Areas of Expertise:
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Paul A. Offit, MD, is the director of the Vaccine Education Center and a professor of pediatrics in the Division of Infectious Diseases at The Children’s Hospital of Philadelphia. He is the Maurice R. Hilleman Professor of Vaccinology at the Perelman School of Medicine at the University of Pennsylvania.
Dr. Offit is an internationally recognized expert in the fields of virology and immunology, and was a member of the Advisory Committee on Immunization Practices to the Centers for Disease Control and Prevention. He is a founding advisory board member of the Autism Science Foundation and the Foundation for Vaccine Research, a member of the Institute of Medicine and co-editor of the foremost vaccine text, Vaccines.
He is a recipient of many awards including the J. Edmund Bradley Prize for Excellence in Pediatrics from the University of Maryland Medical School, the Young Investigator Award in Vaccine Development from the Infectious Disease Society of America, and a Research Career Development Award from the National Institutes of Health.
Dr. Offit has published more than 150 papers in medical and scientific journals in the areas of rotavirus-specific immune responses and vaccine safety. He is also the co-inventor of the rotavirus vaccine, RotaTeq®, recommended for universal use in infants by the CDC. For this achievement, Dr. Offit received the Luigi Mastroianni and William Osler Awards from the University of Pennsylvania School of Medicine, the Charles Mérieux Award from the National Foundation for Infectious Diseases, and was honored by Bill and Melinda Gates during the launch of their Foundation’s Living Proof Project for global health.
In 2009, Dr. Offit received the President’s Certificate for Outstanding Service from the American Academy of Pediatrics. In 2011, he received the Humanitarian of the Year Award from the Biologics Industry Organization (BIO), the David E. Rogers Award from the American Association of Medical Colleges, the Odyssey Award from the Center for Medicine in the Public Interest, and was elected to the Institute of Medicine of the National Academy of Sciences. In 2012, Dr. Offit received the Distinguished Medical Achievement Award from the College of Physicians of Philadelphia and the Drexel Medicine Prize in Translational Medicine from the Drexel University College of Medicine. In 2013, he received the Maxwell Finland award for Outstanding Scientific Achievement from the National Foundation for Infectious Diseases, the Distinguished Alumnus award from the University of Maryland School of Medicine, and the Innovators in Health Award from the Group Health Foundation.
Dr. Offit is the author of six medical narratives:
- The Cutter Incident: How America’s First Polio Vaccine Led to Today’s Growing Vaccine Crisis (Yale University Press, 2005)
- Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases (HarperCollins, 2007), for which he won an award from the American Medical Writers Association
- Autism’s False Prophets: Bad Science, Risky Medicine, and the Search for a Cure (Columbia University Press, 2008)
- Deadly Choices: How the Anti-Vaccine Movement Threatens Us All (Basic Books, 2011), which was selected by Kirkus Reviews and Booklist as one of the best non-fiction books of the year
- Do You Believe in Magic?: The Sense and Nonsense of Alternative Medicine (HarperCollins, 2013), which won the Robert P. Balles Prize in Critical Thinking from the Center for Skeptical Inquiry and was selected by National Public Radio as one of the best books of 2013
- Bad Faith: When Religious Belief Clashes with Modern Medicine (Basic Books, 2015)
- Education and Training
MD - University of Maryland School of Medicine, Baltimore, MD
Pediatrics - Children's Hospital of Pittsburgh, Pittsburgh, PA
Pediatrics - Children's Hospital of Pittsburgh, Pittsburgh, PA
Infectious Diseases - The Children's Hospital of Philadelphia, Philadelphia, PA
American Board of Pediatrics
- Titles and Academic Titles
Attending Physician, Division of Infectious Diseases
Director, Vaccine Education Center
Chairman, Drug Use Evaluation Committee
Adjunct Associate Professor, The Wistar Institute of Anatomy and Biology Professor, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Departments and Services
Offit, P. A., 2015. Bad Faith: When Religious Belief Clashes with Modern Medicine. Basic Books, New York, N.Y.
Offit, P. A. 2013. Killing Us Softly: The Sense and Nonsense of Alternative Medicine. HarperCollins UK, London, England.
Offit, P.A. 2013. Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine. HarperCollins, New York, N.Y.
Plotkin, S.A., Orenstein, W.A., Offit, P.A. (eds.). 2012. Vaccines. Saunders/Elsevier. London, UK.
Offit, P.A. 2011. Deadly Choices: How the Anti-Vaccine Movement Threatens Us All. Basic Books, New York, N.Y.
Offit, P.A., Moser, C.A. 2011. Vaccines and Your Child: Separating Fact from Fiction. Columbia University Press, New York, N.Y.
Plotkin, S.A., Orenstein, W.A., Offit, P.A. (eds.). 2008. Vaccines. Saunders/Elsevier. London, UK.
Offit, P.A. 2008. Autism’s False Prophets: Bad Science, Risky Medicine, and the Search for a Cure. Columbia University Press, New York, N.Y.
Offit, P.A. 2007. Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases. Smithsonian Books, New York, N.Y.
