Jonathan J. Rome, MD, FACC

Jonathan J. Rome, MD, FACC, is an attending cardiologist at CHOP and director of the Cardiac Catheterization Laboratory.

Areas of Expertise: Causes and treatment of stenotic and hypoplastic pulmonary arteries, Device closure of heart defects, Interventional cardiology, Transcatheter treatment in complex heart disease
Locations: Main Campus
Phone: 215-590-4040

  • Background

    Jonathan Rome, MD, is associate chief for clinical affairs for the Division of Cardiology at The Children’s Hospital of Philadelphia and professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

    Since 1994, Dr. Rome has been the director of the cardiac catheterization laboratory and interventional cardiology at CHOP. He is also the medical director of the Cardiac Procedure and Recovery Unit, one of three cardiac units at CHOP.

    “Interventional cardiology” means the use of catheters to place stents, replacement valves and other devices to treat heart problems. Dr. Rome is a national leader and has trained numerous fellows in this highly specialized field, which holds great promise as a less invasive alternative to open heart surgery.

    Dr. Rome has published numerous articles in journals such as Pediatrics, Cardiology in the Young, Congenital Heart Disease and Journal of the American College of Cardiology. He is a reviewer (helping to decide which articles are published) for 10 journals, including Pediatric Cardiology, Annals of Thoracic Surgery, Journal of Thoracic and Cardiovascular Surgery and Circulation. Dr. Rome has authored numerous chapters in textbooks used by medical students and practicing physicians.

    He has lectured around the country and the world on using catheterization to evaluate and treat heart defects in fetuses, infants and children, and on other topics such as the causes and treatment of stenotic and hypoplastic (narrow and malformed) pulmonary arteries and the use of 3-D imaging during catheterization.

    Dr. Rome received a bachelor’s degree from Oberlin College, Oberlin, Ohio, graduating with highest honors in biology, and received his medical degree from Stanford University School of Medicine, Stanford, Calif. He completed his internship and residency in pediatrics at Children’s Hospital Boston and was chief resident there. He also completed his fellowship in pediatric cardiology at Children’s Hospital Boston.
     

  • Education and Training

    Medical School

    MD - Stanford University School of Medicine, Stanford, CA

    Residency

    Children's Hospital, Boston, MA

    Board Certification

    Pediatric Cardiology
    Pediatrics

  • Titles and Academic Titles

    Director, Cardiac Catheterization Laboratory

    Associate Chief for Clinical Affairs

    Attending Cardiologist

    Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Publications

    Books

    Editorials, Reviews, Chapters:

