- Education and Training
MD - Albert Einstein College of Medicine, New York, NY
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
- Titles and Academic Titles
Medical Director, Special Immunology Service
Attending Physician, General Pediatrics
HIV Care Specialist
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Departments and Services
Wood SA, Rutstein RM, Steenhoff AP. Human immunodeficiency virus-exposed neonate and at-risk child. In: Shah SS (ed). Pediatric Practice: Infectious Diseases. New York: McGraw-Hill Publishers, 2009.
Rutstein RM, Steenhoff AP. Prevention of HIV Infection: Post-exposure Prophylaxis. In: Shah SS (ed). Pediatric Practice: Infectious Diseases. New York: McGraw-Hill Publishers, 2009.
Steenhoff AP, Rennert W, Rutstein RM. Infections in HIV-Infected Children. In: Shah SS (ed). Pediatric Practice: Infectious Diseases. New York: McGraw-Hill Publishers, 2009.
Steenhoff AP, Rennert W, Rutstein RM. Care of the HIV-Infected Child. In: Shah SS (ed). Pediatric Practice: Infectious Diseases. New York: McGraw-Hill Publishers, 2009.
Rutstein RM. The Evaluation and Management of Pediatric HIV Infection. In: Bergelson J, Shah SS and Zaoutis T, (eds) Pediatric Infectious Diseases: The Requisites in Pediatrics Series. Philadelphia, PA: Elsevier, 2008.
Rutstein RM, Starr SE: Herpesviruses. In: Zeichner SL and Read, J (eds), Handbook of Pediatric HIV Care. Cambridge University Press, Cambridge, UK. 2006.
Rutstein RM, Ramsden DE, Vincent C. Care of Children with Human Immunodeficiency Virus Infection, in: McConnell MS and Imaizumi SO (eds), Guidelines for Pediatric Home Health Care. American Academy of Pediatrics, Elk Grove Village, IL, 2006
Palmer D, Rutstein RM, Zaoutis T. Human immunodeficiency virus infection. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB (eds). The Philadelphia Guide: Inpatient Pediatrics. Malden, MA: Blackwell Publishing, 2005.
Rutstein RM: Human Immunodeficiency Virus Infection, in: Shah SS (ed), Blueprints: Pediatric Infectious Diseases. Blackwell Publishing, Malden, 2005.
Rutstein RM, Starr SE: Herpesvirus Infections. In: Zeichner SL and Read, J, eds, Textbook of Pediatric HIV Care. Cambridge University Press, 2004.
Rutstein RM and Rudy B: HIV Infection in Children & Adolescents. In: Buckly MR and Gluckman ST (eds), HIV Infection in Primary Care. WB Saunders Company, Philadelphia, 2002.
Rutstein RM, Cleary C, Ramsden DE: Care of Children with Human Immunodeficiency Virus Infection, in: McConnell MS and Imaizumi SO (eds), Guidelines for Pediatric Home Health Care. American Academy of Pediatrics, Elk Grove Village, IL, 2002.
Fein JA, Rutstein R: AIDS, in Orenstein JB, Klein BL, Mayer TA (eds): Pedistat: A Rapid Reference Tool for Pediatric Emergency Medicine. CMC Research, Portland, 1998.
Rutstein RM: Pediatric HIV Infection. In: Altschuler S and Ludwig S, (eds). Current Pediatric Therapy. Current Medicine, Inc., Philadelphia, 1998.
Rutstein RM: Pediatric HIV Infection. In: Schwartz W, Fein J, Curry T, (eds). Pediatric Primary Care. Mosby, St. Louis, 1997.
Rutstein RM, Conlon CJ, Batshaw M: Pediatric HIV Infection and AIDS. In M.L. Batshaw (Ed.). Children with Disabilities, 4th edition. Paul H. Brookes, Baltimore, 1997.
