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David A. Piccoli, MD

Chief, Division of Gastroenterology, Hepatology and Nutrition

Director and Endowed Chair, Fred and Suzanne Biesecker Pediatric Liver Center

Associate Chair for Information, Department of Pediatrics

Fred & Suzanne Biesecker Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2013

Jump C, Loomes KM, Piccoli DA, Blinman TA, Rosh J, AnupindiS, Smith-Whitley K, and Kelsen JR : "Role of Colectomy to Treat Life-Threatening Thrombotic Storm in Pediatric IBD" North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013.

Waisbourd-Zinman O, Mamula P, Friedman J and Piccoli DA: "Severe Bannayan-Riley-Ruvalcaba Syndrome caused by a deletion encompassing both the BMPR1A and PTEN genes," North American Society for Pediatric Gastroenerology, Hepatology and Nutrition Annual Meeting October 2013.

2011

Mouzaki M, Piccoli DA: Modeling liver disease outcome in an international multi-center cohort of Alagille Syndrome patients. AASLD, Anaheim, CA November 2011.

2009

Kamath BM. Loomes KM, Pidkameni G, Munoz, Piccoli DA, Spinner NB, et al. Renal anomalies in Alagille syndrome: prevalence and characterization [abstract]. 60th Annual Meeting of the American Association for the Study of Liver Diseases; 2009 Oct 30-Nov 3; Boston, MA.

Mamula P, Markowitz JE, Piccoli DA, Liacouras CA. Incidence of perforation in pediatric gastrointestinal endoscopy: 11 year experience in a series of 30,177 procedures performed at a tertiary care center [abstract]. 23rd Annual Meeting of the American Gastroenterological Association; 2009 May; Chicago, IL. 

Friedlander JA, Loeben G, Finnegan K, Puma A, Piccoli DA, Mamula P. Improving informed consent in pediatric endoscopy. 23rd Annual Meeting of the American Gastroenterological Association; 2009 May; Chicago, IL. 

2008

Kamath BM, Munoz PS, Chen Z, Zhao H, Spinner NB, Piccoli DA. A Longitudinal study to identify biochemical predictors of liver disease outcome in Alagille syndrome [abstract  oral presentation]. 59th Annual Meeting of the American Association of the Study of Liver Diseases, 2008 Oct 31-Nov 4; San Francisco, CA.

Bales CB, Kamath BM, Munoz PS, Piccoli DA, Spinner NB, Grimberg A, et al.  Fracture risk in Alagille syndrome [abstract]. 59th Annual Meeting of the American Association of the Study of Liver Diseases, 2008 Oct 31-Nov 4; San Francisco, CA.

Awards

2012-2013, Pediatric Resdiency Faculty Honor Roll, The Children's Hospital of Philadelphia
2007, Faculty Mentorship Award, CHOP and University of Pennsylvania
2006, Leadership Award, American Liver Association Delaware Valley Chapter
2005, Outstanding Leadership Award, Crohn's and Colitis Foundation of America
2005, Beverly J. Yandell Mentor Award, Association of Pediatric Gastroenterology and Nutrition Nurses
2005, Named Fred and Suzanne Biesecker Endowed Chair in Pediatrics
1999, Jean A. Cortner Divisional Teaching Award, The Children's Hospital of Philadelphia
1999, Klaus and Mary Hummeler Endowed Research Prize
1998, Komarov Research Prize (mentor), Philadelphia Gastro Research Forum
1996, Physician of the Year, Crohn's and Colitis Foundation, Delaware Valley Chapter
1996, Christian R. and Mary F. Lindback Foundation Award for Distinguished Teaching, University of Pennsylvania
1996, The Best Doctors in America, American Health Magazine, Reader's Digest
1994-1998, The Best Doctors in America Directory, Woodward White, Inc.
1994, Physician of the Year, American Liver Foundation, Delaware Valley Chapter
1993, Class of 1992 Teaching Award, University of Pennsylvania School of Medicine
1993, Faculty Teaching Award, The Children's Hospital of Philadelphia
1992, Blockley-Osler Award for Teaching Clinical Medicine, University of Pennsylvania
1990, Best Doctors, Philadelphia Magazine
1988, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum
1986, Komarov Research Prize, Philadelphia Gastrointestinal Research Forum
1984, Fellows' Teacher of the Year Award, The Children's Hospital of Philadelphia
1983, Sidney Farber House Staff Award, Children's Hospital Boston
1980, American Academy of Pediatrics Residency Fellowship
1975, High Honors, Departmental Honors (Biology), Johns Hopkins University
1974, Phi Beta Kappa, Johns Hopkins University

Books

2008

Liacouras CA, Piccoli DA. Pediatric gastroenterology and nutrition: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008.

