Robert E. Shaddy, MD

Robert E. Shaddy, MD, is chief of the Division of Cardiology and the Jennifer Terker Endowed Chair in Pediatric Cardiology at CHOP.

Locations: Main Campus
Phone: 215-590-4040

  • Background

    Robert E. Shaddy, MD, is Chief of the Division of Cardiology at The Children’s Hospital of Philadelphia and holds the Jennifer Terker Endowed Chair in Pediatric Cardiology. He is Professor of Pediatrics and Vice Chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

    Dr. Shaddy brings more than 25 years of experience as a cardiologist caring for children with heart failure to his role as one of the leaders of the transplant program. The team includes more than 20 doctors, nurse practitioners, social workers, physical therapists and others, all with expertise in transplant patients. Dr. Shaddy has been conducting research into pediatric heart failure and transplantation since the beginning of his career and today is a nationally recognized expert. He lectures on heart failure, heart transplantation and other topics at conferences around the country and the world, and is a member of the International Pediatric Transplant Association, the Society for Pediatric Research, and numerous other professional societies.

    Dr. Shaddy’s extensive research encompasses such topics as the use of echocardiography and other imaging in pediatric heart patients; the effectiveness of certain pharmaceutical drugs in treating heart failure in children; transplant coronary artery disease; the use of ventricular assist devices in pediatric patients; and more.

    He has published more than 120 articles in such journals as Pediatrics, Pediatric Cardiology, Pediatric Transplantation, The Journal of the American Medical Association, Circulation and The Journal of Thoracic and Cardiovascular Surgery. He has authored or co-authored 15 book chapters for textbooks used by medical students and practicing physicians, and authored or co-authored three books about heart defects and heart failure.

    Dr. Shaddy received a bachelor’s degree in psychology from Boston College, Chestnut Hill, Mass., and his medical degree from Creighton University School of Medicine, Omaha, Neb. He completed an internship and a residency in pediatrics at the University of Iowa Hospitals and Clinics, Iowa City, Iowa, and a fellowship in pediatric cardiology at the Cardiovascular Research Institute, University of California, San Francisco.

  • Education and Training

    Medical School

    Creighton University School of Medicine, Omaha, Neb.

    Internship

    University of Iowa Hospitals and Clinics, Iowa City, Iowa

    Residency

    University of Iowa Hospitals and Clinics, Iowa City, Iowa

    Fellowship

    Cardiovascular Research Institute, San Francisco, Cal.

    Board Certification

    American Board of Pediatrics
    American Board of Pediatrics/Pediatric Cardiology

  • Titles and Academic Titles

    Chief, Division of Cardiology

    Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Management of chronic heart failure in children
    Pediatric heart transplantation
    Immunology of valved allografts

  • Publications

    Books

    Chapters

    Shaddy RE, McIntyre T, Prescott S, ZimmermanGA. The role of the endothelium in transplant rejection. In: Hammond EH, ed. The Pathology of Solid Organ Transplantation. Philadelphia: W.B. Saunders Co., 1994: 35-49.

    Allen HD, Gutgesell HP, Clark EB, Driscoll DJ, eds. Moss and Adams' Heart Disease in Infants, Children, and Adolescents — Including the Fetus and Young Adult, 6th edition Philadelphia: Lippincott Williams & Wilkins, 2000:395-407.

    Shaddy RE. Restrictive cardiomyopathy. In: Pediatrics: An On-line Medical Reference. 1st Edition. St. Petersburg. Emedicine Online Textbooks. Ed. Steven Altschuler et al. 1999. Emedicine.com, Inc. www.emedicine.com/PED/topic2503.htm

    Shaddy RE, Jackson WD. Nutrition and Cardiac Disease. AmericanAcademy of Pediatrics Nutrition Handbook (5th Edition). 736-55, 2003.

    Shaddy RE. Beta-adrenergic blockade. In: Chang AC and Towbin JA, eds. Heart Failure in Children and Young Adults: From Molecular Mechanisms to Medical and Surgical Strategies. Philadelphia. Saunders Elsevier, Inc. 509-16.

    Shaddy RE. Medical Management Of Chronic Left Ventricular Dysfunction In Children. In: Shaddy RE and Wernovsky G, eds. Pediatric Heart Failure. Taylor And Francis Group Publishers. Boca Raton, FL, 2005: 589-620.

