-Moab S, Shults J, Burnham JM, Thayu M. Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metal, 2010 Apr;9(4):1681-9. Epub 2010 Feb 15. Cited in PubMed: PMID 20157194. Read the article

    Posters and Presentations

    2009

    Mostoufi-Moab S. Bone health beyond cancer therapy [invited lecture]. The Children's Hospital of Philadelphia/ 2009 May; Philadelphia, Pa.