Rutstein RM: Retropharyngeal Abscess in Schwartz W, Bell, L, Mulberg A, et al (eds). 5 Minute Pediatric Consultant. Williams & Wilkens, Baltimore, 1997.
Rutstein RM: Atypical Mycobacterial Infection in Schwartz W, Bell, L, Mulberg A, et al (eds). 5 Minute Pediatric Consultant. Williams & Wilkens, Baltimore,1997.
Rutstein RM: Toxoplasmosis in Schwartz W, Bell, L, Mulberg A, et al (eds). 5 Minute Pediatric Consultant. Williams & Wilkens, Baltimore, 1997.
Rutstein RM: HIV Infection in Schwartz W, Bell, L, Mulberg A, et al (eds). 5 Minute Pediatric Consultant. Williams & Wilkens, Baltimore, 1997.
Hermetet K, Smith R, Rutstein RM. Structural Equation Modeling and Cognitive Outcomes. PHACS Annual Meeting, Gaithersburg, March 17, 2015.
Monroe A, Voss C, Moore R, Gebo K, J. Fleishman J, Agwu A, Rutstein R, Sharp V, Boswell S, and the HIV Research Network . Combining Multisite Payor Data with Clinical Data to Quantify Medicaid Payments for HIV Care. 22nd Conference on Retrovirus and Opportunistic Infections, Seattle, Feb 24, 2015.
Nichols SL, Brummel SS, Smith RA, Garvie PA, Hunter SJ, Malee KM, Kammerer BL, Wilkins ML, Mellins CA, Rutstein R, Tassiopoulos K, Chernoff MC for the Pediatric HIV/AIDS Cohort Study. Executive Functioning in Children and Adolescents with Perinatal HIV Exposure and/or Infection. 26th APS Annual Convention, San Francisco, CA, May 25, 2014.
Schall J, Zemel B, Dougherty K, Samuel J, Tuluc F, Rutstein R, Stallings V. High-dose Vitamin D3 supplementation and 3-month immunologic outcomes in children and young adults infected with HIV:A randomized placebo controlled trial. 2nd International Conference on Nutrition and Growth, Barcelona, Spain, Feb 1, 2014.
Farmer C, Yehia B, Rutstein R, Berry S, Gebo K, Agwu A. Factors Associated with Successful Retention Among Non-Perinatally HIV-Infected Youth. Abstract/Poster 934. 21st Conference on Retrovirus and Opportunistic Infections, Boston, March 6, 2014.
Crowell CS, Huo Y, Tassiopoulos K, Malee KM, Yogev R, Hazra R, Rutstein RM, Nichols SL, Smith RA, Williams PL, Oleske J, Muller WJ. Early Viral Suppression Improves Neurocognitive Outcomes in HIV-Infected Children. Abstract 851/Platform Presentation. 21st Conference on Retrovirus and Opportunistic Infections, Boston, March 6, 2014.
Rutstein Lazarus J, Rutstein RM, Lowenthal E. Treatment initiation factors and cognitive outcome in youth with perinatally acquired HIV infection. HIV Med. 2015 Jul;16(6):355-61. doi: 10.1111/hiv.12220. Epub 2015 Jan 21.
Rutstein RM, Samson P, Fenton T, Fletcher CV, Kiser JJ, Mofenson LM, Smith E, Graham B, Matthew M, Aldrovandi, G. Long-Term Safety and Efficacy of Atazanavir-Based Therapy in HIV-Infected Infants, Children and Adolescents: The Pediatrics AIDS Clinical Trials Group Protocol P1020A. Pediatr Infect Dis J, Feb 2015.
Stallings VA, Schall JI, Hediger ML, Zemel BS, Tuluc F, Dougherty KA, Samuel JL, Rutstein RM. High-dose Vitamin D3 Supplementation in Children and Young Adults with HIV: A Randomized, Placebo-Controlled Trial. Pediatr Infect Dis J, Feb 2015. PMID:24988118.
Rutstein RM, Volkman KM, Bonda S, Shah SS. Ongoing Maternal-child transmission of HIV in an urban area, 2003-2012. Hosp Pediatr. 2015 Feb;5(2):92-5. doi: 10.1542/hpeds.2014-0102.
Farmer C, Yehia B, Fleisham JA, Rutstein R, Gebo K, Agwu A for the HIV Research Network. Factors Associated with Retention among Non-Perinatally HIV-Infected Youth in the HIV Research Network. Journal of the Pediatric Infectious Diseases Society, in press, September 2014.
Chun RF, Liu NQ, Lee T, Schall JL, Denburg MR, Rutstein RM, Adams JS, Zemel BS, Stallings VA, Hewison M. Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS. J Steroid Biochem Mol Bio 2014 Aug 1 (Epub ahead of print). PMID:25092518.
Dougherty KA, Schall JI, Zemel BS, Tuluc F, Hou Z, Rutstein RM, Stallings VA. Safety and Efficacy of High-Dose Daily Vitamin D3 Supplementation in Children and Young Adults Infected With Human Immunodeficiency Virus. Journal of the Pediatric Infectious Diseases Society 2014;doi:10.1093/jpids/piu012
Agwu AL, Neptune A, Voss C, Yehia B, Rutstein R; for the HIV Research Network. CD4 Counts of Nonperinatally HIV-Infected Youth and Young Adults Presenting for HIV Care Between 2002 and 2010. JAMA Pediatr. 2014 Feb 3. doi: 10.1001/jamapediatrics.2013.4531. [Epub ahead of print] PMID: 24493261.
Berry SA, Gebo KA, Rutstein RM, Althoff KN, Korthuis PT, Gaur AH, Spector SA, Warford R, Yehia BR, Agwu AL. Trends in Hospitalizations among Children and Young Adults with Perinatally Acquired HIV. Pediatr Infect Dis J. 2014;33:488-494. PMID:24378943.
Lowenthal ED, Ellenberg JH, Machine E, Sagdo A, Boiditswe S, Steenhoff A, Rutstein R, Anabwani G, Gross R. Association Between Efavirenz-based Compared With Nevaripine-Based Antiretroviral Regimens and Virologic Failure in HIV-Infected Children. JAMA 2013;309:1803-1809. PMID 23632724.
Neely M, Rutstein RM, Del Bianco G, Heresi G, Barton T, Wiznia A, Wiegand R, Wheeling T, Bohannon B, Dominguez K and the LEGACY Consortium. Use of NRTI-only Regimens in HIV-infected Children and Adolescents. Pediatr Infect Dis J, 2013;7:891-5. PMID:24008749
Bosse KR, Russell EA, Chikwava KR, Rutstein RM, Lowenthal E. Acute Renal Injury in a 14 year old with HIV/AIDS and Tuberculosis. Pediatr Infect Dis J 2013;32:e380-382. PMID:24008750
Connolly MD, Rutstein RM, Lowenthal ED. Virologic testing in infants with perinatal exposure to HIV receiving multidrug prophylaxis. Pediatr Infect Dis J 2013;32:196-197. PMID:23328830
Yehia BR, Agwu A, Schranz A, Korthuis T, Gaur A, Rutstein R, Sharp V, Barry S, Gebo K. Conformity of Pediatric/Adolescent HIV Clinics to the Patient-Centered Medical Home Care Model. AIDS Patient Care and STDS 2013;27:272-279. PMID 23714737.
Groleau V, Herold R, Zemel B, Doughterty K, Rutstein R, Stallings V. Blood Lead Concentration Is Not Altered by High Dose Vitamin D Supplementation in Children and Young Adults with HIV. Journal of Pediatric Gastroenterology and Nutrition 2013;56:316-319. PMID 23059649.
