Charles A. Stanley, MD

Areas of Expertise: Research in hyperinsulinism
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Background

    Charles A. Stanley, MD, is the medical director of the Congenital Hyperinsulinism Center at The Children's Hospital of Philadelphia and a professor emeritus of pediatrics at the Perelman School of Medicine at the University of Pennsylvania. He is a past-president of the Pediatric Endocrine Society (formerly named in honor of Lawson Wilkins) and currently serves on the Awards Committee.

    Dr. Stanley is a world- renowned expert on disorders of insulin regulation in children. He has helped define the various types of hyperinsulinism (HI) and pioneered best practices for diagnosis and treatment of congenital HI.

    Research into the genetic causes of HI (hypoglycemia caused by high levels of insulin in the blood) is an area Dr. Stanley is particularly passionate about. His laboratory is currently supported by a prestigious MERIT award from the NIH.

    “Genetic diagnosis will enable physicians to determine with greater accuracy and speed which babies have the best chance of cure by surgical treatment,” he says.

    Under Dr. Stanley’s mentorship, researchers were able to identify specific mutations in GLUD1, the gene that causes the hyperinsulinism/hyperammonemia (HI/HA) syndrome.

    Under Dr. Stanley’s direction, CHOP’s HI program is one of few in the world that offers qualified patients a special positron emission tomography (PET) scan under research protocols. The 18F-DOPA PET scan helps the medical team distinguish between diffuse HI (spread throughout the pancreas) or focal HI (concentrated in one spot). For children with focal HI, the scan acts as a roadmap which allows the surgeon to remove only the affected part of the child’s pancreas and to cure the patient’s hyperinsulinism while minimizing the chance of diabetes.

    Dr. Stanley has published numerous articles in journals such as The New England Journal of Medicine, Journal of Pediatrics, Diabetes, Journal of Clinical Endocrinology and Metabolism, and The Journal of Biological Chemistry. He was recently co-editor of Monogenic Hyperinsulinemic Hypoglycemia Disorders, volume 21 of “Frontiers in Diabetes.” Additionally, Dr. Stanley has served as an editorial board member, guest editor and reviewer for more than a dozen medical journals.

    In conjunction with his published work, Dr. Stanley has also lectured extensively around the world about the causes and treatment of congenital hyperinsulinism and hypoglycemia (low blood sugar) in neonates and young children. He coordinated two international symposia where thought-leaders converged in Philadelphia to share their research and develop collaborations in the area of congenital hyperinsulinism and monogenic forms of diabetes.

    Dr. Stanley earned his bachelor's degree in biochemical sciences from Harvard University, Cambridge, MA, and his medical degree from the University of Virginia School of Medicine, Charlottesville, VA. He completed his residency in pediatrics and a fellowship in metabolic diseases, both at The Children’s Hospital of Philadelphia, Philadelphia, PA.
     

  • Education and Training

    Medical School

    MD - University of Virginia School of Medicine, Charlottesville, VA

    Residency

    Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

    Fellowship

    Metabolic Diseases - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Pediatric Endocrinology
    Pediatrics

  • Titles and Academic Titles

    Pediatric Endocrinologist

    Emeritus Professor CE of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

  • Conditions Treated
  • Centers and Programs
  • Publications

    Books

    Charles A. Stanley and Diva D. De Leon (Eds): Monogenic Hyperinsulinemic Hypoglycemia Disorders. Frontiers in Diabetes. Karger, 21, Feb 2012.

    Chapters

    2014

    De León DD, and Stanley CA: Permanent Neonatal Diabetes Mellitus. GeneReview. Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Smith RJH, Stephens K (eds.). GeneReviews™ [Internet]. Updated, Jan 23 2014.

    2013

    Blomberg BA, Moghbel MC, Saboury B, Stanley CA, Alavi A.: The value of radiologic interventions and (18)F-DOPA PET in diagnosing and localizing focal congenital hyperinsulinism: systematic review and meta-analysis. Mol Imaging Biol 15(1): 97-105, Feb 2013.

