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Andrei Thomas-Tikhonenko, PhD

Chief, Division of Cancer Pathobiology

Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Awards

2013-2017, Immunogenomics Pediatric Dream Team Investigator, Stand Up To Cancer - St. Baldrick's Foundation

2013, Ethel Brown Foerderer Fund for Excellence Award

2012, Department of Cancer Biology 4th Annual Award for Excellence in Teaching, Perelman School of Medicine at the University of Pennsylvania

2011-present, Mildred L. Roeckle Endowed Chair in Pathology at The Children's Hospital of Philadelphia

2010-2013, Innovation Award, Alex's Lemonade Stand Foundation

2005, Pfizer Award for Research Excellence, Pfizer Animal Health

2000-present, Honorary Member of the Phi Zeta Honor Society of Veterinary Medicine (Beta Chapter)

1999-2005, Elizabeth & William Whitney Clark Developmental Chair in Oncology, University of Pennsylvania

1997-2002, NIH FIRST Award

1994-1997, Special Fellow, Leukemia Society of America

1990, ICRETT Award (short-term exchange), International Union Against Cancer

Books

Cancer genome and tumor microenvironment. A.Thomas-Tikhonenko (eds.). Springer, 2009.

Chapters

2011

E.Sotillo-Pineiro and A.Thomas-Tikhonenko: Shielding the messenger (RNA): microRNA-based anticancer therapies. Pharmacology & Therapeutics 131(1): 18-32, July 2011 Notes: P&T TOP 25 HOTTEST ARTICLES April to June 2011.

E.Sotillo and A.Thomas-Tikhonenko: The long reach of non-coding RNAs. Nature Genet 43(7): 616-617, July 2011 Notes: Nature Genetics TOP CONTENT, July 2011.

2009

P.Sundaram, C.V.Dang, and A.Thomas-Tikhonenko: Myc and control of tumor neovascularization Cancer Genome and Tumor Microenvironment. A.Thomas-Tikhonenko (eds.). Springer New York, 2009.

Arturo Sala, Saverio Bettuzzi, Sabina Pucci, Olesya Chayka, Michael Dews, and Andrei Thomas-Tikhonenko: Regulation of CLU gene expression by oncogenes and epigenetic factors: Implications for tumorigenesis. Adv Cancer Res 105: 115-132. 2009.

A.Thomas-Tikhonenko: Hardwiring tumor progression Cancer Genome and Tumor Microenvironment. A.Thomas-Tikhonenko (eds.). Springer New York, 2009.

2008

A.Thomas-Tikhonenko and D.Cozma: PAX5 and B-cell neoplasms: transformation through presentation. Future Oncology 4(1): 5-9, Feb 2008.

2007

Chung, Elaine Y. Dews, Michael. Maity, Amit. Thomas-Tikhonenko, Andrei.: Aiding and ABT'ing Treatment for Glioblastoma.[comment]. Cancer Biology & Therapy 6(5): 802-4, May 2007.

2006

J.Bertout and A.Thomas-Tikhonenko: Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer. Cancer Treatment & Res 130: 167-97, 2006.

D.Cozma and A.Thomas-Tikhonenko: Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia. Cancer Biol & Ther 5(6): 579-81, Jun 2006.

2004

A.Thomas-Tikhonenko and M.L.Iruela-Arispe: Whence thrombospondin? Cancer Biol & Ther 3(4): 406-7, Apr 2004.

2003

A.Thomas-Tikhonenko and C.A.Hunter: Infection and cancer: the common vein. Cytokine & Growth Factor Rev 14(1): 67-77, Feb 2003.

1987

A.T.Tikhonenko and A.V.Gudkov: [Endogenous proretroviruses and other autonomous retroposons: traces of viral origin or decay?][Russian] Mol Gen Mikrobiol Virusol(7), 3-11, Jul 1987.

A.T.Tikhonenko and A.V.Gudkov: [Endogenous proretroviruses and other autonomous retroposons: traces of viral origin or decay?][Russian] Mol Gen Mikrobiol Virusol(7), 3-11, Jul 1987.