    1. Rome JJ, Lock JE. New developments in pediatric interventional heart catheterization. Giornale Ital di Cardiol 18:255-258, 1989.
    2. Rome JJ.: Transcatheter closure of Atrial Septal Defects. Prog Pediatr Cardiol 1:63-71, 1992.
    3. Rome JJ, Lock JE.: Interventional Catheterisation in Pediatric and Congenital Heart Disease (Chapter 6) in Stark J and de Leval M (Ed.) Surgery for Congenital Heart Defects, W. B. Saunders, Philadelphia, 1993, pp. 95-114.
    4. Rome JJ.: The role of catheter-directed therapies in the treatment of congenital heart disease. Ann Rev Med 46:159-168, 1995.
    5. Bridges ND, Rome JJ.: Hemodynamic Evaluation/Interventional Catheterization in Congenital Heart Disease (Chapter 64) in Kaiser LR, Kron IL, Spray TL (Ed.), Mastery of Cardiothoracic Surgery, Lippincott-Raven, Philadelphia, 1997, pp. 621-634.
    6. Rome JJ, Lock JE.: Cardiac Catheterization in the Critically Ill Cardiac Patient (Chapter 29) in Chang AC, Hanley FL, Wernovsky G, and Wessel DL (Ed.) Pediatric Intensive Care, Williams and Wilkins, Baltimore, 1998, pp. 447-460.
    7. Wernvosky G, Rychik J, Spray TL, Rome JJ.: Postoperative Management of Single Ventricle, in Collins-Nakai RL (Ed.) Pediatric and Clinical Cardiology Self Assessment Program, American College of Cardiology, Bethesda, 1998.
    8. Rome JJ.: Balloon pulmonary valvuloplasty. Pediatr Cardiol 19: 18-24, 1998.
    9. Rome JJ.: Commentary. J Thorac Cardiovasc Surg 118: 679-680, 1999.
    10. Rome JJ, Perry SB.: Defect Closure - Coil Embolization, (Chapter 8) in Lock JE, Keane JF, and Perry SB (Ed.) Diagnostic and Interventional Catheterization in Congenital Heart Disease, Kluwer Academic Publishers, Boston, 2000, pp. 199-220.
    11. Rome JJ. Clamshell Device, in Rao PS (Ed.) Catheter Based Devices for the Treatment of Non-coronary Cardiovascular Disease in Adults and Children, Futura Publishing Co., Armonk, 2001 (in press).
    12. Rome JJ, Kreutzer J. The Role of Cardiac Catheterization During Staged Reconstruction of Hypoplastic Left Heart Syndrome, in Rychik J and Wernovsky G (Ed.) The Hypoplastic Left Heart Syndrome, Kluwer Academic Publishers, Norwell, 2002
    13. Rome JJ. Percutaneous Catheter Interventions, in Yang SC and Cameron DE (Ed.) Current Therapy in Thoracic and Cardiovascular Surgery, Mosby, Philadelphia, 2004.
    14. Rome JJ, Kreutzer J. Pediatric Interventional Catheterization: Reasonable Expectations and Outcomes. Pediatr Clinic North America 51: 1589-1610, 2004.
    15. Allen HD, Bricker JT, Freed MD, Hurwitz RA, McQuinn TC, Schieken RM, Strong WB, Zahka KG, Sanders SP, Colan SD, Cordes TM, Donofrio MT, Ensing GJ, Geva T, Kimball TR, Sahn DJ, Silverman NH, Sklansky MS, Weinberg PM, Beekman RH 3rd, Hellenbrand WE, Lloyd TR, Lock JE, Mullins CE, Rome JJ, Teitel DF, Vetter VL, Silka MJ, Van Hare GF, Walsh EP, Kulik T, Giglia TM, Kocis KC, Mahoney LT, Schwartz SM, Wernovsky G, Wessel DL, Murphy DJ Jr, Foster E, Benson DW Jr, Baldwin HS, Mahoney LT, McQuinn TC; American College of Cardiology Foundation; American Heart Association; American Academy of Pediatrics. ACC/AHA/AAP recommendations for training in pediatric cardiology.
      Pediatrics 116:1574-96, 2005.
    16. Beekman RH 3rd, Hellenbrand WE, Lloyd TR, Lock JE, Mullins CE, Rome JJ, Teitel DF; Society for Cardiovascular Angiography and Interventions; American College of Cardiology Foundation; American Heart Association; American College of Physicians Task Force on Clinical Competence (ACC/AHA/AAP Writing Committee to Develop Training Recommendations for Pediatric Cardiology). ACCF/AHA/AAP recommendations for training in pediatric cardiology. Task force 3: training guidelines for pediatric cardiac catheterization and interventional cardiology endorsed by the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol 46:1388-90, 2005.
    17. Gillespie MJ, Schneider HE, Rome JJ. The use of cardiac catheterization to diagnose and treat heart disease in pediatric patients, in Vetter VL (Ed.) Pediatric Cardiology: The Requisites of Pediatrics, Elsevier Mosby, Philadelphia, 2006.
    18. Wernovsky G, Rome JJ, Tabbutt S, Rychik J, Cohen MS, Paridon SM, Webb G, Dodds KM, Gallagher MA, Fleck DA, Spray TL, Vetter VL, Gleason MM. Guidelines for the outpatient management of complex congenital heart disease. Congenit Heart Dis 1:10-26, 2006.
    19. Bridges ND, Rome JJ.: Hemodynamic assessment and transcatheter therapy for congenital heart disease (Chapter 70) in Kaiser LR, Kron IL, Spray TL (Ed.), Mastery of Cardiothoracic Surgery, Lippincott-Raven, Philadelphia, 2007, pp. 679-692.
    20. Cohen MS, Anderson RH, Cohen MI, Atz AM, Fogel M, Gruber PJ, Lopez L, Rome JJ, Weinberg PM. Controversies, genetics, diagnostic assessment, and outcomes relating to the heterotaxy syndrome. Cardiol Young 17(Suppl. 2): 29–43, 2007.
    21. Friedman AH, Fogel MA, Stephens P, Hellinger JC, Nykanen DG, Tweddell J, Feltes TF, Rome JJ. Identification, imaging, functional assessment and management of congenital coronary arterial abnormalities in children. Cardiol Young 17(Suppl. 2): 56–67, 2007.