    De Leon DD, Stanley CA: Determination of insulin for the diagnosis of hyperinsulinemic hypoglycemia. Best Practice & Research Clinical Endocrinology & Metabolism 27(6): 763-769, Dec 2013.

    De Leon DD, Thornton PS, Stanley CA, Sperling MA: Hypoglycemia in Neonates and Infants. Pediatric Endocrinology, 4th Edition. Mark A. Sperling (eds.). Saunders, 2013.

    De Leon DD, Stanley CA: Hypoglycemia. Contemporary Endocrinology. Sally Radovick (eds.). Springer, 2013.

    Kelly A, Stanley CA: Hyperinsulinism. Pediatric Endocrinology and Inborn Errors of Metabolism, 2nd Edition. Sarafoglou K, Roth KS, Hoffmann GF (eds.). 2013.

    Langdon DR, Stanley CA, Sperling MA.: Hypoglycemia in the Infant and Child. Pediatric Endocrinology, 4th Edition. Mark A. Sperling (eds.). Saunders, 2013.

    Stanley CA: Congenital Hyperinsulinism. Clinical Decision Support: Pediatrics. Bonney, McMillan, Barrett, Jones (eds.). Decision Support in Medicine, LLC, 2013 Notes: online publication.

    Stanley CA, Palmieri F, Bennett MJ: Disorders of the Mitochondrial Carnitine Shuttle. Online Molecular and Metabolic Basis of Inherited Disease. Valle D, Vogelstein B, Kinzler KW, Antonarakis SE, Ballagio A, Gibson KM, Mitchell G (eds.). McGraw Hill, Part 10:2013, 2013.

    2012

    Stanley CA, Matschinsky FM. Historical perspective on the genetic forms. In: Stanley CA, De Leon DD, editors. Monogenic hyperinsulinemic hypoglycemia disorders. Basel (Switzerland): S. Karger AG; 2012. p. 1-6. (Frontiers in diabetes; vol. 21).

    Sayed S, Matschinsky FM, Stanley CA. Hyperinsulinism due to activating mutations of glucokinase. In: Stanley CA, De Leon DD, editors. Monogenic hyperinsulinemic hypoglycemia disorders. Basel (Switzerland): S. Karger AG; 2012. p. 146-57. (Frontiers in diabetes; vol. 21).

    Li C, Matschinsky FM, Stanley CA.  Amino acid-stimulated insulin secretion: the role of the glutamine-glutamate-alpha-ketoglutarate axis. In: Stanley CA, De Leon DD, editors. Monogenic hyperinsulinemic hypoglycemia disorders. Basel (Switzerland): S. Karger AG; 2012. p. 112-124. (Frontiers in diabetes; vol. 21).

    Kelly A, Palladino A, Stanley CA. Congenital hyperinsulinism due to activating mutations of glutamate dehydrogenase: the hyperinsulinism/hyperammonemia syndrome. In: Stanley CA, De Leon DD, editors. Monogenic hyperinsulinemic hypoglycemia disorders. Basel (Switzerland):S.  Karger AG; 2012. p. 100-11. (Frontiers in diabetes; vol. 21).

    De Leon DD, Stanley CA:. Pathophysiology of diffuse ATP-sensitive potassium channel hyperinsulinism.  In: Stanley CA, De Leon DD, editors. Monogenic hyperinsulinemic hypoglycemia disorders. Basel (Switzerland): S. Karger AG; 2012. p. 18-29. (Frontiers in diabetes; vol. 21).

    2011

    Stanley CA, Bennett MJ. Disorders of mitochondrial fatty acid beta-oxidation. In: Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier Saunders; 2011. p. 456-62.

    Hardy OT, Stanley CA. Hypoglycemia. In: Polin RA, Fox, WW, Abman SH, editors. Fetal and neonatal physiology: expert consult. Philadelphia: Elsevier Health Sciences Division; 2011. p. 568-75.