    Tani LY and Shaddy RE. Inflammatory Causes of Heart Failure in Children: Rheumatic Fever and Kawasaki Disease. In: Shaddy RE and Wernovsky G, eds. Pediatric Heart Failure. Taylor And Francis Group Publishers. Boca Raton, FL, 2005: 371-432

    Shaddy RE. Restrictive cardiomyopathy. In: Pediatrics: An On-line Medical Reference. 2nd Edition. St. Petersburg. Emedicine Online Textbooks. Ed. Steven Altschuler et al. 2005. Emedicine.com, Inc. www.emedicine.com/PED/topic2503.htm

    Shaddy RE, Jackson WD. Nutrition and Cardiac Disease. AmericanAcademy of Pediatrics Nutrition Handbook (6th Edition). In Press

    Shaddy RE, Tani LY. Chronic Congestive Heart Failure. In Allen HD, Driscoll DJ, Shaddy RE, Feltes T, eds. Moss and Adams' Heart Disease in Infants, Children, and Adolescents, Including the Fetus and Young Adult, 7th Edition. Lippincott, Williams and Wilkins. Philadelphia. In Press

    Boucek MM, Shaddy RE, Parisi F. Pediatric Heart and Heart-Lung Transplantation. In Allen HD, Driscoll DJ, Shaddy RE, Feltes T, eds. Moss and Adams' Heart Disease in Infants, Children, and Adolescents, Including the Fetus and Young Adult, 7th Edition. Lippincott, Williams and Wilkins. Philadelphia. In Press

    Shaddy RE, Penny DN. Chronic Heart Failure: Physiology and Treatment. In Anderson RH, Baker EJ, Penny DH, Redington AN, Wernovsky G,, eds. Paediatric Cardiology, 3rd Edition. Elsevier. In Press.

    Monographs:

    Shaddy RE. Special Immunologic Issues in Pediatric Heart Transplantation: ABO-Incompatible Heart Transplantation, and Evaluation and Management of HLA Antibodies (J Heart Lung Transplant, In Press)

    Books:

    Shaddy RE and Wernovsky G, eds. Pediatric Heart Failure. Taylor And Francis Group Publishers. Boca Raton, FL, 2005

    Allen HD, Driscoll DJ, Shaddy RE, Feltes T, eds. Moss and Adams' Heart Disease in Infants, Children, and Adolescents, Including the Fetus and Young Adult, 7th Edition. Lippincott, Williams and Wilkins. Philadelphia. In Preparation.

    Abstracts

    Shaddy RE, Lambert LM, Fuller TC, Profaizer T, Thompson DD, Baker S, Osborne KA, Hawkins JA. A prospective, randomized trial of azathioprine in children receiving cryopreserved valved allografts for repair of congenital heart defects. J Am Coll Cardiol 35:502A, 2000. (Poster presentation by Shaddy at 49th Annual Scientific Session, American College of Cardiology, Anaheim, CA, 3/00)

    Shaddy RE, Minich LL, Tani LY, Orsmond GS, DiRusso GB, Hawkins JA. Intra-aortic balloon pumping in children with dilated cardiomyopathy as bridge to transplantation. J Heart Lung Transplant 19:63, 2000. (Poster presentation by Shaddy at International Society of Heart and Lung Transplantation Annual Mtg, Osaka, Japan, 4/00)

    Tani LY, Minich LL, Veasy LG, Williams RV, Shaddy RE. Natural history of clinically "silent" doppler-detected valvular regurgitation in rheumatic fever. J Am Soc Echocardiogr 13:507, 2000. (Presented by Tani at the 11th Annual Scientific Sessions of the American Society of Echocardiography, 6/00)

    Tuohy AM, Tani LY, Shaddy RE, Breinholt JP, Minich LL. Complete Follow-up Echocardiograms are needed to detect stenosis of normally connecting pulmonary veins. J Am Soc Echocardiogr 13:444, 2000. (Presented by Breinholt at the 11th Annual Scientific Sessions of the American Society of Echocardiography, 6/00)

    Tuohy AM, Minich LL, Frank DU, Shaddy RE, Tani LY. Which Echocardiograms are Necessary for Follow-up Evaluation of Patients with Kawasaki Disease? J Am Soc Echocardiogr 13:443, 2000. (Presented by Tuohy at the 11th Annual Scientific Sessions of the American Society of Echocardiography, 6/00)

