I am a dual-certified pediatric oncologist and endocrinologist with clinical expertise in endocrine late effects after childhood cancer therapy.
The development of intensified oncology treatment regimens has greatly improved the survival of children with cancer. Currently, more than 80 percent of children with acute lymphoblastic leukemia (ALL) and upwards of 50 percent of pediatric patients treated for solid tumors will survive into adulthood. Similarly, five year cure rates for childhood Bone Marrow Transplantation (BMT) exceed 60 percent. It is estimated that by 2010, one in every 250 adults will be a survivor of childhood cancer.
However, treatment-related disorders of endocrine systems are common in this growing population of cancer survivors. As the endocrinologist for the Cancer Survivorship Program, I treat childhood cancer survivors with endocrine abnormalities such as abnormal growth, thyroid disorders, pubertal disorders, and thyroid malignancy.
Over the course of my unique dual training, I developed an interest in understanding childhood bone health and cancer treatment-related threats to childhood skeletal development. Cancer survivors are at risk for poor bone health, given their numerous endocrine morbidities. Skeletal development during childhood is characterized by specific changes in bone dimensions with coordinated actions of growth hormone and sex steroids in the setting of adequate biomechanical loading and nutrition.
Chemotherapy, irradiation, steroid exposure, poor muscle strength, vitamin D deficiency and poor nutrition all negatively impact the growing, vulnerable skeleton in this at-risk patient population. Understandably, a multidisciplinary team care approach is necessary to provide comprehensive care for this growing patient population with various treatment-related morbidities. I have been lucky to be part of the wonderful Cancer Survivorship team at Children's Hospital, providing necessary care to these patients.
Children's Hospital houses one of the premier childhood cancer programs for research, training and comprehensive care in the world. The division of oncology treats many newly diagnosed patients from different regions each year, and also has a national referral base for complex cases. We have successfully integrated a state-of-the-art basic, translational and clinical research environment dedicated to eradicating the pain and suffering caused by cancer in children.
My research program focuses on bone health and body composition abnormalities in childhood cancer survivors. My dual training experience provides me with unique expertise for treatment of multiple, complex endocrine abnormalities after various childhood cancer regimens such as high risk neuroblastoma treatment.
As a pediatric oncologist and endocrinologist at Children's Hospital, I have been blessed with outstanding individualized mentorship and role models in providing the best care for children with cancer. Treating children with cancer is my passion and addressing life-long treatment-related challenges in survivors of childhood cancer my ultimate goal. I am proud to be at Children's Hospital and part of the team.
- Education and Training
MD - The Pennsylvania State University-Hershey Medical Center, Hershey, PA
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Endocrinology - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Hematology & Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA
Master of Science in Clinical Epidemiology (MSCE) - University of Pennsylvania, Philadelphia, PA
- Titles and Academic Titles
Assistant Professor, Perelman School of Medicine at the University of Pennsylvania
- Conditions Treated
- Departments and Services
- Research Interests
Bone health in survivors of bone marrow transplantation
Mostoufi-Moab S, Halton J. Bone morbidity in childhood leukemia: Epidemiology, mechanisms, diagnosis and treatment. Curr Osteoporos Rep 12(3): 300-12, 2014. PMID:24986711
Mostoufi-Moab S, Bauer AJ. Differentiated Thyroid Cancer in Children and Adolescents. In: Wartofsky L (eds.), Thyroid Cancer: A Clinical Guide. 3rd Edition. Humana Press, 2012.
Mostoufi-Moab S, Magge S. Diabetes Insipidus. In: Schwartz WM, Bell LM, Bingham PM, Chung EK, Friedman DF, Loomes KM, Mamula P, Mascarenhas MR, Tanel RE (eds.), The 5-Minute Pediatric Consult. 6th Edition. Philadelphia: Lippincott Williams & Wilkins, 2012.
Moshang T, Mostoufi-Moab S. Endocrine Problems in Pediatric Cancer Survivors. In: Sarafoglou K. Pediatric Endocrinology and Inborn Errors of Metabolism. New York: McGraw Hill Companies, 2009.
Mostoufi-Moab S, Yan A. Dermatology. In: Frank G, Shah SS, Catallozzi MC, Zaoutis LB (eds.), Philadelphia Guide to Inpatient Pediatrics. 3rd Edition. Molden, MA: Blackwell Publishing, 2005.