Offit, P.A. 2005. The Cutter Incident: How America’s First Polio Vaccine Led to a Growing Vaccine Crisis. Yale University Press, New Haven, CT
Marshall, GS, Dennehy PH, Greenberg DP, Offit PA, Tan TQ. 2004. The Vaccine Handbook: A Practical Guide for the Clinician, Lippincott Williams & Wilkens, Philadelphia, PA.
Offit, P.A., and L.M. Bell. 2003. Vaccines: What You Should Know. 3rd edition. John Wiley & Sons, New York, N.Y.
Offit, P.A., and L.M. Bell. 1999. Vaccines: What Every Parent Should Know. 2nd edition, Hungry Minds, New York, N.Y.
Offit, P.A., Fass-Offit, B., and Bell, L.M. 1999. Breaking the Antibiotic Habit: A Parent’s Guide to Coughs, Colds, Ear Infections, and Sore Throats. John Wiley & Sons, New York, N.Y.
Offit, P.A., and L.M. Bell. 1998. What Every Parent Should Know about Vaccines. Macmillan Press, New York, N.Y.
Offit, P. A., “Fear of Vaccines,” In: CDC: Health Information for the International Traveler: The Yellow Book, 2014. G. W. Brunette (ed.) Oxford: Oxford University Press, 2014.
Feemster, K. A., P. A. Offit, “‘Compassionate Use’ for Public Health,” Annals of Internal Medicine December 24, 2013, doi: 10.7326/M13-2927.
Plotkin, S. A., P. A. Offit, F. Murphy. In Memoriam: Dr. H Fred Clark (1937-2012), Hum Vaccin Immunother 2012: 1:8.
Offit, P. A. “A Look at Complementary and Alternative Medicine,” Infectious Diseases in Children, 2012;25:3.
Offit, P. A. “Fear of Vaccines,” In: CDC Health Information for International Travel: The Yellow Book 2012, G. W. Brunette (ed.), Oxford: Oxford University Press, 2012.
Offit, P. A., H F. Clark. Rotavirus Vaccines Part II: Raising the Bar for Vaccine Safety, in History of Vaccine Development, S. A. Plotkin (ed.), New York: Springer, 2011.
Gerber, J. Offit, P.A. Vaccines and autism: a tale of shifting hypotheses, Clinical Infectious Diseases 2009;48:456-461
Offit, P.A. Vaccines. 2008. In: J. M. Bergelson, S. S. Shah, and T. E. Zaoutis (eds.): Pediatric Infectious Diseases, pp. 373-384. Mosby Elsevier, Philadelphia, PA.
Offit, P.A., Clark HF. A multivalent bovine-human reassortant rotavirus vaccine (RotaTeq). Pediatr Annals 2006; 35: 29-34.
McMillan, J.A., Abramson, J.S., Katz, S.L., and Offit, P.A. Reducing the risk of pediatric influenza: Prevention strategies help both the young and old. Contemporary Pediatrics [in press]
Ward RL, HF Clark, PA Offit, and RI Glass. 2004. Live vaccine strategies to prevent rotavirus disease. In: M.M. Levine, J.B. Kaper, R. Rappuoli, M. Liu, and M.F. Good (eds.): New Generation Vaccines, pp. 607-620. Marcel Dekker, Inc., New York, NY.
Offit, P.A. 2003. The power of 'box a'. Expert Rev Vaccines 2003;2:1-3.
Offit P.A., and C.J. Hackett. Multiple vaccines and the immune system. In: S.A.Plotkin and W. Orenstein (eds): Vaccines, 2003, pp. 1583-1589, 4th Edition, W.B. Saunders.
Clark, H F., P.A. Offit, R.I. Glass, and RM Ward. Rotavirus vaccines. In: S.A.Plotkin and W. Orenstein (eds): Vaccines, 2003; pp. 1327-1345, 4th Edition, W.B. Saunders.
Offit, PA, HF Clark, and RL Ward. Current state of development of human rotavirus vaccines. In: U. Desselberger and J. Gray (eds.): Viral Gastroenteritis, 2003; pp. 345-356, Elsevier Science BV, Amsterdam, The Netherlands.
Offit, P.A. 2002. The future of rotavirus vaccines. Sem Pediatr Infect Dis 2002;13: 190-195.
Macartney, K.K., and P.A. Offit. How vaccine safety is monitored before and after licensure. Pediatric Annals 2001;30:392-399.
Offit, P.A. 2001. Correlates of protection against rotavirus infection and disease. In Gastroenteritis viruses. Novartis Foundation Symposium 238, pp. 106-124, Wiley, Chichester.
Offit, P.A. 2000. Withdrawal of rotavirus vaccine in the USA. Vaccines: Children and Practice 3:2-3.
Macartney, K.K., and P.A. Offit. 2000. Immunologic methods and correlates of protection. In: Gray, J., and Desselberger, U. (eds.): Methods in Molecular Medicine: Rotaviruses, Humana Press Inc., Totawa, New Jersey.
Offit, P.A., and H F. Clark. 1999. Rotavirus vaccines, pp. 171-195. In: Ellis, R. (ed.): Combination Vaccines, 1st Edition, Humana Press, Totowa, New Jersey.