    DeLeon D, Stanley CA. Hypoglycemia. In: Radovick S, MacGillivray MH, editors. Pediatric endocrinology: a practical clinical guide. 2nd ed. New York: Springer; 2011.

    2008

    Kelly A, Stanley CA. Hyperinsulinism. In: Sarafoglou K, editor. Pediatric endocrinology and inborn errors of metabolism. New York: McGraw Hill; 2008. p. 39-50.

    2007

    Stanley CA, Bennett MJ. Disorders of mitochondiral fatty acid oxidation. In: Kliegman RM, Behrman RE, Jenson HB, Stanton B, editors. Nelson textbook of pediatrics. 18th ed. Philadelphia: Saunders Elsevier; 2007. p. 567-72.

    2006

    Stanley CA, Bennett MJ, Mayatepek E. Disorders of mitochondrial fatty acid oxidation and related metabolic pathways. In: Fernandes J, Saudubray JM, van den Berghe G, Walter JH, editors. Inborn metabolic diseases: diagnosis and treatment. 4th ed. Heidelberg (Germany): Springer Medizin Verlag; 2006. p. 175-90.

    Hardy OT, Stanley CA. Hyperinsulinism of infancy: localization of focal forms. In: Charron M, editor. Practical pediatric PET imaging. New York: Springer; 2006. p. 479-84.

    DeLeon DD, Stanley CA. When to screen for neonatal hypoglycemia. In: Wildschut H, Weiner CP, Peters TJ, editors. When to screen in obstetrics and gynecology. 2nd ed. Philadelphia: Saunders Elsevier; 2006. p. 483-90.

    2005

    Katz LL, Stanley CA. Disorders of glucose and other sugars. In: Spitzer AR, editor. Intensive care of the fetus & neonate. 2nd ed. Philadelphia: Elsevier, Inc.; 2005. p.1167-78.

    2004

    Stanley CA, Pallotto EK. Disorders of carbohydrate metabolism. In: Taeusch HW, Ballard RA, Gleason CA, editors. Avery's diseases of the newborn. 8th ed. Philadelphia: WB Saunders; 2004. p. 1410-22.

    Stanley CA. Hypoglycemia. In: Kleigman RN, Greenbaum LA, Lye PS, editors. Practical strategies in pediatric diagnosis and therapy. 2nd ed. Philadelphia: Elsevier Saunders ; 2004. p. 1121-31. 

    Kelly A, Changhong L, Stanley CA. Glucokinase/glutamate dehydrogenase interactions in the GDH form of congenital hyperinsulinism. In: Matschinsky FM, Magnuson MA, editors. Glucokinase and glycemic disease: from basics to novel therapeutics. Basel (Switzerland): S. Karger AG; 2004. p. 110-24. (Frontiers in Diabetes; vol. 16).

    2003

    Stanley CA, Caplin N. Pathophysiology of hypoglycemia. In: Polin R, Fox W, Abman S, editors. Fetal and neonatal physiology. 3rd ed. Philadelphia: WB Saunders; 2003. p. 494-99.

    Stanley CA. Hypoglycemia. In: Radovick S, MacGillivray MH, editors. Pediatric endocrinology: a practical clinical guide. Totowa (NJ): Humana Press Inc.; 2003. p. 511-21.

    2002

    Thornton PA, Finegold DN, Stanley CA. Hypoglycemia in the infant and child. In: Sperling MA, editor. Pediatric endocrinology. Philadelphia: WB Saunders; 2002. p. 367-84.

    Stanley, CA, Thornton, PS, Finegold, DN, Sperling, MA. Hypoglycemia in neonates and infants.  In: Sperling MA, editor. Pediatric endocrinology. Philadelphia: WB Saunders; 2002. p. 135-159.

    2000

    Stanley CA. Disorders of fatty acid oxidation. In: Fernandes J, Saudubray JM, van den Berghe G, editors. Inborn metabolic diseases. 3rd ed. Heidelberg: Springer-Verlag; 2000. p. 139-50, 2000.

