Bruce R. Pawel, MD

Bruce R. Pawel, MD, is an attending pathologist with the Pediatric Thyroid Center and the Division of Anatomic Pathology at The Children's Hospital of Philadelphia.

Areas of Expertise: Pediatric neoplasia
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Medical School

    MD - University of Medicine and Dentistry of New Jersey - New Jersey Medical School, Newark, NJ


    Internal Medicine - St. Luke's-Roosevelt Hospital Center, New York City, NY


    Anatomic and Clinical Pathology - University of Medicine and Dentistry of New Jersey, Newark, NJ


    Visiting Clinical Fellow - College of Physicians and Surgeons, Columbia University, New York City, NY
    Pediatric Pathology - Children's Hospital, Columbus, OH

    Board Certification

    Anatomic and Clinical Pathology
    Pediatric Pathology

  • Titles and Academic Titles

    Attending Pathologist

    Pathology Director

    Associate Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Publications




    Bruce R. Pawel, Rakhee Sansgiri: Malignant Bone Tumors. Pediatric Malignancies: Pathology and Imaging. Parham DM, Khoury JD, McCarville MB (eds.). Springer, Page: 69-102, 2015.


    Pawel BR: Polyps and tumors of the gastrointestinal tract in childhood  Pathology of Pediatric Gastrointestinal and Liver Disease. Russo P, Ruchelli ED, Picolli DA (eds.). Springer-Verlag, Page: 317-370, 2014 Notes: 2nd Edition.


    Pawel BR: Polyps and tumors of the gastrointestinal tract in childhood. Pathology of Pediatric Gastrointestinal and Liver Disease. Russo P, Ruchelli E, Piccoli DA (eds.). Lippincott Williams & Wilkins, Page: 157-187, 2004.

    Erol B, Dormans JP, States L, Pawel B: Tumors. Orthopaedic Surgery Essentials: Pediatrics. Tornetta III P, Einhorn TA (eds.). Lippincott Williams & Wilkins, Page: 252-272, 2004.


    Pawel BR, Russo P: Management of biopsy tissue in children with possible malignancies. Practical Algorithms in Pediatric Hematology and Oncology. Sills RH Karger, Basel. (eds.). Page: 100-101, 2003.



    Surrey LF, Mufus-McCray D, Pawel BR.: Radiologic, Cytologic, and Histologic Correlation of Pediatric Thyroid Nodules. Society for Pediatric Pathology Spring Meeting, Boston, MA 2015.


    Lee AF, Pawel BR, Sullivan LM: Beta-HCG positive tumor cells are common in pre-treatment osteosarcoma. Society for Pediatric Pathology Spring Meeting, Baltimore, March 2-3, 2013 2013.



    Denburg M, Surrey L, Pawel BR, Kaplan B: Hypertension and Proteinuria: The Needle in the Haystack? J Pediatr Nephrol 2015 Notes: accepted for publication.


    Zhang Ji, Fan Jing, Venneti Sriram, Cross Justin R, Takagi Toshimitsu, Bhinder Bhavneet, Djaballah Hakim, Kanai Masayuki, Cheng Emily H, Judkins Alexander R, Pawel Bruce, Baggs Julie, Cherry Sara, Rabinowitz Joshua D, Thompson Craig B: Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion. Molecular cell Sep 2014.

    Ye Jiangbin, Fan Jing, Venneti Sriram, Wan Ying-Wooi, Pawel Bruce R, Zhang Ji, Finley Lydia W S, Lu Chao, Lindsten Tullia, Cross Justin, Qing Guoliang, Liu Zhandong, Simon M Celeste, Rabinowitz Joshua D, Thompson Craig B: Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer discovery Sep 2014.

    Lee Anna F, Pawel Bruce R, Sullivan Lisa M: Significant immunohistochemical expression of human chorionic gonadotropin in high-grade osteosarcoma is rare, but may be associated with clinically elevated serum levels. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 17(4): 278-85, Jul-Aug 2014.

    Bosse Kristopher R, Shukla Aseem R, Pawel Bruce, Chikwava Kudakwashe R, Santi Mariarita, Tooke Laura, Castagna Katherine, Biegel Jaclyn A, Bagatell Rochelle: Malignant rhabdoid tumor of the bladder and ganglioglioma in a 14 year-old male with a germline 22q11.2 deletion. Cancer genetics May 2014.

    Oshrine Benjamin R, Olsen Molly N, Heneghan Mallorie, Wertheim Gerald, Daber Robert, Wilmoth Donna M, Biegel Jaclyn A, Pawel Bruce, Aplenc Richard, King Rebecca L: Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor. Cancer genetics 207(4): 153-9, Apr 2014.

    Li Qiaoli, Brodsky Jill L, Conlin Laura K, Pawel Bruce, Glatz Andrew C, Gafni Rachel I, Schurgers Leon, Uitto Jouni, Hakonarson Hakon, Deardorff Matthew A, Levine Michael A: Mutations in the ABCC6 Gene as a Cause of Generalized Arterial Calcification of Infancy: Genotypic Overlap with Pseudoxanthoma Elasticum. The Journal of investigative dermatology 134(3): 658-65, Mar 2014.