    Abstracts

    1. Zeltzer I, Menteer J, Gaynor JW, Clark BJ, Rome JJ. Impact of re-coarctation following Norwood operation on survival in the balloon angioplasty era. Circulation 106(suppl): 2002.
    2. Paolillo JA, Kreutzer J, Clark BJ, Rome JJ. Flow Characteristics predict in-stent restenosis in congenital heart disease. J Am Coll Cardiol 41: 488A 2003.
    3. Schneider HE, Kreutzer J, Cohen MS, Spray TL, Rome JJ. Intermediate-term outcome of neonates with critical aortic stenosis after valvotomy in the Ross era. Circulation 108:IV-678 2003.
    4. Pettit C, Kreutzer J, Gillespie MJ, Rome JJ. Endovascular Stenting for Relief of Cyanosis in Single Ventricle Patients with Graft Obstruction after Shunt or Right-Ventricle to Pulmonary-Artery Conduit. World Congress of Pediatric Cardiology and Cardiothoracic Surgery, 2005.
    5. Al-Ammouri I, Petit C, Gillespie M, Rome JJ. Comparison between stenting and balloon interventions for intact or restrictive atrial septum in hypoplastic left heart syndrome. Catheter Cardiovasc Int: 67:837 2006.
    6. Javois A, Rome J, Jones TK, Fagan T, Zahn E, Rhodes JF, Latson L. US FDA Phase II Helex trial data: clinical success and safety evaluation at 12 month follow-up. Catheter Cardiovas Int 69:S CO-2 2007.
    7. Al-Ammouri I, Gillespie M, Paolillo J, Kreutzer J, Rome JJ. Re-stenosis of pulmonary artery stents in congenital heart disease. Catheter Cardiovas Int 69: S CO-6 2007.
       

    Papers

    Ballweg JA, Dominguez TE, Tabbutt S, Rome JJ, Gaynor JW, Nicolson SC, Spray TL, Ravishankar C. Reintervention for arch obstruction after stage 1 reconstruction does not adversely affect survival or outcome at Fontan completion. J Thorac Cardiovasc Surg. 2010 Sep;140(3):545-9. Read abstract.

    Collins RT 2nd, Kaplan P, Somes GW, Rome JJ. Long-term outcomes of patients with cardiovascular abnormalities and williams syndrome. Am J Cardiol. 2010 Mar 15;105(6):874-8.

    Collins RT 2nd, Kaplan P, Rome JJ. Stenosis of the Thoracic Aorta in Williams Syndrome. Pediatr Cardiol. 2010 Apr 22. [Epub ahead of print].

    Schwartz M, Glatz AC, Rome JJ, Gillespie MJ. The amplatzer vascular plug and amplatzer vascular plug II for vascular occlusion procedures in 50 patients with congenital cardiovascular disease. Catheter Cardiovasc Interv. 2009 Nov 10.