    Stanley CA. Hypoglycemia. In: Stockman JA, Lohr JA, editors. Essence of office pediatrics. Philadelphia: WB Saunders; 2000. p. 213.

    Stanley CA. Lethargy and vomiting in a 14 month-old boy. In: Burg FD, Vaughan VC, Nelson KG, editors. Pediatrics: a problem-based review.  Philadelphia: W.B. Saunders Company; 2000. p. 232-35.

    Stanley CA. Disorders of carbohydrate metabolism. In: Walker WA, Durie PR, Hamilton JR, Walker-Smith JA, Watkins JB, editors. Pediatric gastrointestinal disease. Philadelphia: Decker; 2000.

    1999

    Stanley CA. The hyperinsulinism-hyperammonemia syndrome: gain-of-function mutations of glutamate dehydrogenase. In: O'Rahilly S, Dunger DB, editors. Genetic insights in pediatric endocrinology and metabolism. Bristol (UK): BioScientifica, Ltd.; 1999. p. 23-30.

    Satin-Smith MS, Stanley CA. Hypoglycemia. In: Burg FD, Ingelfinger JR, Wald ER, Polin RA, editors. Gellis and Kagan's current pediatric therapy. 16th ed. Philadelphia: W.B. Saunders; 1999. p. 772-74.

    1998

    Stanley CA. Defects in metabolism of lipids. In:  Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Pediatrics. 16th ed. Philadelphia: Saunders; 1998.

    Stanley CA. Defects in metabolism of lipids. In: Altschuler S, Ludwig S, editors. Endocrinology.  McGraw-Hill Publishing; 1998. Chapter 72, 90, 94, 96, 98 Pediatrics at a Glance, 1998.

    Stanley CA. Neonatal carnitine metabolism. In: Cowett RM, editor. Principles of neonatal metabolism. 2nd ed. New York: Springer Verlaq; 1998. 

    Nestorowicz A, Stanley CA, Landau H, Glaser B, Permutt MA. Familial hyperinsulinism in Ashkenazi Jews. In: Desnick RJ, editor. Advances in Jewish genetic diseases. New York: Oxford University Press;1998.

    1995

    Katz L, Stanley CA. Disorders of glucose and other sugars. In: Spitzer AR, editor. Intensive care of the fetus and neonate. Philadelphia: Mosby - Yearbook; 1996. p. 982-92.

    Stanley CA. Carnitine/acylcarnitine translocase deficiency. In: Neurobase. Arbor Publishing Company; 1995.

    Stanley CA: Carnitine palmitoyl transferase-1 (CPT-1) deficiency. In: Neurobase. Arbor Publishing Company; 1995.

    Stanley CA: Medium-chain acyl-CoA dehydrogenase deficiency. In: Neurobase. Arbor Publishing Company; 1995.

    1994

    Stanley CA. Disorders of fatty acid oxidation. In: Fernandes J, Saudubray JM, Van Den Berghe T, editors. Inborn metabolic diseases: diagnosis and treatment. 2nd ed. Berlin (Germany): Springer-Verlag; 1994. p. 133-43.

    Stanley CA. Defects in metabolism of lipids: disorders of mitochondrial fatty acid oxidation. In: Behrman RE, Kliegman RM, Arvin AM, Nelson WE, editors. Nelson's textbook of pediatrics. 15th ed. Philadelphia: WB Saunders; 1994. p. 360-63.

    1992

    Thornton PS, Berry GT, Stanley CA. Disorders of intermediary metabolism: organ system failure. In: Holbrook P, editor. Pediatric critical care; 1992. p. 725-40.

    Stanley CA. Disorders of fatty acid oxidation. In:  Nelson's textbook of pediatrics. 14th ed. Philadelphia: W.B. Sauders; 1992. p. 336-38.

    1991

    Stanley CA. Disorders of carbohydrate metabolism. In: Durie PR, Hamilton JR, Walker-Smith JA, Watkins JB, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. Philadelphia: BC Decker; 1991. p. 936-43.