Clark, H F., R.I. Glass, and P.A. Offit. 1999. Rotavirus vaccines. In: S.A.Plotkin and W. Orenstein (eds): Vaccines, pages 987-1005, 3rd Edition, W.B. Saunders.
Offit, P.A., and H.F. Clark. 1998. The rotavirus vaccine. Current Opinion in Pediatrics, Lippincott, Williams and Wilkins.
Offit, P.A. 1998. Rotavirus, In: F.D. Burg, J.R. Ingelfinger, and E.R.Wald, R.A. Polin (eds.): Gellis and Kagan's Current Pediatric Therapy, pages 132-133, 14th Edition, W.B. Saunders.
Coffin, S.E., and P.A. Offit. 1997. New vaccines against mucosal pathogens: rotavirus and respiratory syncytial virus. Adv. Pediatr. Infect. Dis. 13: 333-348.
Offit, P.A., Kapikian, A.Z., and Clark, HF. 1997. Vaccines against rotavirus. In: M.M. Levine, G.C. Woodrow, J.B. Kaper, and G.S. Cobon (eds.): New Generation Vaccines, Marcel Dekker, Inc., New York, NY, pages 659-671.
Clark, HF., Offit, P.A., Ellis, R.W., Krah, D., Shaw, A.R., Eiden, J.J., Pichichero, M., and Treanor, J.J. 1996. WC3 reassortant vaccines in children: brief review. Arch. Virol. [Suppl] 12: 187-198.
Conner, M.E., Estes, M.K., Offit, P.A., Clark, HF., Franco, M., Feng, N., and Greenberg, H.B. 1996. Development of a mucosal rotavirus vaccine. In: H. Kiyono, P.L. Ogra, and J.R. McGhee (eds.): Mucosal Vaccines: New Trends in Immunization, Academic Press, pp. 325-344.
Offit, P.A. Viral gastroenteritis. 1996. In: A.M. Rudolph, J.I.E. Hoffman, and C.D. Rudolph (eds.): Rudolph's Pediatrics, 20th Edition, Appleton and Lange, pp. 642-643.
Offit, P.A. and Clark, H.F. 1995. Vaccines for enteric viral pathogens. pp. 1471-8, In: Blaser, M.J., Smith, P.D., Ravdin, J.I., Greenberg, H.B., and Guerrant, R.L. (eds.). Infections of the Gastrointestinal Tract. Raven Press, New York, N.Y.
Offit, P.A., and Clark, HF. 1994. Rotaviruses. In: Mandell, G.L., Bennett, J.E., and Dolin, R. (eds.). Principles and Practice of Infectious Diseases, pp. 1448-1455. 4th Edition, Churchill Livingstone.
Offit, P.A. 1994. Rotaviruses: immunological determinants of protection against infection and disease. Advances in Virus Research 44: 161-202.
Offit, P.A. 1994. Virus-specific cellular immune response to intestinal infection. pp. 89-100. In: D.A.J. Tyrell and A.Z. Kapikian (eds.): Virus infections of the gastrointestinal tract, 2nd Edition, Marcel Dekker, Inc.
Clark, H F., and P.A. Offit. 1994. Rotavirus vaccines. pp. 809-822. In: S.A. Plotkin and E.A. Mortimer, Jr. (eds): Vaccines, 2nd Edition, W.B. Saunders.
Offit, P.A. 1994. Immunologic determinants of protection against rotavirus challenge. Current Topics in Microbiology and Immunology, 1993;185:229-254, Springer-Verlag Publishers, Berlin, West Germany.
Greenberg H.B., H.F. Clark, and P.A. Offit. 1994. Rotavirus pathology and pathophysiology. Current Topics in Microbiology and Immunology, 1993;255-283, Springer-Verlag Publishers, Berlin, West Germany.
Offit, P.A. 1993. Rotavirus. In: F.D. Burg, J.R. Ingelfinger, and E.R. Wald (eds.): Gellis and Kagan's Current Pediatric Therapy, pages 652-653. 14th Edition, W.B. Saunders.
Offit, P.A. 1991. Viral gastroenteritis. In: A.M. Rudolph and J.I.E. Hoffman (eds.): Rudolph's Pediatrics, 19th Edition, Appleton and Lange, 1991: 670-671.
Greenberg, H.B., P.A. Offit, and R.D. Shaw. 1988. Neutralization of rotaviruses in vitro and in vivo: molecular determinants of protection and role of local immunity. pp. 319-330, In: W. Strober, M.E. Lamm, J.R. McGhee, and S.P. James (eds.): Mucosal Immunity and Infections at Mucosal Surfaces.
Offit, P.A., G. Blavat, H.F. Clark, R. Shaw, and H.B. Greenberg. 1986. Role of gene segments 4 and 9 in determining rotavirus virulence and protection against rotavirus challenge. pp. 267-273, In: R.M. Chanock and R.M. Lerner (eds.): Vaccines '86: New Approaches to Immunization.
Greenberg, H.B., and P.A. Offit. 1986. Gene coding assignments for rotavirus surface proteins. pp. 221-225. In: Development of Vaccines and Drugs against Diarrheal Diseases, Studentlitteratur, Lund, Sweden.
