David A. Piccoli, MD

David A. Piccoli, MD, is the chief of the Division of Gastroenterology, Hepatology and Nutrition at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Background

    David A. Piccoli, MD, is Chief of the Division of Gastroenterology, Hepatology and Nutrition at The Children's Hospital of Philadelphia.

    He is a graduate of Johns Hopkins University (1975) and Harvard Medical School (1979). He was a resident from 1979 to 1982 and chief resident in Pediatrics from 1982-83 at the Children's Hospital, Boston.

    Dr. Piccoli completed his clinical and research Fellowship in Gastroenterology and Nutrition at The Children's Hospital of Philadelphia from 1983 to 1986. He became training director, section chief and then division chief in 1996. Dr. Piccoli is also the Director of the Fred and Suzanne Biesecker Pediatric Liver Center and holds the Biesecker Professorship and Endowed Chair in Pediatrics at CHOP and the Perelman School of Medicine at the University of Pennsylvania.

    Dr. Piccoli has been the Associate Chair for Information at the Department of Pediatrics at CHOP since 1996. During his tenure as chief, the Division has nearly tripled in size, and has vastly expanded its clinical and research mission in gastrointestinal and nutritional disorders. At the same time, the Division has trained 100 fellows.

    Dr. Piccoli's main areas of clinical and research interest are metabolic and genetic liver diseases, and inflammatory bowel diseases. He is a member of the group that discovered Jagged1 and NOTCH2 as the primary causes of Alagille Syndrome. He has authored more than 90 papers, 40 chapters, 130 research abstracts and edited 4 books on areas of pediatric gastroenterology, hepatology and nutrition.

    Dr. Piccoli has received a number of awards from institutions for his clinical care, teaching, mentorship, research and work with charitable foundations. He has served on local and several national boards, including the Crohn's and Colitis Foundation of America and the American Liver Foundation. Dr. Piccoli is currently actively involved in expanding the Lustgarten Center for Pediatric Motility Disorders at CHOP, and he is actively involved in the leadership of the obesity center.

  • Education and Training

    Medical School

    MD - Harvard Medical School, Boston, MA

    Internship

    Pediatrics - Children's Hospital, Boston, MA

    Residency

    Pediatrics - Children's Hospital, Boston, MA (Chief Resident)

    Fellowship

    Pediatric Gastroenterology and Nutrition (clinical and research) - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    American Board of Pediatrics
    American Board of Pediatrics/Pediatric Gastroenterology
    Diplomate, National Board of Medical Examiners

    Undergraduate Degree

    BA - Johns Hopkins University, Baltimore, MD

  • Titles and Academic Titles

    Chief, Division of Gastroenterology, Hepatology and Nutrition

    Director and Endowed Chair, Fred and Suzanne Biesecker Pediatric Liver Center

    Associate Chair for Information, Department of Pediatrics

    Fred & Suzanne Biesecker Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Alagille syndrome
    Bile duct disorders
    Inflammatory bowel diseases

     

  • Publications

    Books

    2008

    Liacouras CA, Piccoli DA. Pediatric gastroenterology and nutrition: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008.

    2004

    Russo P, Ruchelli E, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag; 2004.

    Chapters

    2010

    Kamath BM, Loomes KM, Piccoli DA. JAGGED1NOTCH2 sequence in Alagille syndrome. In: Murray K, Larson AM, editors. Fibrocystic disease of the liver. 1st ed. New York: Springer-Verlag; 2010.

    2008

    Kamath BM, Piccoli DA. Alagille syndrome. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008. p. 227-232. 

    2007

    Kamath BM, Spinner NB, Piccoli DA. Alagille syndrome. In: Suchy F, Balistreri W, Sokol RJ, editors. Liver disease in children. 3rd ed. New York: Cambridge University Press; 2007. p. 326-345.

    2005

    Graham-Maar RC, Piccoli DA. Gastroenterology (10), esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.

    Graham-Maar RC, Piccoli DA. Esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 100-102.

    Graham-Maar RC, Piccoli DA. Hepatobiliary system. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.

    Graham-Maar RC, Piccoli DA. Small and large intestine. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005.

    2004

    Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, Kleinman RE, Sherman PM, Schneider BL, Sanderson IR, editors. Pediatric gastrointestinal disease. Shelton: PMPH USA; 2004.

    2003

    Kamath BM, Piccoli DA. Alagille syndrome. In: Grand RI, editor. Encyclopedia of pediatric gastroenterology. Philadelphia: Elsevier; 2003.

    2001

    Piccoli DA. Alagille syndrome. In: Suchy F, editor. Liver disease in children. 2nd ed. Philadelphia: WB Saunders; 2001. p. 327-342.

    2000

    Piccoli DA. Disorders of the biliary tract: extrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.

    Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.