2004

Russo P, Ruchelli E, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag; 2004.

Chapters

2010

Kamath BM, Loomes KM, Piccoli DA. JAGGED1NOTCH2 sequence in Alagille syndrome. In: Murray K, Larson AM, editors. Fibrocystic disease of the liver. 1st ed. New York: Springer-Verlag; 2010.

2008

Kamath BM, Piccoli DA. Alagille syndrome. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008. p. 227-232. 

2007

Kamath BM, Spinner NB, Piccoli DA. Alagille syndrome. In: Suchy F, Balistreri W, Sokol RJ, editors. Liver disease in children. 3rd ed. New York: Cambridge University Press; 2007. p. 326-345.

2005

Graham-Maar RC, Piccoli DA. Gastroenterology (10), esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.

Graham-Maar RC, Piccoli DA. Esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 100-102.

Graham-Maar RC, Piccoli DA. Hepatobiliary system. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.

Graham-Maar RC, Piccoli DA. Small and large intestine. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005.

2004

Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, Kleinman RE, Sherman PM, Shneider BL, Sanderson IR, editors. Pediatric gastrointestinal disease. Shelton: PMPH USA; 2004.

2003

Kamath BM, Piccoli DA. Alagille syndrome. In: Grand RI, editor. Encyclopedia of pediatric gastroenterology. Philadelphia: Elsevier; 2003.

2001

Piccoli DA. Alagille syndrome. In: Suchy F, editor. Liver disease in children. 2nd ed. Philadelphia: WB Saunders; 2001. p. 327-342.

2000

Piccoli DA. Disorders of the biliary tract: extrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.

Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.

Mamula P, Markowitz, Baldassano RN, Piccoli DA, Liacouras CA. Gastroenterology. In: Polin R, editor. Pediatric secrets. 3rd ed. Philadelphia: Hanley & Belfus, Inc.; 2000.

1999

Wenner WJ, Piccoli DA. Viral hepatitis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 445-450.

Piccoli DA, Peck SN. Inflammatory bowel disease in children and adolescents. In: Stein SH, Rood RP, editors. Inflammatory bowel disease: a guide for patients and their families. Philadelphia: Lippincott-Raven; 1998. p. 79-92.

Piccoli DA. Hepatic fibrosis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Curchill Livingstone; 1998. p. 391-396.

Piccoli DA. Hirschsprung disease. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Curchill Livingstone; 1998. p. 1399-1403. 

Piccoli DA. Breath testing. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Curchill Livingstone; 1998. p. 567-574.

Gibson J, Piccoli DA, Berry G. Pathophysiology of metabolic disease of the liver. In: Polin R, Fox W, editors. Fetal and neonatal physiology. 2nd ed. Philadelphia: WB Saunders; 1998. p. 1514-20.

1997

Piccoli DA. Rectal bleeding. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed. Philadelphia: Mosby-Year Book, Inc.; 1997. p. 346-354.

Editorial and Academic Positions

Academic committees

2012-present, Compensation Committee, Department of Pediatrics, The Children's Hospital of Philadelphia
2012-present, Perioperative IS Design Executive Sponsor Committee
2012-2013, Department of Medicine Review Committee, University of Pennsylvania Perelman School of Medicine
2012-2013, NIH-TAC Final Task Force Summit, University of Pennsylvania School of Medicine
2011-present, Optimization Management Group, Epic IS, Chair
2009-present, HUP CHOP Joint Center for Digestive, Liver and Pancreatic Disease, Co-Director
2008-present, Epic Care CHOPlink implementation, Ambulatory Advisory Team, The Children's Hospital of Philadelphia
2008-present, Bollig Provider Committee
2008-2009, Leader, IMO Implementation, Epic Care CHOPlink Committee
2008-2009, Department of Pediatrics Compensation Committee, University of Pennsylvania
2006-2008, EpicCare, CHOPlink Implementation, Executive Sponsor, Ambulatory, The Children's Hospital of Philadelphia
2004-present, Biesecker Liver Center Internal Scientific Advisory Committee, The Children's Hospital of Philadelphia