Greenberg, H.B., P.A. Offit, C. Tran, A. Kapikian, W. Robinson, R. Shaw, R. Gaeta, and R. Bellamy. 1985. Vaccine strategies for the prevention of rotavirus diarrhea. pp. 447-455. In: S. Tzipori (ed.), Infectious diarrhea in the young: strategies for control in humans and animals. Elsevier Science Publishers, Amsterdam, The Netherlands.
Offit, P.A., and D. Rubin. 1982. Viral diseases: infections of the gastrointestinal tract. Comprehensive Therapy 8: 21-26.
Feemster KA, Prasad P., Smith MJ, Feudtner C, Caplan A, Offit PA, Coffin SE. 2011. Health care worker support of an influenza vaccine mandate at a large pediatric tertiary care hospital. Vaccine 29: 1762-1769.
Vesikari T, Clark HF, Offit PA, Dallas MJ, DiStefano DJ, Goveia MG, Ward RL, Schödel F, Karvonen A, DiNubile MJ, Heaton PM. 2006. Effects of potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants. Vaccine 24:4821-4829.
Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z, Dallas MJ, Heyse JF, Gouveia MG, Black SB, Shinefield HR, Christie C, Ylitalo S, Itzler RF, Coia ML, Onorato MT, Adeyi BA, Marshall GS, Gothefors L, Campens D, Karvonen A, Watt JP, O’Brien KL, DiNubile MJ, Clark HF, Boslego JW, Offit PA, Heaton PM. 2006. Safety and efficacy of pentavalent human-bovine (WC3) reassortant rotavirus vaccine in preventing rotavirus gastroenteritis and associated healthcare contacts. N. Engl. J. Med 354:13-23.
Offit, P.A. 2005. The Cutter Incident, 50 years later. N. Engl. J. Med. 352:1411-1412.
Offit, P.A. 2005. Why are pharmaceutical companies gradually abandoning vaccines? Health Affairs Journal, 24:622-630.
Clark HF, Bernstein DI, Dennehy P, Offit P, Pichichero M, Treanor J, Ward RL, Krah DL, Shaw A, Dallas MJ, Eiden JJ, Ivanoff N, Kaplan KM, Heaton P. 2004. Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants. J. Pediatr. 144:184-190.
Clark HF, Lawley D, Shrager D, Jean-Guillaume D, Offit P, Eiden JJ, Bennett PS, Kaplan, KM, Shaw A. 2004. Infant immune response to human rotavirus serotype G1 vaccine candidate reassortant WI79-9: Different dose response patterns to virus surface proteins vp7 and vp4. Pediatr. Infect. Dis. J. 23:206-211.
Clark HF, Burke CJ, Volkin DV, Offit, P, Ward RL, Breese JS, Dennehy P, Gooch WM, Malacaman E, Matson D, Walter E, Watson B, Krah DL, Dallas MJ, Schödel F, Kaplan KM, Heaton P. 2003. Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation. Pediatr. Infect. Dis. J. 22:914-920.
Offit, P.A. and Peter G. 2003. The meningococcal vaccine: public policy and individual choices. N. Engl. J. Med. 349:2353-2356; Offit, P.A., Peter, G. Choices about meningococcal vaccine. [correspondence] N. Engl. J. Med. 2004;350:1156.
Offit, P.A. and Coffin, S.E. 2003. Communicating science to the public: MMR vaccine and autism. Vaccine 22:1-6.
Offit, P.A., Jew, R.K. 2003. Addressing parents’ concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics 112:1394-1401.
Chow, A.A., Moser C.A., Speaker, T.J., and Offit, P.A. 2003. Determination of efficiency of attachment of biotinylated antibodies to avidin-linked, aqueous-based microcapsules by flow cytometry. J. Immunol. Methods 2003;277:135-139.
Offit, P.A. and Hackett, C.J. 2003. Addressing parents’ concerns: Do vaccines cause allergic or autoimmune diseases? Pediatrics 111:653-659.
Offit, P.A., Gerber, M.A., Hackett, C., Marcuse, E., and Gellin, B. 2002. Too many vaccines? (correspondence). Pediatrics 110:649.
Offit, P.A., Quarles, J., Gerber, M.A., Hackett, C.J., Marcuse, E.K., Kollman, T.R., Gellin, B.G., and Landry, S. 2002. Addressing parents’ concerns: Do multiple vaccines overwhelm or weaken the infant’s immune system? Pediatrics 109:124-129.
Brubaker, J.O., K.K. Macartney, T.J. Speaker, and P.A. Offit. 2002. Specific attachment of covalently modified aqeous-based microcapsules to macrophages, B cells, and dendritic cells. J. Microencapsulation 19:213-223.
Moser, C.A. and P.A. Offit. 2001. Distribution of rotavirus-specific memory B cells in gut-associated lymphoid tissue after primary immunization. J. Gen. Virol. 82:2271-2274.
Clark, HF, D. Lawley, D. Shrager, D. Jean-Guillaume, P.A. Offit, J. Eiden, and A.R. Shaw. 2001. Immune response of infants to bovine human rotavirus serotype G1 reassortant WI79-9: the dose response pattern to virus surface protein vp7 differs from that to vp4. Pediatr Infect Dis J. 2004 Mar;23(3):206-11.