    Mamula P, Markowitz, Baldassano RN, Piccoli DA, Liacouras CA. Gastroenterology. In: Polin R, editor. Pediatric secrets. 3rd ed. Philadelphia: Hanley & Belfus, Inc.; 2000.

    1999

    Wenner WJ, Piccoli DA. Viral hepatitis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 445-450.

    Piccoli DA, Peck SN. Inflammatory bowel disease in children and adolescents. In: Stein SH, Rood RP, editors. Inflammatory bowel disease: a guide for patients and their families. Philadelphia: Lippincott-Raven; 1998. p. 79-92.

    Piccoli DA. Hepatic fibrosis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Curchill Livingstone; 1998. p. 391-396.

    Piccoli DA. Hirschsprung disease. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 1399-1403. 

    Piccoli DA. Breath testing. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 567-574.

    Gibson J, Piccoli DA, Berry G. Pathophysiology of metabolic disease of the liver. In: Polin R, Fox W, editors. Fetal and neonatal physiology. 2nd ed. Philadelphia: WB Saunders; 1998. p. 1514-20.

    1997

    Piccoli DA. Rectal bleeding. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed. Philadelphia: Mosby-Year Book, Inc.; 1997. p. 346-354.

    Abstracts

    2013

    Jump C, Loomes KM, Piccoli DA, Blinman TA, Rosh J, Anupindi S, Smith-Whitley K, and Kelsen JR : "Role of Colectomy to Treat Life-Threatening Thrombotic Storm in Pediatric IBD" North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013.

    Waisbourd-Zinman O, Mamula P, Friedman J and Piccoli DA: "Severe Bannayan-Riley-Ruvalcaba Syndrome caused by a deletion encompassing both the BMPR1A and PTEN genes," North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting October 2013.

    2011

    Mouzaki M, Piccoli DA: Modeling liver disease outcome in an international multi-center cohort of Alagille Syndrome patients. AASLD, Anaheim, CA November 2011.

    2009

    Kamath BM. Loomes KM, Pidkameni G, Munoz, Piccoli DA, Spinner NB, et al. Renal anomalies in Alagille syndrome: prevalence and characterization [abstract]. 60th Annual Meeting of the American Association for the Study of Liver Diseases; 2009 Oct 30-Nov 3; Boston, MA.

    Mamula P, Markowitz JE, Piccoli DA, Liacouras CA. Incidence of perforation in pediatric gastrointestinal endoscopy: 11 year experience in a series of 30,177 procedures performed at a tertiary care center [abstract]. 23rd Annual Meeting of the American Gastroenterological Association; 2009 May; Chicago, IL. 

    Friedlander JA, Loeben G, Finnegan K, Puma A, Piccoli DA, Mamula P. Improving informed consent in pediatric endoscopy. 23rd Annual Meeting of the American Gastroenterological Association; 2009 May; Chicago, IL. 

    2008

    Kamath BM, Munoz PS, Chen Z, Zhao H, Spinner NB, Piccoli DA. A Longitudinal study to identify biochemical predictors of liver disease outcome in Alagille syndrome [abstract  oral presentation]. 59th Annual Meeting of the American Association of the Study of Liver Diseases, 2008 Oct 31-Nov 4; San Francisco, CA.

    Bales CB, Kamath BM, Munoz PS, Piccoli DA, Spinner NB, Grimberg A, et al.  Fracture risk in Alagille syndrome [abstract]. 59th Annual Meeting of the American Association of the Study of Liver Diseases, 2008 Oct 31-Nov 4; San Francisco, CA.

    Papers

    2013

    Hsu E, Chugh P, Kronman M, Markowitz J, Piccoli D, Mamula P: Incidence of perforation in pediatric GI endoscopy and colonoscopy: an 11 year experience. Gastrointest Endosc 77(6): 960-966, 2013.

    2012

    Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K: Renal anomalies in Alagille Syndrome: A disease-defining feature. Amer J Med Gen 158A(1): 85-89, January 2012.

    Kamath BM, Piccoli DA, Magee JC, Sokol RJ : Pancreatic insufficiency is not a prevalent problem in Alagille syndrome. Childhood Liver Disease Research and Education Network Journal of Pediatric Gastroenterology & Nutrition 55(5): 612-4, Nov 2012.

    Kamath BM, Bauer RC, Loomes KM, Chao G, Gerfen J, Hutchinson A, Hardikar W, Hirschfield G, Jara P, Krantz ID, Lapunzina P, Leonard L, Ling S, Ng L, Hoang PL, Piccoli DA and Spinner NB: NOTCH2 Mutations in Alagille Syndrome. J Med Gen 49: 138-44, 2012.