    Stanley CA: Neonatal carnitine metabolism. In: Cowett RM, editor. Principles of neonatal metabolism. New York: Springer Verlag; 1991. p. 465-71.

    1990

    Stanley CA: Disorders of fatty acid oxidation. In: Fernandes J, Bremer E, Saudubray JM, editors. Inborn metabolic diseases: diagnosis and treatment. New York: Springer Verlag; 1990. p. 394-410.

    Marx B, Stanley CA. Diabetes mellitus. In: Schwartz MW, Charney EB, Curry TA, Ludwig S, editors. Pediatric primary care. Chicago: Yearbook Medical Publishers; 1990. p. 423-29.

    1987

    Stanley CA. A 3-month old infant with a seizure. In: Clini-Pearls New York: Creative Medical Publications, Inc.; 1987. p. 1-4.

    Marx B, Stanley CA. Diabetes. In: Schwartz MW, Ludwig S, Curry TA, Charney EB, editors. Principles and practice of clinical pediatrics. Chicago: Yearbook Medical Publishers; 1987. p. 348-54.

    1985

    Stanley CA. Intragastric feeding in glycogen storage disease and other disorders of fasting. In: Walker WA, Watkins JB, editors. Nutrition in pediatrics. Boston: Little, Brown & Co; 1985. p. 781-94.

    1978

    Stanley CA, Baker L. Hypoglycemia. In: Kaye R, Oski F, Barness L, editors. Core textbook of pediatrics. Philadelphia: J.B. Lippincott Co.; 1978; p. 280-305.

    Baker L, Stanley CA. Diabetes in childhood. In:DeGroot l, Winegrad AI, editors. Endocrinology metabolic basis of clinical practice. New York: Grune and Stratton; 1978. p. 1057-60.

    1977

    Baker L, Stanley CA. Hyperinsulinism in infancy: a patho-physiologic approach to diagnosis and treatment. In: Chiumello G, editor. Rec Prog Pediatr Endocrinol. New York: Academic Press; 1977. p. 89-100.

    Abstracts

    2014

    Li CH, Patel P, Givler S, Liu CY, Matschinsky F, Naji A, Stanley CA, De Leon DD: Functional and Metabolic Evaluation of Islets from Infants with KATP Hyperinsulinism. 2014 Mid-Atlantic Diabetes Research Symposium, Poster presentation, NIH January 2014.

    Kalish JM, Boodhansingh K, Conlin LK, Bhatti T, Ganguly A, Bartolomei M, Palladino A, Adzick NS, Stanley CA, De Leon DD, Deardorff MA: The Spectrum of Hyperinsulinism in Mosaic Beckwith-Wiedemann Syndrome: Dissection of 11p15 Paternal Uniparental Isodisomy. Research Poster Day, Children's Hospital of Philadelphia Feb 2014.

    Bhatti T, Ganapathy K, Huppmann A, Conlin L, Ernst L, MacMullen C, Becker S, Ganaguly A, Stanley CA, Ruchelli E: Spectrum Of Histopathologic and Molecular Features Of Pediatric Insulinomas. 2014 Spring Symposium and Kroc Lecture, Institute for Diabetes, Obesity, and Metabolism, Perlman School of Medicine, University of Pennsylvania April 2014 Notes: This poster won the Outstanding poster award for patient-oriented research in the basic science category.

    Ferrara CT, Boodhansingh KE, Hughes N, Givler S, Ganguly A, Palmieri F, Stanley CA: Mitochondrial Uncoupling Protein 2 (UCP2) mutations underlying congenital hyperinsulinism (HI). 2014 Spring Symposium and Kroc Lecture, Institute of Diabetes, Obesity, and Metabolism, Perlman School of Medicine, University of Pennsylvania April 2014.

    Li CH, Misfeldt A, Patel P, Boodhansingh K, Palladino A, Bhatti TR, Adzick NS, Stanley CA, De Leon DD: KATP channel dysfunction in beta-cell leads to hypoglycemia in Beckwith-Wiedemann syndrome. American Diabetes Association 74th Annual Meeting for poster presentation, San Francisco June 2014.