Kushnir, N., N.A. Bos, A.W. Zuercher, S.E. Coffin, C.A. Moser, P.A. Offit, and J.J. Cebra. 2001. B2 but not B1 B cells can contribute to CD4+ T cell-mediated clearance of rotavirus in SCID mice. J. Virol. 75:5482-5490.
Moser, C.A., D.V. Dolfi, M.L. DiVietro, P.A. Offit, and H F. Clark. 2001. Hypertrophy, hyperplasia, and infectious virus in gut-associated lymphoid tissue of mice after oral inoculation with simian-human or bovine-human reassortant rotaviruses. J. Infect. Dis. 183:1108-1111.
Brown, K.A., J.A. Kriss, C.A. Moser, W.J. Wenner, and P.A. Offit. 2000. Circulating rotavirus-specific antibody-secreting cells (ASC) predict the presence of rotavirus-specific ASC in the human small intestinal lamina propria. J. Infect. Dis. 182:1039-1043.
Macartney, K.M., D. Baumgart, S.R. Carding, J.O. Brubaker, and P.A.Offit. 2000. Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection. J. Virol. 74:5597-5603.
Brubaker, J., R. Patel, T.J. Speaker, and P.A. Offit. 2000. A quantitative luminescence assay for measuring cell uptake of aqueous-based microcapsules in vitro. J. Immunol. Methods 237:85-93.
Coffin, S.E., Moser, C.A., Cohen, S., Speaker, T.J., and Offit, P.A. 1999. Viral microencapsulation delays protection after intramuscular inoculation of mice with rotavirus. Drug Delivery 6:253-257.
Coffin, S.E., Clark, S.A., Bos, N.A., Brubaker, J.O., and Offit, P.A. 1999. Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization. J. Immunol. 163:3064-3070.
Moser, C.A., Speaker, T.J., and Offit, P.A. 1998. Effect of water-based microencapsulation on protection against EDIM rotavirus challenge in mice. J. Virol. 72:3859-3862.
Coffin, S.E., and Offit, P.A. 1998. Induction of rotavirus-specific memory B cells in gut-associated lymphoid tissue after intramuscular immunization. J. Virol. 72:3479-3483.
Brown, K.A. and Offit, P.A. 1998. Rotavirus-specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissue. Microbial Pathogen. 24:327-331.
Moser, C.A., Coffin, S.E., Cookinham, S., and Offit, P.A. 1998. Relative importance of rotavirus-specific effector and memory B cell responses in protection against challenge. J. Virol. 72:1108-1114.
Coffin, S.E., Moser, C.A., Cohen, S., Clark, HF., and Offit, P.A. 1997. Immunologic correlates of protection against challenge after intramuscular immunization of mice with rotavirus. J. Virol. 71:7851-7856.
Moser, C.A., Speaker, T.J., and Offit, P.A. 1997. Effect of microencapsulation on immunogenicity of a bovine herpes virus glycoprotein and inactivated influenza virus in mice. Vaccine 15: 1767-1772.
Lomotan, E.A., Brown, K.A., Speaker, T.J., and Offit, P.A. 1997. Aqueous-based microcapsules are detected primarily in gut-associated dendritic cells after oral inoculation of mice. Vaccine 15:1959-1962.
Moser, C.A., Speaker, T.J., Berlin, J.A., and Offit, P.A. 1996. Aqueous-based microencapsulation enhances rotavirus-specific humoral immune responses after parenteral inoculation of mice. Vaccine 14:1235-1238.
Coffin, S.E., Klinek, M., and Offit, P.A. 1995. Induction of virus-specific antibody production by lamina propria lymphocytes following intramuscular inoculation with rotavirus. J. Infect. Dis. 172: 874-878.
Khoury, C.A., Moser, C.A., Speaker, T.J., and Offit, P.A. 1995. Oral inoculation of mice with low doses of microencapsulated, noninfectious rotavirus induces virus-specific antibodies in gut-associated lymphoid tissue. J. Infect. Dis. 172: 870-874.
Brown, K.A., Moser, C.A., Khoury, C.A., Kim, J.E., and P.A. Offit. 1995. Enhancement by microencapsulation of rotavirus-specific intestinal immune responses in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture. J. Infect. Dis. 171:1334-1338.
Treanor, J.J., Clark, HF., Pichichero, M., Christy, C., Gouvea, V., Shrager, D., Pallazo, S., and Offit, P.A. 1995. Evaluation of the protective efficacy of a serotype 1 bovine-human rotavirus reassortant vaccine in infants. Pediatr. Infect. Dis. J. 14:301-307.
Khoury, C.A., Brown, K., Kim, J., and Offit, P.A.. 1994. Rotavirus-specific intestinal immune response in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture. Clin. Diag. Lab. Immunol. 1:722-728.
Offit, P.A., Khoury, C.A., Moser, C.H., Clark, HF., and Speaker T.J. 1994. Enhancement of rotavirus immunogenicity by microencapsulation. Virology 203:134-143.