    Gillespie MJ, Rome JJ. Transcatheter treatment for systemic-to-pulmonary artery shunt obstruction in infants and children. Catheter Cardiovasc Interv. 2008 Jun 1;71(7):928-35. PMID: 18383162

    Wernovsky G, Rome JJ, Tabbutt S, Rychik J, Cohen MS, Paridon SM, Webb G, Dodds KM, Gallagher MA, Fleck DA, Spray TL, Vetter VL, Gleason MM. Guidelines for the outpatient management of complex congenital heart disease. Congenit Heart Dis. 2006 Jan;1(1-2):10-26. Review. PMID: 18373786

    Petit CJ, Webb GD, Rome JJ. Creation of a coronary sinus to atrial communication in coronary sinus ostial atresia improves cardiac function after Fontan. Catheter Cardiovasc Interv. 2007 Nov 15;70(6):897-9. PMID: 18022916

    Glatz JA, Tabbutt S, Gaynor JW, Rome JJ, Montenegro L, Spray TL, Rychik J. Hypoplastic left heart syndrome with atrial level restriction in the era of prenatal diagnosis. Ann Thorac Surg. 2007 Nov;84(5):1633-8. PMID: 17954074

    Pinto NM, Weinberg PM, Rome JJ. Membranous remnant of left venous valve of inferior vena cava: implications for device closure of atrial septal defects. Catheter Cardiovasc Interv. 2007 Apr 1;69(5):732-4. PMID: 17295332

    Mercer-Rosa L, Seliem MA, Fedec A, Rome J, Rychik J, Gaynor JW. Illustration of the additional value of real-time 3-dimensional echocardiography to conventional transthoracic and transesophageal 2-dimensional echocardiography in imaging muscular ventricular septal defects: does this have any impact on individual patient treatment? J Am Soc Echocardiogr. 2006 Dec;19(12):1511-9. PMID: 17138037

    Pettit C, Kreutzer J, Gillespie MJ, Rome JJ. Endovascular stents for relief of cyanosis in single-ventricle patients with shunt or conduit-dependent pulmonary blood flow. Catheter Cardiovasc  Interv. 68:280-286, 2006.

    Gillespie MJ, Golden A, Sivarajan VB, Rome JJ.  Transcatheter closure of patent ductus venosus  with the Amplatzer vascular plug in twin brothers. Pediatr Cardiol. 27(1):142-5, 2006.

    Levy RJ, Stern WB, Minger KI, Montenegro LM, Ravishankar C, Rome JJ, Nicolson SC, Jobes DR. Evaluation of tissue saturation as a noninvasive measure of mixed venous saturation in children.  Pediatr Crit Care Med. 6:671-5, 2005.

    Gillespie MJ, Kreutzer J, Rome JJ. Novel approach to percutaneous stent implantation for coarctation of the aorta: The railway technique. Catheter Cardiovasc Interv 65:584-7, 2005.

    Pastuszko P, Rome JJ, Gleason MM, Bellah RD, Montenegro LM, Gaynor JW. Hemoptysis after CardioSEAL device embolization of a venous collateral after the Fontan operation.
    J Thorac Cardiovasc Surg  129:1447-8, 2005.

    Zeltzer I, Menteer J, Gaynor JW, Clark BJ, Kreutzer J, Rome JJ. Impact of re-coarctation following Norwood operation on survival in the balloon angioplasty era. J Am Coll Cardiol 45:1844-1848, 2005.

    Levy RJ, Chiavacci RM, Nicolson SC, Rome JJ, Lin RJ, Helfaer MA, Nadkarni VM. An evaluation of a noninvasive cardiac output measurement using partial carbon dioxide rebreathing in children. Anesth Analg 99:1642-1647, 2004.