    2013

    Ferrara CT,Stanley CA, Kelly A: Hyperinsulinism Profile: Emerging Biomarkers for Diagnosing Disease. Poster presentation. Pediatric Academic Society/Pediatric Endocrine Society Meeting, Washington, DC May 2013.

    Misfeldt AA, Freeze HH, Morava E, Ficicioglu C, Stanley CA : Hypoglycemia and Increased Insulin Secretion in a New Form of Glycogen Storage Disease Due to Phosphoglucomutase-1 Deficiency. Platform presentation. Pediatric Academic Society/Pediatric Endocrinology Society Meeting. Washington, DC May 2013.

    2012

    Laje P, States LJ, Becker SA, Palladino AA, Stanley CA, Adzick NS. Accuracy of PET/CT scan in the diagnosis of the focal form of congenital hyperinsulinism [abstract]. British Association of Pediatric Surgeons; 2012.

    States LJ, Becker S, Zhuang H, Adzick NS, Stanley CA. Detection of a focal lesion of congenital hyperinsulinism using 18[F]-DOPA PET/CT: lessons learned from 100 consecutive studies with histologic confirmation performed at the Children's Hospital of Philadelphia [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium,  The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA.

    Stanescu DE, Hughes N, Kaplan B, Stanley CA, De Leon DD. Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA.

    Snider KE, Ganguly A, Becker S, Boyajian L, Shyng SL, MacMullen C, et al.  Genotype-phenotype correlation in 440 children with congenital hyperinsulinism (HI) [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA. 

    Pinney SE, Ganapathy K, Bradfield J, Givler S, Becker S, Hughes N, et al. Novel form of autosomal dominant hyperinsulinism maps to chromosome 10q21 [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA. 

    Patel P, Li C, Givler S, Matschinsky F, Stanley CA, De Leon DD. Functional evaluation of islets from infants with KATP hyperinsulinism [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA. 

    Lord K, Snider K, MacMullen C, Becker S, Ganguly A, Stanley CA. "Missing" mutations: post-zygotic mosaicism in congenital hyperinsulinism [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA. 

    Li C, Patel P, Zhang T, Chen P, Givler S, Liu C, et al.  [U-13C]-glucose metabolism in islets from infants with KATP hyperinsulinism [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA.

    Kalish JM, Snider K, Conlin KL, Bhatti T, Ganguly A, Stanley CA, et al. The spectrum of hyperinsulinism in mosaic Beckwith-Wiedemann syndrome: dissection of 11p15 paternal uniparental isodisomy [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA. 

    Hughes N, Snider K, Carrie Coleman-Campbell C, Sayed S, Shen G, Boyajian L, et al. Mitochondrial uncoupling protein 2 (UCP2) mutations in CHOP hyperinsulinism (HI) patients [abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA.

    Conlin LK, Thiel BD, Mulchandani S, Kalish JM, Snider KE, Bhatti TR, et al. Detection and quantification of mosaic isodisomy in Beckwith-Wiedemann patients using SNP arrays {abstract]. Monogenic Disorders of Insulin Secretion: Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar 15-16; Philadelphia, PA. 

    2011

    Stanescu D, Hughes N, Kaplan B, Stanley CA, DeLeon DD. Novel presentations of congenital hyperinsulinism due to mutations in hepatocyte nuclear factor 1 and 4 alpha [abstract].  Eastern Society of Pediatric Research; 2011 Mar 25-27; Philadelphia, PA.

    Stanescu D, Hughes N, Kaplan B, Stanley CA, DeLeon DD. Novel presentations of congenital hyperinsulinism due to mutations in hepatocyte nuclear factor 1 and 4 alpha [abstract]. Pediatric Endocrine Society/PAS Meeting; 2011 Apr 30 - May 3; Denver, CO.

    Lord K, Snider K, MacMullen C, Becker S, Ganguly A, Stanley CA. Missing mutations: post-zygotic mosaicisim in congenital hyperinsulinism [abstract]. CHOP Research Poster Day, 2011 Feb; Philadelphia, PA.