Santos, N., Riepenhoff-Talty, M., Clark, H.F., Offit, P, and Gouvea, V. 1994. Vp4 genotyping of human rotavirus in the USA. J. Clin. Microbiol. 32:205-208.
Offit, P.A., B.E.H. Coupar, Y. M. Svoboda, R.J. Jenkins, M.A. McRae, A. Abraham, N.L. Hill, D.B. Boyle, and G.W. Both. 1994. Induction of rotavirus-specific cytotoxic T lymphocytes by vaccinia virus recombinants expressing individual rotavirus genes. Virology 198:10-16.
Christy, C., P.A. Offit, H F. Clark, and J. Treanor. 1993. Evaluation of a bovine-human rotavirus reassortant vaccine in infants. J. Infect. Dis. 168:1598-1599.
Offit, P.A., E.J. Hoffenberg, N. Santos, and V. Gouvea. 1993. Rotavirus-specific humoral and cellular immune response after primary, symptomatic infection. J. Infect. Dis. 167:1436-1440.
Ammari, L.K., P.A. Offit, A.B. Campbell. 1992. Unusual presentation of group B streptococcus osteomyelitis. Pediatr. Infect. Dis. J. 11:1066-1067.
Offit, P.A., E.J. Hoffenberg, E.S. Pia, P.A. Panackal, and N.L. Hill. 1992. Rotavirus-specific helper T cell response in newborns, infants, children, and adults. J. Infect. Dis. 165:1107-1111.
Nadel, S., P.A. Offit, R. Hodinka, R. Gesser, and L.M. Bell. 1992. Upper airway obstruction in perinatally-acquired herpes simplex virus infection. J. Pediatr. 120:127-129.
Brussow, H., P.A. Offit, J. Sidoti. 1991. Neutralizing antibodies to heterologous animal rotavirus serotypes 5, 6, 7, and 10 in sera from Ecuadorian children. J. Clin. Microbiol. 29:869-873.
Offit, P.A., D.B. Boyle, G.W. Both, N.L. Hill, Y.M. Svoboda, S.L. Cunningham, R.J. Jenkins, and M.A. McCrae. 1991. Surface glycoprotein vp7 is recognized by crossreactive rotavirus-specific cytotoxic T lymphocytes. Virology 184:563-568.
Offit, P.A., S.L. Cunningham, and K.I. Dudzik. 1991. Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTLp after rotavirus infection. J. Virol. 65:1318-1324.
Offit, P.A. and K.I. Dudzik. 1990. Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice. J. Virol. 64:6325-6328.
Matsuda Y., O. Nakagomi, and P.A. Offit. 1990. Presence of three P types (vp4 serotypes) and two G types (vp7 serotypes) among bovine rotavirus strains. Arch. Virol. 115:199-207.
Brussow H., P.A. Offit, G. Gerna, A. Bruttin, and J. Sidoti. 1990. Polypeptide specificity of anti-viral serum antibodies in children naturally infected with human rotavirus. J. Virol. 64:4130-4136.
Offit, P.A. and Y.M. Svoboda. 1989. Rotavirus-specific cytotoxic T lymphocyte response of mice after oral inoculation with candidate rotavirus vaccine strains RRV or WC3. J. Infect. Dis. 160:783-788.
Offit, P.A., H.B. Greenberg, and K.I. Dudzik. 1989. Rotavirus-specific protein synthesis is not necessary for recognition of infected cells by virus-specific cytotoxic T lymphocytes. J. Virol. 63: 3279-3283.
Offit, P.A., and K.I. Dudzik. 1989. Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection. J. Virol. 63: 3507-3512.
Matsui, S., P.A. Offit, P.T. Vo, E.R. Mackow, D.A. Benfield, R.D. Shaw, L. Padilla-Noriega, and H.B. Greenberg. 1989. Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of vp7 and the vp8 fragment of vp4. J. Clin. Microbiol. 27: 780-782.
Offit, P.A., and K.I. Dudzik. 1989. Noninfectious rotavirus (strain RRV) induces and immune response which protects against rotavirus challenge. J.Clin. Microbiol. 27: 885-888.
Offit, P.A., and K.I. Dudzik. 1988. Rotavirus-specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes. J. Virol. 62:127-131.
Liu, M., P.A. Offit, and M.K. Estes. 1988. Identification of the simian rotavirus SA11 genome segment 3 product. Virology 163: 26-32.
Clark, H.F., Y. Hoshino, L.M. Bell, J. Groff, P. Bachman, and P.A. Offit. 1987. A rotavirus isolate WI61 representing a presumptive new human serotype. J. Clin. Microbiol. 25: 1757-1762.
Bell, L.M., H.F. Clark, E.A. O'Brien, M.J. Kornstein, S.A. Plotkin, and P.A. Offit. 1987. Gastroenteritis caused by human rotaviruses (serotype 3) in a suckling mouse model. Proc. Soc. Exp. Biol. Med. 184: 127-132.
Bell, L.M., H.F. Clark, P.A. Offit, P.H. Slight, A.M. Arbeter, and S.A. Plotkin. 1987. Rotavirus serotype-specific neutralizing activity in human milk. Am. J. Dis. Child. 142: 275-278.