    Venditti CP, Harris MC, Huff D, Peterside I, Munson D, Weber HS, Rome J, Kaye EM, Shanske S, Sacconi S, Tay S, DiMauro S, Berry GT. Congenital cardiomyopathy and pulmonary hypertension: another fatal variant of cytochrome-c oxidase deficiency. J Inherit Metab Dis 27:735-9, 2004.

    Knauth AL, Lock JE, Perry SB, et al. Transcatheter device closure of congenital and postoperative residual ventricular septal defects. Circulation 110:501-507, 2004.

    Ro PS, Rychik J, Cohen MS, Mahle WT,  Rome JJ. Diagnostic assessment before Fontan operation in patients with bi-directional cavopulmonary anastomosis: are noninvasive methods sufficient? J Am  Coll Cardiol 44:184-187, 2004.

    Kreutzer J, Rome JJ. Open-cell design stents in congenital heart disease: a comparison of Intrastent vs. Palmaz stents. Cathet Cardiovasc Intervent. 56:400-409, 2002.

    Kreutzer J, Rome JJ. Open-cell design stents in congenital heart disease: a comparison of Intrastent vs. Palmaz stents. Cathet Cardiovasc Intervent. 56:400-409, 2002

    Scherpereel A, Rome JJ, Wiewrodt R, Watkins SC, Harshaw DW, Alder S, Christofidou-Solomidou M, Haut E, Murciano JC, Nakada M, Albelda SM, Muzykantov VR. Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature.  J  Pharmacol Exp Ther. 300: 777-86, 2002.

    McElhinney DB, Yang SG, Hogarty AN, Rychik J, Gleason MM, Zachary CH, Rome JJ, Karl TR, DeCampli WM, Spray TL, Gaynor JW. Recurrent arch obstruction after repair of isolated coarctation of the aorta in neonates and young infants: is low birth weight a risk factor? J Thorac Cardovasc Surg. 122: 883-90,2001.

    Mahle WJ, Rychik J, Gaynor JW, Spray TL, Rome JJ. Restrictive inter-atrial communication following reconstructive surgery for hypoplastic left heart syndrome. Am J Cardiol. 88: 1454-1457, 2001.

    Ro PS, Weinberg PM, Delrosario J, Rome JJ. Predicting the identity of decompressing veins after cavopulmonary anastomoses. Am J Cardiol. 88: 31-34, 2001.

    Robinson A, Bridges ND, Fellows KE, Rome JJ. Effectiveness of pharmecomechanical thrombolysis in infants and children. Am J Cardiol. 87: 496-498, 2001.

    Bush DM, Hoffman TM, Del Rosario J, Eiriksson H, Rome JJ.  Frequency of restenosis after balloon pulmonary arterioplasty and its causes. Am J Cardiol. 86:1205-1209, 2000.

    Watzman HM, Kurth CD, Montenegro LM, Rome J, Steven JM, Nicolson SC.
    Arterial and venous contributions to near-infrared cerebral oximetry. Anesthesiology.93:947-53. 2000.

    Gaynor JW, Wernovsky G, Rychik J, Rome JJ, DeCampli WM, Spray TL. Outcome following single-stage repair of coarctation with ventricular septal defect.  European J Cardiothorac Surg 18:62-67, 2000.

    Mahle WT, Rychik J, Rome JJ. Clinical significance of pulmonary arteriovenous malformations after staging bidirectional cavopulmonary anastomosis. Am J Cardiol. 86:239-41, 2000.

    Badran S, Schachtner SK, Baldwin HS, Rome JJ.  Optimization of adenoviral vector-mediated gene transfer to pulmonary arteries in newborn swine. Human Gene Therapy 11:1113-1121, 2000.

    Rychik J, Rome JJ, Collins MH, DeCampli WM, Spray TL. The hypoplastic left heart syndrome with intact atrial septum: atrial morphology, pulmonary vascular histopathology, and outcome. J Am Coll Cardiol 34:554-560, 1999.

    Rychik J, Suh EJ, Rome JJ, Jacobs ML. Experience with late fenestration for complications after the Fontan operation. Circulation 96(1):33-36, 1997.