    Frank DU, Minich LL, Shaddy RE, Tani LY. Is doppler an accurate predictor of cath gradients for postoperative branch pulmonary stenosis? J Am Soc Echocardiogr 13:444, 2000. (Presented by Frank at the 11th Annual Scientific Sessions of the American Society of Echocardiography, 6/00)

    Williams RV, Tani LY, Shaddy RE. Comparison of the intermediate effects of metoprolol versus carvedilol in children with decreased left ventricular systolic function. Pediatr Cardiol 21:593, 2000 (Oral presentation by Williams at the American Academy of Pediatrics Annual Mtg, Chicago, Il, 10/00)

    Williams RV, Shaddy RE, Minich LL, Pagotto LT, Tani LY. Doppler evaluation of pulmonary regurgitation: comparison to angiography. Circulation (Oral presentation by Williams at the American Academy of Pediatrics Annual Mtg, Chicago, Il, 10/00)

    Tani LY, Minich LL, Francis J, Veasy LG, Shaddy RE. Is the presentation of rheumatic fever different for children younger than 5 years of age? Pediatr Cardiol 21:592, 2000 (Oral presentation by Tani at the American Academy of Pediatrics Annual Mtg, Chicago, Il, 10/00)

    Williams RV, Shaddy RE, Minich LL, Pagotto LT, Tani LY. Doppler evaluation of pulmonary regurgitation: comparison to angiography. Circulation (Suppl II) 102:II-772-3 (Oral presentation by Williams at the AHA Annual Mtg, New Orleans, LA, 11/00).

    Williams RV, Minich LL, Shaddy RE, Veasy LG, Tani LY. Cardiac Troponin I in acute rheumatic carditis. J Am Coll Cardiol 37:462A, 2001. (Poster presentation by Williams at the 50th Annual Scientific Session, AmericanCollege of Cardiology, Orlando, Fl, 3/01).

    Balfour I, Naftel D, Fricker J, Friedman B, Frazier E, Shaddy R, Kirklin J, Morrow W. Interaction of volume and era on survival of children listed for cardiac transplantation. J Heart Lung Transplant 20:262, 2001. (Oral presentation by Balfour at International Society of Heart and Lung Transplantation Annual Mtg, Vancouver, BCCanada, 4/01)

    Etheridge SE, Shaddy RE. QT dispersion after beta-blocker therapy in children with heart failure. Pediatr Res 49:36A, 2001. (Poster presentation by Etheridge at Annual Mtg of the Society for Pediatric Research, Baltimore, 4/01)

    Williams RV, Shaddy RE, Tani LY, Taggart EW, Byington CL. Are cardiac troponin I levels elevated in infants with enteroviral infections? Pediatr Res 49:40A, 2001.

    Tani LY, Minich LL, Paul JJ, Williams RV, Pagotto LT, Shaddy RE. Does remodeling occur in children with left ventricular dysfunction? J Am Soc Echocardiogr 14:430,2001. (Oral presentation by Tani at the 12th Annual Scientific Sessions of the American Society of Echocardiography, 6/01)

    Paul JJ, Minich LL, Shaddy RE, Tani LY. Spectrum of ventricular dysfunction in potential pediatric organ donors. Pediatr Cardiol 22:440, 2001 (Oral presentation by Paul at American Academy of Pediatrics Annual Mtg, San Francisco, 10/01)

    Bradley JD, Cowley CG, Shaddy RE. Initial experience with plasma B-type natriuretic peptide (BNP) levels in children with heart disease. J Investigat Med 50:8A, 2002 (Oral presentation by Bradley at the Western Society for Pediatric Research Annual Mtg, Carmel, CA, 2/02)

    Cowley CG, Bradley JD, Shaddy RE. Plasma B-type natriuretic peptide in children with heart disease. Pediatr Res 51:37A, 2002. (Poster presentation by Cowley at Annual Mtg of the Society for Pediatric Research, WashingtonDC, 4/02)

    Lozier JS, Cowley CG, Day RW, Orsmond GS, Shaddy RE. Safety of endomyocardial biopsy in pediatric patients. Catheter Cardiovasc Intervent 56:155, 2002. (Poster presentation by Lozier at the Annual Mtg of the Society for Cardiac Angiography and Interventions, SeattleWA, 5/02)