    Bonvini P, Zin A, Alaggio R, Pawel B, Bisogno G, Rosolen A: High ALK mRNA expression has a negative prognostic significance in rhabdomyosarcoma. British journal of cancer 109(12): 3084-91, Dec 2013. PMCID: PMC3859940

    Rader Julieann, Russell Mike R, Hart Lori S, Nakazawa Michael S, Belcastro Lili T, Martinez Daniel, Li Yimei, Carpenter Erica L, Attiyeh Edward F, Diskin Sharon J, Kim Sunkyu, Parasuraman Sudha, Caponigro Giordano, Schnepp Robert W, Wood Andrew C, Pawel Bruce, Cole Kristina A, Maris John M: Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 19(22): 6173-82, Nov 2013. PMCID: PMC3844928

    Sullivan Lisa M, Folpe Andrew L, Pawel Bruce R, Judkins Alexander R, Biegel Jaclyn A: Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 26(3): 385-92, Mar 2013. PMCID: PMC3556344

    Chan Elaine S, Pawel Bruce, Corao Diana, Venneti Sriram, Russo Pierre, Santi Maria Rita, Sullivan Lisa M: Immunohistochemical Expression of Glypican-3 in Pediatric Tumors: An Analysis of 414 Cases. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 16(4): 272-7, Mar 2013.

    Russell Mike R, Levin Kirill, Rader JulieAnn, Belcastro Lili, Li Yimei, Martinez Daniel, Pawel Bruce, Shumway Stuart D, Maris John M, Cole Kristina A: Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma. Cancer research 73(2): 776-84, Jan 2013. PMCID: PMC3548976

    Posters and Presentations


    Queenan MB, Corao DA, Pawel BR, Zhang PJ, Sullivan LM,: Expression of aberrant immunohistochemical markers in rhabdomyosarcoma after excluding biphenotypic sarcoma. Society for Pediatric Pathology Spring Meeting  San Diego March 2014 Notes: Poster presentation.

    Invited Lectures


    Pediatric peripheral nerve sheath tumors: Pathology and associated syndromes, Society for Pediatric Pathology Workshop, Spring Meeting, Boston, MA, March 2015.

    "Chondromyxoid fibroma-like osteosarcoma", Case 2 of Specialty Conference: Soft Tissue and Bone Neoplasia Potpourri, United States and Canadian Academy of Pathology Spring Meeting, Boston. MA, March 2015.


    Ewing sarcoma: looks can be deceiving, Department of Pathology and Laboratory Medicine Grand Rounds, Nationwide Children's Hospital, Columbus, OH, October 2014.

    Slide Seminar on fetal and pediatric thoracic pathology: "Concurrent mediastinal germ cell tumor and hematologic malignancy", European Congress of Pathology, London, United Kingdom, September 2014.

    Slide Seminar on pediatric head and neck pathology: "Myoepithelial Carcinoma", Joint Meeting of the Paediatric Pathology Society and the Society for Pediatric Pathology, Birmingham, United Kingdom, September 2014.

    Ewing sarcoma:  looks can be deceiving, Department of Pathology and Laboratory Medicine Grand Rounds, The Children's Hospital of Los Angeles, March 2014.


    Peripheral Neuroblastic Tumors in Children: An Update", Society for Pediatric Pathology Workshop, Baltimore, MD, March 2013.

  • Awards and Honors

    1980, Phi Beta Kappa
    1976, Echols Scholar, University of Virginia

  • Editorial and Academic Positions

    Editorial Positions

    2015-present, Journal of Cutaneous Pathology, ad-hoc reviewer
    2013-present, Histopathology, ad-hoc reviewer
    2012-present, Pediatric and Developmental Pathology, editorial board
    2012-present, Cancer Genetics, ad-hoc reviewer
    2010-present, International Journal of Clinical and Experimental Pathology, editorial board
    2010-present, Human Pathology, ad-hoc reviewer
    2009-present, International Journal of Pediatric Otorhinolaryngology, ad-hoc reviewer
    2006-present, Pediatric Blood & Cancer, ad-hoc reviewer

    Academic and Institutional Committees

    2014-present, Search Committee for Assistant Director, Clinical Chemistry
    2013-2014, Search Committee for Academic Pediatric Hematopathologist
    2013, Mentoring Committee for Dr. Rebecca King, chair
    2013-present, Mentoring Committee for Dr. Kaede Ota, chair
    2013-present, Anatomic pathology representative, LIS Replacement Executive Steering Committee
    2012-present, MyChart Review Committee, Dept of Pathology and Laboratory Medicine
    2011-present, Institute for Translational Medicine and Therapeutics

  • Leaderships

    Memberships in Professional Organizations


    2015-present, International Pediatric Pathology Association
    - 2015-present, Treasurer
    - 2015-present, Council
    2008-present, Connective Tissue Oncology Society
    2005-present, United States and Canadian Academy of Pathology
    - 2012-2015, Abstract Review Board Subcommittee
    2013-2015, Lead Reviewer: Pediatrics
    1991-present, Society for Pediatric Pathology
    - 2014-present, Research Committee


    2009-present, The American Board of Pathology
    - Test Development and Advisory Committee on Pediatric Pathology
    2005-present, Children's Oncology Group
    1992-present, College of American Pathologists
    - 2014-present, Cancer Protocol Panel: Pediatric Tumors
    1992-present, American Society of Clinical Pathologists