Offit, P.A., G. Blavat, H.F. Clark, and H.B. Greenberg. 1986. Reassortant rotaviruses containing structural proteins vp3 and vp7 from different parents induce antibodies protective against each parental serotype. J. Virol. 60: 491-496.
Shaw, R.D., T.V. Phuoc, P.A. Offit, B.S. Coulson, and H.B. Greenberg. 1986. Antigenic mapping of the surface proteins of rhesus rotavirus. Virology 155: 434-451.
Clark, H.F., T. Furukawa, L.M. Bell, P.A. Offit, P.A. Parrella, and S.A. Plotkin. 1986. Immune response of infants and children to low-passage bovine rotavirus (strain WC-3). Am J. Dis. Child. 140:350-356.
Clark, H.F., P.A. Offit, K.T. Dolan, A. Tezza, K. Gogalin, E.M. Twist, and S.A. Plotkin. 1986. Response of adult human volunteers to oral administration of bovine and bovine/human reassortant rotaviruses. Vaccine 4: 25-31.
Offit, P.A., R. Shaw, and H.B. Greenberg. 1986. Protection against rotavirus-induced gastroenteritis in newborn mice by monoclonal antibodies to surface proteins vp3 and vp7. J. Virol. 58: 700-703.
Offit, P.A., and G. Blavat. 1986. Identification of the two rotavirus genes determining neutralization specificities. J. Virol. 57: 376-378.
10. Offit, P.A., G. Blavat, H.B. Greenberg, and H.F. Clark. 1986. Molecular basis of rotavirus virulence: role of gene segment 4. J. Virol. 57: 46-49.
Clark, H.F., P.A. Offit, K. Dolan, T. Furukawa, L. Bell, and S.A. Plotkin. 1985. Rotavirus (RV) of bovine and human origin: immune response of adults and children following oral administration. Pediatr. Res. 19: 290 A.
Offit, P.A., and H.F. Clark. 1985. Maternal antibody-mediated protection against gastroenteritis due to rotavirus in neonatal mice is dependent on both serotype and titer of antibody. J. Infect. Dis. 152: 1152-1158.
Offit, P.A., and H.F. Clark. 1985. Protection against rotavirus-induced gastroenteritis in a murine model by passively-acquired gastrointestinal but not circulating antibodies. J. Virol. 54: 58-64.
Offit, P.A., H.F. Clark, A.H. Taylor, R.G. Hess, P.A. Bachman, and S.A. Plotkin. 1984. Rotavirus-specific antibodies in fetal bovine serum and commercial preparations of serum albumin. J. Clin. Microbiol. 20: 266-270.
Offit, P.A., Clark, H.F., M. Kornstein, and S.A. Plotkin. 1984. A murine model for oral infection with a primate rotavirus (simian strain SA-11). J. Virol. 51: 233-236.
Offit, P.A., H.F. Clark, and S.A. Plotkin. 1983. Experimental analysis of the immune response to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque-reduction neutralization. Infect. Immun. 42: 293-300.
Offit, P.A., H.F. Clark, W.G. Stroop, E.M. Twist, and S.A. Plotkin. 1983. The cultivation of human rotavirus, strain 'WA', to high titer in cell culture and characterization of the viral structural polypeptides. J. Virol. Methods 7: 29-40.
Offit, P.A., S. Starr, P. Zolnick, and S.A. Plotkin. 1982. Acyclovir treatment in neonatal herpes simplex virus infection. Ped. Infect. Dis. 1: 253-255.
Offit, P.A., J. Campos, and S.A. Plotkin. 1982. Ampicillin-resistant, beta-lactamase negative, Haemophilus influenza type b. Pediatrics 69: 230-232.
Offit, P.A., G.B. Fleischer, N. Koven, and S.A. Plotkin. 1981. Severe pneumonia in Epstein-Barr virus infection. J. Adol. Health Care 2: 121-125.
