Joseph W. St. Geme, MD

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Background

    Joseph W. St. Geme III, MD, received his bachelor’s degree from Stanford University, Stanford, CA, and his medical degree from Harvard Medical School, Boston, MA. He completed a pediatric residency and chief residency at The Children’s Hospital of Philadelphia and pursued postdoctoral training in microbiology and infectious diseases at Stanford University.

    From 1992 to 2005, Dr. St. Geme was a member of the faculty in the Department of Pediatrics and the Department of Molecular Microbiology at Washington University in St. Louis, MO. There he served as director of pediatric infectious diseases and co-leader of the Pediatric Infection, Immunity and Inflammation Research Unit. In 2005, Dr. St. Geme was recruited to Duke University, Durham, NC, where he was the James B. Duke professor and chairman of pediatrics, the chief medical officer of Duke Children’s Hospital, and a professor of molecular genetics and microbiology.

    In 2013, Dr. St. Geme relocated to Philadelphia to assume new responsibilities as the chairman of the Division of Pediatrics and physician-in-chief at The Children’s Hospital of Philadelphia. In addition, he is also chairman of Pediatrics and professor of pediatrics and microbiology at the Perelman School of Medicine at the University of Pennsylvania.

    Dr. St. Geme has an active laboratory research program that focuses on the molecular basis of host-pathogen interactions involving pathogenic bacteria, with particular emphasis on Haemophilus influenzae and Kingella kingaeHaemophilus influenzae is common in the nasopharynx and is the leading cause of otitis media and sinusitis in children, and exacerbations of chronic obstructive pulmonary disease in adults.Kingella kingae is common in the posterior pharynx and has emerged as a major cause of bone and joint infections in young children.

    Dr. St. Geme and his research team are using genetic methods, protein chemistry, X-ray crystallography, high-resolution microscopy, microarray analysis, and cell biology approaches to study the molecular and cellular determinants of Haemophilus influenzae and Kingella kingae disease, aiming to understand how these organisms:

    1. Initiate infection
    2. Establish a state of commensalism
    3. Transition from a state of commensalism to produce disease

    The team's long-term goals are to identify common mechanisms in bacterial pathogenesis and to develop new antimicrobials with activity against a wide range of pathogenic gram-negative bacteria.

    Dr. St. Geme has been elected to the Society for Pediatric Research, the American Pediatric Society, the American Society for Clinical Investigation, the Association of American Physicians, the American Academy of Microbiology, the American Association for the Advancement of Science, and the Institute of Medicine.

  • Education and Training

    Medical School

    MD - Harvard Medical School, Boston, MA

    Internship

    Pediatrics — The Children's Hospital of Philadelphia, Philadelphia, PA

    Residency

    Pediatrics — The Children's Hospital of Philadelphia, Philadelphia, PA (Chief Resident)

    Additional Training

    Postdoctoral Fellow, Department of Microbiology and Immunology — Stanford University, Stanford, CA
    Postdoctoral Fellow, Department of Pediatrics, Division of Infectious Diseases — Stanford University, Stanford, CA

    Board Certification

    Pediatrics
    Pediatric Infectious Diseases

  • Titles and Academic Titles

    Chairman of the Department of Pediatrics

    Leonard and Madlyn Abramson Professor, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests
    • Host-bacterial interactions
    • Haemophilus influenzae pathogenicity
    • Haemophilus influenzae vaccine development
    • Bacterial protein secretion
    • Innate immune mechanisms
    • Kingella kingae pathogenicity
    • Haemophilus cryptic genospecies pathogenicity
  • Publications

    Papers

    Spahich NA, Kenjale R, McCann J, Meng G, Ohashi T, Erickson H, St Geme JW. Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin. Microbiology. 2014 Mar 31.

    McCann JR, Sheets AJ, Grass S, St Geme JW 3rd. The Haemophilus cryptic genospecies Cha adhesin has at least two variants that differ in host cell binding, bacterial aggregation, and biofilm formation properties. J Bacteriol. 2014 May;196(9):1780-8.

    Starr KF, Porsch EA, Heiss C, Black I, Wang Z, Azadi P, St. Geme JWIII. Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide. PLoS One. 2013 Sep 30;8(9):e75409

    Porsch EA, Johnson MDL, Broadnax AD, Garrett CG, Redinbo MR, St. Geme JWIII. Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility. J Bacteriol. 2013 Feb;195(4):886-95

    Porsch EA, Kehl-Fie TE, St. Geme JWIII. Modulation of Kingella kingae adherence to human epithelial cells by type IV pili, capsule, and a novel trimeric autotransporter. mBio, 2012;3(5):00372.

    Spahich NA, Hood DW, Moxon ER, St. Geme JWIII. Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter. J Bacteriol. 2012 Apr;194(7):1815-22.