Leadership

Memberships in professional organizations

2005-present, American Liver Foundation, National Board

  • 2005-2008, President, Board of Directors

1995-present, National Alagille Syndrome Alliance
1993-present, National Crohn's and Colitis Foundation of America

  • 2004-present, National Board of Trustees
  • 1991-2011, Board of Trustees, Delaware Valley Chapter
  • 2004-2011, National Board
  • National Board, Chapter Services Committee
  • 2004-2009, National Board, Research Committee

1989-present, American Gastroenterological Association

1989-present, American Association for the Study of Liver Diseases

1988-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

  • 2008-2011, Finance Committee
  • 2005-2008, Internet Committee
  • 2005-2008, Training and Education Committee
  • 2005-2008, Executive Council

New Media

2011

Kelsen JR, Mamula P, Vargas JH, Windle ML, Piccoli DA, Cuffari C: Ulcerative Colitis in Children. Medscape September 2011.

2009

Piccoli DA. Alagille syndrome. A video for families and practitioners [online video]. Philadelphia: The Children's Hospital of Philadelphia; 2009. Available from: http://www.chop.edu/video/alagille-syndrome/alagille-syndrome-intro.html#transcript.

Original Papers

2013

Hsu E, Chugh P, Kronman M, Markowitz J, Piccoli D, Mamula P: Incidence of perforation in pediatric GI endoscopy and colonoscopy: an 11 year experience. Gastrointest Endosc 77(6): 960-966, 2013.

2012

Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K: Renal anomalies in Alagille Syndrome: A disease-defining feature. Amer J Med Gen 158A(1): 85-89, January 2012.

Kamath BM, Piccoli DA, Magee JC, Sokol RJ : Pancreatic insufficiency is not a prevalent problem in Alagille syndrome. Childhood Liver Disease Research and Education Network Journal of Pediatric Gastroenterology & Nutrition 55(5): 612-4, Nov 2012.

Kamath BM, Bauer RC, Loomes KM, Chao G, Gerfen J, HutchinsonA, Hardikar W, Hirschfield G, Jara P, Krantz ID, LapunzinaP, Leonard L, Ling S, Ng L, Hoang PL, Piccoli DA and Spinner NB: NOTCH2 Mutations in Alagille Syndrome. J Med Gen 49: 138-44, 2012.

2011

Friedlander JA, Loeben GS, Finnegan PK, Puma AE, Zhang X, de Zoeten EF, et al. A novel method to enhance informed consent: a prospective and randomised trial of form-based versus electronic assisted informed consent in paediatric endoscopy. J Med Ethics. 2011 Apr;37(4):194-200. Epub 2011 Jan 18. Cited in PubMed; PMID 21245476. Read the abstract

2010

Kamath BM, Loomes KM, Piccoli DA. Medical management of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):580-6. Cited in PubMed; PMID 20479679. Read the abstract

Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A, Loomes KM. Pathologic lower extremity fractures in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):66-70. Cited in PubMed; PMID 20453673. Read the abstract

Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB, Piccoli DA. A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 May;50(5):526-30. Cited in PubMed; PMID 20421762. Read the article

Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet. 2010 May 15;19(10):2059-67. Epub 2010 Feb 22. Cited in PubMed; PMID 20176734. Read the article

2009

Kamath BM, Thiel BD, Gai X, Conlin LK, Munoz PS, Glessner J, et al. SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation. Hum Mutat. 2009 Mar;30(3):371-8. Cited in PubMed; PMID 19058200. Read the article

Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet. 2009 Mar;84(3):399-405. Epub 2009 Feb 26. Cited in PubMed; PMID 19249008. Read the article

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec;41(12):1335-40. Epub 2009 Nov 15. Cited in PubMed; PMID 19915574. Read the abstract

Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Cited in PubMed; PMID 19590456. Read the abstract

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