Rutter MM, Jha P, Schultz KA, Sheil A, Harris AK, Bauer AJ, Field AL, Geller J, Hill DA. DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association. J Clin Endocrinol Metab. 2015 Nov 10:jc20152169. [Epub ahead of print]
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460.
Kovatch KJ, Bauer AJ, Isaacoff EJ, Prickett KK, Adzick NS, Kazahaya K, Sullivan LM, Mostoufi-Moab S. Pediatric Thyroid Carcinoma in Patients with Graves’ Disease: The Role of Ultrasound in Selecting Patients for Definitive Therapy. Horm Res Paediatr. 2015 Apr 15. [Epub ahead of print]
Mostoufi-Moab S, Magland J, Isaacoff EJ, Sun W, Rajapakse CS, Zemel B, Wehrli F, Shakdar K, Baker J, Long J, Leonard MB. Adverse Fat Depots and Marrow Adiposity Are Associated with Skeletal Deficits and Insulin Resistance in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation. J Bone Miner Res. 2015 Sep;30(9):1657-66. doi: 10.1002/jbmr.2512. Epub 2015 May 10.
Jonklaas J1, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association task force on thyroid hormone replacement. Thyroid. 2014 Dec;24(12):1670-751. doi: 10.1089/thy.2014.0028.
Baker JF, Von Feldt J, Mostoufi-Moab S, Nosieh G, Taratuta E, Kim W, Leonard MB. Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis. Arthritis Care Res. 2014 Nov;66(11):1612-8. PMID:24664868
Yeh MW1, Bauer AJ, Bernet VA, Ferris RL, Loevner LA, Mandel SJ, Orloff LA, Randolph GW, Steward DL. American Thyroid Association Statement on Preoperative Imaging for Thyroid Cancer Surgery. Thyroid. 2014 Sep 29. [Epub ahead of print]
Mostoufi-Moab S, Leonard MB. Re: Slipped capital femoral epiphysis after total body irradiation. Pediatr Blood Cancer. 2014 Jun;61(6):1141. PMID:24375952
Isaacoff E, Dimitriadi FF, Barrows F, Pawel BR, Mattei P, Mostoufi-Moab S. Acanthosis nigricans associated with an adrenocortical tumor in a pediatric patient. Case Rep in Endocrinol, 2013. PMID:23819073
Mostoufi-Moab S, Isaacoff EJ, Spiegel D, Gruccio D, Ginsberg JP, Hobbie W, Shults J, Leonard MB. Childhood cancer survivors exposed to total body irradiation are at significant risk for slipped capital femoral epiphysis during recombinant growth hormone therapy. Pediatr Blood Cancer 60(11): 1766-71, 2013. PMID:23818448
Kalish JM, Conlin LK, Bhatti TR, Dubbs HA, Harris MC, Izumi K, Mostoufi-Moab S, Saitta S, States LJ, Swarr D, Wilkens AB, Zackai EH, Zelley K, Bartolomei MS, Nichols KE, Palladino AA, Spinner NB, Deardorff MA. Clinical features of three girls with genome-wide paternal uniparental disomy. Am J Med Genet 161(8): 1929-39, 2013. PMID:23804593
Kalish JM, Conlin, LK, Mostoufi-Moab S, Wilkens AB, Mulchandani S, Zelley K, Kowalski M, Bhatti TR, Russo P, Mattei P, Mackenzie WG, LiVolsi V, Nichols KE, Biegel JA, Spinner NB, Deardorff MA. Bilateral pheochromocytomas, hemihyperplasia, and subtle somatic mosaicism: The importance of detecting low-level uniparental disomy. Am J Med Genet 161(5): 993-1001, 2013. PMID:23532898
Posters and Presentations
Barakat LP, Mostoufi-Moab S, Pierce L, Linton K, Bauer AJ. Health-related quality of life among adolescents and young adults with differentiated thyroid carcinoma: Family risk and posttraumatic stress and growth. 2015 AAP National Conference and Exhibition Washington DC October 2015 (Poster presentation)
Mostoufi-Moab S, Seidel K, Leisenring WM, Armstrong GT, Oeffinger KC, Green DM, Stovall M, Meacham LR, Ginsberg J, Robinson LL, Sklar CA. Endocrine disorders in adult survivors of childhood cancer: A report from the childhood cancer survivor study (CCSS). 14th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer Arlington, VA June 2015 (Oral platform presentation)