    Hawkins JA, Hillman ND, Lambert LM, Jones J, Di Russo GB, Profaizer T, Fuller TC, Minich LL, Williams RV, Shaddy RE. Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allografts. (Oral presentation by Hawkins at the 82nd Annual Meeting of the American Association for Thoracic Surgery, Washington, DC, 5/02)

    Cowley CG, Orsmond GS, McQuillan L, Feola P, Shaddy RE. Long-term comparison of balloon angioplasty and surgery for native coarctation of the aorta. Pediatr Cardiol 23:680-1, 2002. (Oral presentation by Cowley at American Academy of Pediatrics Annual Mtg, Boston, MA, 10/02).

    Cowley CG, Bradley JD, Shaddy RE. Plasma B-type natriuretic peptide levels in children with left ventricular outflow tract obstruction. Pediatr Cardiol 23:671, 2002 (Oral presentation by Cowley at American Academy of Pediatrics Annual Mtg, Boston, MA, 10/02)

    The incidence and impact of transplant coronary artery disease in pediatric recipients: a 9-year multi-institutional study. Circulation 106:II-396, 2002 (Oral presentation by Pahl at 75th Annual AHA Scientific Sessions. Chicago, IL, 11/02)

    Shaddy RE, Fuller TC, Anderson JB, Lambert LM, Brinkman MK, Profaizer T, Hawkins JA. Mycophenolic mofetil reduces the alloimmune response of children to surgical valved allograft implantation. J Heart Lung Transplant 22:S214-5, 2003. (Oral presentation by Shaddy at International Society of Heart and Lung Transplantation Annual Mtg, Vienna, Austria, 4/03)

    Anderson JB, Hawkins JA, Fuller TC, Lambert LM, Brinkman M, Profaizer T, Shaddy RE. Effect of mycophenolic mofetil on the alloimmune response of children to cryopreserved allograft implantation. Pediatr Res 53:38A, 2003. (Oral presentation by Anderson at Annual Mtg of the Society for Pediatric Research, Seattle, WA 5/03)

    Kefalopoulos GW, Williams RV, Tani LY, Shaddy RE. Assessment of heart failure in children following repair of conotruncal defects. Pediatr Cardiol 24:615, 2003 (Oral presentation by Kefalopoulos at American Academy of Pediatrics Annual Mtg, New Orleans, LA, 10/03)

    Schwartz SM, Gajarski R, Shaddy R, VanVliet T, Bogenschutz L, King K, Liggett SB, Goins S, Lynch R, Dorn GW. Alpha2B-adrenergic receptor ID polymorphism affects vasopressor use after Norwood procedure. Circulation 108:IV-466, 2003. (Poster presentation by Schwartz at 76th Annual AHA Scientific Sessions, Orlando, FL 11/03).

    Tani LY, Veasy LG, Minich LL, Francis J, Pollard H, Shaddy RE. Clinical and echocardiographic findings at presentation predict the development of rheumatic heart disease. Circulation 108:IV-536, 2003. (Oral presentation by Tani at 76th Annual AHA Scientific Sessions, Orlando, FL 11/03).

    Mahle WT, NaftelDC, Rusconi P, Edens RE, Shaddy RE. Panel-reactive antibody cross-reactivity and outcomes in the pediatric heart transplant study group. J Heart Lung Transplant 23:S167, 2004. (Oral presentation by Mahle at International Society of Heart and Lung Transplantation Annual Mtg, San Francisco, CA, 4/04).

    Hooper DK, Hawkins JA, Fuller TC, Profaizer T, Shaddy RE. Prospective follow-up of panel reactive antibodies in children 5 years following implantation of cryopreserved allografts. J Heart Lung Transplant 23:S167, 2004. (Oral presentation by Hooper at International Society of Heart and Lung Transplantation Annual Mtg, San Francisco, CA, 4/04).

    JB, Fuller TC, Hawkins JA, Brinkman M, Shaddy RE. Long-term reduction of panel reactive HLA antibodies in children receiving mycophenolate mofetil after valved allograft placement. Pediatr Res 57:2460, 2005. (Poster presentation by Anderson at Annual Mtg of the Society for Pediatric Research, Washington, DC 5/05).

    Vulevic B, Cowley C, Berry J, Hawkins J, Shaddy R. Prognostic value of BNP levels in patients undergoing surgical palliation of single ventricle congenital heart disease. Pediatr Res 57:2446, 2005. (Poster presentation by Vulevic at Annual Mtg of the Society for Pediatric Research, Washington, DC 5/05).

    Shaddy R, Boucek M, Hsu D, Boucek R, Canter C, Mahony L, Ross R, Pahl E, Blume E, Dodd D, Rosenthal D, Tani L. Multicenter, randomized, placebo-controlled double-blind trial of carvedilol in children with heart failure. Late-Breaking Clinical Trials JACC Supplement D: 47 (11), D18-19, 2006. (Oral presentation by Shaddy at the 55th Annual Scientific Session, American College of Cardiology, Atlanta, GA, 3/06).

    Price JF, Blume ED, Kanto PF, Lamour JM, Shaddy RE, Towbin JA. Clinical characteristics, treatment and outcomes of children hospitalized with heart failure: Rationale, methods and pilot data for the Pediatric Acute Decompensated Heart Failure (PEDEHEF) Study. Pediatr Cardiol. (Poster presentation at the Second International Conference on Heart Failure in Children and Young Adults. Laguna Nigel, CA, 11/06)

    Papers

    2010

    O'Connor MJ, Rosenthal DN, Shaddy RE. Outpatient management of pediatric heart failure. Heart Fail Clin. 2010 Oct;6(4):515-29, ix. Read abstract.

    Petko C, Minich LL, Everitt MD, Holubkov R, Shaddy RE, Tani LY. Echocardiographic Evaluation of Children With Systemic Ventricular Dysfunction Treated With Carvedilol. Pediatr Cardiol. 2010 Apr 14. [Epub ahead of print]. Read abstract.

    Shaddy RE, Denne SC; Committee on Drugs and Committee on Pediatric Research. Clinical report — guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations. Pediatrics. 2010 Apr;125(4):850-60. Epub 2010 Mar 29. Read abstract.

    Petko C, Minich LL, Everitt MD, Holubkov R, Shaddy RE, Tani LY. Echocardiographic Evaluation of Children With Systemic Ventricular Dysfunction Treated With Carvedilol. Pediatr Cardiol. 2010 Apr 14. Read abstract.

    Clinical report: guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations. Shaddy RE, Denne SC; Committee on Drugs and Committee on Pediatric Research. Pediatrics. 2010 Apr;125(4):850-60. Epub 2010 Mar 29. Read abstract.

    Auerbach SR, Richmond ME, Lamour JM, Blume ED, Addonizio LJ, Shaddy RE, Mahony L, Pahl E, Hsu DT. BNP Levels Predict Outcome in Pediatric Heart Failure Patients: Post-hoc Analysis of the Pediatric Carvedilol Trial. Circ Heart Fail. 2010 Jun 23.

    Burch PT, Kaza AK, Lambert LM, Holubkov R, Shaddy RE, Hawkins JA. Clinical performance of decellularized cryopreserved valved allografts compared with standard allografts in the right ventricular outflow tract. Ann Thorac Surg. 2010 Oct;90(4):1301-5; discussion 1306. Read abstract.

    Foerster SR, Canter CE, Cinar A, Sleeper LA, Webber SA, Pahl E, Kantor PF, Alvarez JA, Colan SD, Jefferies JL, Lamour JM, Margossian R, Messere JE, Rusconi PG, Shaddy RE, Towbin JA, Wilkinson JD, Lipshultz SE. Ventricular Remodeling and Survival Are More Favorable for Myocarditis Than For Idiopathic Dilated Cardiomyopathy in Childhood: An Outcomes Study From the Pediatric Cardiomyopathy Registry. Circ Heart Fail. 2010 Nov 1;3(6):689-697. Epub 2010 Sep 10. Read abstract.

    Auerbach SR, Richmond ME, Lamour JM, Blume ED, Addonizio LJ, Shaddy RE, Mahony L, Pahl E, Hsu DT. BNP levels predict outcome in pediatric heart failure patients: post hoc analysis of the Pediatric Carvedilol Trial. Circ Heart Fail. 2010 Sep 1;3(5):606-11. Epub 2010 Jun 23. Read abstract.