- Awards and Honors
2014, 7th Annual Sheldon C. Siegel Lectureship, Department of Pediatrics, UCLA School of Medicine
2014, Robert P. Balles Prize in Critical Thinking, The Committee for Skeptical Inquiry and Skeptical Inquirer Magazine
2014, Honoree, Autism Science Foundation, 5th Anniversary Celebration
2014, Visiting Professor, Department of Biology, Haverford College
2014, Visiting Professor, Department of Biology, University of Richmond
2013, Innovators in Health Award, Group Health Foundation
2013, Honor Award and Gold Key, Distinguished Alumnus Award, University of Maryland School of Medicine
2013, Maxwell Finland Award for Scientific Achievement, National Foundation for Infectious Diseases
2012, Elected to the John Morgan Society, University of Pennsylvania
2012, Drexel Medicine Prize in Translational Medicine, Drexel University College of Medicine
2012, Jonathan M. Mann Memorial Lecture, Council of State and Territorial Epidemiologists
2012, Distinguished Medical Achievement Award, The College of Physicians of Philadelphia
2012, The CSL Behring Visiting Professor, A. I. Dupont Nemours Hospital for Children
2012, Fellow, American Academy of Microbiology
2011, Inducted into the Institute of Medicine of the National Academies
2011, Board Member, The Franklin Institute
2011, Odyssey Award, Center for Medicine in the Public Interest
2011, David E. Rogers Award, American Association of Medical Colleges
2011, Humanitarian of the Year Award, Biotechnology Industries Organization (BIO)
2010, Lawrence T. Taft Memorial Lecture, Robert Wood Johnson School of Medicine
2010, 35th Hattie Alexander Memorial Lecture, Columbia University College of Physicians and Surgeons
2010, Ashley Weech Visiting Professor, Children’s Hospital of Cincinnati
2010, Ralph D. Feigin Award for Excellence, 2010, for “Outstanding Advocacy for Immunizations,”
2010, 37th Lori Haker Visiting Professor, Medical College of Wisconsin
2009, Honored by Bill and Melinda Gates at the Bill and Melinda Gates Foundation’s Living Proof Project for Global Health
2009, 16th Annual Frontiers in Vaccinology Lecture, Center for Vaccine Development, University of Maryland School of Medicine
2009, Fiser Lecturer, University of Arkansas Medical Sciences
2009, President’s Certificate for Outstanding Service, American Academy of Pediatrics
2009, William Osler Patient Oriented Research Award, University of Pennsylvania School of Medicine for the co-invention of the RotaTeq and for the creation of the Vaccine Education Center at the Children’s Hospital of Philadelphia
2009, Humanitarian of the Year Award, National
2009, Dr. Charles Mérieux Award for Achievement in Vaccinology and Immunology from the National Foundation for Infectious Diseases
2008, Saul Krugman Memorial Lectureship, “The Rotavirus Vaccine: From Bench to Bedside,” New York University School of Medicine
2008, Luigi Mastroianni Clinical Innovator Award, University of Pennsylvania School of Medicine for the co-invention of RotaTeq
2008, AMWA (American Medical Writers Association) Medical Book Award, Public/Healthcare Consumer Category for “Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases”
2008, 16th Annual Dorothy Horstmann Lecture, Yale University School of Medicine
2008, Stanley A. Plotkin Award for Outstanding Achievement in Vaccines, Pediatric Infectious Diseases Society
2008, Stevens Distinguished Visiting Professor, LeBonheur Children’s Hospital and the University of Tennessee Medical Center
2007, Canon Ely Distinguished Professor, Boston Children’s Hospital
2006, Jonas Salk Bronze Medal from the Association for Professionals in Infection Control and Epidemiology for the co-invention of RotaTeq
2006, Gold Medal Award from the Children’s Hospital of Philadelphia for the co-invention of RotaTeq
2006, The Joseph W. Mountin Lecturer, CDC
2006, Howard Mermelstein Lecture, Children’s Hospital of Pittsburgh
2006, Jeryl Lynn Hilleman Lecture, CDC Foundation
2006, John H. Erskine Lecture in Infectious Diseases, St.
Jude Children’s Research Hospital
2004, Recipient of the Maurice R. Hilleman Chair in Vaccinology from the University of Pennsylvania School of Medicine
2003, Fellow, College of Physicians of Philadelphia
2001, “Excellence in Service” Award from the Delaware Valley Immunization Coalition
1998, Elected to the Executive Committee of the Joseph Stokes, Jr. Research Institute
1997, Recipient of the Werner and Gertrude Henle Chair in Pediatric Immunologic and Infectious Diseases at the Children’s Hospital of Philadelphia
1997, Elected to the council of the Society of Pediatric Research
1991, Research Achievement Award, The Children’s Hospital of Philadelphia
1988, The University of Pennsylvania Research Foundation Award
1988, Lederle Young Investigator Award in Vaccine Development
1981, Fellow's Annual Teaching Award, The Children's Hospital of Philadelphia
1977, J. Edmund Bradley Prize for Excellence in Pediatrics, University of Maryland Medical School
- Editorial and Academic Positions
2007-present, American Baby Magazine, Advisory Board
2006-present, American Council on Science and Health, Advisory Board
2006-present, Every Child By Two, Advisory Board
2005-present, Clinical and Diagnostic Laboratory Immunology, , Editorial Board
2003-present, Infectious Diseases in Children, Associate Editor
1990-present, Virology, Editorial Board
1999-present, Child Magazine, Advisory Board
1999-present, Immunization Action Coalition, Advisory Board
1999-present, PKIDS, Advisory Board
Academic and institutional committees
2008-present, The Center for Vaccine Ethics and Policy, Co-Director
2006-present, Cell and Molecular Biology Graduate Group
2005-present, Graduate Program in Public Health Studies
1989-present, Molecular Biology Graduate Group
1989-present, Immunology Graduate Group
Memberships in professional organizations
American Academy of Pediatrics
American Association of Immunologists
American Gastroenterological Association
American Pediatric Society
American Society for Microbiology
American Society for the Advancement of Science
American Society for Virology
Association for the Prudent Use of Antibiotics
International Society for Vaccines
Institute for Science in Medicine
Pediatric Infectious Disease Society
Society for Experimental Biology and Medicine
Society for Mucosal Immunology
Society for Pediatric Research
Union of Concerned Scientists
- Awards and Honors