    Lord K, Snider K, MacMullen C, Becker S, Ganguly A, Stanley CA. Missing mutations: post-zygotic mosaicisim in congenital hyperinsulinism [abstract]. Eastern Society for Pediatric Research Annual Meeting; 2011 Mar 25-27; Philadelphia, PA.

    Lord K, Snider K, MacMullen C, Becker S, Ganguly A, Stanley CA. Missing mutations: post-zygotic mosaicisim in congenital hyperinsulinism [abstract]. Pediatric Academic Societies Annual Meeting; 2011 Apr 30 - May 3;  Denver, CO.

    2010

    Schiffman A, Becker S, Langson D, Stanley CA. Insulinomas in childhood: twenty year experience at the Children's Hospital of Philadelphia [abstract]. ENDO Society; 2010 Jun 19-22; San Diego, CA.

    Papers

    2014

    Tegtmeyer LC, Rust S, van Scherpenzeel M, Ng BG, Losfeld ME, Timal S, Raymond K, He P, Ichikawa M, Veltman J, Huijben K, Shin YS, Sharma V, Adamowicz M, Lammens M, Reunert J, Witten A, Schrapers E, Matthijs G, Jaeken J, Rymen D, Stojkovic T, Laforet P, Petit F, Develaux I, Piraud M, Stanley CA, Matalon R, Burda P, Seyyedi S, Debus V, Socha P, Sykut-Cegielska J, van Spronsen F, de Meirleir L, Vajro P, DeClue T, Ficicioglu C,Wada Y, Wevers RA, Vanderschaeghe D, Callewaert N, Fingerhut R, van Schaftingen E, Freeze HH, Morava E, Lefeber DJ, Marquardt T: Multiple phenotypes in phosphoglucomutase 1 deficiency. New Eng J Med 370(6): 533-42, Feb 2014.

    Boodhansingh KE, Cresio A, De Leon DD, Stanley CA: A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child JPEM 2014 Notes: Accepted for Publication.

    2013

    Laje P, States LJ, Becker SA, Palladino AA, Stanley CA, Adzick NS: Accuracy of PET/CT Scan in the diagnosis of the focal form of congenital hyperinsulinism. J Pediatr Surg 48(2): 388-93, Feb 2013.

    Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A: Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by Gamma-Hydroxybutyrate and Glycine. J Biol Chem 288(6): 3938-51, Feb 2013.

    Snider K E, Becker S, Boyajian L, Shyng S-L, Macmullen C, Hughes N, Ganapathy K, Bhatti T, Stanley C A, Ganguly A: Genotype and Phenotype Correlations in 417 Children With Congenital Hyperinsulinism. J Clin Endocrinol Metab 98(2): E355-63, Feb 2013.

    Faletra F, Snider K, Shyng SL, Bruno I, Athanasakis E, Gasparini P, Dionisi-Vici, Ventura A, Zhou Q, Stanley CA, Burlina A: Co-inheritance of two ABCC8 mutations causing an unresponsive congenital hyperinsulinism: Clinical and functional characterization of two novel ABCC8 mutations. Gene 516(1): 122-5, Mar 2013.

    Huang T, Kelly A, Becker SA, Cohen MS, Stanley CA: Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism. Arch Dis Child Fetal Neonatal Ed. 98(4), Jul 2013 Notes: [Epub ahead of print]

    Laje P, Palladino AA, Bhatti TR, States LJ, Stanley CA, Adzick NS: Pancreatic surgery in infants with Beckwith-Wiedemann Syndrome and Hyperinsulinism. J Pediatr Surg 48(12): 2511-16, Dec 2013.

    Peranteau WH, Palladino AA, Bhatti TR, Becker SA, States LJ, Stanley CA, Adzick NS: The surgical management of insulinomas in children. J Pediatr Surg 48(12): 2517-24, Dec 2013.