    2011

    Friedlander JA, Loeben GS, Finnegan PK, Puma AE, Zhang X, de Zoeten EF, et al. A novel method to enhance informed consent: a prospective and randomised trial of form-based versus electronic assisted informed consent in paediatric endoscopy. J Med Ethics. 2011 Apr;37(4):194-200. Epub 2011 Jan 18. Cited in PubMed; PMID 21245476. Read the abstract

    2010

    Kamath BM, Loomes KM, Piccoli DA. Medical management of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):580-6. Cited in PubMed; PMID 20479679. Read the abstract

    Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A, Loomes KM. Pathologic lower extremity fractures in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):66-70. Cited in PubMed; PMID 20453673. Read the abstract

    Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB, Piccoli DA. A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 May;50(5):526-30. Cited in PubMed; PMID 20421762. Read the article

    Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet. 2010 May 15;19(10):2059-67. Epub 2010 Feb 22. Cited in PubMed; PMID 20176734. Read the article

    2009

    Kamath BM, Thiel BD, Gai X, Conlin LK, Munoz PS, Glessner J, et al. SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation. Hum Mutat. 2009 Mar;30(3):371-8. Cited in PubMed; PMID 19058200. Read the article

    Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet. 2009 Mar;84(3):399-405. Epub 2009 Feb 26. Cited in PubMed; PMID 19249008. Read the article

    Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec;41(12):1335-40. Epub 2009 Nov 15. Cited in PubMed; PMID 19915574. Read the abstract

    Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Cited in PubMed; PMID 19590456. Read the abstract

  • Awards and Honors

    2012-2013, Pediatric Residency Faculty Honor Roll, The Children's Hospital of Philadelphia
    2007, Faculty Mentor Award - The Children's Hospital of Philadelphia
    2006, Beverly Mandell Physician Mentorship Award - APGNN
    2006, Leadership Award, American Liver Foundation, Delaware Valley Chapter
    2005-2012, Best Doctors, Philadelphia Magazine
    2005, Outstanding Leadership Award, Crohn's and Colitis Foundation of America
    2005, The Fred and Suzanne Biesecker Endowed Chair in Pediatrics
    2004-2012, Castle Connolly America's Top Doctors
    1999, Jean A. Cortner Divisional Teaching Award, The Children's Hospital of Philadelphia
    1999, Klaus and Mary Hummeler Endowed Research Prize
    1998, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum
    1996, The Best Doctors in America, American Health Magazine, Reader's Digest
    1996, Christian R. and Mary F. Lindback Foundation Award for Distinguished Teaching, University of Pennsylvania
    1996, Physician of the Year, Crohn's and Colitis Foundation, Delaware Valley Chapter
    1994-1998, The Best Doctors in America Directory, Woodward White, Inc.
    1994, Physician of the Year, American Liver Foundation, Delaware Valley Chapter
    1993, Class of 1992 Teaching Award, University of Pennsylvania School of Medicine
    1993, Faculty Teaching Award, The Children's Hospital of Philadelphia
    1992, Blockley-Osler Award for Teaching Clinical Medicine, Blockley Section, College of Physicians of Philadelphia, University of Pennsylvania School of Medicine
    1988, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum
    1986, Komarov Research Prize, Philadelphia Gastrointestinal Research Forum
    1984, Fellows' Teacher of the Year Award, The Children's Hospital of Philadelphia
    1983, Sidney Farber House Staff Award, The Children's Hospital, Boston, MA
    1980, American Academy of Pediatrics Residency Fellowship
    1975, High Honors, Departmental Honors (Biology), Johns Hopkins University
    1974, Phi Beta Kappa, Johns Hopkins University

  • Editorial and Academic Positions

    Academic committees

    2012-present, Compensation Committee, Department of Pediatrics, The Children's Hospital of Philadelphia
    2012-present, Perioperative IS Design Executive Sponsor Committee
    2012-2013, Department of Medicine Review Committee, University of Pennsylvania Perelman School of Medicine
    2012-2013, NIH-TAC Final Task Force Summit, University of Pennsylvania School of Medicine
    2011-present, Optimization Management Group, Epic IS, Chair
    2009-present, HUP CHOP Joint Center for Digestive, Liver and Pancreatic Disease, Co-Director
    2008-present, Epic Care CHOPlink implementation, Ambulatory Advisory Team, The Children's Hospital of Philadelphia
    2008-present, Bollig Provider Committee
    2008-2009, Leader, IMO Implementation, Epic Care CHOPlink Committee
    2008-2009, Department of Pediatrics Compensation Committee, University of Pennsylvania
    2006-2008, EpicCare, CHOPlink Implementation, Executive Sponsor, Ambulatory, The Children's Hospital of Philadelphia
    2004-present, Biesecker Liver Center Internal Scientific Advisory Committee, The Children's Hospital of Philadelphia

  • Leaderships

    Memberships in professional organizations

    American Association for the Study of Liver Diseases
    American Gastroenterological Association
    American Liver Foundation
    National Alagille Syndrome Alliance
    National Crohn's and Colitis Foundation of America
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition