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Alix E. Seif, MD, MPH

Attending physician
Assistant professor, Perelman School of Medicine at the University of Pennsylvania

Abstracts

2011

Seif AE, Rheingold SR, Fisher BT, Huang Y-SV, Li Y, Kersun LS, et al. Pediatric acute lymphoblastic leukemia (ALL) induction mortality: a population-based report from the Pediatric Health Information Systems (PHIS) database,1999-2009 [abstract]. Pediatric Blood & Cancer (ASPHO Annual Meeting Abstracts); 2011;56(6): 895-1002. 

2010

Reid GSD, Seif AE, Grupp SA. Immunotherapy approaches for acute lymphoblastic leukemia: clues from pre-leukemia studies [abstract]. National Cancer Institute Immunotherapy in Pediatric Oncology Conference; 2010 Oct; Houston, TX.

Barrett DM, Seif AE, Carpenito C, June CH, Grupp SA, Reid GS. Bioluminescent tracking of mouse and human leukemia engraftment patterns: influence of host immunocompetence and source species. Blood (ASH Annual Meeting Abstracts), 2010;116: 2140.

Seif AE, Rheingold SR, Fisher BT, Huang Y-SV, Li Y, Kersun LS, et al. Induction mortality in pediatric acute lymphoblastic leukemia (ALL): a retrospective cohort analysis from the Pediatric Health Information Systems (PHIS) database, 1999-2009. Blood (ASH Annual Meeting Abstracts), 2010;116: 3239.

2009

Seif AE, Barrett DM, Brown VI, Grupp SA, Reid GSD. Generation of long-term protection from acute lymphoblastic leukemia by an immune stimulant in a syngeneic murine model. American Association of Immunologists Annual Meeting; 2009 May; Seattle, WA.

Reid GSD, Seif AE, Grupp SA. Immune-mediated depletion of pre-leukemic cells delays disease onset in a murine spontaneous disease model. American Association of Immunologists Annual Meeting, 2009 May; Seattle, WA.

Seif AE, Barrett DM, Brown VI, Grupp SA, Reid GSD. Durable immune-mediated protection from acute lymphoblastic leukemia (ALL) is induced by CpG oligodeoxynucleotides in a syngeneic mouse model. American Society of Pediatric Hematology/Oncology; 2009 Apr; San Diego, CA.

Awards

2010, Canuso Family Foundation Innovation Award

2010,  ASBMT/Robert A. Good New Investigator Award, American Society of Blood and Marrow Transplantation

2009,  ASPHO Young Investigator Award, American Society of Pediatric Hematology/Oncology

2008,  Excellence in Translational Research Award, Joseph E. Stokes, Jr. Research Institute, Children’s Hospital of Philadelphia

2008,  ASPHO Young Investigator Travel Award, American Society of Pediatric Hematology/Oncology

2006,  AAI Immunology Course Award, Center for Clinical Immunology, U. of Pennsylvania

2005,  Resident Humanitarian Award, Children’s Hospital of Philadelphia

2005,  Anne E. Dyson Advocacy Award, Children’s Hospital of Philadelphia

2002,  Alpha Omega Alpha Honor Society, Oregon Health Sciences University

2000,  Student Scholar, Cardiovascular Disease & Stroke, American Heart Association

2000,  N.L. Tartar Trust Fellow, Oregon Health Sciences University

1999-2000,  OHSU Laurel Scholar, Oregon Health Sciences University

1992,  University Scholar, McGill University

1990-1991,  Faculty Scholar, McGill University

Editorial and Academic Positions

Editorial positions

2010-present, Editorial Advisory Board, Cytotherapy
2008 to present, Ad hoc reviewer, Biol Blood Marrow Transplant  

Academic positions

2009-present, Leukemia & Lymphoma Clinical Committee

Leadership

Memberships in professional organizations

2006-present, American Society for Blood and Marrow Transplantation
2006-present, American Society of Clinical Oncology
2006-present, American Society of Hematology
2006-present, American Society of Pediatric Hematology/Oncology

Original Papers

2011

Seif AE. Pediatric leukemia predisposition syndromes: clues to understanding leukemogenesis. Cancer Genet. 2011 May; 204(2011):227-44. Cited in PubMed: PMID 21665176. Read the abstract

2010

Seif AE, Manno CS, Sheen C, Grupp SA, Teachey DT. Identifying Autoimmune Lymphoproliferative Syndrome (ALPS) in children with Evans syndrome: a multi-institutional study. Blood. 2010; 115: 2142-2145. Cited in PubMed: PMID 20068224. Read the article

Seif AE, Sutter JA, Rheingold SR. Secondary adrenal insufficiency in an infant after intrathecal triple chemotherapy. Pediatr Blood Cancer. 2010 Aug; 55(2):386-9. Cited in PubMed: PMID 20582966. Read the abstract

Teachey DT, Seif AE, Grupp SA. Advances in the management and understanding of Autoimmune Lymphoproliferative Syndrome (ALPS). Br J Haematol. 2010 Jan; 148(2):205-16. Epub 2009 Nov 23. Cited in PubMed: PMID 19930184. Read the article

Commander L, Seif AE, Rheingold SR. Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory pediatric T-cell lymphoblastic leukemia and lymphoma. Br J Haematol. 2010 Aug; 150(3):345-51. Cited in PubMed: PMID 20528871. Read the abstract 

Seif AE, Reilly AF, Rheingold SR. Intrathecal liposomal cytarabine in relapsed or refractory infant and pediatric leukemias: The Children's Hospital of Philadelphia experience and review of the literature. J Pediatr Hematol Oncol. 2010 Nov; 32(8): e349-52. Cited in PubMed: PMID 20962675. Read the abstract

2009

Seif AE, Barrett DM, Milone M, Brown VI, Grupp SA, Reid GSD. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood. 2009; 114(12):2459-66. Read the abstract

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