Editorial and Academic Positions

Editorial positions

2013-present, BMC Biology Direct, Editorial Board Member
2012-present, American Journal of Cancer Research, Senior Editorial Board Member
2011-present, Frontiers in Non-Coding RNA, Editorial Board Member
2010-present, Journal of Clinical Investigation, Associate Editor
2009-2012, Hem-Onc, Editorial Board Member
2007-present, Cancer Microenvironment, Editorial Board Member
2001-present, Cancer Biology & Therapy, Editorial Board Member / Receiving Editor

Academic and institutional committees

2013-present, Member, Department of Pathology & Laboratory Medicine Academic Appointments and Promotions Committee (AAPC)
2012-present, Swiss National Science Foundation, Grant Reviewer
2012-present, Member, Sarcoma Researcher Search Committee, Abramson Family Cancer Research Institute - Center for Childhood Cancer Research
2012-2013, NCI Special Emphasis Panels: Omnibus R03/R21, Grant Reviewer
2012, NCI Special Emphasis Panel: Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01), Grant Reviewer

Leadership

International

2010-present, International CCN Society
2007-present, International Cancer Microenvironment Society

National

2008-present, American Society of Hematology
2006-2011, Tumor Progression and Metastasis Study Section, NIH
1999-present, American Association for Cancer Research

  • 2013, Annual Meeting Program Committee
  • 2012-2013, Scientific Review Committee
  • 2012-2013, AACR-Aflac, Inc. Career Development Award for Pediatric Cancer Research
  • 2009-2010, Tellers Committee

Original Papers

2013

J.L.Fox, M.Dews, A.J.Minn, A.Thomas-Tikhonenko: Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma. RNA 19(2): 177-190, Feb 2013. Read the abstract

2012

E.Y.Chung, J.N.Psathas, D.Yu, Y.Li, M.J.Weiss, and A.Thomas-Tikhonenko: CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest 122(6): 2257-2266, June 2012. Read the abstract

Posters and Presentations

2013

J.N.Psathas, J.Schug, and A.Thomas-Tikhonenko : A novel oncogenic feed-forward loop: the Myc-mir-17~92 axis stimulates the B-cell receptor response and its own expression via inhibition of ITIM proteins. Keystone Symposia - Noncoding RNAs in Development and Cancer (A7); 2013 Jan 20-25, Vancouver, BC.

J.L.Fox, M.Dews, A.J.Minn, and A.Thomas-Tikhonenko: Targeting of TGFβ signature and its essential component CTGF/CCN2 by miR-18 correlates with improved survival in glioblastoma. Keystone Symposia - Noncoding RNAs in Development and Cancer (A7); 2013 Jan 20-25, Vancouver, BC.

E.Sotillo-Piñeiro and A.Thomas-Tikhonenko: Transient up-regulation of Myc in B-cell lymphomas enhances p53-independent apoptotic responses to chemotherapy. American Association for Cancer Research Annual Meeting; 2013 Apr 6-10, Washington, DC.

2012

E.Sotillo-Piñeiro, L.Xu, L.Nguyen, T.Laver, E.Attiyeh, K.Cole, S.Diskin, J.Maris, and A.Thomas-Tikhonenko: 3'UTR polymorphisms affect expression and activity of IGF1R, a therapeutic target in pediatric neuroblastoma. American Association for Cancer Research Annual Meeting; 2012 Mar 31-Apr 4, Chicago, IL.

E.Sotillo-Piñeiro, L.Xu, L.Nguyen, T.Laver, E.Attiyeh, K.Cole, S.Diskin, J.Maris, and A.Thomas-Tikhonenko: 3'UTR polymorphisms affect expression and activity of IGF1R, a therapeutic target in pediatric neuroblastoma. American Association for Cancer Research Annual Meeting; 2012 Mar 31-Apr 4, Chicago, IL.

2011

P.Sundaram, S.Hultine, L.Smith, D.Biyashev, J.M.Schelter, M.A.Cleary, O.Volpert, and A.Thomas-Tikhonenko: miR-194 counterbalances transcriptional activation of the anti-angiogenic factor thrombospondin-1 by p53. American Association for Cancer Research Annual Meeting; 2011 Apr 2-6, Orlando, FL.

J.N.Psathas, J.Schug, and A.Thomas-Tikhonenko : The microRNA component of MYC-induced B-lymphomagenesis. Keystone Symposia - MicroRNAs and Non-Coding RNAs and Cancer; 2011 Feb 2-6, Banff, Alberta Canada.

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