Posters and Presentations
Agwu A, Mahiane G, Nonyane BAS, Althoff K, Yehia B, Berry S, Rutstein R, Gebo K. Greater Early CD4 Responses to CART Initiation not Maintained for Non-Perinatal Youth. Abstract/Poster 931. 21st Conference on Retrovirus and Opportunistic Infections, Boston, March 6, 2014.
Crowell TA, Gebo KA, Blankson JN, Yehia B, Rutstein RM, Berry SA. HIV Elite Controllers Are Hospitalized More Often Than Persons With Medically Controlled HIV. Abstract/Poster 556. 21st Conference on Retrovirus and Opportunistic Infections, Boston, March 5, 2014.
Conforto A, Guay J, Rutstein R, Abraham P, & McGrath M. Executive functioning in children, adolescents, and young adults with perinatally acquired HIV. Poster presented at the annual National Conference on Pediatric Psychology, New Orleans, April10, 2013.
Steenhoff A, Schall J, Seme B, Marape M, Tsimako I, L Mazhani, Rutstein R, Stallings V. Vitamin D3 Supplementation (4000 or 7000 IU/d) in Batswana Children and Adults with HIV. Abstract/Poster 965. 20th Conference on Retrovirus and Opportunistic Infections, Atlanta, March 4, 2013.
Agwu AL, Neptune A, Rutstein R, Korthuis T, Gebo K. CD4 Count at Presentation to Care among Youth Infected with HIV through Risk Behaviors (2002-2010). Abstract/Poster V-147. 20th Conference on Retrovirus and Opportunistic Infections, Atlanta, March 4, 2013.
- Awards and Honors
2014, Member, Academy of Master Clinicians, Perelman School of Medicine, University of Pennsylvania
2011, Blockley-Osler Education Award, University of Pennsylvania School of Medicine
2010, Master Clinician Award, Children’s Hospital of Philadelphia
1999-, Yearly recognition on “Honor Roll of Teaching”
1997-1998, Faculty Teacher of the Year, The House Staff of the Children’s Hospital of Philadelphia
1995-1996, Dean's Award for Excellence in Clinical Teaching, University of Pennsylvania School of Medicine
1988-1989, Ambulatory Care Teacher of the Year Award, West Jersey Hospital System Family Practice, Residency Program
1985-1986, Teacher of the Year Award-Cooper Hospital, Pediatric Residency Program
- Editorial and Academic Positions
2010-present, Medical Editor, Children’s Doctor, The Children’s Hospital of Philadelphia Quarterly Newsletter
2000-present, Pediatric Infectious Disease Journal
1997-present, Pediatric Emergency Care
1992-present, AIDS/IMPAACT Clinical Trial Group, Executive Committee
2006-[resent, Chair, Subcommittee on Blood Borne Pathogens/HIV
Memberships in Professional Organizations
Fellow, American Academy of Pediatrics
Member, Ambulatory Pediatric Association
Member, HIV Medical Association
Member, The American Academy of HIV Medicine
Member, HRSA National Pediatric Antiretroviral Working Group, 2007-present
Member, CDC Panel on Prevention and Treatment of Opportunistic Inf., 2009-present
Member, CDC Panel on Revision of Pediatric AIDS Diagnosis Criteria, May 2011-June 2013
NIH IMPAACT HIV Network:
- 1994-2014, Site investigator under NIH network funding
- 2014-, Site investigator under NICHD network funding
- 2005-2014, Member, Primary Therapy Committee
- 2000-present, Chair, Protocol 1020a-Domestic/International Phase I/II Study of ATV
- 2010-present, Chair, Protocol 1090- Domestic/International Phase I/II Study of ETV
NIH PHACS HIV Network:
- 2009-present, consultant
- 2009-present, member-Neurodevelopmental Work Group
AHRQ HIV Research Network
- 2001-present, site investigator
- 2001-2013 member, Data Subcommittee
- 2013-present, Chair, Data Subcommittee
- Awards and Honors