    Pinney SE, Ganapathy K, Bradfield J, Stokes D, Sasson A, Mackiewicz K, Boodhansingh K, Hughes N, Becker S, Givler S, Macmullen C, Monos D, Ganguly A, Hakonarson H, Stanley CA.: Dominant Form of Congenital Hyperinsulinism Maps to HK1 Region on 10q. Horm Res Paediatr 80(1): 18-27, 2013.

    2012

    Palladino Andrew A, Chen Jie, Kallish Staci, Stanley Charles A, Bennett Michael J: Measurement of tissue acyl-CoAs using flow-injection tandem mass spectrometry: acyl-CoA profiles in short-chain fatty acid oxidation defects. Mol Genet Metab 107(4): 679-83, Dec 2012.

    Calabria AC, Li C, Gallagher PR, Stanley CA, De León DD. GLP-1 Receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel. Diabetes. Epub 2012 Aug 1. Cited in PubMed; PMID 22855730. Read the abstract

    Stanescu DE, Hughes N, Kaplan B, Stanley CA, De León DD. Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A. J Clin Endocrinol Metab. Epub 2012 Jul 16. Cited in PubMed; PMID 22802087.  Read the abstract

    Blomberg BA, Moghbel MC, Saboury B, Stanley CA, Alavi A. The value of radiologic interventions and (18)F-DOPA PET in diagnosing and localizing focal congenital hyperinsulinism: systematic review and meta-analysis. Mol Imaging Biol. Epub 2012 Jul 3. Cited in PubMed; PMID 22752652. Read the abstract

    Narayan SB, Master SR, Sireci AN, Bierl C, Stanley PE, Li C, et al. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PLoS One. 2012;7(4):e35048. Epub 2012 Apr 9. Cited in PubMed; PMCID: PMC3322157. Read the article 

    Laje P, Stanley CA, Palladino AA, Becker SA, Adzick NS. Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism. J Pediatr Surg. 2012 Jan;47(1):130-5. Cited in PubMed; PMID 22244405. Read the abstract

    Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, Sotiris J, et al. Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E87-E102. Epub 2011 Sep 27. Cited in PubMed; PMID 21952036. Read the abstract

    Posters and Presentations

    2012

    Abrams P, MacMullen C, De Leon D, Stanley CA. A case of late-onset hyperinsulinemic hypoglycemia worsened by exercise [poster presentation]. Pediatric Academic Society/Lawson Wilkins Pediatric Endocrine Society Meeting; 2010 May 1-4; Vancouver, BC.

    Stanley CA. Diagnosis and management of hypoglycemia in infants and children [presentation]. George H. Lowrey Lecture in Pediatric Endocrinology Grand Rounds, University of Michigan; 2012 Apr; Ann Arbor, MI.

    Stanley CA. Welcome, Introductions and symposium overview [presentation]. Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar; Philadelphia, PA.

    Stanley CA. KATP-channel hyperinsulinism variations [presentation]. Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar; Philadelphia, PA.

    Stanley CA. Glucokinase hyperinsulinism [presentation]. Congenital Hyperinsulinism and Neonatal Diabetes Symposium, The Children's Hospital of Philadelphia; 2012 Mar; Philadelphia, PA.

    Stanley CA. Perinatal stress hyperinsulinism [presentation]. Monogenic disorder of insulin secretion: management of glucose in the preterm infant. NEO Conference; 2012 Feb; Orlando, FL.

  • Editorial and Academic Positions

    Editorial Positions

    2013-present, FDA Endocrinology Metabolism Diabetes Advisory Committee
    1994-present, NIH Medical Biochemistry Study Section, Ad Hoc Reviewer
    1986-present, NIH Site Visitor, GCRC, Cincinnati
    1985-present, NIH Site Visitor, GCRC, Cleveland
    1983-present, NIH Site Visitor, GCRC, Duke University
    1981-present, NICHD Site Visitor, Cleveland, Ohio
    Associate Editor, Diabetes

    Academic and Institutional Committees

    1985-present, GCRC Advisory Committee (Ex officio)
    2000-present, DERC Executive Committee