My clinical efforts focus on pediatric hematopoietic stem cell transplantation (HSCT), with a specific emphasis on HSCT for patients with inherited and acquired bone marrow failure. Through my combined clinical activities in the Bone Marrow Failure Center within the Division of Hematology and the Blood and Marrow Transplant Section within the Division of Oncology, my goal is to facilitate outstanding care for patients with inherited bone marrow failure and acquired aplastic anemia during their transition from diagnostic evaluation to treatment through HSCT.
In coordination with these clinical efforts, my clinical research program seeks to retrospectively and prospectively assess outcomes for patients undergoing HSCT due to inherited and acquired bone marrow failure syndromes, defined and stratified by distinct cytogenetic abnormalities. Our ultimate goal is to develop targeted clinical trials which will serve to define optimal treatment strategies for patients with distinct genetic and immunologic etiologies of bone marrow failure.
The goal of my laboratory research program is to improve HSCT outcomes by identifying methods to decrease the incidence of graft failure following HSCT, which is a particularly critical challenge in the setting of transplant for non-malignant conditions such as bone marrow failure. We are specifically examining methods to enhance donor hematopoietic stem cell (HSC) engraftment efficiency following HSCT through enhancement of the functions of specialized areas of the bone marrow microenvironment, known hematopoietic stem cell niches. We are currently testing therapeutic strategies that can be applied to enhance niche activity and receptivity for donor stem cells, which could be utilized to improve donor engraftment efficiency following clinical HSCT.
- Education and Training
MD - University of Virginia School of Medicine, Charlottesville, VA
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA
PhD in Molecular Physiology - University of Virginia, Charlottesville, VA
- Titles and Academic Titles
Attending Physician</br>Instructor in Pediatric Hematology-Oncology</br>Clinical associate in Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Centers and Programs
Posters and Presentations
TS Olson, A Caselli, S Otsuru, T Hofmann, and EM Horwitz. Enhancement of hematopoietic stem cell engraftment efficiency through upregulation of host megakaryocyte-driven endosteal stem cell niche expansion following radioablative conditioning [oral presentation]. The Future of Stem Cell Transplantation Meeting; 2012 Jan; Atlanta, GA.
TS Olson, A Caselli, S Otsuru, T Hofmann, and EM Horwitz. Host-derived megakaryocytes enable efficient hematopoietic stem cell engraftment following radioablation through facilitation of osteoblastic stem cell niche expansion [oral presentation]. American Society of Pediatric Hematology/Oncology 24th Annual Meeting; 2011 Apr 13-16; Baltimore, MD.
TS Olson, A Caselli, S Otsuru, T Hofmann, and EM Horwitz. Novel role for host-derived megakaryocytes in facilitating stem cell engraftment through enhancement of osteoblastic niche restoration following radioablation [oral presentation]. American Society of Hematology 52nd Annual Meeting; 2010 Dec 4-7; Orlando, FL.