Mostoufi-Moab S, Magland J, Isaacoff E, Sun W, Rajapakse CS, Zemel B, Wehrli F, Shekdar K, Baker J, Long J, Leonard MB. Adverse fat depots, marrow adiposity, and skeletal deficits in long-term survivors of pediatric hematopoietic stem cell transplantation. 2015 ASCO Annual Meeting Chicago, IL May 2015 (Poster presentation)
Mostoufi-Moab S, Sun W, Maglan J, Isaacoff E, Ginsberg JP, Wherli F, Leonard MB. Increased vertebral marrow adiposity in long-term survivors of pediatric allogeneic hematopoietic stem cell transplant is associated with deficits in trabecular microarchitecture. Endocrine Society Chicago, IL June 2014 (Oral platform presentation)
Mostoufi-Moab S, Sun W, Magland J, Bunin NJ, Ginsberg JP, Isaacoff E, Wehrli F, Shults J, Leonard MB. Increased vertebral marrow adiposity in long-term survivors of pediatric allogeneic hematopoietic stem cell transplant is associated with deficits in trabecular microarchitecture. AACR Special Conference on Pediatric Cancer at the Crossroads: Translating Discovery Into Improved Outcomes. AACR Pediatric Cross Roads San Diego, CA November 2013 (Poster presentation)
Impact of Childhood Cancer Therapy on Pediatric Bone Accrual, MSKCC Pediatric Oncology Grand Rounds, New York, NY, November 2014.
Childhood Cancer Therapy Impact on Bone Accrual: A Survivorship Perspective, Emory Pediatric Oncology Grand Rounds, Atlanta, Georgia, September 2014.
Endocrine Late Effects in Survivors of High Risk Neuroblastoma, Neuroblastoma Parent Conference, Chicago, IL, July 2014.
Skeletal Deficits and Enhanced Adiposity in Survivors of Childhood Hematopoietic Stem Cell Transplantation, Endocrine Society Fat & Bone Symposium, Chicago, IL, June 2014.
American Austrian Foundation, Pediatric Endocrine Course, Salzburg, Austria, May 2014.
Bone Metabolism and Impact of Childhood Cancer Therapy on Bone Accrual, ASPHO Bone in Pediatric Cancer Symposium, Chicago, IL, May 2014.
Impact of Childhood Cancer on Bone Accrual: A Survivorship Perspective, St. Jude Oncology Grand Rounds, November 2013.
Endocrine Abnormalities in Thalassemia, Thalassemia Society, Philadelphia, PA, June 2013.
- Awards and Honors
2011, Pediatric Blood and Marrow Transplant Consortium Travel Grant Recipient
2007, Genentech Clinical Fellows Travel Grant Recipient
2004, William Pottash Fellow Teacher of the Year Award
2003, The Children’s Hospital of Philadelphia Physician Partnering Award
2000, Janet M. Glasgow Memorial Award
2000, Department of Pediatrics Award for Outstanding Achievement
2000, The Endocrine Society Medical Student Outstanding Achievement
2000, Medical Student Research Symposium Award
1998, Alpha Omega Alpha
1996 - 1999, Hammond Jr. Memorial Scholarship Award for Academic Achievement
1996, McGraw Hill Award for Academic Achievement 1996
1991 - 1995, University of Missouri full tuition merit scholarship
1995, University of Missouri Outstanding Biological Student Award
1995, Phi Beta Kappa
1994, Mortar Board
1993, Golden Key National Honor Society Outstanding Junior Award
1992, Wurdack Agriculture Scholarship for Academic Achievement
1992, Phi Eta Sigma
- Editorial and Academic Positions
2013-present, Journal of Clinical Oncology
2012-present, Journal of Bone Mineral Research
2011-present, Pediatric Blood and Cancer
2010-present, Journal of Clinical Endocrine & Metabolism
Memberships in Professional Organizations
2012-present, American Society of Clinical Oncology
2012-present, American Thyroid Association
2010-present, American Society of Pediatric Hematology & Oncology
2006-present, Endocrine Society
- Awards and Honors