    Jacobs ML, Rychik J, Rome JJ, Apostolopoulou S, Pizarro C, Murphy JD, Norwood WI. Early reduction of the volume work of the single ventricle: The hemi-Fontan operation. Ann Thorac Surg  62:456-461, 1996.

    McDonald-McGinn DM, Driscoll DA, Bason L, Christensen K, Lunch D, Sullivan K, Canning D, Zavod W, Quinn, N, Rome JJ, Paris Y, Weinberg P, Clark BJ, Emanuel BS, Zackai EH. Autosomal dominant "Opitz" GBBB syndrome due to a 22q11.2 deletion. Am J Med Genet 59:103-111, 1995.

    Sable C, Martin GR, Rome JJ, Karr SS. Indications for echocardiography in the diagnosis of infective endocarditis in children. Am J Cardiol 75:801-4, 1995.

    Kapur S, Rome JJ, Chandra RS, Diffuse pulmonary arteriovenous malformation in a child with polysplenia syndrome. Ped Pathol 15:463-468, 1995.

    Farrell SK, Rome JJ, Hoyt RF, Newman KD, Virmani R, Dichek DA. In vivo adenovirus-mediated gene transfer via the pulmonary artery of rats.  Circ Res 76:701-9, 1995.

    Rome JJ, Shayani V, Newman KD, Farrell S, Lee SW, Virmani R, Dichek DA. Adenoviral Vector-mediated gene transfer into sheep arteries using a double balloon catheter. Human Gene Therapy 5:1249-1258, 1994.

    Rome JJ, Shayani V, Flugelman MY, Newman KD, Farb A, Virmani R, Dichek DA. Anatomic Barriers influence the distribution of in vivo gene transfer into the arterial wall: modeling with microscopic tracer particles and verification with a recombinant adenoviral vector. Arteriosclerosis and Thrombosis 14:148-161, 1994.

    Rome JJ, Mayer JE, Castaneda AR, Lock JE. Tetralogy of Fallot with pulmonary  atresia: rehabilitation of diminutive pulmonary arteries. Circulation 88:1691-1698, 1993.

    Hourihan M, Keane JF, Perry SB, Bittl JA, Mandell VS, Rome JJ, Lock JE. Transcatheter umbrella closure of valvar and paravalvar leaks. J Am Coll Cardiol 20:1371-1377, 1992.

    Perry SB, Rome JJ, Keane JF, Baim DS, Lock JE. Transcatheter closure of coronary artery fistulas. J Am Coll Cardiol 20:205-209, 1992.

    Di Donato RM, Jonas RA, Lang P, Rome JJ, Mayer JE, Castaneda AR. Neonatal  repair of tetralogy of Fallot with and without pulmonary atresia. J Thorac Cardiovasc Surg 101:126-137, 1991.

    Rome JJ, Keane JF, Perry SB, Spevak PJ, Lock JE. Double umbrella closure of atrial defects: initial clinical applications. Circulation 82:751-758, 1990.

    Zeevi B, Rome JJ, Keane JF. A newly designed double pressure balloon catheter: clinical use in congenital heart disease. Journal of Invasive Cardiology 1:129-136, 1989.


    •  
    Lock JE, Rome JJ, Davis R, Van Praagh S, Perry S, Van Praagh R, Keane JF. Transcatheter closure of atrial septal defects: Experimental Studies. Circulation 79:1091-1099, 1989.

  • Editorial and Academic Positions

    Editorial Positions:
    1992 - Guest Editor, Progress in Pediatric Cardiology - Transcatheter Treatment of Congenital Heart Defects.

    Current Reviewer:
    American Journal of Cardiology, Annals of Thoracic Surgery, Catheterization and Cardiovascular Interventions, Chest, Circulation, Journal of the American College of Cardiology, Journal of Pediatrics, Journal of Thoracic and Cardiovascular Surgery.